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1. 发明公开

EP4286360A3 NEW BED MATERIAL FOR THERMOLYTIC FRAGMENTATION OF SUGARS 审中-实审
公开(公告)号：EP4286360A3
公开(公告)日：2024-03-13
申请号：EP23203502.2
申请日：2020-08-13
申请人： Topsoe A/S
发明人： OSMUNDSEN, Christian, Mårup , TAARNING, Esben , LARSEN, Morten Boberg
IPC分类号： C07C45/60 , C07C47/19 , C07C47/04 , C07C47/27 , C07C49/17 , C07C49/185
摘要： The present invention relates to a process for thermolytic fragmentation of a sugar into a composition comprising C 1 -C 3 oxygenates. In particular, it relates to the use of heat carrying particles providing improved yields of C 1 -C 3 oxygenates and improved fluidization characteristics making it suitable for industrial scale production of e.g. glycolaldehyde. It also regards a circulating fluidized bed system comprising the heat carrying particles.

2. 发明公开

EP3571274A1 COMPOSITION HAVING A MUGUET ODOR 有权转让
公开(公告)号：EP3571274A1
公开(公告)日：2019-11-27
申请号：EP18702932.7
申请日：2018-01-17
申请人： Firmenich SA
发明人： SAUDAN, Lionel , SANTORO, Francesco , WALTHER, Eric
IPC分类号： C11B9/00 , C07C45/50 , C07C33/30 , C07C47/27

3. 发明公开

EP3571273A1 COMPOSITION HAVING A MUGUET ODOR 有权转让
公开(公告)号：EP3571273A1
公开(公告)日：2019-11-27
申请号：EP18702931.9
申请日：2018-01-17
申请人： Firmenich SA
发明人： WALTHER, Eric , COULOMB, Julien
IPC分类号： C11B9/00 , C07C45/45 , C07C47/27
摘要： The present invention relates to a composition of matter comprising a) at least one compound of formula (I) in the form of any one of its isomers or a mixture thereof; wherein R1 represents a hydrogen atom or a C1-2 alkyl group; R2 represents a hydrogen atom or a methyl group; and R represents a group of formula –[CH2]nC(Me)2OH, wherein n is 1 or 2; said R being, relative to position 1, an ortho, meta or para substituent of the aromatic ring; and b) at least one compound of formula (II) in the form of any one of its isomers or a mixture thereof; wherein R1, R2 and R have the same meaning as defined in formula (I); said R being, relative to position 1, an ortho, meta or para substituent of the aromatic ring; their uses as perfuming ingredients as well as the composition and consumer product including such a composition of matter and the process to prepare it.

4. 发明授权

EP3322786B1 COMPOUND HAVING A MUGUET ODOR 有权转让
公开(公告)号：EP3322786B1
公开(公告)日：2019-04-24
申请号：EP16735896.9
申请日：2016-07-07
申请人： Firmenich SA
发明人： COULOMB, Julien
IPC分类号： C11B9/00 , A61Q13/00 , C07C47/27 , C11D3/50

5. 发明授权

EP0906091B1 AMIDINOHYDRAZONES AS PROTEASE INHIBITORS 失效
标题翻译：脒基蛋白酶抑制剂
公开(公告)号：EP0906091B1
公开(公告)日：2006-10-04
申请号：EP97919990.8
申请日：1997-03-27
申请人： Ortho-McNeil Pharmaceutical, Inc.
发明人： SOLL, Richard, M. , LU, Tianbao , FEDDE, Cynthia, L. , TOMCZUK, Bruce, E. , ILLIG, Carl
IPC分类号： A61K31/18 , A61K31/24 , A61K31/40 , A61K31/41 , A61K31/44 , A61K31/47 , A61K31/155 , A61K31/275 , C07C47/24 , C07C47/27 , C07C47/228 , C07C317/40 , C07D215/36 , C07C231/18
CPC分类号： C07D285/14 , C07C45/29 , C07C45/71 , C07C47/277 , C07C281/18 , C07C309/73 , C07C309/74 , C07C309/75 , C07C309/77 , C07C311/21 , C07C323/66 , C07C2601/02 , C07D213/71 , C07D215/36 , C07D217/02 , C07D231/18 , C07D233/52 , C07D317/40 , C07D333/34 , C07C47/575
摘要： Amidino and benzamidino compounds, including compounds of formula (I), wherein R?1-R4, R6-R9¿, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of formula (I).

6. 发明公开

EP1638912A2 PROCESS FOR THE PREPARATION OF CINNAMALDEHYDE COMPOUNDS 审中-公开
标题翻译：制备肉桂醛化合物的方法
公开(公告)号：EP1638912A2
公开(公告)日：2006-03-29
申请号：EP04737208.1
申请日：2004-06-29
申请人： Lymphosign Inc.
发明人： RUHA, Olivier , OSWALD, Thomas
IPC分类号： C07C45/45 , C07C253/30 , C07C47/27 , C07C255/41 , C07C255/42
CPC分类号： C07C253/30 , C07C45/59 , C07C45/673 , C07C47/27 , C07D317/50 , C07F9/4015 , C07C255/41
摘要： A process for the preparation of cinnamaldehyde, a,ß-unsaturated cyanoester, and cyanoamide compounds using a Heck reaction is described. Methods for further elaboration of these aldehydes are also provided.
摘要翻译：描述了使用Heck反应制备肉桂醛，α，β-不饱和氰酯和氰基酰胺化合物的方法。还提供了进一步阐述这些醛的方法。

8. 发明公开

EP0142323A2 Process for making erythro-dihydroxyalkenoic acide derivatives 有权
标题翻译： Verfahren zur Herstellung von erythro-Bishydroxyalkensaüre-Derivaten。
公开(公告)号：EP0142323A2
公开(公告)日：1985-05-22
申请号：EP84307659.7
申请日：1984-11-06
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC
发明人： Harris, Gregory David
IPC分类号： C07D319/06 , C07D319/08 , C07D307/20 , C07D307/32 , C07C59/48 , C07C311/02 , C07C47/27
CPC分类号： C07D307/33 , C07C59/64 , C07D307/20 , C07D319/08
摘要： The invention provides a novel process for making novel (4-phenyl-1,3-dioxan-cis-5-yllalkenoic acids of the formula I in which Ra and Rb are independently hydrogen, alkenyl, alkyl, halogenoalkyl, pentafluorophenyl, aryl or aryl-(1-4C)alkyl; or Ra and Rb together are polymethylene; Rc is hydroxy or (1-6C)alkanesulphonamido, A is vinylene, n is 1, Y is polymethylene, and benzene ring B bears various optional substituents. The process involves the reaction of an aldehyde of formula II with an ylid to give an erythro-diol of formula 111 which is then cyclised to the required dioxane derivative of formula I. The invention also provides a novel process for making the aldehydes of formula II from the corresponding lactols of formula IIa, which are themselves obtained with the correct trans-stereochemistry by two selective reductions of a trans-phenylparaconic acid of formula V. The compounds of formula I are useful as therapeutic agents.
摘要翻译：本发明提供了制备式I的新型（4-苯基-1,3-二恶烷 - 顺式-5-基）链烯酸的新方法，其中Ra和Rb独立地是氢，烯基，烷基，卤代烷基，五氟苯基，芳基或芳基 - （1-4C）烷基; 或Ra和Rb一起是聚亚甲基; Rc是羟基或（1-6C）烷基磺酰氨基，A是亚乙烯基，n是1，Y是多亚甲基，苯环B具有各种任选的取代基。该方法涉及式II醛与内鎓盐的反应，得到式III的赤式二醇，然后将其分解成所需的式I的二烷衍生物。本发明还提供了制备式II的醛的新方法来自相应的式IIa的乳糖，其本身通过两种选择性还原式V的反式苯基正康酸以正确的反式立体化学方法获得。式I化合物可用作治疗剂。

9. 发明授权

EP0033156B1 1-Phenyl-2-cyclohexen-1-alkylamin-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel 有权
标题翻译： 1-苯基-2-环己基-1-烷基胺衍生物及其制备方法及含有它们的药物
公开(公告)号：EP0033156B1
公开(公告)日：1984-10-17
申请号：EP81100576.8
申请日：1981-01-27
申请人： F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft
发明人： Bruderer, Hans, Dr. , Fischli, Albert Eduard, Prof. Dr. , Pfister, Rudolf, Dr.
IPC分类号： C07C91/30 , C07C93/14 , C07C103/38 , C07C103/737 , C07C125/065 , C07C43/225 , C07D209/12 , C07C47/27 , A61K31/135
CPC分类号： C07D209/12

10. 发明授权

EP4013737B1 NEW BED MATERIAL FOR THERMOLYTIC FRAGMENTATION OF SUGARS 有权转让
公开(公告)号：EP4013737B1
公开(公告)日：2024-08-07
申请号：EP20757287.6
申请日：2020-08-13
IPC分类号： C07C45/60 , C07C47/19 , C07C47/04 , C07C47/27 , C07C49/17 , C07C49/185
CPC分类号： C07C45/60

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