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1. 发明公开

EP2872896A1 STATUS OF TUBERCULOSIS INFECTION IN AN INDIVIDUAL 有权
标题翻译： EINEM INDIVIDUUM中的状态DER TUBERKULOSEINFEKTION
公开(公告)号：EP2872896A1
公开(公告)日：2015-05-20
申请号：EP13737831.1
申请日：2013-07-16
申请人： Lionex GmbH
发明人： SINGH, Mahavir , DELIOS, Mario M. , DELLA BELLA, Chiara
IPC分类号： G01N33/569
CPC分类号： G01N33/6863 , G01N2333/35 , G01N2333/55 , G01N2333/90616
摘要： In a first aspect, the present invention relates to a method for diagnosing or determining the status of tuberculosis infection in an individual afflicted with or suspected to be afflicted with tuberculosis infection. In a further aspect, a method for the stratification of the therapeutic regimen of an individual with tuberculosis infection is provided as well as a method for predicting a clinical outcome or determining treatment course in an individual afflicted with tuberculosis infection. Moreover, the present invention provides a method for monitoring the change from latent into active status of tuberculosis infection or vice versa in an individual. Furthermore, the present invention relates to a kit for use in diagnosing or detecting the status of tuberculosis infection as well as to Mycobacterium tuberculosis alanine dehydrogenase for use in specifically differentiating latent status from active diseases status of tuberculosis in an individual.
摘要翻译：在第一方面，本发明涉及一种诊断或确定患有或怀疑患有结核感染的个体的结核病感染状况的方法。另一方面，提供了一种用于结核病感染个体的治疗方案分层的方法，以及用于预测患有结核感染的个体的临床结果或确定治疗过程的方法。此外，本发明提供了一种用于监测个体中结核病感染的潜伏状态到活动状态的变化或反之亦然的方法。此外，本发明涉及用于诊断或检测结核病感染状况以及结核分枝杆菌丙氨酸脱氢酶的试剂盒，用于特异性区分潜在状态与个体中结核病的活动性疾病状态。

2. 发明公开

EP2779900A1 ANALAYSEGERÄT ZUM NACHWEIS MINDESTENS EINES ANALYTEN IN EINER PROBE 有权转让
标题翻译： ANALAYSEGERÄT至少一种被分析物在样品检测的
公开(公告)号：EP2779900A1
公开(公告)日：2014-09-24
申请号：EP12784007.2
申请日：2012-11-12
申请人： Roche Diagnostics GmbH , F.Hoffmann-La Roche AG
发明人： PETRICH, Wolfgang , HORN, Carina , STEINKE, Nelli , RINGEMANN, Christian , VON KETTELER, Alexa
IPC分类号： A61B5/145 , G01N35/00 , G01N21/64
CPC分类号： C12Q1/52 , A61B5/14532 , A61B5/1495 , A61B2560/0233 , C12Q1/006 , C12Q1/32 , G01N21/6428 , G01N21/8483 , G01N35/00663 , G01N2021/6439 , G01N2035/00673 , G01N2333/904 , G01N2333/90616
摘要： An analytical apparatus (130) is proposed for detecting at least one analyte in a sample (126), in particular for detecting blood glucose, wherein the analytical apparatus (130) is designed to perform at least one analyte measurement, during which analyte measurement at least one changeable property of at least one test chemical (119) of a test element (110) is detected, in particular an electrical and/or optical property, and the analytical apparatus (130) is furthermore designed to conduct at least one quality measurement on the test chemical (119), at least one characteristic luminescence of the test chemical (119) being detected in the quality measurement, and a conclusion being drawn from the characteristic luminescence about the quality of the test chemical (119), especially a degradation.

3. 发明公开

EP2687848A1 Status of tuberculosis infection in an individual 审中-公开
标题翻译：在einem个体中的结果显示
公开(公告)号：EP2687848A1
公开(公告)日：2014-01-22
申请号：EP12176506.9
申请日：2012-07-16
申请人： Lionex GmbH
发明人： Singh, Mahavir , Delios, Mario M. , Della Bella, Chiara
IPC分类号： G01N33/569
CPC分类号： G01N33/6863 , G01N2333/35 , G01N2333/55 , G01N2333/90616
摘要： In a first aspect, the present invention relates to a method for diagnosing or determining the status of tuberculosis infection in an individual afflicted with or suspected to be afflicted with tuberculosis infection. In a further aspect, a method for the stratification of the therapeutic regimen of an individual with tuberculosis infection is provided as well as a method for predicting a clinical outcome or determining treatment course in an individual afflicted with tuberculosis infection. Moreover, the present invention provides a method for monitoring the change from latent into active status of tuberculosis infection or vice versa in an individual. Furthermore, the present invention relates to a kit for use in diagnosing or detecting the status of tuberculosis infection as well as to Mycobacterium tuberculosis alanine dehydrogenase for use in specifically differentiating latent status from active diseases status of tuberculosis in an individual.
摘要翻译：在第一方面，本发明涉及一种诊断或确定患有或怀疑患有结核感染的个体的结核病感染状况的方法。另一方面，提供了一种用于结核病感染个体的治疗方案分层的方法，以及用于预测患有结核感染的个体的临床结果或确定治疗过程的方法。此外，本发明提供了一种用于监测个体中结核病感染的潜伏状态到活动状态的变化或反之亦然的方法。此外，本发明涉及用于诊断或检测结核病感染状况以及结核分枝杆菌丙氨酸脱氢酶的试剂盒，用于特异性区分潜在状态与个体中结核病的活动性疾病状态。

4. 发明公开

EP1824991A4 DEVICE AND METHOD FOR DETECTION OF ANALYTES 有权
标题翻译：设备和检测方法的分析物
公开(公告)号：EP1824991A4
公开(公告)日：2011-11-30
申请号：EP05852268
申请日：2005-11-23
申请人： TECHLAB INC
发明人： BOONE JAMES H , LYERLY DAVID M , WILKINS TRACY D
IPC分类号： C12Q1/00 , C12M1/36 , C12M1/38 , C12M3/00 , G01N33/53 , G01N33/543 , G01N33/554 , G01N33/558 , G01N33/567
CPC分类号： G01N33/54366 , G01N33/573 , G01N33/6803 , G01N33/6845 , G01N2333/33 , G01N2333/79 , G01N2333/906 , G01N2333/90611 , G01N2333/90616 , G01N2333/91097

5. 发明公开

EP3380457A1 MONOSULFONIC PHENYLTETRAZOLE COMPOUNDS WITH APPLICATIONS 有权
公开(公告)号：EP3380457A1
公开(公告)日：2018-10-03
申请号：EP16863619.9
申请日：2016-11-09
申请人： Hangzhou Jennifer Biotech Co., Ltd.
发明人： RUAN, Benfang, Helen , RUAN, Jennifer, Jin
IPC分类号： C07D257/04 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N21/31 , C12Q1/34 , C12Q1/32
CPC分类号： C07D257/04 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C12Q1/32 , G01N21/78 , G01N2333/90611 , G01N2333/90616
摘要： A class of compounds of monosulfonic phenyltetrazole, with the structure of 2-(R1 phenyl)-5 (2-sulfonic phenyl)-2H-tetrazole. The 2-sulfonic phenyl tetrazolium salt of this invention has advantages of low toxicity, short synthetic route, easy control of purity and quality. As the 2-sulfonic phenyl tetrazolium salts has almost no absorption at 450 nm where the reduzate has greater absorption, spectrophotometry can simply and rapidly determine the activity of glutamate dehydrogenase, or the content of NADH/NADPH.

6. 发明公开

EP2985349A1 DEVICE FOR DETECTION OF ANALYTES 有权
标题翻译： VORRICHTUNG ZUR ERKENNUNG VON ANALYTEN
公开(公告)号：EP2985349A1
公开(公告)日：2016-02-17
申请号：EP15184922.1
申请日：2005-11-23
申请人： TechLab, Inc.
发明人： BOONE, James, H. , LYERLY, David, M. , WILKINS, Tracy, D.
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/554 , G01N33/567 , C12M1/36 , C12M1/38 , C12M3/00 , G01N33/558 , G01N33/543
CPC分类号： G01N33/54366 , G01N33/573 , G01N33/6803 , G01N33/6845 , G01N2333/33 , G01N2333/79 , G01N2333/906 , G01N2333/90611 , G01N2333/90616 , G01N2333/91097
摘要： The present invention discloses a device for detecting at least one substance of interest in a liquid sample, the device comprising:
(a) a receptacle comprising a porous material for receiving the liquid sample, wherein the porous material is capable of absorbing and transmitting at least a portion of the liquid sample, and
(b) a porous membrane that comprises a specific binding pair member that is specific for the substance of interest or a substance bound to the substance of interest, wherein the specific binding pair member is an antibody,

wherein the receptacle and porous membrane are each shaped to permit the porous membrane to be in direct contact with the porous material over at least a portion of the porous membrane that comprises the specific binding pair member,
wherein the porous material is in physical contact with a bottom side of the porous membrane comprising the specific binding pair member, the specific binding pair member being located above the porous material, the porous membrane being in direct contact with the porous material at a site where the specific binding pair member is located.
摘要翻译：本发明公开了一种用于检测液体样品中至少一种感兴趣物质的装置，该装置包括：（a）容器，包括用于接收液体样品的多孔材料，其中多孔材料能够至少吸收和传播液体样品的一部分，和（b）多孔膜，其包含特异性结合对成员，所述特异性结合对成员对所述目的物质特异性或与所述目的物质结合的物质，其中所述特异性结合对成员是抗体，其中容器和多孔膜各自被成形为允许多孔膜在包括特定结合对构件的多孔膜的至少一部分上与多孔材料直接接触，其中多孔材料与底部物理接触所述多孔膜的一侧包括特定的结合对构件，所述特异性结合对构件位于多孔材料上方，在与特定结合对构件所处的位置处直接接触多孔材料。

8. 发明授权

EP2872896B1 STATUS OF TUBERCULOSIS INFECTION IN AN INDIVIDUAL 有权
标题翻译：结核病感染在个体中的现状
公开(公告)号：EP2872896B1
公开(公告)日：2017-12-27
申请号：EP13737831.1
申请日：2013-07-16
申请人： Lionex GmbH
发明人： SINGH, Mahavir , DELIOS, Mario M. , DELLA BELLA, Chiara
IPC分类号： G01N33/68
CPC分类号： G01N33/6863 , G01N2333/35 , G01N2333/55 , G01N2333/90616

9. 发明公开

EP2841593A4 CLOSTRIDIUM DIFFICILE DEHYDROGENASE AND TOXIN AS A BIOMARKER 有权
标题翻译：梭状杆菌难溶性脱氢酶和毒素作为生物标志物
公开(公告)号：EP2841593A4
公开(公告)日：2015-11-11
申请号：EP12838635
申请日：2012-10-31
申请人： TECHLAB INC
发明人： BOONE JAMES HUNTER , LYERLY DAVID M , CARMAN ROBERT J
IPC分类号： C12Q1/37 , G01N33/569 , G01N33/573 , G01N33/68
CPC分类号： G01N33/56911 , G01N33/573 , G01N33/6893 , G01N2333/33 , G01N2333/79 , G01N2333/90611 , G01N2333/90616 , G01N2800/52 , G01N2800/56
摘要： Clostridium difficile disease involves a range of clinical presentations ranging from carrier status with other causes of symptoms to mild and self-limiting diarrhea to life-threatening pseudomembranous colitis and megacolon. Cases of C. difficile are treated differently depending on the presence and then the severity of disease. Patients that are carriers may not receive treatment with concern of causing the disease. Mild to moderate cases may be treated with metronidazole while severe and relapsing cases are often treated with vancomycin or fidaxomicin. Current molecular assays are highly sensitive for detecting toxigenic C. difficile and cannot rule out carrier status. Utilization of a biomarker panel that includes C. difficile antigen (GDH), toxins A and B, and fecal lactoferrin allows clinicians to differentiate between a carrier state and active state of C. difficile and allows for monitoring to evaluate the effectiveness of treatment.

10. 发明授权

EP2779900B1 ANALAYSEGERÄT ZUM NACHWEIS MINDESTENS EINES ANALYTEN IN EINER PROBE 有权转让
标题翻译： ANALAYSEGERÄTZUM NACHWEIS MINDESTENS EINESTEN IN EINER PROBE
公开(公告)号：EP2779900B1
公开(公告)日：2015-09-16
申请号：EP12784007.2
申请日：2012-11-12
申请人： Roche Diagnostics GmbH , F.Hoffmann-La Roche AG
发明人： PETRICH, Wolfgang , HORN, Carina , STEINKE, Nelli , RINGEMANN, Christian , VON KETTELER, Alexa
IPC分类号： A61B5/145 , G01N35/00 , G01N21/64
CPC分类号： C12Q1/52 , A61B5/14532 , A61B5/1495 , A61B2560/0233 , C12Q1/006 , C12Q1/32 , G01N21/6428 , G01N21/8483 , G01N35/00663 , G01N2021/6439 , G01N2035/00673 , G01N2333/904 , G01N2333/90616

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