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    • 8. 发明公开
    • Esters and amides of substituted phenyl acetic acids
    • Estern und Amiden von substituteierterPhenylessigsäure。
    • EP0485158A2
    • 1992-05-13
    • EP91310205.9
    • 1991-11-05
    • FGN, INC.THE UNIVERSITY OF ARIZONA
    • Pamukcu, RifatGross, PaulBrendel, Klaus
    • A61K47/48C08B37/00C08F8/00C08G73/04
    • C08B37/003A61K47/58A61K47/59A61K47/61A61K47/645C08B11/14C08F8/14C08F8/30C08F8/34C08G73/0206
    • Esters and amides of substituted phenyl acetic acids having the formula

      wherein Q is a deprotonated residue of a polymer or macromolecular structure having a molecular weight of at least 1000 containing at least two primary and/or secondary amino groups and/or hydroxy groups ;

      n is an integer of at least 2 ;
      R 1 and R 2 are independently selected from
      hydrogen, halogen, alkyl, alkenyl, alkinyl or halo alkyl ;
      R 3 is one or more substituents selected from halogen, alkyl, alkenyl or alkinyl, cycloalkyl, oxo-substituted alkylcycloalkyl, haloalkyl, alkoxy, alkenyloxy, alkinyloxy, alkylamino, alkenylamino, alkinylamino, alkysulfonyl, alkenylsulfonyl, alkinylsulfonyl, alkylsulfinyl, alkenylsulfinyl, alkinylsulfinyl, alkylsulfenyl, alkenylsulfenyl, alkinylsulfenyl, pyrrolyl, piperidinyl, benzoyl, imidazolpyridinyl, isoindolyl, oxo-substituted isoindolyl, thionylcarbonyl, phenyl, phenoxy and halo-substituted phenoxy are useful in the treatment of colonic polyps.
    • 具有式CHEM的取代的苯基乙酸的酯和酰胺,其中Q是分子量至少为1000的含有至少两个伯和/或仲氨基和/或羟基的聚合物或大分子结构的去质子化残基 ; n为至少2的整数; R 1和R 2独立地选自氢,卤素,烷基,烯基,炔基或卤代烷基; R3是一个或多个选自卤素,烷基,烯基或炔基的取代基,环烷基,氧代取代的烷基环烷基,卤代烷基,烷氧基,烯氧基,烷氧基,烷基氨基,烯基氨基,烷基氨基,烷基磺酰基,烯基磺酰基,炔基磺酰基,烷基亚磺酰基,烯基亚磺酰基, 链烯基硫基,链烯基硫基,吡咯基,哌啶基,苯甲酰基,咪唑基吡啶基,异吲哚基,氧代取代的异吲哚基,亚硫酰基羰基,苯基,苯氧基和卤代取代的苯氧基可用于治疗结肠息肉。