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1. 发明授权

EP1171031B1 CARDIAC MOTION TRACKING USING CINE HARMONIC PHASE (HARP) MAGNETIC RESONANCE IMAGING 有权
标题翻译：心脏活动通过KINEHARMONISCHEN相态磁成像测量
公开(公告)号：EP1171031B1
公开(公告)日：2012-02-15
申请号：EP00922265.4
申请日：2000-04-14
申请人： JOHNS HOPKINS UNIVERSITY
发明人： PRINCE, Jerry, L. , OSMAN, Nael F.
IPC分类号： G01R33/563
CPC分类号： A61B5/055 , A61B5/4519 , A61B5/7257 , G01R33/563 , G01R33/56333 , Y10S128/922
摘要： The present invention relates to a method of measuring motion of an object such as a heart by magnetic resonance imaging. A pulse sequence is applied to spatially modulate a region of interest of the object and at least one first spectral peak is acquired from the Fourier domain of the spatially modulated object. The inverse Fourier transform information of the acquired first spectral-peaks is computed and a computed first harmonic phase image is determined from each spectral peak. The process is repeated to create a second harmonic phase image from each second spectral peak and the strain is determined from the first and second harmonic phase images. In a preferred embodiment, the method is employed to determine strain within the myocardium and to determine change in position of a point at two different times which may result in an increased distance or reduced distance. The method may be employed to determine the path of motion of a point through a sequence of tag images depicting movement of the heart. The method may be employed to determine circumferential strain and radial strain.

2. 发明公开

EP1171031A4 CARDIAC MOTION TRACKING USING CINE HARMONIC PHASE (HARP) MAGNETIC RESONANCE IMAGING 有权
标题翻译：心脏活动通过KINEHARMONISCHEN相态磁成像测量
公开(公告)号：EP1171031A4
公开(公告)日：2006-05-10
申请号：EP00922265
申请日：2000-04-14
申请人： UNIV JOHNS HOPKINS
发明人： PRINCE JERRY L , OSMAN NAEL F
IPC分类号： G01R33/48 , A61B5/055 , G01R33/563
CPC分类号： A61B5/055 , A61B5/4519 , A61B5/7257 , G01R33/563 , G01R33/56333 , Y10S128/922
摘要： The present invention relates to a method of measuring motion of an object such as a heart by magnetic resonance imaging. A pulse sequence is applied to spatially modulate a region of interest of the object and at least one first spectral peak is acquired from the Fourier domain of the spatially modulated object. The inverse Fourier transform information of the acquired first spectral-peaks is computed and a computed first harmonic phase image is determined from each spectral peak. The process is repeated to create a second harmonic phase image from each second spectral peak and the strain is determined from the first and second harmonic phase images. In a preferred embodiment, the method is employed to determine strain within the myocardium and to determine change in position of a point at two different times which may result in an increased distance or reduced distance. The method may be employed to determine the path of motion of a point through a sequence of tag images depicting movement of the heart. The method may be employed to determine circumferential strain and radial strain.

3. 发明公开

EP1171031A1 CARDIAC MOTION TRACKING USING CINE HARMONIC PHASE (HARP) MAGNETIC RESONANCE IMAGING 有权
标题翻译：心脏活动通过KINEHARMONISCHEN相态磁成像测量
公开(公告)号：EP1171031A1
公开(公告)日：2002-01-16
申请号：EP00922265.4
申请日：2000-04-14
申请人： The Johns Hopkins University
发明人： PRINCE, Jerry, L. , OSMAN, Nael F.
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/4519 , A61B5/7257 , G01R33/563 , G01R33/56333 , Y10S128/922
摘要： The present invention relates to a method of measuring motion of an object such as a heart by magnetic resonance imaging. A pulse sequence is applied to spatially modulate a region of interest of the object and at least one first spectral peak is acquired from the Fourier domain of the spatially modulated object. The inverse Fourier transform information of the acquired first spectral-peaks is computed and a computed first harmonic phase image is determined from each spectral peak. The process is repeated to create a second harmonic phase image from each second spectral peak and the strain is determined from the first and second harmonic phase images. In a preferred embodiment, the method is employed to determine strain within the myocardium and to determine change in position of a point at two different times which may result in an increased distance or reduced distance. The method may be employed to determine the path of motion of a point through a sequence of tag images depicting movement of the heart. The method may be employed to determine circumferential strain and radial strain.

4. 发明公开

EP0557083A2 Quantitative measurement of blood flow at multiple positions using comb excitation and fourier velocity encoding 失效
标题翻译：在使用腔室情感和傅立叶速编码的多个位置的定量血流量测量。
公开(公告)号：EP0557083A2
公开(公告)日：1993-08-25
申请号：EP93301179.3
申请日：1993-02-18
申请人： GENERAL ELECTRIC COMPANY
发明人： Dumoulin, Charles Lucian
IPC分类号： A61B5/026 , G01R33/56 , G01F1/716
CPC分类号： G01R33/563 , G01R33/56333
摘要： A method of imaging and quantitatively measuring blood velocity distribution within a selected vessel employs Nuclear Magnetic Resonance excitation of a number of regions of a subject to be imaged by an rf excitation pulse applied in a magnetic field gradient. The rf excitation pulse has several frequency bands with the frequencies between the bands having essentially no amplitude. A frequency band causes excitation of a region of the subject. Each frequency band is encoded with a unique phase angle offset so that the signals from each region may be separated. The excited regions are Fourier velocity encoded along a second axis based upon their flow velocities. A re-radiated signal is acquired in the presence of a readout gradient to provide resolution along a selected axis and reconstruct a velocity profile. This method can be combined with cardiac synchronization to measure flow dynamics or it can be applied without synchronization to measure steady flow. The geometry of the measurement is flexible in that the directions of flow sensitivity and geometric resolution are independent.
摘要翻译：成像的选定容器内的方法和定量地测量血流速度分布采用多个对象的区域的要被通过在一个磁场梯度施加的RF激励脉冲中成像的核磁共振激励。 RF激励脉冲具有与具有基本上没有振幅的频带之间的频率的若干频带。频率带引起对象的区域的激励。每个频带进行编码的唯一相角偏移，使得没有来自各区域的信号可以被分离。被激发的区域是沿着基于它们的流速的第二轴编码傅立叶速度。甲再辐射的信号在读出梯度的存在下获得的，以提供沿一选定的轴分辨率和重建速度分布图。此方法可以与心脏同步组合，以测量流动动力学或它可以在不同步地应用于测量稳流。测量的几何形状是柔性的，DASS流敏感度和几何分辨率的方向是独立的。

5. 发明公开

EP1451603A1 MULTIPLE PREPARATORY EXCITATIONS AND READOUTS DISTRIBUTED OVER THE CARDIAC CYCLE 审中-公开
标题翻译：若干初步建议和关于心脏周期分配的信号记录阶段
公开(公告)号：EP1451603A1
公开(公告)日：2004-09-01
申请号：EP02795654.9
申请日：2002-11-19
申请人： Koninklijke Philips Electronics N.V. , Philips Medical Systems (Cleveland), Inc.
发明人： WU, Dee, H.
IPC分类号： G01R33/563
CPC分类号： G01R33/563 , G01R33/56333
摘要： A magnetic resonance cardiac imaging method for imaging during a cardiac cycle interval includes monitoring an electrocardiographic signal (90) associated with the imaged heart for a first trigger event (102). Responsive to the first trigger event, a data acquisition sequence (112, 120, 314, 330, 400, 402) is applied, including a first preparation sequence block (114, 316), a first imaging sequence block (116, 318) having at least one readout interval that collects first data, a second preparation sequence block (122, 332, 404), and a second imaging sequence block (124, 334, 406) having at least one readout interval that collects second data. The data acquisition sequence (112, 120, 314, 330, 400, 402) occupies an acquisition time interval which is less than the cardiac cycle interval of the imaged heart.

6. 发明授权

EP0507392B1 Magnetic resonance imaging method and device for monitoring motion of a part of an object 失效
标题翻译：为对象的一部分的监视运动核磁共振方法和装置
公开(公告)号：EP0507392B1
公开(公告)日：1998-06-10
申请号：EP92200885.9
申请日：1992-03-30
申请人： Philips Electronics N.V.
发明人： KcKinnon, Graeme , Fischer, Stefan , Boesiger, Peter
IPC分类号： G01R33/48 , G01R33/56
CPC分类号： G01R33/56333 , G01R33/5617 , G01R33/5673

7. 发明授权

EP0507391B1 Magnetic resonance imaging method and device for monitoring motion of a part of an object based on stimulated echoes. 失效
标题翻译：受激回波的基础上的物体的一部分的监视运动核磁共振方法和装置
公开(公告)号：EP0507391B1
公开(公告)日：1998-06-10
申请号：EP92200884.2
申请日：1992-03-30
申请人： Philips Electronics N.V.
发明人： KcKinnon, Graeme , Fischer, Stefan , Boesiger, Peter
IPC分类号： G01R33/48 , G01R33/56
CPC分类号： G01R33/56333 , G01R33/5617 , G01R33/5673

8. 发明公开

EP0557083A3 Quantitative measurement of blood flow at multiple positions using comb excitation and fourier velocity encoding 失效
标题翻译：使用组合激励和傅立叶变换编码的多个位置的血液流量的量化测量
公开(公告)号：EP0557083A3
公开(公告)日：1994-11-30
申请号：EP93301179.3
申请日：1993-02-18
申请人： GENERAL ELECTRIC COMPANY
发明人： Dumoulin, Charles Lucian
IPC分类号： A61B5/026 , G01R33/56 , G01F1/716
CPC分类号： G01R33/563 , G01R33/56333
摘要： A method of imaging and quantitatively measuring blood velocity distribution within a selected vessel employs Nuclear Magnetic Resonance excitation of a number of regions of a subject to be imaged by an rf excitation pulse applied in a magnetic field gradient. The rf excitation pulse has several frequency bands with the frequencies between the bands having essentially no amplitude. A frequency band causes excitation of a region of the subject. Each frequency band is encoded with a unique phase angle offset so that the signals from each region may be separated. The excited regions are Fourier velocity encoded along a second axis based upon their flow velocities. A re-radiated signal is acquired in the presence of a readout gradient to provide resolution along a selected axis and reconstruct a velocity profile. This method can be combined with cardiac synchronization to measure flow dynamics or it can be applied without synchronization to measure steady flow. The geometry of the measurement is flexible in that the directions of flow sensitivity and geometric resolution are independent.

9. 发明公开

EP0543928A4 ANALYZING HEART WALL MOTION USING SPATIAL MODULATION OF MAGNETIZATION 失效
标题翻译：使用空间调制方法分析心墙运动
公开(公告)号：EP0543928A4
公开(公告)日：1993-06-30
申请号：EP91916359
申请日：1991-08-19
申请人： UNIV PENNSYLVANIA
发明人： AXEL, LEON , SHINNAR, MEIR
IPC分类号： A61B5/055 , G01R33/48 , G01R33/563 , G01R33/567
CPC分类号： G01R33/56333 , G01R33/56509
摘要： A technique for generating "optimal" radio frequency pulses for use in creating SPAMM imaging stripes and for quantitatively determining the displacements of the imaging stripes during a pre-imaging interval. The imaging operator selects the desired stripe parameters (304) so that the resulting SPAMM imaging stripe will have the desired narrowness, sharpness, flatness and the like. These parameters are then used by an optimal pulse generating system (212) to generate the input radio frequency pulse sequence which will produce the desired stripes. Tagging of the heart wall or some other soft tissue structure with a grid of planes of altered magnetization is then used to provide finite element analysis to quantify regional heart wall motion and the like. The intersections of the tagging stripes are used as a set of fiducial marks within the heart wall, and the motion of these intersections through the heart cycle is used to track the motion of the underlying tissue.

10. 发明授权

EP2161568B1 MRI system and method for tracking a tissue point using a double pencil beam RF pulse 有权
标题翻译： MRI装置和方法用于使用具有双杆形激励区域的RF脉冲跟踪点材料
公开(公告)号：EP2161568B1
公开(公告)日：2014-08-13
申请号：EP09168539.6
申请日：2009-08-25
申请人： General Electric Company
发明人： Zur, Yuval
IPC分类号： G01N24/08 , G01R33/48 , G01R33/563 , G01R33/567 , G01R33/28 , G01R33/483 , G01R33/56
CPC分类号： G01R33/56333 , G01R33/285 , G01R33/4814 , G01R33/4836 , G01R33/5608

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