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1. 发明公开

EP4051252A1 CRYSTALLINE SOLIDS OF 3-PALMITOYL-AMIDO-1,2-PROPANEDIOL AND 3-PALMITOYL-AMIDO-2-HYDROXY-1-DIMETHOXYTRIPHENYLMETHYLETHER-PROPANE AND METHODS OF MAKING AND USING THE SAME 审中-实审
公开(公告)号：EP4051252A1
公开(公告)日：2022-09-07
申请号：EP20883255.0
申请日：2020-10-23
申请人： GERON CORPORATION
发明人： ALBANEZE-WALKER, Jennifer E.
IPC分类号： A61K31/164 , C07C233/16 , C07C233/18

2. 发明公开

EP3917509A1 TRANS-4-HYDROXYCYCLOHEXYL PHENYL AMIDE MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：EP3917509A1
公开(公告)日：2021-12-08
申请号：EP20748001.3
申请日：2020-01-23
申请人： Mitochondria Emotion, Inc.
发明人： DORN, II, MD, Gerald W.
IPC分类号： A61K31/165 , C07C233/16 , C07C233/22 , A61P25/00

4. 发明公开

EP2108036A4 PROCESS FOR THE PRODUCTION OF ALKANOLAMIDE 无效
标题翻译：用于生产链烷醇酰胺
公开(公告)号：EP2108036A4
公开(公告)日：2010-09-15
申请号：EP07861678
申请日：2007-11-02
申请人： CRODA UNIQEMA INC
发明人： CHEN XIN , PROKOP HOWARD W , COLMERY STEPHEN HOWARD
IPC分类号： C10M129/00 , C07C233/16 , C10L1/22 , C10M105/08 , C10M133/20 , C11D1/66
CPC分类号： C07C231/02 , C10L1/224 , C10M133/16 , C10M2215/08 , C07C233/18

5. 发明授权

EP0904400B1 ENZYMATIC PROCESS FOR STEREOSELECTIVE PREPARATION OF THERAPEUTIC AMIDES 失效
标题翻译：酶法对于治疗酰胺的STEREO选择性地生产
公开(公告)号：EP0904400B1
公开(公告)日：2005-03-16
申请号：EP97915612.2
申请日：1997-04-07
申请人： AstraZeneca AB
发明人： CROSBY, John , HOLT, Robert, Antony, Zeneca Bio Products , PITTAM, John, David
IPC分类号： C12P41/00 , C12P13/02 , C12P7/42 , C12P13/00 , C12P7/40 , C07C255/11 , C07C255/14 , C07C233/16 , C07C69/675
CPC分类号： C12P13/00 , C07C255/11 , C07C255/14 , C12P7/40 , C12P7/42 , C12P13/02 , C12P41/004 , C12P41/005
摘要： The present invention provides enzymatic processes for preparing optically active compounds of Formula (I) wherein X, E and * have the meanings defined in the specification. The invention also provides chiral intermediates useful for preparing compound of Formula (I) and enzymatic processes for preparing such chiral intermediates.

6. 发明授权

EP0318551B1 POLYMERS, AND THEIR USE AS GELS FOR ELECTROPHORESIS 有权
标题翻译：聚合物，以及它们作为电泳的凝胶
公开(公告)号：EP0318551B1
公开(公告)日：1993-05-12
申请号：EP88905199.1
申请日：1988-06-10
申请人： Kozulic, Branko, Dr. , MOSBACH, Klaus, Prof. Dr.
发明人： Kozulic, Branko, Dr. , MOSBACH, Klaus, Prof. Dr.
IPC分类号： C07K3/14 , G01N27/26 , C07C233/16 , C08F220/58
CPC分类号： C08F220/58 , G01N27/44747 , Y10S524/916
摘要： A novel synthesis of N-acryloyl-tris-(hydroxymethyl)aminomethane (NAT) is described. The polymerization kinetics and transparency of the poly(NAT) gels crosslinked by a crosslinker (CL) e.g. N,N'-methylenebisacrylamide (Bis), i.e. poly(NAT + Bis) polymer, are shown. Poly(NAT + Bis) gradient (4-24 %) gels were prepared and found to resolve native proteins according to their size. The exclusion limit of these gels is over 3 x 106 Da. This is more than threefold higher than the exclusion limit of the polyacrylamide gradient gel of the same concentration. Therefore poly(NAT + CL) gels are better than polyacrylamide gels for the resolution of large proteins. It was demonstrated that poly(NAT + CL)-polyacrylamide composite gels could be prepared. The poly(NAT + CL) gels were found to be advantageous also for isoelectric focussing in carrier ampholytes or immobilized pH gradients. Poly(NAT + CL) gels are also very good for separation of nucleic acids. The resolution is particularly good in the range between several hundred to 4-5000 base pairs. Under the optimized conditions, DNA molecules of more than 20 kbases can be perfectly resolved.

7. 发明授权

EP0373092B1 Powdered imidazoline product and method for producing same 失效
标题翻译：粉状咪唑啉产品及其生产方法
公开(公告)号：EP0373092B1
公开(公告)日：1992-11-25
申请号：EP89630139.7
申请日：1989-08-24
申请人： SHEREX CHEMICAL COMPANY, INC.
发明人： Hughes, Leonard , Fuller, James G. , Earl, Gary W.
IPC分类号： C07C233/16
CPC分类号： C07D233/16

8. 发明授权

EP0221677B1 p-Aminophenols, derivatives thereof and use for manufacture of a medicament 失效
标题翻译： P-氨基苯酚，其衍生物和用于制造药物的用途
公开(公告)号：EP0221677B1
公开(公告)日：1992-09-09
申请号：EP86307616.2
申请日：1986-10-02
申请人： E.R. Squibb & Sons, Inc.
发明人： Misra, Raj N.
IPC分类号： C07C215/74 , C07C217/78 , C07C219/34 , C07C323/15 , C07C233/16 , C07C229/68 , C07D215/16 , A61K31/135 , A61K31/16 , A61K31/19
CPC分类号： C07D215/12 , C07D215/38 , Y10S514/826 , Y10S514/863

9. 发明公开

EP0373591A3 Polyhydroxybenzyloxypropanolamines 失效
公开(公告)号：EP0373591A3
公开(公告)日：1991-03-20
申请号：EP89122921.3
申请日：1989-12-12
申请人： THE DU PONT MERCK PHARMACEUTICAL COMPANY
发明人： Patil, Ghanshyam , Matier, William L. , Mai, Khuong H.X.
IPC分类号： C07C217/28 , A61K31/135 , C07C233/16 , A61K31/16 , C07C233/62 , C07C233/78
CPC分类号： C07C233/62 , C07C217/28 , C07C233/18 , C07C233/78
摘要： Compounds of the present invention, are represented by the general formula
wherein R₁ group which may be alkyl of from 1 to about 6 carbon atoms, alkenyl of from 2 to about 6 carbon atoms, alkynyl of from 2 to about 10 carbon atoms, alkoxy wherein the alkyl group contains from 1 to about 6 carbon atoms, halogen, acetamido, amino, nitro, alkylamino of from 1 to about 6 carbon atoms, hydroxy, hydroxyalkyl of from 1 to about 6 carbon atoms, cyano or arylalkoxy wherein the alkyl group contains from 1 to about 6 carbon atoms R₂, R₃ and R₄ are hydrogen or hydroxyl groups or the combination of either hydrogen or hydroxyl groups; W represents alkylene of from 1 to about 10 carbon atoms; and B represents -NHCOR₅, -NHCONR₅R₆, or -NHCOOR₅ wherein R₅ and R₆ may be the same or different and represent hydrogen, alkyl of from 1 to about 6 carbon atoms, alkoxyalkyl wherein the alkyl groups may be the same or different and contain from 1 to about 6 carbon atoms, cycloalkyl of from 3 to about 8 carbon atoms, alkenyl of from 2 to about 6 carbon atoms, alkynyl of from 2 to about 6 carbon atoms, phenyl which may be unsubstituted or substituted with alkyl of 1 to 6 carbon atoms; furanyl, thiophenyl, imidazole, oxazole or indole, aralkyl wherein the alkyl group contains from 1 to about 6 carbon atoms and the aryl group represents phenyl unsubstituted or substituted with alkyl of from 1 to about 6 carbon atoms, or R₅ and R₆ may together with N form a pyrrolidine, piperidine, piperazine, morpholine or thiomorpholine ring and except that R₅ is not hydrogen when B is -NHCOOR₅; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment or prophylaxis of cardiac disorders or in the treatment of glaucoma.
摘要翻译：本发明化合物由下列通式表示：其中R 1基团可以是1至约6个碳原子的烷基，2至约6个碳原子的链烯基，2至约10个碳原子的炔基，烷基含有1至约6个碳原子的卤素，乙酰氨基，氨基，硝基，1至约6个碳原子的烷基氨基，羟基，1至约6个碳原子的羟基烷基，氰基或芳基烷氧基，其中烷基含有 1至约6个碳原子，R 2，R 3和R 4是氢或羟基或氢或羟基的组合; W表示1至约10个碳原子的亚烷基; 和B代表-NHCOR 5，-NHCONR 5 R 6或-NHCOOR 5，其中R 5和R 6可以相同或不同，代表氢，1至约6个碳原子的烷基，烷氧基烷基，其中烷基可以相同或不同，并且含有 1至约6个碳原子的环烷基，3至约8个碳原子的环烷基，2至约6个碳原子的烯基，2至约6个碳原子的炔基，可以未被取代或被1至6个碳原子; 呋喃基，噻吩基，咪唑，恶唑或吲哚，其中烷基含有1至约6个碳原子的芳烷基和芳基表示未被取代或被1至约6个碳原子的烷基取代的苯基，或者R 5和R 6可以与 N形成吡咯烷，哌啶，哌嗪，吗啉或硫代吗啉环，并且当B是-NHCOOR 5时R 5不是氢; 或其药学上可接受的盐。该化合物可用于治疗或预防心脏疾病或治疗青光眼。

10. 发明公开

EP0221677A3 p-Aminophenols, derivatives thereof and use for manufacture of a medicament 失效
标题翻译： P-氨基苯酚，其衍生物及其使用方法
公开(公告)号：EP0221677A3
公开(公告)日：1989-01-25
申请号：EP86307616.2
申请日：1986-10-02
申请人： E.R. Squibb & Sons, Inc.
发明人： Misra, Raj N.
IPC分类号： C07C215/74 , C07C217/78 , C07C219/34 , C07C323/15 , C07C233/16 , C07C229/68 , C07D215/16 , A61K31/135 , A61K31/16 , A61K31/19
CPC分类号： C07D215/12 , C07D215/38 , Y10S514/826 , Y10S514/863
摘要： p-Aminophenols are provided having the structure
wherein m is 0 to 5; X is CH or N; R 1 and R 2 maybe the same or different and are H, lower alkyl, aryl, hydroxy, hydroxyalkyleneoxy, alkylthio, alkoxy, alkanoyloxy, aryloxy, halo, carboxy, alkoxycarbonyl or amido; R 3 is H, lower alkyl, alkanoyl or aroyl; and R" is H, lower alkyl or alkanoyl, and including acid-addition salts thereof, with the proviso that when X is CH, m is 0 and R 1 is H, and when R 4 is H, R 2 is other than alkoxy, H or hydroxy, and when R 4 is benzoyl, R 2 is other than H. These compounds together with the compounds defined in the above proviso are useful as inhibitors of leukotriene production and as such are useful as antiallergy, anti-inflammatory and anti-psoriatic agents.

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