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1. 发明授权

EP1232173B1 FUSIDIC ACID DERIVATIVES 有权
标题翻译： FUSIDINSÄURE衍
公开(公告)号：EP1232173B1
公开(公告)日：2003-05-28
申请号：EP00967616.4
申请日：2000-10-12
申请人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB)
发明人： DUVOLD, Tore , VON DAEHNE, Welf
IPC分类号： C07J9/00 , A61K31/575 , C07J13/00
CPC分类号： C07J9/00 , C07J13/00
摘要： Novel 17,20-dihydrofusidic acid derivatives are used in pharmaceutical compositions for the treatment of infections, in particular in topical compositions for the treatment of skin or eye infections.

2. 发明公开

EP1232173A1 FUSIDIC ACID DERIVATIVES 有权
标题翻译：夫西地衍生物
公开(公告)号：EP1232173A1
公开(公告)日：2002-08-21
申请号：EP00967616.4
申请日：2000-10-12
申请人： LEO PHARMACEUTICAL PRODUCTS LTD. A/S(LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB)
发明人： DUVOLD, Tore , VON DAEHNE, Welf
IPC分类号： C07J9/00 , A61K31/575 , C07J13/00
CPC分类号： C07J9/00 , C07J13/00
摘要： Novel 17,20-dihydrofusidic acid derivatives are used in pharmaceutical compositions for the treatment of infections, in particular in topical compositions for the treatment of skin or eye infections.

3. 发明公开

EP2688418A1 STIGMASTEROL-RICH PHYTOSTEROL COMPOSITION AND USE 有权转让
标题翻译：豆甾醇丰富ZUZAMMENSETZUNG及其用途
公开(公告)号：EP2688418A1
公开(公告)日：2014-01-29
申请号：EP12711534.3
申请日：2012-03-21
申请人： Diageo Great Britain Limited
发明人： GREEN, Daniel, Albert , ROSENFELD, David, H. , DOBY, Michael Jonathan , WINSTON, Scott , LEVINE, Harry , SLADE, Louise , BROOKS, Dennis
IPC分类号： A23G9/04 , A23L1/03 , A23G9/32
CPC分类号： C07J13/00 , A23G9/045 , A23G9/42 , A23G9/52 , A23G2200/14 , A23L2/52 , A23L33/11 , C07J75/00
摘要： A stigmasterol-rich phytosterol composition is prepared wherein the composition comprises at least 50% stigmasterol, based on the total weight of phytosterols, no more than 1000 ppm water, no more than 50 ppm ethanol, and wherein stigmasterol is at least 98% in the anhydrous form. A ready-to-freeze beverage is provided comprising the stigmasterol-rich composition and water, with optional additives. A frozen beverage is prepared from the ready-to-freeze beverage as a pourable slush. There are further provided processes to prepare the ready-to-freeze beverage and the frozen slush beverage.

4. 发明公开

EP1658305A1 NOVEL FUSIDIC ACID DERIVATIVES 审中-公开
标题翻译：新夫西地衍生物
公开(公告)号：EP1658305A1
公开(公告)日：2006-05-24
申请号：EP04738988.7
申请日：2004-07-09
申请人： LEO PHARMA A/S
发明人： DUVOLD, Tore , BRETTING, Claus, Aage, Svensgaard , RASMUSSEN, Poul, Rodbroe , BOUÉRAT DUVOLD, Laetitia, Maud, Elysa , THORHAUGE, Jacob
IPC分类号： C07J9/00
CPC分类号： C07J9/00 , C07J9/005 , C07J13/00 , C07J13/002 , C07J51/00 , C07J53/00
摘要： The present Invention relates to novel fusidic acid derivatives of general formula (I) wherein X represents halogen, trifluoromethyl, cyano, azido, alkyl, alkenyl or aryl, wherein. said alkyl, alkenyl or aryl are optionally substituted by one or more, same or. different substituents selected from the group consisting of alkyl, alkenyl, aryl, alkoxy, nitro, alkylthio, halogen, azido, trifluoromethyl and cyano; Y and Z both' represent hydrogen, or together with the C-17/C-20 bond form a double bond between C-17 and C-20, or together are methylene and form a cyclopropane ring in combination with C-17 and C-20; A represents a bond,. O, S or S(O); B represents C1-6 alkyl, C2-6 alkenyl, CI-6 acyl, C3-7 cycloalkylcarbonyl or benzoyl, all of which are optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, alkoxy, aryl, heteroaryl and azido, or, if A represents a bond, B may also represent hydrogen; Q1 and 'Q2 independently represent. -CH2-, -C(O)-, -(CHOR)-, -(CHOR)-, -(CHSH)-, - (NH)-, -(CHNH2)- or -(CHW)-., wherein R represents CI-6alkyl and W represents halogen, cyano, azido or trifluoromethyi; Q3 represents -CH2-, -C(O)- or -CHOH-; G represents hydrogen, OH or O-CO-CH3; two bonds in the pentacyclic ring being depicted with full and dotted lines to indicate that either of the two bonds may be a double bond, in which case Y is absent and Z represents hydrogen; the bond between C-1 and C-2 being either a single or a double bond; and pharmaceutically acceptable salts and easily hydrolysable esters thereof, to pharmaceutical compositions comprising said derivatives, as well as to their use in therapy.

5. 发明公开

EP2638806A4 METHOD FOR PRODUCING OIL OR FAT THAT CONTAINS y-ORYZANOL 审中-公开
标题翻译：工艺用于生产油或γ脂肪谷维素
公开(公告)号：EP2638806A4
公开(公告)日：2014-04-02
申请号：EP11839755
申请日：2011-11-08
申请人： TSUNO FOOD IND CO LTD
发明人： TSUNO TAKUO , YAMANAKA TAKASHI , SEGOSHI HIROAKI
IPC分类号： A23D9/007 , A23K1/00 , A23K1/16 , A23L1/30 , C07J13/00 , C11B3/04 , C11B13/02
CPC分类号： A61K31/575 , A23D9/007 , A23K20/158 , A23L33/115 , C07J13/00 , C11B3/04 , C11B3/06 , C11B5/0035 , C11B13/02 , Y02W30/74

6. 发明公开

EP1640009A1 Estrogenic compounds as antimitotic agents 失效
标题翻译：雌二醇抗炎药
公开(公告)号：EP1640009A1
公开(公告)日：2006-03-29
申请号：EP05016659.4
申请日：1994-08-02
申请人： CHILDREN'S MEDICAL CENTER CORPORATION
发明人： D'Amato, Robert John , Folkman, Moses Judah
IPC分类号： A61K31/56 , C07J41/00 , C07J31/00 , C07J13/00 , C07J9/00 , C07J5/00 , C07J7/00 , C07J63/00 , C07J1/00
CPC分类号： A61K31/567 , A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/59 , C07J1/00 , C07J1/0059 , C07J1/007 , C07J1/0096 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/899 , Y10S514/912 , Y10S514/914
摘要： The application discloses methods of making medicaments for treating mammalian diseases characterised by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of general formulae found above in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.
摘要翻译：本申请公开了通过以足以抑制细胞有丝分裂的剂量施用包括秋水仙素或考布司他汀A-4结构基序的雌二醇衍生物来治疗以异常细胞有丝分裂为特征的哺乳动物疾病的药物的方法。该申请公开了用于该方法的新化合物。

7. 发明公开

EP1631580A2 PROCEDES DE PREPARATION DE DERIVES DE LA DHEA 审中-公开
标题翻译：用于生产脱氢表雄酮衍生物
公开(公告)号：EP1631580A2
公开(公告)日：2006-03-08
申请号：EP04742438.7
申请日：2004-04-06
申请人： MAYOLY-SPINDLER
发明人： CRITON, Marc , GLOUX, Damien , MONTERO, Jean-Louis
IPC分类号： C07J75/00 , C07J21/00 , C07J1/00 , C07J51/00 , A61K31/566 , A61K31/568 , A61K8/00 , A61P17/00
CPC分类号： A61K31/568 , A61K8/63 , A61K31/566 , A61K31/5685 , A61Q19/08 , C07J9/00 , C07J13/00 , C07J75/00
摘要： The invention relates to a method for the production of DHEA derivatives, such as 7-oxo-DHEA and 7-hydroxy-DHEA, from DHEA itself.

8. 发明公开

EP1927359A2 2-Methoxyestradiol for the treatment of inflammatory disorders 失效
标题翻译： 2-Methoxyestradiol zur Behandlung vonentzündlichenErkrankungen
公开(公告)号：EP1927359A2
公开(公告)日：2008-06-04
申请号：EP08002915.0
申请日：1994-08-02
申请人： CHILDREN'S MEDICAL CENTER CORPORATION
发明人： D'Amato, Robert John , Folkman, Moses Judah
IPC分类号： A61K31/56 , C07J41/00 , C07J31/00 , C07J13/00 , C07J9/00 , C07J5/00 , C07J7/00 , C07J63/00 , C07J1/00
CPC分类号： A61K31/567 , A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/59 , C07J1/00 , C07J1/0059 , C07J1/007 , C07J1/0096 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/899 , Y10S514/912 , Y10S514/914
摘要： The applications discloses the treatment of inflammatory disorders, in particular those associated with rheumatoid, arthritis, gout, gouty arthritis and Behcet's syndrome, with 2-methoxyestradiol.
摘要翻译：应用公开了用2-甲氧基雌二醇治疗炎症性疾病，特别是与类风湿，关节炎，痛风，痛风性关节炎和白塞氏综合征相关的炎性疾病。

9. 发明公开

EP0713393A4 ESTROGENIC COMPOUNDS AS ANTI-MITOTIC AGENTS 失效
标题翻译：雌激素化合物为活性抗有丝分裂
公开(公告)号：EP0713393A4
公开(公告)日：2000-10-25
申请号：EP94924120
申请日：1994-08-02
申请人： CHILDRENS MEDICAL CENTER
发明人： D AMATO ROBERT JOHN , FOLKMAN MOSES JUDAH
IPC分类号： A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/567 , A61K31/59 , A61P43/00 , C07J1/00 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00
CPC分类号： A61K31/567 , A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/59 , C07J1/00 , C07J1/0059 , C07J1/007 , C07J1/0096 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/899 , Y10S514/912 , Y10S514/914

10. 发明公开

EP0713393A1 ESTROGENIC COMPOUNDS AS ANTI-MITOTIC AGENTS 失效
标题翻译：雌激素化合物作为抗血管生成物质
公开(公告)号：EP0713393A1
公开(公告)日：1996-05-29
申请号：EP94924120.0
申请日：1994-08-02
申请人： The Children's Medical Center Corporation
发明人： D'AMATO, Robert John , FOLKMAN, Moses Judah
IPC分类号： A61K31 , A61P43 , C07J1 , C07J3 , C07J5 , C07J7 , C07J9 , C07J13 , C07J31 , C07J41 , C07J63
CPC分类号： A61K31/567 , A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/59 , C07J1/00 , C07J1/0059 , C07J1/007 , C07J1/0096 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/899 , Y10S514/912 , Y10S514/914
摘要： The application discloses methods of making medicaments for treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of general formulae found above in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.

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