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1. 发明公开

EP2825653A1 GENERATING TARGETED SEQUENCE DIVERSITY IN FUSION PROTEINS 审中-公开
标题翻译：创造靶向序列融合蛋白的多样性
公开(公告)号：EP2825653A1
公开(公告)日：2015-01-21
申请号：EP13761957.3
申请日：2013-03-14
申请人： Innovative Targeting Solutions Inc.
发明人： GALLO, Michael , KANG, Jaspal Singh , PIGOTT, Craig Robin
IPC分类号： C12N15/63 , C07K14/575 , C07K14/605 , C07K16/00 , C07K19/00 , C12N15/09 , C12N15/11 , C12N15/13 , C12N15/62 , C12N15/85
CPC分类号： C12N15/625 , C07K14/4723 , C07K14/522 , C07K14/5421 , C07K14/57563 , C07K14/605 , C07K14/71 , C07K14/78 , C07K16/00 , C07K16/2839 , C07K16/2866 , C07K16/2869 , C07K16/32 , C07K2317/565 , C07K2318/10 , C07K2319/00 , C07K2319/01 , C07K2319/03 , C12N15/62 , C12N15/85 , C12N2800/30
摘要： Methods of generating fusion protein variants are provided that comprise introducing sequence diversity at the junction region or regions in the fusion and allows for the generation of variants having a desired activity. Examples include immunoglobulins comprising a domain or polypeptide inserted into, or replacing, a CDR. Also provided are polynucleotides encoding a fusion protein and comprising two or more RSSs, and compositions and host cells comprising same, as well as fusion proteins variants produced by the described methods.

2. 发明公开

EP2311866A1 GAG binding proteins 审中-公开
标题翻译： GAG-bindende蛋白
公开(公告)号：EP2311866A1
公开(公告)日：2011-04-20
申请号：EP10180909.3
申请日：2004-12-02
申请人： Protaffin Biotechnologie AG
发明人： Kungl, Andreas
IPC分类号： C07K14/475 , C07K14/52 , C07K14/54
CPC分类号： C07K14/523 , A61K38/00 , C07K14/5421
摘要： A method for providing a modified GAG binding growth factor protein is provided, wherein the GAG binding region in said GAG binding growth factor protein is modified by substitution, insertion, and/or deletion of at least one amino acid in order to increase the relative amount of basic amino acids in said GAG binding region, and/or reduce the amount of bulky and/or acidic amino acids in said GAG binding region preferably at a solvent exposed position, so that the GAG binding affinity of said modified GAG binding growth factor is increased compared to the GAG binding affinity of said GAG binding wild-type growth factor.
摘要翻译：提供了一种提供修饰的GAG结合生长因子蛋白的方法，其中通过至少一个氨基酸的取代，插入和/或缺失来修饰所述GAG结合生长因子蛋白中的GAG结合区，以增加相对量的所述GAG结合区域中的碱性氨基酸，和/或优选在溶剂暴露位置减少所述GAG结合区域中的体积和/或酸性氨基酸的量，使得所述修饰的GAG结合生长因子的GAG结合亲和力为与所述GAG结合野生型生长因子的GAG结合亲和力相比增加。

3. 发明授权

EP1934251B1 INTERLEUKIN-8 LABELLED VIA ONE OR MORE SITE SPECIFICALLY CONJUGATED HYDRAZINONICOTINAMIDE (HYNIC) MOIETIES AND ITS USE IN DIAGNOSIS OF INFECTION AND INFLAMMATION 有权
标题翻译：由一个或多个特定位置结合型HYDRAZINE尼古丁阿米德（HYNIC）PARTS LABELED白细胞介素-8及其用于医疗诊断感染和炎症
公开(公告)号：EP1934251B1
公开(公告)日：2010-06-16
申请号：EP06831859.1
申请日：2006-10-13
申请人： Stichting Katholieke Universiteit
发明人： RENNEN, Huub , BOERMAN, Otto
IPC分类号： C07K14/54 , G01N33/68
CPC分类号： C07K14/5421

4. 发明公开

EP2126091A1 CHEMOKINE-CHAPERONE FUSION PROTEINS 审中-公开
标题翻译：趋化因子的分子伴侣融合蛋白
公开(公告)号：EP2126091A1
公开(公告)日：2009-12-02
申请号：EP07845303.2
申请日：2007-12-20
申请人： Protaffin Biotechnologie AG
发明人： KUNGL, Andreas
IPC分类号： C12N15/62
CPC分类号： C07K14/522 , C07K14/521 , C07K14/523 , C07K14/5421 , C07K2319/35
摘要： The present invention relates to a fusion protein comprising at least one chemokihe or a derivative or fragment thereof and at least one peptide derived from a chaperone. Additionally, the invention also provides a pharmaceutical preparation containing a fusion protein and its use for the treatment of inflammatory conditions or cancer.

5. 发明授权

EP1752470B1 Gag binding proteins 有权
标题翻译： GAG结合蛋白
公开(公告)号：EP1752470B1
公开(公告)日：2009-08-12
申请号：EP06117339.9
申请日：2004-12-02
申请人： Protaffin Biotechnologie AG
发明人： Kungl, Andreas J.
IPC分类号： C07K14/52 , C07K14/54
CPC分类号： C07K14/523 , A61K38/00 , C07K14/5421

6. 发明公开

EP1934251A2 INTERLEUKIN-8 LABELLED VIA ONE OR MORE SITE SPECIFICALLY CONJUGATED HYDRAZINONICOTINAMIDE (HYNIC) MOIETIES AND ITS USE IN DIAGNOSIS OF INFECTION AND INFLAMMATION 有权
标题翻译：由一个或多个特定位置结合型HYDRAZINE尼古丁阿米德（HYNIC）PARTS LABELED白细胞介素-8及其用于医疗诊断感染和炎症
公开(公告)号：EP1934251A2
公开(公告)日：2008-06-25
申请号：EP06831859.1
申请日：2006-10-13
申请人： Stichting Katholieke Universiteit
发明人： RENNEN, Huub , BOERMAN, Otto
IPC分类号： C07K14/54 , G01N33/68
CPC分类号： C07K14/5421
摘要： Interleukin-8, or an analog or derivative thereof, labelled via one or more hydrazinonicotinamide (HYNIC) moieties site-specifically conjugated to one or 5 more internal lysines and/or an N-terminal amino acid, for use in diagnosis of infection and inflammation.

7. 发明公开

EP1926495A2 THERAPEUTIC USE OF OUTER SHIGELLA PROTEIN F (OS PF) 审中-公开
标题翻译： OUTER志贺氏菌蛋白F的治疗用途（OS PF）
公开(公告)号：EP1926495A2
公开(公告)日：2008-06-04
申请号：EP06793556.9
申请日：2006-09-15
申请人： INSTITUT PASTEUR , INSERM (Institut National de la Santé et de la Recherche Médicale)
发明人： ARBIBE, Laurence , SANSONETTI, Philippe , PARSOT, Claude , DONG WOOK, Kim , PHALIPON, Armelle
IPC分类号： A61K39/02 , A61K38/16 , A61P35/00 , A61P31/04
CPC分类号： A61K38/164 , A61K38/45 , A61K39/0283 , A61K2039/521 , C07K14/4702 , C07K14/4703 , C07K14/4747 , C07K14/5421 , C07K14/5434 , C12N9/1205 , C12N9/16 , Y02A50/476
摘要： The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain of Shigella flexneri containing an inactivated ospF gene is also provided.

8. 发明公开

EP1752470A1 Gag binding proteins 有权
标题翻译： GAG-bindende蛋白
公开(公告)号：EP1752470A1
公开(公告)日：2007-02-14
申请号：EP06117339.9
申请日：2004-12-02
申请人： Protaffin Biotechnologie AG
发明人： Kungl, Andreas J.
IPC分类号： C07K14/52 , C07K14/54
CPC分类号： C07K14/523 , A61K38/00 , C07K14/5421
摘要： A method is provided for introducing a GAG binding site into a protein comprising the steps:
- identifying a region in a protein which is not essential for structure maintenance
- introducing at least one basic amino acid into said site and/or deleting at least one bulky and/or acidic amino acid in said site,

whereby said GAG binding site has a GAG binding affinity of Kd ≤ 10µM, preferably ≤ 1µM, still preferred ≤ 0.1µM, as well as modified GAG binding proteins.
摘要翻译：提供了一种用于将GAG结合位点引入蛋白质的方法，包括以下步骤： - 鉴定蛋白质中对结构维持不是必需的区域 - 将至少一个碱性氨基酸引入所述位点和/或删除至少一个笨重的和/或酸性氨基酸，其中所述GAG结合位点具有Kd‰¤10μM，优选‰¤1μM，仍然优选‰¤0.1μM的GAG结合亲和力，以及修饰的GAG结合蛋白。

9. 发明公开

EP1673388A2 NOVEL CXCL8 ANTAGONISTS 有权
标题翻译： CXCL8拮抗剂
公开(公告)号：EP1673388A2
公开(公告)日：2006-06-28
申请号：EP04791294.4
申请日：2004-10-22
申请人： Applied Research Systems ARS Holding N.V.
发明人： PROUDFOOT, Amanda , SHAW, Jeffrey
IPC分类号： C07K14/54 , C12N15/24 , C12N15/62 , A61K38/20 , A61K31/713
CPC分类号： C07K14/5421 , A61K38/00
摘要： Novel antagonists of the chemokine CXCL8 (also known as Interleukin-8) can be obtained by generating mutants having specific combinations of non-.conservative substitutions of basic amino acids located in the C-terminal region. Compounds prepared in accordance with the present invention can be used to block CXCL8 activity in vivo, thereby providing therapeutic compositions for use in the treatment or prevention of CXCL-8-related diseases.

10. 发明公开

EP1451581A4 TOLL-LIKE RECEPTOR 3 SIGNALING AGONISTS AND ANTAGONISTS 审中-公开
标题翻译：激动剂和信令的Toll样受体3的拮抗剂
公开(公告)号：EP1451581A4
公开(公告)日：2006-01-11
申请号：EP02800882
申请日：2002-10-03
申请人： COLEY PHARM GMBH
发明人： LIPFORD GRAYSON
IPC分类号： G01N33/50 , C07K14/52 , C07K14/54 , C07K14/56 , C07K14/565 , C07K14/705 , C12N5/08 , C12N15/09 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , C07H21/04 , C12N5/06 , C12N5/10 , C12N15/63
CPC分类号： C07K14/5412 , C07K14/523 , C07K14/5421 , C07K14/5434 , C07K14/56 , C07K14/565 , C07K14/705
摘要： Compositions and methods are provided to identify, characterize, and optimize immunostimulatory compounds, their agonists and antagonists, working through TLR3.

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