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1. 发明公开

EP0264795A3 Aminosäurederivate 失效
标题翻译：氨基酸衍生物
公开(公告)号：EP0264795A3
公开(公告)日：1990-03-28
申请号：EP87114975.3
申请日：1987-10-13
申请人： MERCK PATENT GmbH
发明人： Raddatz, Peter, Dr. , Schmitges, Claus J., Dr. , Minck, Klaus Otto, Dr.
IPC分类号： C07K5/06 , A61K37/02 , C07C127/17 , A61K31/17 , C07D233/64
CPC分类号： C07D233/64 , A61K38/00 , C07K5/0227 , C07K5/06078
摘要： Neue Aminosäurederivate der Formel I
X-Z-NR²-CHR³-CHOH-(CH₂) n -NR⁴-E-Y I
worin
X, Z, R², R³, R⁴, E, Y und n die in Patentanspruch 1 angegebene Bedeutung haben,
sowie ihre Salze hemmen die Aktivität des menschlichen Plasmarenins.
摘要翻译：其中X，Z，R 2，R 3，R 4，E，Y和n具有权利要求1所述的含义的式Ⅰ“IMAGE”的氨基酸衍生物，其盐抑制人血浆肾素活性。

2. 发明公开

EP0286242A2 Ethanolamine derivates, processes for their preparation and pharmaceutical compositions containing them 失效
标题翻译：乙醇胺衍生物，它们的制备方法和含有它们的化合物的药物组合物。
公开(公告)号：EP0286242A2
公开(公告)日：1988-10-12
申请号：EP88302151.1
申请日：1988-03-11
申请人： GLAXO GROUP LIMITED
发明人： Skidmore, Ian Frederick , Finch, Harry , Mitchell, William Leonard , Naylor, Alan , Lunts, Lawrence Henry , Hartley, David
IPC分类号： C07C93/08 , C07C149/32 , C07C143/75 , C07C127/17 , C07C103/76 , C07D213/65 , C07D215/52 , A61K31/10 , A61K31/135 , A61K31/165
CPC分类号： C07D213/30 , C07D213/32 , C07D213/63
摘要： This invention relates to compounds of the general formula (I)
and physiologically acceptable salts and solvates thereof where Ar represents
where

R 3 is a bond or a straight or branched C 1 2 alkylene group,
R 4 is a hydroxy group or a group R 5 NH-where
R 5 represents a group CH 3 SO 2 -, HCO-or NH 2 CO-,

where R 6 is a chlorine atom or the group F 3 C-,

k represents an integer from 1 to 8,
m represents zero or an integer from 2 to 7 and
n represents an integer from 2 to 7 with the proviso that the sum total of k. m and n is 4 to 12;
R 1 and R 2 each represents a hydrogen atom or a methyl or ethyl group with the proviso that the sum total of carbon atoms in R 1 and R 2 is not more than 2;
R 30 represents hydrogen or C 12 alkyl;
X represents an oxygen or sulphur atom: and
Y and Q may each represent a bond or an oxygen or sulphur atom with the provisos that at least one of Y and Q represents an oxygen or sulphur atom and when Y is a bond m is zero, or when Y represents an oxygen or sulphur atom m is an integer from 2 to 7:
P represents a phenyl group otionally substituted by one or more substituents selected from halogen atoms, or the groups C 1 3 alkyl, C 1 3 alkoxy, hydroxy, -CH 2 OH-, -(CH 2 ) 2 OH, -CO 2 H. -CO 2 CH 3 , ·CO 2 (CH 2 )- 2 CH 3 , -R 7 , COR 7 , -NHCOR s and ·NR 9 SO 2 R 10 ; where
R 7 represents an amino, aminoC 1 3 alkyl, aminoC, 3 dialkyl, pyrrolidino. piperidino. hexamethyleneimino, piperazino, N-methylpiperazino or morpholino group;
R 8 represents a hydrogen atom or a C, 4 alkyl, C, 4 alkoxy, phenyl or amino group;
R 9 represents a hydrogen atom or a methyl group;
R 10 represents a methyl, phenyl, amino or dimethylamino group;

or P represents a pyridyl group optionally substituted by one or two substitutents selected from halogen atoms or hydroxy, C, 3 alkyl and C 1 3 alkoxy groups.
The compounds have a stimulant action at β 2 -adrenoreceptors and are useful, in particular, in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.
摘要翻译：本发明涉及通式（I）生理学上可接受的盐的化合物和和它们的溶剂合物，其中Ar darstellt 其中R <3>是一个键或直链或支链的C 1-2亚烷基团，R <4> 为羟基或基团R <5> NH，其中R <5> darstellt的基团CH 3 SO 2，HCO或NH 2 CO--，其中R <6>是氯原子或基团F3C ，ķdarstellt在整数从1到8，M darstellt为零或整数2至在整数7和n darstellt从2至7，条件的总和K，M没有和n是4到12; [R <1>和R <2>每一个darstellt氢原子或甲基或乙基，条件的总和中的R的碳原子的那样<1>和R <2>不大于2; [R <3> <0> darstellt氢或C1-2烷基; X darstellt到氧或硫原子; 和Y和Q可以各自代表一个键或氧或硫原子，条件没有氧或硫原子的Y和Q darstellt中的至少一个，并且当Y是键，m是零，或当氧或硫Y的darstellt 原子，m为2至7的整数; P表示被选自卤素原子中的一种或多种取代基，或基团C 1-3烷基，C 1-3烷氧基，羟基，-CH2OH-，otionally取代的苯基 - （CH 2）2 OH，-CO 2 H，-CO 2 CH 3，-CO 2（CH 2 ）2 CH 3，-R <7>，COR <7>，-NHCOR <8>和-NR <9> SO 2 <1> <0>; 其中R <7> darstellt氨基的，aminoC1-3alkyl，aminoC1-3dialkyl，吡咯烷基，哌啶子基，六亚甲基亚，哌嗪子基，N-甲基哌嗪基或吗啉代基团; [R <8>表示一个氢原子或一个C 1-4烷基，C 1-4烷氧基，苯基或氨基; [R <9>代表氢原子或甲基; [R <1> <0>表示一个甲基，苯基，氨基或二甲基氨基; 或P被选自卤素原子或羟基，C 1-3烷基C 1-3烷氧基和基团的一个或两个取代基darstellt吡啶基，任选substituiertem。所述化合物具有在β-2肾上腺素能受体兴奋剂作用和是有用的，特别是，在与可逆气道阻塞相关的疾病的治疗：如哮喘和慢性支气管炎。

3. 发明公开

EP0264795A2 Aminosäurederivate 失效
标题翻译： Aminosäurederivate。
公开(公告)号：EP0264795A2
公开(公告)日：1988-04-27
申请号：EP87114975.3
申请日：1987-10-13
申请人： MERCK PATENT GmbH
发明人： Raddatz, Peter, Dr. , Schmitges, Claus J., Dr. , Minck, Klaus Otto, Dr.
IPC分类号： C07K5/06 , A61K37/02 , C07C127/17 , A61K31/17 , C07D233/64
CPC分类号： C07D233/64 , A61K38/00 , C07K5/0227 , C07K5/06078
摘要： Neue Aminosäurederivate der Formel I
X-Z-NR²-CHR³-CHOH-(CH₂) n -NR⁴-E-Y I
worin
X, Z, R², R³, R⁴, E, Y und n die in Patentanspruch 1 angegebene Bedeutung haben,
sowie ihre Salze hemmen die Aktivität des menschlichen Plasmarenins.
摘要翻译：其中X，Z，R 2，R 3，R 4，E，Y和n具有权利要求1所述的含义的式Ⅰ“IMAGE”的氨基酸衍生物，其盐抑制人血浆肾素活性。

4. 发明授权

EP0107948B1 Leather with fluorochemical finish 有权
标题翻译：皮革与荧光化妆
公开(公告)号：EP0107948B1
公开(公告)日：1987-03-25
申请号：EP83306286.2
申请日：1983-10-17
申请人： MINNESOTA MINING AND MANUFACTURING COMPANY
发明人： Patel, Kalyanji U. Minnesota Mining and Manf.Com.
IPC分类号： C14C9/00 , C07C143/822 , C07C125/065 , C07C125/067 , C07C125/073 , C07C125/075 , C07C127/15 , C07C127/17 , C07C127/19 , C07C143/68
CPC分类号： C14C9/00

5. 发明公开

EP0097273A1 Benzylharnstoff-Derivate, Verfahren zu ihrer Herstellung und Fungizide für Landwirtschaft und Gartenbau 有权
标题翻译：苄脲衍生物，它们的制备方法和杀菌剂用于农业和园艺。
公开(公告)号：EP0097273A1
公开(公告)日：1984-01-04
申请号：EP83105537.1
申请日：1983-06-06
申请人： NIHON TOKUSHU NOYAKU SEIZO K.K.
发明人： Yamada, Yasuo , Saito, Junichi , Tamura, Tatsuo , Sakawa, Shinji
IPC分类号： C07C127/17 , C07C127/19 , C07C157/07 , C07C157/09 , A01N47/32
CPC分类号： A01N47/32
摘要： Die vorliegende Erfindung betrifft neue Benzylharnstoff-Derivate der allgemeinen Formel (I)
in der

R 1 , R 2 und X die in der Beschreibung gegebene Bedeutung haben.

Sie könnnen nach bekannten Verfahren z.B. aus Aminen und Isocyanaten hergestellt werden.
Die neuen Verbindungen der Formel (I) zeichnen sich durch eine hohe Wirksamkeit, besonders eine fungizide Wirksamkeit, aus.
摘要翻译：本发明涉及通式（I）的新颖苄脲衍生物，其中R 1，R 2和X具有说明书中给出的含义。用户可以根据例如已知的方法安装由胺和异氰酸酯制备。式（I）的新化合物是由高功效区分，特别是杀真菌活性，从。

6. 发明公开

EP0219350A3 Ethanolamine compounds 失效
标题翻译：乙醇胺化合物乙醇胺化合物
公开(公告)号：EP0219350A3
公开(公告)日：1988-06-08
申请号：EP86307976
申请日：1986-10-15
申请人： GLAXO GROUP LIMITED
发明人： Finch, Harry , Lunts, Lawrence Henry Charles , Naylor, Alan , Skidmore, Ian Frederick
IPC分类号： C07C93/08 , C07C93/10 , A61K31/135 , C07D213/18 , C07C93/14 , C07C103/76 , C07C103/38 , C07C125/065 , C07C127/17 , C07C143/75 , C07D295/08
CPC分类号： A61K31/135
摘要： The invention provides compounds of the general formula
wherein
Ar represents a phenyl group optionally substituted by one or more substituents selected from halogen atoms, or the groups C 1-6 alkyl, nitro, -(CH 2 )qR, [where R is hydroxy, C 1-6 alkoxy. -NR 3 R 4 each represents a hydrogen atom, or a C 1-4 alkyl group. or -NR 3 R 4 forms a saturated heterocyclic amino group which has 5-7 ring members and optionally contains in the ring one or more atoms selected from -O- or -S- or a group -NH- or -N(CH 3 )-), -NR 5 COR 6 (where R 5 represents a hydrogen atom or a C 1-4 alkyl group, and R 6 represents a hydrogen atom or a C I - 4 alkyl, C I - 4 alkoxy, phenyl or -NR 3 R 4 group), -NR 5 SO 2 R (where R 7 represents a C 1-4 alkyl, phenyl or -NR 3 R 4 group), -COR 8 (where R 8 represents hydroxy, C 1-4 alkoxy or -NR 3 R 4 , -SR9 (where R 9 is a hydrogen atom, or a C 1-4 alkyl or phenyl group), -SOR 9 , -S0 2 R 9 , or -CN, and q represents an integer from 0 to 3], or -O(CH 2 ) t R 11 [where R 11 represents a hydroxy or C 1-4 alkoxy group and t is 2 or 3], or Ar is a phenyl group substituted by an alkylenedioxy group of formula -O(CH 2 )pO-, where p represents 1 or 2; R 1 and R 2 each represent a hydrogen atom or a C I - 3 alkyl group, with the proviso that the sum total of carbon atoms in R 1 and R 2 is not more than 4; R 30 represents a hydrogen atom or a C 1-3 alkyl group; X represents a C 2 - 8 alkylene chain optionally substituted by one or two C 1-3 alkyl groups, or, when one carbon atom is substituted by two methyl groups, they may be linked to form an ethylene group, and Y represents a C 1-7 alkylene chain optionally substituted by one or two C 1-3 alkyl groups, or, when one carbon atom is substituted by two alkyl groups, they may be linked to form an alkylene group; with the proviso that the sum total of carbon atoms in X and Y is 4 to 12; and with the further proviso that at least one of X and Y is substituted by one or two C 1-3 alkyl groups or an alkylene group; Q represents (where R 12 is a straight or branched Ci.3 alkylene group).

(where one or R 13 and R 14 is a hydroxy group and the other is a hydrogen or halogen atom or a hydroxy group).

[where R' 5 is a group R 16 CO-, R 16 NHCO-, R 16 R 17 NS0 2 - or R 18 SO 2 - (where R 16 and R 17 is each a hydrogen atom or a C 1-3 alkyl group and R 18 is a C 1-3 alkyl group) and p is an integer 0 or 1],

(where R 26 and R 27 is each a hydrogen atom or a C 1-3 alkyl group or, when R 26 is a hydrogen atom, R 27 may also be a C 1-4 alkoxycarbonyl group),

(where R 19 is a C I - 3 alkyl group),
and physiologically acceptable salts and solvates (e.g. hydrates) thereof. The compounds have a stimulant action at β2-adrenorecep- tors and may be used in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.

7. 发明公开

EP0203879A3 Functionalized monomers from 1-(1-isocyanato-1-methylethyl)-3 or 4-(1-methylethenyl) benzene 失效
标题翻译： 1-（1-异丙基-1-甲基乙基）-3或4-（1-甲基乙烯基）苯甲酮的官能化单体
公开(公告)号：EP0203879A3
公开(公告)日：1987-10-07
申请号：EP86630092
申请日：1986-05-27
申请人： THE GOODYEAR TIRE & RUBBER COMPANY
发明人： Colvin, Howard Allen , Cottman, Kirkwood Storer , Parker, Dane Kenton
IPC分类号： C07C149/437 , C07C125/067 , C07C125/065 , C07C127/19 , C07C127/17 , C07C155/02 , C07D211/46 , C08F12/26
CPC分类号： C08G18/728 , C07C273/1827 , C07D211/46 , C08F12/26 , C07C275/24 , C07C275/40
摘要： @ This invention is directed to the preparation of polymerizable monomers that are prepared from 1-(1-isocyana- to-1-methylethyl)-3-(1-methylethenyl) benzene (m-TMI) and 1-(1-isocyanato-1-methylethyl)-4-(1-methylethenyl) benzene (p-TMI). The monomers prepared from m- and p-TMI can contain numerous chemical moieties, and when polymerized, produce polymers that have chemically bonded to the polymeric backbone the functional moiety. More specifically, these TMI derived monomers may contain chain breaking antioxidant moieties, peroxide decomposing antioxidant moieties, ultraviolet stabilizing moieties, triplet quenching moieties, and other chemical moieties that are useful in polymers.

8. 发明公开

EP0148401A1 Neue Amine, Verfahren zu deren Herstellung sowie deren Verwendung in radikalisch polymerisierbaren Massen 有权
标题翻译：新胺，其制备方法及其在自由基聚合群众使用。
公开(公告)号：EP0148401A1
公开(公告)日：1985-07-17
申请号：EP84114605.3
申请日：1984-12-01
申请人： BAYER AG
发明人： Winkel, Jens, Dr. , Klein, Gerhard, Dr. , Meier, Helmut-Martin, Dr. , Süling, Carlhans, Dr. , Arlt, Dieter, Prof. Dr.
IPC分类号： C07C125/06 , C07C127/17 , C08K5/18 , C08K5/21 , C08F299/04
CPC分类号： A61K6/083 , C07C275/24 , C08F20/36
摘要： Die Erfindung betrifft neue, ungesättigte Gruppen aufweisende tertiäre aromatische Amine, Verfahren zu deren Herstellung sowie diese Amine als Aktivatoren enthaltende radikalisch polymerisierbare Massen, insbesondere Dentalmassen.
摘要翻译：本发明涉及新的不饱和基团的芳族叔胺，涉及它们的制备方法和胺作为含有自由基聚合性组合物，特别是牙科材料的活化剂。

9. 发明公开

EP0000494A1 Ester von acylierten Aminocarbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung beim Färben von Textilmaterialien 失效
标题翻译：酰化氨基羧酸，它们的制备方法和它们在纺织材料的染色使用的酯。
公开(公告)号：EP0000494A1
公开(公告)日：1979-02-07
申请号：EP78100355.3
申请日：1978-07-11
申请人： BAYER AG
发明人： Walz, Klaus, Dr. , Tamer, Ergun, Dipl.-Ing.
IPC分类号： C07H13/04 , D06P1/642 , D06P1/649 , C11D1/38 , C07C103/46 , C07C103/84 , C07C125/06 , C07C127/15 , C07C127/17 , C07C127/19
CPC分类号： D06P1/649 , C07C275/16 , C07H13/04 , D06P1/48 , D06P1/6427
摘要： Oberflächenaktive Ester von mindestens 3 Hydroxylgruppen enthaltenden aliphatischen Polyolen und Acylaminocarbonsäuren, der Formel
in der R für H; für C,-C.-Alkyl, C 1 -C 22 -Alkoxy, C 3 -C 22 - Alkenoxy, Aryt, Aralkyl, Aroxy Aralkoxy oder für den Rest
steht, R 1 , R. und R, für H, C 1 -C 22 Alkyl, C 3 -C 22 - Alkenyl, Cycloalkyl, Aryl oder Aralkyl stehen, oder R, für einen Rest
zweiwertiger organischer Rest steht.

R 1 für H, COOH, COO C 1 -C 4 -Aikyl oder C 1 -C 4 -Alkyl,
R 3 für C 1 -C 10 -Alkylen und
x für 0 oder 1 stehen, wobei mindestens einer der Reste R, bis R, mindestens 6 Kohlenstoffatome enthält, die Alkyl-, Alkenyl- und cyclischen Resten Substituenten tragen können und die Gesamtkohlenstoffzahl 20-60 beträgt, wenn R, durch den genannten Hamstoffrest substituiert ist, und für alle anderen Fälle 12 - 30 beträgt;

Verfahren zu ihren Herstellung, und ihre Verwendung als Hilfsmittel beim Färben von Textilmaterialien.
摘要翻译：式其中R是H，C1-C4烷基，C1-C22烷氧基，C3-C22链烯氧基，芳基，芳烷基，芳氧基芳烷氧基或至少34含羟基的脂族多元醇与酰基羧酸，Oberflächenakative酯其余是，R1，R4和R5是H，C1-C22烷基，C3-C22链烯基，环烷基，芳基或芳烷基，或R 5为二价有机基团为基团。 R 2为H，COOH，COO C1-C4烷基或C1-C6烷基，R3代表C1-C10亚烷基，x是0或1，其中，通过R5 R1中的至少一个含有至少6个碳原子，烷基，可以携带烯基和环状基团的取代基，和20的总碳原子数 - 是60，当R 5是由所述尿素部分取代，以及用于所有其他情况下是12 - 30; 它们的制备方法，以及它们作为在纺织材料的染色助剂的用途。

10. 发明授权

EP0118564B1 4-AMINO-TETRAHYDRO-2-NAPHTHOIC ACID DERIVATIVES 失效
标题翻译： 4-氨基四氢-2-萘甲酸衍生物
公开(公告)号：EP0118564B1
公开(公告)日：1987-04-22
申请号：EP83902818.0
申请日：1983-08-30
申请人： Yoshitomi Pharmaceutical Industries, Ltd.
发明人： TAHARA, Tetsuya , ARITA, Masafumi , KURODA, Tsuyoshi
IPC分类号： C07C101/38 , C07C103/737 , C07C127/17 , A61K31/195 , A61K31/215
CPC分类号： C07D209/80
摘要： 4-Amino-tetrahydro-2-naphthoic acid derivatives represented by the general formula (I), wherein X represents halogen, n represents 1 or 2, R1 represents hydroxy, lower alkoxy or amino, and R2 represents hydrogen, lower alkanoyl or carbamoyl, and salts thereof. These are useful as hypotensive diuretics.

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