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1. 发明公开

EP2394147A4 OPTICAL MEASUREMENT ARRANGEMENT 失效
公开(公告)号：EP2394147A4
公开(公告)日：2017-12-20
申请号：EP10738280
申请日：2010-02-07
申请人： POCARED DIAGNOSTICS LTD
发明人： INGBER GAL
IPC分类号： G01J3/42
CPC分类号： G01J1/32 , G01J3/42 , G01J2003/2866 , G01N21/031 , G01N21/253 , G01N2201/0415 , G01N2201/0469 , G01N2201/0692
摘要： A method and device for enhancing the power correction of optical measurements in an optical measurement arrangement, the steps including: providing a light source for producing a light beam; splitting the light beam into two beams; directing a first split light beam through an interrogation area and into an optics separation device; directing the light beams from the optics separation device and a second split light beam representing the intensity of the illumination of the main light beam of the light source into cells of a detector array; measuring and assessing the information obtained in the cells; and using this information to calculate the corrected value for the cells receiving the light beams from the optics separation device in order to adjust the power for the intensity of the light beam of the light source and/or to correct the intensity of the light beams from the interrogation area.

2. 发明授权

EP2317304B1 SAMPLE ANALYSIS DEVICE 有权
标题翻译：样品分析装置
公开(公告)号：EP2317304B1
公开(公告)日：2017-11-29
申请号：EP09803019.0
申请日：2009-07-30
申请人： Hitachi High-Technologies Corporation
发明人： ADACHI, Sakuichiro , HARADA, Kunio , YAMAZAKI, Isao , KIYAMA, Masaharu , FUJITA, Takeshi
IPC分类号： G01N21/25 , G01N35/02 , G01N35/04 , G01N21/03
CPC分类号： G01N21/253 , G01N21/0332 , G01N21/255 , G01N35/025 , G01N2035/00386 , G01N2035/0455 , G01N2201/0231 , G01N2201/0415 , G01N2201/0453 , G01N2201/0624 , G01N2201/0627
摘要： Using an LED element as a light source, a photometric unit including the light source, a light receiving element and other components therebetween is reduced in size. A holder 30 detachable from the device as a unit holds a light emission unit 15 formed of an LED and a light receiving element 21, and the holder is placed inside a thermostatic chamber 18 which holds a constant temperature fluid 17. Thus, the photometric unit is reduced in size.

3. 发明公开

EP2957897A1 Streulichtmesssystem mit Karussell für zylindrische oder eckige Probenhalter und einer Strahlblende für ungestreutes Licht, welche derart vergrössert ist, dass das vom Probenhalter gebrochene, ungestreute Licht aufgefangen wird 审中-公开
标题翻译：散射光测量系统与转盘为圆柱形或方形样品保持器和波束停止对于未散射的光，使得从所述样品保持器的破碎，未散射光被收集被放大
公开(公告)号：EP2957897A1
公开(公告)日：2015-12-23
申请号：EP14172742.0
申请日：2014-06-17
申请人： Siemens Healthcare Diagnostics Products GmbH
发明人： Beier, Axel , Meller, Paul , Nerreter, Stefan
IPC分类号： G01N21/51
CPC分类号： G01N21/51 , G01N2201/0415
摘要： Die Erfindung betrifft ein Streulichtmesssystem mit mindestens einer Lichtquelle (20) zur Erzeugung eines Strahlenbündels (34), einer Aufnahmevorrichtung für eine Messzelle (17) oder mehrere Messzellen und einen Photodetektor zur Aufnahme insbesondere von Streulicht aus der Messzelle (Nephelometrie). Erfindungsgemäß ist vorgesehen, dass die Messzelle (17) und das Strahlenbündel (34) derart relativ zueinander beweglich sind, dass das Strahlenbündel (34) auf einem bestimmten Wegabschnitt (37) durch die Messzelle wandert. Hinter der Messzelle (17) ist eine Sammeloptik (29) angeordnet, die das Strahlenbündel (34), welches nicht gemessen werden soll, auf eine vorzugsweise streifenförmig ausgebildete Zentralblende (24) wirft, so dass dieses nicht durch den Photodetektor registriert wird. Das zu messende Streulicht aus der Messzelle (17) gelangt mit seinem Hauptanteil jedoch an der Zentralblende (24) vorbei und kann durch den Photodetektor daher gemessen werden. Die Zentralblende (24) ermöglicht es daher vorteilhaft, dass sich das Strahlenbündel (34) und die Messzelle (17) während der Messung relativ zueinander bewegen können. Hierdurch wird die Effizienz des Messverfahrens, welches ebenfalls unter Schutz gestellt ist, vorteilhaft erhöht.
摘要翻译：本发明涉及一种具有用于产生辐射光束（34），用于测量电池（17）或多个测量单元，以及用于从所述测量池（比浊法），特别是散射光的接收光检测器的接收设备的至少一个光源（20）的散射光测量系统。根据本发明，所述测量单元（17）和梁（34）是相对于彼此可移动的上一个特定的路径部分（37）的光束（34）穿过测量池。后面的测量单元（17）被布置成收集光学器件（29）的辐射束（34），它是不被测定，优选地带状中心孔（24）升高，使得它不会被光检测器注册。然而，从测量单元（17）所测量的散射光通过与所述中心孔（24）经过其主要部分，因此可以通过光检测器来测量。中心孔（24）允许因此，有利的是，辐射光束（34）和所述测量单元（17）可以在测量期间相对于彼此移动。由此，该测量方法，其也被放置在保护的效率，有利地提高。

4. 发明公开

EP2818848A1 AUTOMATIC ANALYSIS DEVICE 有权
标题翻译：自动分析装置
公开(公告)号：EP2818848A1
公开(公告)日：2014-12-31
申请号：EP13751468.3
申请日：2013-02-12
申请人： Hitachi High-Technologies Corporation
发明人： YAMASHITA Kotaro , IIJIMA Masahiko
IPC分类号： G01N21/49 , G01N35/00
CPC分类号： G01N21/55 , G01N21/253 , G01N21/274 , G01N21/51 , G01N21/78 , G01N21/82 , G01N33/48 , G01N33/49 , G01N33/493 , G01N35/00 , G01N35/00623 , G01N2021/0325 , G01N2021/0389 , G01N2021/3129 , G01N2021/513 , G01N2021/825 , G01N2035/009 , G01N2201/0415
摘要： An automatic analyzer including: a multi-wavelength light source 44 that irradiates with multi-wavelength light a reaction cuvette 2 containing a liquid mixture of a sample to be analyzed and a reagent; a transmitted-light quantity detector 45 that detects the amount of light transmitted through the reaction cuvette 2 and internal contents of the reaction cuvette; a single-wavelength light source 14 that irradiates the reaction cuvette 2 with single-wavelength light; a transmitted-light quantity detector 15 that detects the amount of single-wavelength light scattered from the reaction cuvette 2 and the internal contents of the reaction cuvette; and a memory 11 for storing a result of the transmitted-light quantity detection with the transmitted-light quantity detector 45 and a result of the scattered-light quantity detection with the scattered-light quantity detector 15; wherein deterioration states of the single-wavelength light source 14, multi-wavelength light source 15, and reaction cuvette 2 are determined in accordance with measurement results of cell blank measurements conducted on the reaction cuvette where a predetermined reference solution is stored to detect the amount of light transmitted through and the amount of light scattered from. A decrease in analytical accuracy can be thereby suppressed.
摘要翻译：自动分析装置包括：多波长光源44，其用多波长光照射包含待分析样品和试剂的混合液的反应容器2; 透射光量检测器45，其检测透过反应容器2和反应容器的内容物的光量; 单波长光源14，其以单波长光照射反应容器2; 透射光量检测器15，其检测从反应容器2散射的单波长光的量和反应容器的内容物; 以及存储器11，用于存储透射光量检测器45的透射光量检测结果和散射光量检测器15的散射光量检测结果; 其中，根据存储预定参考溶液的反应容器中进行的细胞空白测量的测量结果，确定单波长光源14，多波长光源15和反应容器2的劣化状态，以检测量透过的光线和从中散射的光线量。由此可以抑制分析精度的降低。

5. 发明公开

EP2154513A4 PHOTOMETRIC DEVICE AND AUTOMATIC ANALYZER 审中-公开
标题翻译：测光装置和分析机
公开(公告)号：EP2154513A4
公开(公告)日：2011-11-23
申请号：EP08752283
申请日：2008-05-01
申请人： BECKMAN COULTER INC
发明人： OGAWA YUJI
IPC分类号： G01N21/01 , G01N21/25 , G01N35/02
CPC分类号： G01N21/253 , G01N35/025 , G01N2021/3181 , G01N2201/0415 , G01N2201/0627
摘要： A photometric apparatus and an automatic analyzer in which liquid samples contained in vessels are measured with light of different wavelengths while the vessels are transferred are provided. A photometric apparatus (13) includes light sources (13b) that are arranged in the movement direction of a vessel (5) and emit light of different wavelengths, light-receiving devices (13d) that are located opposing the light sources with the vessels interposed inbetween and receive light of different wavelengths emitted from the light sources. The arrangement length (L) of light sources along the movement direction of the vessels is shorter than the arrangement pitch (P) of the vessels.

6. 发明公开

EP2333561A2 System for performing multi-formatted assays 审中-公开
标题翻译：系统zumDurchführenvon测试mehreren格式化
公开(公告)号：EP2333561A2
公开(公告)日：2011-06-15
申请号：EP11075041.1
申请日：2006-03-10
申请人： Gen-Probe Incorporated
发明人： Knight, Byron J. , Haito, Li
IPC分类号： G01N35/02 , C12Q1/68
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： A system for detecting two or more different optical signals emitted from each of a plurality of reaction receptacles, wherein the reaction receptacles are disposed in a fixed arrangement with respect to each other, said system comprising: a plurality of optical sensors, each of said optical sensors being configured to detect one of the two or more optical signals and being associated with one of the reaction receptacles so that each reaction receptacle has associated therewith one optical sensor for each optical signal to be detected, whereby said optical sensors associated with each of the plurality of reaction receptacles are arranged in a configuration that enables each optical sensor to detect the associated optical signal emitted from the associated reaction receptacle; and a transport mechanism constructed and arranged to effect relative movement between the plurality of reaction receptacles and the optical sensors to sequentially place each reaction receptacle into a signal-detecting position with respect to one of its associated optical sensors, wherein (1) said plurality of optical sensors are arranged so that only one of the plurality of reaction receptacles at a time can be in a signal-detecting position with respect to one of its associated optical sensors, and (2) optical sensors configured to detect each of the two or more optical signals are arranged in groups so that each of the reaction receptacles is placed in a signal-detecting position with respect to an associated optical sensor configured to detect one optical signal before any of the reaction receptacles is placed in signal-detecting position with respect to an associated optical sensor configured to detect a different optical signal.
摘要翻译：一种用于检测从多个反应容器中的每一个发射的两个或更多个不同的光信号的系统，其中所述反应容器相对于彼此以固定的布置设置，所述系统包括：多个光学传感器，每个所述光学传感器被配置为检测所述两个或更多个光信号中的一个并且与所述反应容器之一相关联，使得每个反应容器具有与要检测的每个光信号相关联的一个光学传感器，由此所述光传感器与多个反应容器被布置成使得每个光学传感器能够检测从相关联的反应容器发射的相关联的光信号; 以及运送机构，其构造和布置成实现所述多个反应容器和所述光学传感器之间的相对运动，以将每个反应容器顺序地相对于其相关联的光学传感器之一放置在信号检测位置，其中（1）所述多个光学传感器被布置成使得多个反应容器中的每一个只能在一个相关的光学传感器中处于信号检测位置，并且（2）配置成检测两个或更多个中的每一个的光学传感器光信号被分组布置，使得每个反应容器相对于相关联的光学传感器被置于信号检测位置，所述相关联的光学传感器被配置为在反应容器中的任何一个放置在相对于被配置为检测不同光信号的相关联的光学传感器。

7. 发明公开

EP2154513A1 PHOTOMETRIC DEVICE AND AUTOMATIC ANALYZER 审中-公开
标题翻译：光谱仪VORRICHTUNG UND ANALYSEAUTOMAT
公开(公告)号：EP2154513A1
公开(公告)日：2010-02-17
申请号：EP08752283.5
申请日：2008-05-01
申请人： Beckman Coulter, Inc.
发明人： OGAWA, Yuji
IPC分类号： G01N21/01 , G01N35/02
CPC分类号： G01N21/253 , G01N35/025 , G01N2021/3181 , G01N2201/0415 , G01N2201/0627
摘要： A photometric apparatus and an automatic analyzer in which liquid samples contained in vessels are measured with light of different wavelengths while the vessels are transferred are provided. A photometric apparatus (13) includes light sources (13b) that are arranged in the movement direction of a vessel (5) and emit light of different wavelengths, light-receiving devices (13d) that are located opposing the light sources with the vessels interposed inbetween and receive light of different wavelengths emitted from the light sources. The arrangement length (L) of light sources along the movement direction of the vessels is shorter than the arrangement pitch (P) of the vessels.
摘要翻译：提供了一种测量装置和自动分析器，其中容纳在容器中的液体样品在容器被转移的同时用不同波长的光测量。一种测光装置（13）包括沿容器（5）的移动方向布置并发射不同波长的光的光源（13b），与容器相对置的光接收装置（13d）中间并接收从光源发射的不同波长的光。沿着容器的运动方向的光源的布置长度（L）比容器的排列间距（P）短。

8. 发明公开

EP2112497A2 Blood analysis apparatus and method of setting a measurement position in a blood analysis apparatus 审中-公开
标题翻译： Blutanalysegerätund Einstellungsverfahrenfüreine Messe在einem Blutanalysegertt
公开(公告)号：EP2112497A2
公开(公告)日：2009-10-28
申请号：EP09158687.5
申请日：2009-04-24
申请人： Ushio Denki Kabushiki Kaisha
发明人： Tomita, Mamoru
IPC分类号： G01N21/07 , G01N21/59
CPC分类号： G01N21/07 , G01N21/59 , G01N35/00584 , G01N35/025 , G01N2035/00148 , G01N2201/0415 , G01N2201/0446 , G01N2201/1247
摘要： A blood analysis apparatus is provided. The blood analysis apparatus includes: a chip holding portion (22) having an aperture (23) which allows light to pass therethrough and holding a µ-TAS chip for holding a measurement liquid; a rotary body (25) on which the chip holding portion (22) is mounted; a light source (41); and a light-receiving unit (43). A measurement position of the rotary body (25) at which the measurement liquid is to be measured with the light from the light source (41) is set by: rotating the rotary body (25) to obtain a light value of light which is emitted from the light source (41) and received by the light-receiving unit (43) through the aperture (23); and setting a rotational position of the rotary body (25) where the light value is a threshold value or more, as the measurement position.
摘要翻译：提供血液分析装置。血液分析装置包括：具有孔（23）的芯片保持部（22），其允许光通过并保持用于保持测量液体的μ-TAS芯片; 旋转体（25），其上安装有芯片保持部分（22）; 光源（41）; 和光接收单元（43）。用来自光源（41）的光测量测量液体的旋转体（25）的测量位置通过以下方式设定：旋转体（25）旋转以获得发射的光的光值从所述光源（41）通过所述孔（23）被所述光接收单元（43）接收; 并且将光值为阈值以上的旋转体（25）的旋转位置设定为测定位置。

9. 发明公开

EP1992936A1 Analyzing apparatus 有权转让
标题翻译： Analysegerät
公开(公告)号：EP1992936A1
公开(公告)日：2008-11-19
申请号：EP08008946.9
申请日：2008-05-14
申请人： Hitachi High-Technologies Corporation
发明人： Adachi, Sakuichiro
IPC分类号： G01N21/25 , G01J3/04 , G01J3/42 , G01N35/00
CPC分类号： G01N21/253 , G01J3/02 , G01J3/0218 , G01J3/0229 , G01J3/0262 , G01J3/04 , G01J3/36 , G01J3/42 , G01N21/13 , G01N21/255 , G01N2021/0325 , G01N2021/115 , G01N2021/3155 , G01N2201/0415 , G01N2201/0446 , G01N2201/0453 , G01N2201/0618
摘要： A light amount is increased and an analyzing accuracy can be increased in accordance with an enlargement of a load angle.. However, scattered light tends to be loaded into a light receiving element in an analysis accompanied by scattered light, and the dynamic range of a concentration which can be measured becomes narrow. In the invention, light is dispersed by a light dispersing portion (20), a load angle of the received light is changed per wavelength, the load angle is made larger for light of a wavelength having a small light amount, and the load angle is made smaller for light of a wavelength having a large light amount and used for an analysis accompanied by scattered light. Accordingly, it is possible to gain a dynamic range of a concentration which can be measured in the analysis accompanied by scattered light, while increasing the light amount and maintaining the analyzing accuracy.
摘要翻译：光量增加，并且可以根据负载角度的增大来提高分析精度。然而，散射光倾向于在伴随散射光的分析中被加载到光接收元件中，并且动态范围可测量的浓度变窄。在本发明中，光被光分散部分（20）分散，每波长改变接收光的负载角，对于具有小光量的波长的光，负载角度变大，负载角为对于具有大光量的波长的光而较小，并用于伴随散射光的分析。因此，在增加光量并保持分析精度的同时，可以获得在伴随散射光的分析中可以测量的浓度的动态范围。

10. 发明公开

EP1861721A2 SYSTEMS AND METHODS TO PERFORM ASSAYS FOR DETECTING OR QUANTIFYING ANALYTES WITHIN SAMPLES 有权
标题翻译：用于执行测试系统和方法来检测或分析物的样品数量化
公开(公告)号：EP1861721A2
公开(公告)日：2007-12-05
申请号：EP06737943.8
申请日：2006-03-10
申请人： GEN-PROBE INCORPORATED
发明人： CARRICK, James M. , DAVIS, Christopher Brandon , HEINZ, Robert E. , KNIGHT, Byron J. , LAIR, Gary D. , LI, Florence F. , LI, Haito , LIGHT, James P. , MACIOSZEK, Jerzy A. , NGUYEN, Thanh N. , SCALESE, Robert F.
IPC分类号： G01N35/02
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
摘要翻译：确定性采矿感兴趣的样品中的分析物的量的计算机实现的方法，所述方法包括（a）形成的扩增产物从与感兴趣的分析物，（b）收集信号数据用的信号与放大的形成测量装置兼产品，所收集的信号数据包括：由所述样品发射的信号的电平的周期性测量，worin由样品发射的信号的电平对应于扩增产物通过样品，（c）中形成的量在存储所收集的信号数据计算机可读介质; 以及使用与在算法，其编程的计算机（d）中，当由计算机执行时，被配置为使访问存储在步骤（c）的数据，并调整在步骤（b）以去除背景收集的数据的计算机到具有比所关注的分析物的存在其他源相关联的测量水平的贡献，由测得的最大电平，调节到去除背景的贡献将经调整的数据归一化在步骤（d）调整的数据（1），近似的曲线通过结合存储在计算机可读介质中的预定的低和结合的预定的高存储在计算机可读介质上，在在哪个曲线，在步骤（d）中的逼近出苗时间确定性矿之间的调整，归一化的数据的一个部分（3）的杂交预定阈值水平的数据和确定的矿通过比较在步骤（d）开采的出现时间的确定性的感兴趣的分析物的量（4）与阈值时间确定开采的中的分析物的已知量的 terest和存储在计算机可读介质上。

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