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1. 发明公开

EP3359666A1 EARLY POST-TRANSFECTION ISOLATION OF CELLS (EPIC) FOR BIOLOGICS PRODUCTION 审中-实审
公开(公告)号：EP3359666A1
公开(公告)日：2018-08-15
申请号：EP16788603.5
申请日：2016-10-07
申请人： Genzyme Corporation
发明人： CAIRNS, Victor, R. , DEMARIA, Christine , VITKO, Jason
IPC分类号： C12N15/10 , G01N33/537
CPC分类号： G01N15/14 , C07K16/00 , C07K2317/10 , C12N15/1086 , C12N15/85 , C12N2510/02 , G01N33/5044 , G01N2015/149 , G01N2333/70592
摘要： Provided herein are methods and compositions for batch production of producer cells using fluorescence activated cell sorting (FACS). In some aspects, the disclosure provides a drug-selection-free method for batch production of producer cells using FACS. Such batch production methods and compositions can be further utilized to generate clonal populations of producer cells, e.g., for large-scale manufacturing of a polypeptide of interest.

2. 发明公开

EP2538217A1 Method of identifying risk for thyroid disorder 审中-公开
标题翻译： Verfahren zur Feststellung des RisikosfürSchilddrüsenkrankheit
公开(公告)号：EP2538217A1
公开(公告)日：2012-12-26
申请号：EP12176625.7
申请日：2008-02-15
申请人： Genzyme Corporation
发明人： Margolin, David H.
IPC分类号： G01N33/50 , G01N33/53 , G01N33/74 , G01N33/68
CPC分类号： G01N33/6854 , G01N33/5047 , G01N33/6893 , G01N2333/635 , G01N2333/70592 , G01N2800/046
摘要： A method for identifying a patient that is at risk for developing a thyroid disorder that occurs subsequent to treatment with a regimen that depletes lymphocytes, comprising determining whether antibodies directed against thyroid peroxidase or thyroid microsomes are present in the patient, wherein if the antibodies are present in the patient then the patient is at increased risk for developing a thyroid disorder. A particular embodiment is a method for identifying a patient with multiple sclerosis that is at risk for developing a thyroid disorder that occurs subsequent to treatment with a regimen that depletes CD52-positive cells, comprising determining whether antibodies directed against thyroid peroxidase or thyroid microsomes are present in the patient, wherein if the antibodies are present in the patient then the patient is at risk for developing the thyroid disorder.
摘要翻译：一种用于鉴定在用消耗淋巴细胞的方案治疗后发生甲状腺疾病的风险的患者的方法，包括确定是否存在针对甲状腺过氧化物酶或甲状腺微粒体的抗体存在于患者体内，其中如果存在抗体在患者身上，患者发生甲状腺功能障碍的风险增加。一个特定的实施方案是用于鉴定患有多发性硬化症的患者，该患者处于发生甲状腺疾病的风险中，所述甲状腺疾病在用消耗CD52阳性细胞的方案治疗后发生，包括确定是否存在针对甲状腺过氧化物酶或甲状腺微粒体的抗体在患者体内，如果抗体存在于患者中，则患者处于发展甲状腺疾病的风险中。

3. 发明公开

EP2064337A2 A FACS-AND REPORTER PROTEIN-BASED SYSTEM FOR HIGH THROUGHPUT DEVELOPMENT OF THERAPEUTIC PROTEINS 有权
标题翻译：流式细胞仪及报告蛋白为基础的系统来开发具有高吞吐量的治疗性蛋白质
公开(公告)号：EP2064337A2
公开(公告)日：2009-06-03
申请号：EP07838397.3
申请日：2007-09-18
申请人： Genzyme Corporation
发明人： DEMARIA, Christine , ESTES, Scott , KAREY, Kenneth, P. , CAIRNS, Victor
IPC分类号： C12Q1/00
CPC分类号： C12N15/1086 , G01N33/537 , G01N33/6863 , G01N2333/70592 , G01N2333/70596
摘要： Methods are disclosed to identify, select and produce a clonal population of recombinant eukaryotic host cells thai stably and highly express a polypeptide of interest. Also disclosed herein are products produced by the disclosed methods and assemblies of components useful to conduct the methods.

4. 发明公开

EP3359665A2 IMPROVED FLARE (FLOW CYTOMETRY ATTENUATED REPORTER EXPRESSION) TECHNOLOGY FOR RAPID BULK SORTING 有权转让
公开(公告)号：EP3359665A2
公开(公告)日：2018-08-15
申请号：EP16788602.7
申请日：2016-10-07
申请人： Genzyme Corporation
发明人： CAIRNS, Victor, R. , CHAVIDA, Jose, Ignacio, Sancho , DEMARIA, Christine
IPC分类号： C12N15/10 , G01N33/537
CPC分类号： G01N15/14 , C07K16/00 , C07K2317/10 , C12N15/1086 , C12N15/85 , C12N2510/02 , G01N33/5044 , G01N2015/149 , G01N2333/70592
摘要： Provided herein are methods and compositions for batch production of producer cells using fluorescence activated cell sorting (FACS). In some aspects, the disclosure provides a drug-selection-free method for batch production of producer cells using FACS. Such batch production methods and compositions can be further utilized to generate clonal populations of producer cells, e.g., for large-scale manufacturing of a polypeptide of interest.

5. 发明公开

EP3155428A1 METHODS FOR SEPARATING CELLS 审中-公开
标题翻译： VERFAHREN ZUR TRENNUNG VON ZELLEN
公开(公告)号：EP3155428A1
公开(公告)日：2017-04-19
申请号：EP15730092.2
申请日：2015-06-09
申请人： Centre Hospitalier Universitaire Vaudois (CHUV)
发明人： CASTELLA, Vincent , GROSJEAN, Frédéric
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , G01N2333/70592
摘要： The invention is in the field of analysis of cell populations and cell separation and the compositions obtained thereby. More particularly, the invention concerns a method for separating cells of interest according to a specific marker expressed on their surface.
摘要翻译：本发明在分析细胞群体和细胞分离领域以及由此获得的组合物。更具体地，本发明涉及根据在其表面上表达的特异性标记物分离感兴趣的细胞的方法。

6. 发明授权

EP2130044B1 METHOD OF IDENTIFYING RISK FOR THYROID DISORDER 有权
标题翻译：方法固定位置的风险甲状腺疾病
公开(公告)号：EP2130044B1
公开(公告)日：2016-10-26
申请号：EP08725657.4
申请日：2008-02-15
申请人： Genzyme Corporation
发明人： MARGOLIN, David, H.
IPC分类号： G01N33/50 , G01N33/53 , G01N33/74
CPC分类号： G01N33/6854 , G01N33/5047 , G01N33/6893 , G01N2333/635 , G01N2333/70592 , G01N2800/046

7. 发明公开

EP2919799A4 SOLUBLE MEDIATOR 有权转让
标题翻译： INSTANT MEDIATOR
公开(公告)号：EP2919799A4
公开(公告)日：2016-08-03
申请号：EP13855431
申请日：2013-03-25
申请人： INST MEDICAL W & E HALL
发明人： HARRISON LEONARD CHARLES , RASHIDI MARYAM , ZHANG YUXIA
IPC分类号： A61K38/10 , A61P37/06 , C12N5/0783 , C12N15/12 , C12N15/86 , G01N33/15 , G01N33/50
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/70592 , C07K16/2803 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K2317/76 , C07K2319/30 , C12N5/0637 , G01N33/502 , G01N33/564 , G01N33/6872 , G01N33/6893 , G01N2333/70592 , G01N2800/26 , G01N2800/285 , G01N2800/50 , G01N2800/52
摘要： The present disclosure relates to the use of a soluble CD52 glycoprotein in treating diseases regulated by effector T-cells, for example sepsis or multiple sclerosis. The present disclosure also relates to diagnostic methods based on the detection of CD52 expression levels in a subject.

8. 发明公开

EP2955521A1 Methods for separating cells 审中-公开
标题翻译： Verfahren zur Trennung von Zellen
公开(公告)号：EP2955521A1
公开(公告)日：2015-12-16
申请号：EP14171937.7
申请日：2014-06-11
申请人： Centre Hospitalier Universitaire Vaudois (CHUV)
发明人： Grosjean, Frédéric , Castella, Vincent
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , G01N2333/70592
摘要： The invention is in the field of analysis of cell populations and cell separation and the compositions obtained thereby. More particularly, the invention concerns a method for separating cells of interest according to a specific marker expressed on their surface.
摘要翻译：本发明在分析细胞群体和细胞分离领域以及由此获得的组合物。更具体地，本发明涉及根据在其表面上表达的特异性标记物分离感兴趣的细胞的方法。

9. 发明公开

EP2919799A1 SOLUBLE MEDIATOR 有权转让
标题翻译：可溶性介质
公开(公告)号：EP2919799A1
公开(公告)日：2015-09-23
申请号：EP13855431.6
申请日：2013-03-25
申请人： The Walter and Eliza Hall Institute of Medical Research
发明人： HARRISON, Leonard Charles , RASHIDI, Maryam , ZHANG, Yuxia
IPC分类号： A61K38/10 , C12N15/12 , C12N15/86 , G01N33/15 , G01N33/50 , A61P37/06
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/70592 , C07K16/2803 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K2317/76 , C07K2319/30 , C12N5/0637 , G01N33/502 , G01N33/564 , G01N33/6872 , G01N33/6893 , G01N2333/70592 , G01N2800/26 , G01N2800/285 , G01N2800/50 , G01N2800/52
摘要： The present disclosure relates to the use of a soluble CD52 glycoprotein in treating diseases regulated by effector T-cells, for example sepsis or multiple sclerosis. The present disclosure also relates to diagnostic methods based on the detection of CD52 expression levels in a subject.
摘要翻译：本公开涉及可溶性CD52糖蛋白在治疗由效应T细胞调节的疾病中的用途，所述疾病例如脓毒症或多发性硬化症。本公开还涉及基于检测受试者中的CD52表达水平的诊断方法。

10. 发明授权

EP2064337B1 A FACS-AND REPORTER PROTEIN-BASED SYSTEM FOR HIGH THROUGHPUT DEVELOPMENT OF THERAPEUTIC PROTEINS 有权
标题翻译：流式细胞仪及报告蛋白为基础的系统来开发具有高吞吐量的治疗性蛋白质
公开(公告)号：EP2064337B1
公开(公告)日：2012-07-18
申请号：EP07838397.3
申请日：2007-09-18
申请人： Genzyme Corporation
发明人： DEMARIA, Christine , ESTES, Scott , KAREY, Kenneth, P. , CAIRNS, Victor
IPC分类号： C12N15/10
CPC分类号： C12N15/1086 , G01N33/537 , G01N33/6863 , G01N2333/70592 , G01N2333/70596
摘要： Methods are disclosed to identify, select and produce a clonal population of recombinant eukaryotic host cells thai stably and highly express a polypeptide of interest. Also disclosed herein are products produced by the disclosed methods and assemblies of components useful to conduct the methods.

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