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1. 发明公开

EP3043864A2 METHODS AND SYSTEMS FOR BEAM INTENSITY-MODULATION TO FACILITATE RAPID RADIATION THERAPIES 无效转让
标题翻译：方法和系统的辐射强度调制激活FAST RADIO疗法
公开(公告)号：EP3043864A2
公开(公告)日：2016-07-20
申请号：EP14876485.5
申请日：2014-09-11
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： BHARADWAJ, Vinod , DOLGASHEV, Valery, A. , FAHRIG, Rebecca , LOO, Billy, Wiseman , MAXIM, Peter, G. , TANTAWI, Sami , LIMBORG, Cecile , NICOLAS, Ludovic
IPC分类号： A61N5/10 , H05H1/00
CPC分类号： A61N5/1084 , A61N5/1039 , A61N5/1043 , A61N5/1045 , A61N5/1064 , A61N5/1067 , A61N5/1078 , A61N5/1081 , A61N7/02 , A61N2005/1055 , A61N2005/1058 , A61N2005/1076 , A61N2005/1089 , A61N2005/1091 , A61N2005/1098 , H05H9/048 , H05H2007/048
摘要： Methods and system for facilitating rapid radiation treatments are provided herein and relate in particular to radiation generation and delivery, electron source design, beam control and shaping/intensity-modulation. The methods and systems described herein are particularly advantageous when used with a compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided; or when used with a high-current electron accelerator system of energy range more conventionally used in photon radiation therapy to produce much faster delivery of intensity-modulated photon radiation therapy, that can in both cases deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a equal or better degree of dose conformity or sculpting compared to conventional photon therapy.
摘要翻译：在提供的方法和系统，用于促进快速放射治疗，特别是涉及到放射线生成和传递，电子源设计，光束控制和整形/强度调制。在所描述的方法和系统是特别有利的。当具有结构紧凑的高梯度使用的，非常高的能量的电子（VHEE）加速器和递送系统（和相关过程）能够治疗从以极快的速度多个波束方向的患者，使用的所有电磁或射频偏转转向设置; 或当与能量范围的高电流电子加速器系统在光子放射疗法更常规使用的用于产生强度调制的光子辐射治疗的快得多输送，并能在这两种情况下购买兑现整个剂量或高剂量辐射的分数充分治疗几乎冻结生理运动，但与相同或更好的程度剂量适形性或雕刻的相比于常规光子疗法。

2. 发明公开

EP4391730A3 VOLTAGE REGULATOR CIRCUITS, RADIATION DEVICES AND RADIATION SYSTEMS INCLUDING THE SAME 审中-公开
公开(公告)号：EP4391730A3
公开(公告)日：2024-09-04
申请号：EP23216794.0
申请日：2023-12-14
申请人： Varian Medical Systems Inc
发明人： POEHLMANN-MARTINS, Flavio , SABEV, Ogy , MAIN, William Thompson , CAHILL, Alexander , ALIBAZI BEHBAHANI, Reza , PAI, Raj
IPC分类号： H05H9/00 , H05H7/02 , H05H9/04
CPC分类号： H05H7/02 , H05H9/048
摘要： A radiation system includes a modulator (218) and at least one voltage regulator circuit (30, 302, 402, 602, 1002, 1202, 1402). The modulator (218) is configured to output a voltage for operation of a magnetron (216) and an electron gun (220) of the radiation system. The at least one voltage regulator circuit (30, 302, 402, 602, 1002, 1202, 1402) is electrically connected between the modulator and at least one of the magnetron (216) or the electron gun (220), and configured to control a magnitude of the voltage output from the modulator (218) for operation of the magnetron (216) and the electron gun (220).

3. 发明公开

EP3043864A4 METHODS AND SYSTEMS FOR BEAM INTENSITY-MODULATION TO FACILITATE RAPID RADIATION THERAPIES 无效转让
标题翻译： VERFAHREN UND SYSTEME ZUR STRAHLENINTENSENSITTSMODULATION ZUR AKTIVIERUNG SCHNELLER RADIOTHERAPIEN
公开(公告)号：EP3043864A4
公开(公告)日：2017-07-26
申请号：EP14876485
申请日：2014-09-11
申请人： UNIV LELAND STANFORD JUNIOR
发明人： BHARADWAJ VINOD , DOLGASHEV VALERY A , FAHRIG REBECCA , LOO BILLY WISEMAN , MAXIM PETER G , TANTAWI SAMI , LIMBORG CECILE , NICOLAS LUDOVIC
IPC分类号： A61N5/10 , G21K5/04 , H05H1/00 , H05H7/04 , H05H9/04 , H05H15/00
CPC分类号： A61N5/1084 , A61N5/1039 , A61N5/1043 , A61N5/1045 , A61N5/1064 , A61N5/1067 , A61N5/1078 , A61N5/1081 , A61N7/02 , A61N2005/1055 , A61N2005/1058 , A61N2005/1076 , A61N2005/1089 , A61N2005/1091 , A61N2005/1098 , H05H9/048 , H05H2007/048
摘要： Methods and system for facilitating rapid radiation treatments are provided herein and relate in particular to radiation generation and delivery, electron source design, beam control and shaping/intensity-modulation. The methods and systems described herein are particularly advantageous when used with a compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided; or when used with a high-current electron accelerator system of energy range more conventionally used in photon radiation therapy to produce much faster delivery of intensity-modulated photon radiation therapy, that can in both cases deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a equal or better degree of dose conformity or sculpting compared to conventional photon therapy.
摘要翻译：本文提供了用于促进快速辐射治疗的方法和系统，并且具体涉及辐射产生和输送，电子源设计，束控制和成形/强度调制。本文描述的方法和系统当与紧凑的高梯度，超高能量电子（VHEE）加速器和递送系统（以及相关处理）一起使用时特别有利，其能够使用全电磁波或提供射频偏转转向; 或者当与通常用于光子放射疗法的能量范围的高电流电子加速器系统一起使用以产生更快速的强度调制光子放射治疗的递送时，可以在两种情况下递送全剂量或部分高剂量辐射治疗足以快速冻结生理运动，但与常规光子疗法相比，具有相同或更好的剂量一致性或雕刻程度。

4. 发明公开

EP3043863A1 ARRAYS OF ACCELERATING STRUCTURES AND RAPID IMAGING FOR FACILITATING RAPID RADIATION THERAPIES 有权转让
标题翻译：加速结构安排和快速成像FAST RADIOTHERAPIE
公开(公告)号：EP3043863A1
公开(公告)日：2016-07-20
申请号：EP14844431.8
申请日：2014-09-11
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： FAHRIG, Rebecca , LOO, Billy Wiseman , MAXIM, Peter G. , TANTAWI, Sami
IPC分类号： A61N5/10
CPC分类号： A61N5/1084 , A61N5/1039 , A61N5/1043 , A61N5/1045 , A61N5/1064 , A61N5/1067 , A61N5/1078 , A61N5/1081 , A61N7/02 , A61N2005/1055 , A61N2005/1058 , A61N2005/1076 , A61N2005/1089 , A61N2005/1091 , A61N2005/1098 , H05H9/048 , H05H2007/048
摘要： Methods and system for facilitating rapid radiation treatments are provided herein and relate in particular to radiation generation and delivery, electron source design, beam control and shaping/intensity-modulation. The methods and systems described herein are particularly advantageous when used with a compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided; or when used with a high-current electron accelerator system of energy range more conventionally used in photon radiation therapy to produce much faster delivery of intensity-modulated photon radiation therapy, that can in both cases deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a equal or better degree of dose conformity or sculpting compared to conventional photon therapy.
摘要翻译：在提供的方法和系统，用于促进快速放射治疗，特别是涉及到放射线生成和传递，电子源设计，光束控制和整形/强度调制。在所描述的方法和系统是特别有利的。当具有结构紧凑的高梯度使用的，非常高的能量的电子（VHEE）加速器和递送系统（和相关过程）能够治疗从以极快的速度多个波束方向的患者，使用的所有电磁或射频偏转转向设置; 或当与能量范围的高电流电子加速器系统在光子放射疗法更常规使用的用于产生强度调制的光子辐射治疗的快得多输送，并能在这两种情况下购买兑现整个剂量或高剂量辐射的分数充分治疗几乎冻结生理运动，但与相同或更好的程度剂量适形性或雕刻的相比于常规光子疗法。

5. 发明公开

EP2938169A1 LINEAR ACCELERATOR 有权
标题翻译： LINEARBESCHLEUNIGER
公开(公告)号：EP2938169A1
公开(公告)日：2015-10-28
申请号：EP15164871.4
申请日：2015-04-23
申请人： Elekta AB (publ)
发明人： Harasimowicz, Janusz , Shinton, Ian
IPC分类号： H05H7/22 , H05H9/04
CPC分类号： H05H7/22 , H05H7/02 , H05H9/00 , H05H9/048 , H05H2007/025 , H05H2007/227 , H05H2277/11
摘要： A linear accelerator is disclosed, having a series of interconnected cavities through at least some of which an rf signal and an electron beam are sent, comprising at least one variable coupler projecting into a cavity of the series, a control apparatus adapted to interpret an electrical signal from the coupler and derive diagnostic information as to the electron beam therefrom, wherein the control apparatus is further adapted to vary the interaction of the at least one coupler with the rf signal in dependence on the diagnostic information. Thus, the accelerator properties can be adjusted by encouraging or inciting an Higher-Order Mode ("HOM") having a desired effect such as bunching and/or deflecting. The coupler could be rotateable, and partially or fully retractable, to allow its influence to be adjusted and/or for it to be removed from service when not needed. Several such probes could be available, approaching the cavity from different directions or at different locations, or approaching different cavities. The coupler can be asymmetric, in order to exert an appropriate influence on the cavity and provoke a useful HOM. For example, it can be elongate with at least one directional deviation, such as a hockey stick. Generally, however, the appropriate shape for the coupler will be dependent on the shape of the cavity with which it is working and the specific HOMs that are to be excited.
摘要翻译：公开了一种线性加速器，其具有通过至少一些其中的一些RF信号和电子束被发送的一系列互连的空腔，包括突出到该系列的空腔中的至少一个可变耦合器，适于解释电气来自耦合器的信号并从其中导出关于电子束的诊断信息，其中控制装置还适于根据诊断信息改变至少一个耦合器与rf信号的相互作用。因此，可以通过鼓励或煽动具有期望效果的高阶模式（“HOM”）来调节加速器特性，例如聚束和/或偏转。联接器可以是可旋转的，并且部分地或完全可缩回的，以允许其影响被调整和/或在不需要的时候使其脱离服务。可以使用若干这样的探针，从不同方向或不同位置接近腔，或接近不同的腔。耦合器可以是不对称的，以便对腔体施加适当的影响并引起有用的HOM。例如，它可以用至少一个方向偏移来延伸，例如曲棍球棒。然而，通常，耦合器的适当形状将取决于其正在工作的腔体的形状和要激发的特定HOM。

6. 发明公开

EP2319281A2 INTERLACED MULTI-ENERGY RADIATION SOURCES 有权转让
标题翻译：巢状多能量辐射源
公开(公告)号：EP2319281A2
公开(公告)日：2011-05-11
申请号：EP09806964.4
申请日：2009-08-12
申请人： Varian Medical Systems, Inc.
发明人： CHEN, Gongyin , TURNER, John , EATON, Douglas, W.
IPC分类号： H05H7/02 , H05H7/04 , H05H7/22 , H05H9/00
CPC分类号： H05H7/02 , H01J2235/08 , H05H9/00 , H05H9/048 , H05H2007/022 , H05H2007/025
摘要： Multi-energy radiation sources comprising charged particle accelerators driven by power generators providing different RF powers to the accelerator, capable of interlaced operation, are disclosed. Automatic frequency control techniques are provided to match the frequency of RF power provided to the accelerator with the accelerator resonance frequency. In one example where the power generator is a mechanically tunable magnetron, an automatic frequency controller is provided to match the frequency of RF power pulses at one power to the accelerator resonance frequency when those RF power pulses are provided, and the magnetron is operated such that frequency shift in the magnetron at the other power at least partially matches the resonance frequency shift in the accelerator when those RF power pulses are provided. In other examples, when the power generator is a klystron or electrically tunable magnetron, separate automatic frequency controllers are provided for each RF power pulse. Methods and systems are disclosed.

7. 发明授权

EP3231260B1 TEILCHENBESCHLEUNIGER ZUR ERZEUGUNG EINES GEBUNCHTEN TEILCHENSTRAHLS UND BETRIEBSVERFAHREN DAZU 有权
公开(公告)号：EP3231260B1
公开(公告)日：2018-11-28
申请号：EP15816386.5
申请日：2015-12-09
申请人： Ampas GmbH
发明人： ARNOLD, Wolfgang
IPC分类号： H05H7/02 , H05H9/04
CPC分类号： H05H7/02 , H05H9/048 , H05H2007/025

8. 发明公开

EP3389055A1 RÖNTGENEINRICHTUNG ZUR ERZEUGUNG VON HOCHENERGETISCHER RÖNTGENSTRAHLUNG 审中-实审转让
公开(公告)号：EP3389055A1
公开(公告)日：2018-10-17
申请号：EP17165888.3
申请日：2017-04-11
申请人： Siemens Healthcare GmbH
发明人： Möller, Marvin , Müller, Sven , Koschmieder, Martin , Willing, Stefan
IPC分类号： G21K1/02 , H01J35/00 , H05H7/00
CPC分类号： H01J35/12 , G21K1/02 , G21K1/10 , H01J35/00 , H01J2235/08 , H01J2235/1262 , H05H6/00 , H05H9/048
摘要： Eine Röntgeneinrichtung (1) zur Erzeugung von hochenergetischer Röntgenstrahlung umfasst einen Linearbeschleuniger (2) und ein Target (3). Der Linearbeschleuniger (2) ist zur Erzeugung von Röntgenstrahlung (R) dazu ausgebildet, einen auf das Target (3) gerichteten Elektronenstrahl (E) zu erzeugen, dessen kinetische Energie pro Elektron zumindest 1MeV beträgt. Gemäß der Erfindung ist eine Blende (4) im Strahlengang des Elektronenstrahls (E) zwischen Linearbeschleuniger (2) und Target (3) angeordnet, welche einen eine Blendenöffnung (5) umgebenden Randbereich (B) aufweist, dessen Materialstärke in Propagationsrichtung (P) des Elektronenstrahls (E) weniger als 10% der mittleren Reichweite von Elektronen der erzeugten kinetischen Energie im Material des Randbereichs (B) beträgt.

9. 发明公开

EP3321716A1 VERFAHREN ZUM BETRIEB EINES LINEARBESCHLEUNIGERS UND LINEARBESCHLEUNIGER 审中-公开
标题翻译：线性加速器和线性加速器的操作方法
公开(公告)号：EP3321716A1
公开(公告)日：2018-05-16
申请号：EP17194212.1
申请日：2017-09-29
申请人： Siemens Healthcare GmbH
发明人： MÜLLER, Sven , KOSCHMIEDER, Martin , MÖLLER, Marvin , WILLING, Stefan
IPC分类号： G01V5/00 , H05H9/04
CPC分类号： H05H7/02 , G01V5/0016 , G01V5/0041 , H05H9/04 , H05H9/048 , H05H2007/022 , H05H2007/025 , H05H2007/084
摘要： Bei einem Verfahren zum Betrieb eines Linearbeschleunigers (1) werden geladene Teilchen von einer Teilchenquelle (2) emittiert und in einer Beschleunigungsvorrichtung (3) mittels eines hochfrequenten Wechselfelds derart beschleunigt, dass Pulse von geladenen Teilchen erzeugt werden. Der Beschleunigungsvorrichtung (3) wird zur Erzeugung des hochfrequenten Wechselfelds eine Hochfrequenzleistung (P HF ) periodisch mittels Hochfrequenzpulse zugeführt. Gemäß der Erfindung wird ein von der Teilchenquelle (2) emittierter Teilchenstrom innerhalb einer HF-Pulsdauer (Δt) des Hochfrequenzpulses derart variiert, dass der innerhalb der HF-Pulsdauer (Δt) geformte Puls zumindest zwei Teilpulse mit unterschiedlichen mittleren Energien pro Teilchen aufweist. Die Erfindung betrifft ferner einen Linearbeschleuniger, der zur Durchführung des Verfahrens ausgebildet ist und eine Einrichtung der materialdiskriminierenden Radioskopie mit einem derartigen Linearbeschleuniger.
摘要翻译：在操作线性加速器（1）的方法中，带电粒子从粒子源（2）发射并且借助于高频交变场在加速器（3）中加速，使得产生带电粒子的脉冲。提供加速装置（3）以通过高频脉冲周期性地产生高频交变场，即高频功率（PHF）。根据本发明而变化发出的高频脉冲的RF脉冲持续时间（AT）内的颗粒以这样的粒子源（2）的，所述HF脉冲的持续时间（AT）至少整形脉冲具有每个颗粒不同平均能量的两个部分脉冲的内部。本发明还涉及一种线性加速器，该线性加速器被设计成用这种线性加速器来执行用于材料鉴别透视的方法和装置。

10. 发明授权

EP2938169B1 LINEAR ACCELERATOR 有权
标题翻译：线性加速器
公开(公告)号：EP2938169B1
公开(公告)日：2017-08-23
申请号：EP15164871.4
申请日：2015-04-23
申请人： Elekta AB (publ)
发明人： Harasimowicz, Janusz , Shinton, Ian
IPC分类号： H05H7/22 , H05H9/04
CPC分类号： H05H7/22 , H05H7/02 , H05H9/00 , H05H9/048 , H05H2007/025 , H05H2007/227 , H05H2277/11

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