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1. 发明公开

EP2468879A4 A-87774 COMPOUND OR SALT THEREOF, METHOD FOR PRODUCING THE COMPOUND OR SALT THEREOF, AND AGROCHEMICAL CONTAINING THE COMPOUND OR SALT THEREOF AS ACTIVE INGREDIENT 有权转让
标题翻译： A-87774相关或其盐，其制造方法的化合物或其盐和农业化学与连接或其盐作为有效
公开(公告)号：EP2468879A4
公开(公告)日：2013-04-10
申请号：EP10809925
申请日：2010-08-13
申请人： MITSUI CHEMICALS AGRO INC
发明人： SHIGEMATSU YOSHIO , SUGIE YOSHIKO , KIZUKA MASAAKI
IPC分类号： C12P9/00 , A01N63/02 , A01P13/00 , A01P21/00 , C07G11/00 , C12N1/20 , C12P1/06 , C12P11/00
CPC分类号： A01N57/00 , A01N63/02 , C07H99/00 , C12P1/06 , C12P9/00 , C12P11/00 , C12R1/465
摘要： There are provided novel A-87774 compounds or salts thereof having a herbicidal activity or a plant growth regulating activity, a microorganism producing the same, a production method thereof, an agrochemical (in particular, herbicide or plant growth regulator) containing the same as an active ingredient, a method for using the same, and a culture of the microorganism.

2. 发明公开

EP2287324A3 Fermentation processes with low concentrations of carbon- and nitrogen-containing nutrients 审中-公开
标题翻译：碳和含氮食品使用的发酵过程的低浓度
公开(公告)号：EP2287324A3
公开(公告)日：2011-06-29
申请号：EP10178179.7
申请日：2004-04-01
申请人： DSM IP Assets B.V.
发明人： Hollander, De, Johannes Abraham , Eswilder, Freddy Ronald , Zanden, Van Der, Paulus Petrus Maria
IPC分类号： C12P1/00 , C12P1/04 , C12P19/62 , C12R1/01 , C12R1/04 , C12R1/465
CPC分类号： C12P1/06 , C12P19/626
摘要： The present invention describes a fermentation process for the production of a desired compound (such as natamycin) comprising cultivating a filamentous bacterial strain in a liquid fermentation medium, wherein the carbon containing nutrients and nitrogen containing nutrients are maintained at low concentrations in the fermentation medium. The process of the invention reduces the viscosity of the culture medium and therefore increases the yield of the desired compound.

3. 发明公开

EP2308970A1 Antibiotic compositions, methods for providing the same and Streptomyces coelicolor mutants for use in such methods 审中-公开
标题翻译：抗生素的组合物，其用于提供方法和在该方法中使用的链霉菌突变体
公开(公告)号：EP2308970A1
公开(公告)日：2011-04-13
申请号：EP09172463.3
申请日：2009-10-07
申请人： Rijksuniversiteit Groningen
发明人： Wietzorrek-Takano, Eriko , Gottelt, Marco , Kol, Stefan
IPC分类号： C12N15/00 , C12N15/52 , C12P1/06
CPC分类号： C12P1/06 , C12N9/0004 , C12N15/52 , C12R1/465
摘要： The present invention relates to the field of preventive and therapeutic medicine. In particular, it relates to methods for providing microbial antibiotic extracts and compounds and use of those extracts and compounds in the treatment of a bacterial infection. Also provided are mutant strains of Streptomyces coelicolor and the use thereof in the production of an antibiotic composition.
摘要翻译：本发明涉及预防和治疗药物领域。特别是，它涉及用于在细菌感染的治疗中提供的微生物的抗生素提取物和化合物和使用这些提取物的和化合物。所以提供了天蓝色链霉菌，制备抗菌素组合物的其用途的突变菌株。

4. 发明公开

EP1646646A1 ANTIBIOTIC 107891, ITS FACTORS A1 AND A2, PHARMACEUTICALLY ACCEPTABLE SALTS AND COMPOSITIONS, AND USE THEREOF. 有权
标题翻译：抗生素107891，ITS因子a1和a2，药学上可接受的盐和组合物，及其用途
公开(公告)号：EP1646646A1
公开(公告)日：2006-04-19
申请号：EP04740916.4
申请日：2004-07-12
申请人： Vicuron Pharmaceuticals, Inc.
发明人： LAZZARINI, Ameriga , GASTALDO, Luciano , CANDIANI, Gianpaolo , CICILIATO, Ismaela , LOSI, Daniele , MARINELLI, Flavia , SELVA, Enrico , PARENTI, Franco
IPC分类号： C07K14/195 , C07K2/00 , C07K4/04 , C12P1/06 , A61K38/02 , A61P31/04 , A23K1/17 , C12R1/01
CPC分类号： C12R1/01 , A23K20/195 , A61K38/00 , C07K14/37 , C12P1/06
摘要： The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated antibiotic 107891 which is produced by fermentation of Microbispora sp. ATCC PTA-5024, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes. Antibiotic 107891, which is a complex comprising two Factors, denominated Factors Al and A2, has a peptide structure containing lanthionine and methyllanthionine as constituents which are typical characteristics of the antibiotics of the lantibiotics group. Antibiotic 107891 and its Factors Al and A2 show a good antibacterial activity against Gram-positive bacteria including methicillin resistant and van comycin resistant strains, and is active also against some Gram-negative bacteria such as M. catharralis, Neisseria species and H. influenzae and Mycobacteria.

5. 发明公开

EP1227158A4 METHOD FOR DEGRADING POLYLACTATE RESINS 审中-公开
标题翻译：方法去除POLYLAKTATHARZEN的
公开(公告)号：EP1227158A4
公开(公告)日：2006-02-01
申请号：EP00913053
申请日：2000-03-31
申请人： NAT INST OF ADVANCED IND SCIEN , TOKIWA YUTAKA
发明人： TOKIWA YUTAKA
IPC分类号： C12N1/20 , C12P1/06 , C12S99/00 , B09B3/00 , C08J11/10 , C12R1/01
CPC分类号： C12P1/06 , Y10S435/822

6. 发明公开

EP1481986A1 Antibiotic 97518, pharmaceutically acceptable salts and compositions, and use thereof 审中-公开
标题翻译：抗生素97518，药学上可接受的盐和组合物，以及它们的用途
公开(公告)号：EP1481986A1
公开(公告)日：2004-12-01
申请号：EP03012422.6
申请日：2003-05-30
申请人： Vicuron Pharmaceuticals, Inc.
发明人： Losi, Daniele , Cavaletti, Linda , Lazzarini, Ameriga , Candiani, Gianpaolo , Castiglione, Franca , Marinelli, Flavia
IPC分类号： C07K14/195 , C12P1/06 , A61K38/02 , A61P31/04 , A23K1/17
CPC分类号： C12P1/06 , A23K20/195 , C07K14/195
摘要： The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated 97518 which is produced by fermentation of Planomonospora sp. DSM 14920, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having inhibitory activity versus susceptible microbes or as animal growth promoter.
摘要翻译：抗生素97518（I）具有电喷射条件下从乙腈和水（50:50）（V / V），得到一个双质子化离子一个为0.01mg / ml的溶液在记录1097米/ Z上的Thermofinnigan LCQ DECA仪器质谱：如喷雾电压（4.5千伏），毛细管温度（200℃），毛细管电压（28 V）和输注模式（5微升/分钟）。抗生素97518（I）具有：（a）由在乙腈和水（50:50）（V / V），得到一个双质子化离子一个为0.01mg / ml的溶液在Thermofinnigan LCQ DECA仪器记录在1097米/ Z质谱电喷雾条件下进行：如喷雾电压（4.5千伏），毛细管温度（200℃），毛细管电压（28 V）和输注模式（5微升/分钟）; （B）记录在溴化钾用Bruker FT-IR分光光度计模型IFS 48，其表现出最大吸收红外光谱（以cm> 1>）3295，3058，2970，2930，1660，1531，1411，1336，1263和 1109; （C）在MeOH UV光谱用Perkin-Elmer公司分光光度计LAMBDA 16，其表现出在279和288纳米的两个肩部演出; （D）1> H-NMR谱在25℃] C对在Bruker AMX 600光谱仪上施加水抑制序列记录在混合物H 2 O / D 2 O / CD 3 CN 80/10/10（pH为2.6的HCl），采用作为内标乙腈的混合物在1.99 ppm的残留信号，其示出1> H信号：如[delta，它是一个PPM多重性，（归属）] 0.79 D（CH 3），0.84 D（CH 3），0.86 D（CH 3），0.97 D（ CH 3），1.1 D（CH 3），1.20 D（CH 3），1.71 D（CH 3），2.33 q（CH 2），2.4-3.6米（肽阿尔法CH'S），3.6-5.1米（肽阿尔法CH'S），5.27-5.82 S（CH 2），6时49 q（CH），6.9-8.57 T和D（芳香CH'S）和7.74-9.1 D和米（芳族CH的和肽的NH'S）; （E）1>在25℃]下在使用Bruker AMX 600光谱仪作为内标物的剩余信号记录在混合物H 2 O / D 2 O / CD 3 CN 80/10/10（pH为2.6的HCl）3> C-NMR谱乙腈中，在1.39 ppm的118.69表示1> 3> C信号：如[，δ= ppm的;（归属）] 10.27-20.95（脂肪族CH 3的），23.42-48.15（脂肪族CH2的），48.77-66.6（肽阿尔法CH'S）， 108-136（芳族和双键CH的和季碳）和166.12-176.3（肽羰基）; 和（f）的酸水解物（盐酸6N，105 [℃，24小时），显示出耐酸氨基酸的衍生化之后的存在下，用6-氨基喹啉基-N-羟基琥珀酰亚胺基氨基甲酸酯：如羊毛硫氨酸，methyllanthionine，甘氨酸，苏氨酸，脯氨酸，缬氨酸，谷氨酸，组氨酸和异亮氨酸，及其与酸和碱，其中质谱，红外光谱，紫外光谱和NMR谱的如本说明书中给出的盐。因此独立权利要求中包括了：（1）生产（M1）（I）及其与酸和如文中提到的碱的盐（I）包括培养Planomonospora藻。 DSM 14920或其变体或突变体保持生产（I）在有氧条件下在，氮气在含碳的可同化源的wässrige营养培养基的能力，和无机盐，从菌丝体和/或过滤的培养物中分离（I）肉汤和纯化（I）; （2）药物组合物（II）包含（i）或其与酸和碱的盐; 和（3）Planomonospora菌种的生物纯培养物。 DSM 14920，或其变体或突变体保持生产式（I）的能力当的碳，氮和无机盐的可同化源的存在下在有氧条件下培养。活动：抗菌。无生物数据给出。作用机理：没有给出。

7. 发明公开

EP1227158A1 METHOD FOR DEGRADING POLYLACTATE RESINS 审中-公开
标题翻译： VERFAHREN ZUM ABBAU VON POLYLAKTATHARZEN
公开(公告)号：EP1227158A1
公开(公告)日：2002-07-31
申请号：EP00913053.5
申请日：2000-03-31
申请人： National Institute of Advanced Industrial Science and Technology , Tokiwa, Yutaka
发明人： TOKIWA, Yutaka
IPC分类号： C12P1/06 , C12N1/20 , B09B3/00 , C08J11/10
CPC分类号： C12P1/06 , Y10S435/822
摘要： The present invention provides novel microorganisms that directly biodegrade polylactide resins and plastics containing the same as well as a method therefor. Specifically, the present invention provides a method for degrading polylactide resins, wherein the polylactide resins are degraded by an actinomycete belonging to the genus Saccharothrix, Streptoalloteichus, Kibdelosporangium, Lentzea, Actinokineospora, Saccharomonospora, Saccharopolyspora, or Actinopolyspora.
摘要翻译：本发明提供直接生物降解聚丙交酯树脂和含有其的塑料的新型微生物及其方法。具体地说，本发明提供一种降解聚交酯树脂的方法，其中所述聚交酯树脂由属于Saccharothrix，Streptoalloteichus，Kibdelosporangium，Lentzea，Actinokineospora，Saccharomonospora，Saccharopolyspora或Actinopolyspora的放线菌降解。

8. 发明公开

EP1043328A4 NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCE SULPHOSTIN, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF 有权
标题翻译：新的生理活性物质sulphostatin，生产及其用途
公开(公告)号：EP1043328A4
公开(公告)日：2001-01-03
申请号：EP98953075
申请日：1998-11-17
申请人： ZAIDAN HOJIN BISEIBUTSU
发明人： TAKEUCHI TOMIO , HAMADA MASA , MURAOKA YASUHIKO , AKIYAMA TETSUO , ABE MASATOSHI , NAGANAWA HIROSHI , TAKAHASHI YOSHIKAZU
IPC分类号： A61K38/00 , C07G99/00 , C07K14/36 , C12N9/99 , C12P1/06 , C07G17/00 , A61K35/74 , C12N1/20
CPC分类号： C12N9/99 , A61K38/00 , C07K14/36 , C12P1/06 , C12R1/465
摘要： This invention provides a physiologically active substance having a strong dipeptidyl peptidase IV inhibitory activity. The physiologically active substance sulphostin is obtained by culturing a microorganism belonging to the genus Streptomyces and having an ability to produce the physiologically active substance sulphostin, producing and accumulating this substance in the cultures, and harvesting it from the cultures.

9. 发明公开

EP1015555A1 ANTIFUNGAL BIOCONTROL AGENTS, A PROCESS FOR PREPARING AND TREATING THE SAME 失效
标题翻译：杀菌剂BIOKONTROLLWIRKSTOFFE和方法生产和使用。
公开(公告)号：EP1015555A1
公开(公告)日：2000-07-05
申请号：EP98902271.0
申请日：1998-01-24
申请人： Suh, Hyung Won
发明人： Suh, Hyung Won
IPC分类号： C12N1/20 , A01N63/00
CPC分类号： C12R1/465 , A01N63/00 , C12P1/06 , Y10S435/886
摘要： The present invention relates to antifungal biocontrol agents which enhance plant growth and reduce plant diseases by suppressing fungal pathogens, and the manufacturing and application methods thereof. The antifungal biocontrol agents of the present invention consist of one of the newly isolated strains of Streptomyces sp. WYE 20 (KCTC 0341BP) and WYE 324 (KCTC 0342BP) and a delivery medium which canies and stabilizes the cells. In particular, WYE 20 and WYE 324 of the present invention exhibit strong antifungal activity against Rhizoctonia solani and Phytophthora capsici and can be used in various ways to reduce fungal diseases in plants such as cucumber (Cucumis sativus L.), pepper (Capsicum annuum L.), and golf course turfgrasses.

10. 发明授权

EP0300294B1 Novel compound DC-107 and process for its preparation 失效
标题翻译：化合物的DC-107和它们的制备方法。
公开(公告)号：EP0300294B1
公开(公告)日：1993-11-03
申请号：EP88110939.1
申请日：1988-07-08
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： Nakano, Hirofumi , Hara, Mitsunobu , Takahashi, Isami , Asano, Kozo , Iida, Takao , Morimoto, Makoto
IPC分类号： C07G11/00 , C12P1/06 , A61K35/66 , C12N1/20
CPC分类号： C12P1/06 , C12R1/465 , Y10S435/886
摘要： A novel compound, DC-107, with the following physicochemical properties: (1) Molecular formula: C22H26N2O6S3 (2) Molecular weight: 510 Found by high resolution FAB mass spectrum : 511.1041 Calculated for C22H27N2O6S3 : 511.1031 (3) Melting point: 160 DEG C (decomposed) (4) Specific rotation: [ alpha ]25_D = 140 DEG (c=0.1, methanol) obtained by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.

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