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1. 发明公开

EP1928853A4 PROCESS FOR PRODUCTION OF DELTA-9-TETRAHYDROCANNABINOL 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON DELTA-9-TETRAHYDROCANNABINOL
公开(公告)号：EP1928853A4
公开(公告)日：2011-02-16
申请号：EP06804207
申请日：2006-09-28
申请人： AMR TECHNOLOGY INC
发明人： BURDICK DAVID C , COLLIER STEVEN J , JOS FREDERIC , BIOLATTO BETINA , PAUL BERNHARD J , MECKLER HAROLD , HELLE MARK A , HABERSHAW ALICIA J
IPC分类号： C07D311/78
CPC分类号： C07C29/00 , C07C37/16 , C07C67/343 , C07C2601/16 , C07C35/16 , C07C39/23 , C07C69/94

2. 发明公开

EP0712827A4 PROCESS FOR PRODUCING D-(CHIRO)-INOSITOL 失效
标题翻译：用于生产D-手性肌醇
公开(公告)号：EP0712827A4
公开(公告)日：1996-11-06
申请号：EP94923085
申请日：1994-08-08
申请人： HOKKO CHEM IND CO , ZAIDAN HOJIN BISEIBUTSU
发明人： SATO KIYOSHI , YOSHIDA MAKOTO , KANBE KENJI , HIRAZAWA KIYOSHI , TAKEUCHI TOMIO
IPC分类号： C07C29/10 , C07C35/16
CPC分类号： C07C35/16 , C07B2200/07 , C07C29/10 , C07C2601/14
摘要： A process for producing D-chiro-inositol which comprises either mixing an aqueous solution of kasugamycin or a salt thereof with a strongly acidic ion-exchange resin (of H type) in a reactor or bringing the aqueous solution into contact with the resin in a column packed therewith, heating the aqueous solution and the resin under normal or applied pressure to effect hydrolysis of kasugamycin to thereby prepare an acidic reaction solution containing D-chiro-inositol, separating the acidic reaction solution from the resin, and recovering D-chiro-inositol from the solution. In this stage, it is possible to obtain efficiently high-purity D-chiro-inositol by passing the acidic reaction solution first through a column packed with a strongly acidic ion-exchange resin (of H type) and then through another column packed with a strongly basic ion-exchange resin (of OH type) to prepare a neutral eluate containing D-chiro-inositol, and concentrating the eluate to effect deposition of D-chiro-inositol crystals.

3. 发明授权

EP0524082B1 Procédé de préparation du cis-inositol, du méso-inositol, de l'épi-inositol et/ou du cis-quercitol éventuellement deutérés 失效
标题翻译：一种用于生产任选氘化顺 - 肌醇，内消旋肌醇，表 - 肌醇和/或顺式栎醇方法。
公开(公告)号：EP0524082B1
公开(公告)日：1995-10-18
申请号：EP92402031.6
申请日：1992-07-15
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE
发明人： Odier, Léon
IPC分类号： C07C35/16 , C07C29/17 , C07C29/76
CPC分类号： C07C29/175 , C07B2200/05 , C07C29/76 , C07C35/16 , C07C2601/14 , C07C35/14

4. 发明公开

EP2578561A1 Processes for the production of cannabidiol derivatives and intermediates thereof 审中-公开
标题翻译： Verfahren zur Herstellung von Cannavbidiolderivaten und deren Intermediaten
公开(公告)号：EP2578561A1
公开(公告)日：2013-04-10
申请号：EP12191320.6
申请日：2006-09-28
申请人： Albany Molecular Research, Inc.
发明人： Burdick, David C , Collier, Steven J , Jos, Frédéric , Biolatto, Betina , Paul, Bernhard J , Meckler, Harold , Helle, Mark A , Habershaw, Alicia J
IPC分类号： C07C29/00 , C07C37/16 , C07C67/343
CPC分类号： C07C29/00 , C07C37/16 , C07C67/343 , C07C2601/16 , C07C35/16 , C07C39/23 , C07C69/94
摘要： This invention relates to a process for the preparation of a product compound of the formula:

wherein:
R 1 is H, substituted or unsubstituted alkyl, carboxylic ester, or acyl;
R 2 is H, OH, protected hydroxyl, substituted or unsubstituted alkyl, alkenyl, alkynyl, acyl, aryl, or heteroaryl;
R 3 is H, substituted or unsubstituted alkyl, carboxylic ester, or acyl;
R 4 is H, substituted or unsubstituted alkyl, silyl, hetero-substituted or unsubstituted acyl, alkylsulfonyl, arylsulfonyl, alkylphosphoryl, or arylphosphoryl; and
R 6 is H, substituted or unsubstituted alkyl, silyl, hetero-substituted or unsubstituted acyl, alkylsulfonyl, arylsulfonyl, alkylphosphoryl, or arylphosphoryl.
摘要翻译：本发明涉及制备下式的产物化合物的方法：其中：R 1是H，取代或未取代的烷基，羧酸酯或酰基; R 2是H，OH，保护的羟基，取代或未取代的烷基，烯基，炔基，酰基，芳基或杂芳基; R 3是H，取代或未取代的烷基，羧酸酯或酰基; R 4为H，取代或未取代的烷基，甲硅烷基，杂取代或未取代的酰基，烷基磺酰基，芳基磺酰基，烷基磷酰基或芳基磷酰基。和R 6是H，取代或未取代的烷基，甲硅烷基，杂取代或未取代的酰基，烷基磺酰基，芳基磺酰基，烷基磷酰基或芳基磷酰基。

5. 发明授权

EP0663915B1 SYNTHESES OF D-CHIRO-3-INOSOSE AND (+)-D-CHIRO-INOSITOL 失效
标题翻译：（+） - D-CHIRO-INOSITOL合成维生素D-CHIRO-3-INOSOSE
公开(公告)号：EP0663915B1
公开(公告)日：2002-12-04
申请号：EP93922377.2
申请日：1993-09-23
申请人： VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
发明人： HUDLICKY, Tomas , MANDEL, Martin c/o Virginia Tech Intel. Prop.,Inc.
IPC分类号： C07D493/04 , C07C35/16 , C07D317/46 , C07D493/14 , A61K31/045
CPC分类号： C07D493/04 , C07C29/145 , C07C35/16 , C07C2601/14 , C07D317/46 , C07D493/14
摘要： There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon (12) made by reacting a protected diol (acetonide) with permanganate under appropriate conditions. Such synthon is useful of the synthesis of various pharmaceutically important compounds such as D-chiro-inositol and D-chiro-3-inosose. Also, there are disclosed novel compounds, including specifically the synthon (12) and compounds derived therefrom.
摘要翻译：描述了用于合成各种氧化化合物的新型生物催化和化学方法。特别地，描述了通过在适当条件下使被保护的二醇（丙酮酸）与高锰酸盐反应制备的有用的合成子（12）的合成方法。这样的合成物可用于合成各种药学上重要的化合物，如D-手性肌醇和D-手 - 三烯糖。另外公开了新颖的化合物，特别包括合成子（12）和由其衍生的化合物。

6. 发明公开

EP1225175A1 Synthesis of D-chiro-3-inosose and (+)-D-chiro-inositol 失效
标题翻译：中间体D-手性肌糖的制备方法和（+） - D-手性肌醇
公开(公告)号：EP1225175A1
公开(公告)日：2002-07-24
申请号：EP02007823.4
申请日：1993-09-23
申请人： VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
发明人： Hudlicky, Tomas , Mandel, Martin, c/o Virginia Tech Intellect. Prop.
IPC分类号： C07D493/04 , C07C35/16 , C07D317/46 , C07D493/14 , A61K31/045
CPC分类号： C07D493/04 , C07C29/145 , C07C35/16 , C07C2601/14 , C07D317/46 , C07D493/14
摘要： There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon (12) made by reacting a protected diol (acetonide) with permanganate under appropriate conditions. Such synthon is useful of the synthesis of various pharmaceutically important compounds such as D- chiro -inositol and D- chiro -3-inosose. Also, there are disclosed novel compounds, including specifically the synthon (12) and compounds derived therefrom.

7. 发明授权

EP0790970B1 IMPROVED PROCESSES FOR THE PREPARATION OF D-CHIRO-INOSITOL 失效
标题翻译：改进的方法生产D-手性肌醇
公开(公告)号：EP0790970B1
公开(公告)日：1999-06-09
申请号：EP95939080.8
申请日：1995-11-09
申请人： Abbott Laboratories
发明人： RILEY, David, A. , BHATIA, Ashok, V. , CHAMBERLIN, Steven, A. , ROBINSON, Gregg, E.
IPC分类号： C07C29/10 , C07C35/16
CPC分类号： C07C69/013 , C07C29/095 , C07C35/16
摘要： A method for the preparation D-chiro-inositol (I) from kasugamycin (II), comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.

8. 发明公开

EP2545023A4 PROCESS FOR THE PREPARATION OF SCYLLO-INOSITOL 审中-公开
标题翻译：用于生产鲨肌醇
公开(公告)号：EP2545023A4
公开(公告)日：2017-04-12
申请号：EP11742947
申请日：2011-02-14
申请人： ABBVIE INC
发明人： REDDY RAJARATHNAM E , CHEMBURKAR SANJAY R , SPAULDING DOUGLAS R , PAN YI , CAO LEI , RESTITUYO JOSE A , LORENZINI RICHARD , DEMARCO MICHAEL
IPC分类号： C07C35/16 , C07H1/06
CPC分类号： C12P7/18 , C07B2200/07 , C07C29/12 , C07C2601/14 , C07H3/02 , C07C35/16

9. 发明公开

EP2663540A1 METHODS OF SYNTHESIS OF SCYLLITOL AND RELATED COMPOUNDS 审中-公开
标题翻译： VERFAHREN ZUR SYNTHESE VON SCYLLITOL UND VERWANDTE VERBINDUNGEN
公开(公告)号：EP2663540A1
公开(公告)日：2013-11-20
申请号：EP11791073.7
申请日：2011-10-13
申请人： Elan Pharmaceuticals, Inc.
发明人： GREENFIELD, Scott
IPC分类号： C07C29/132 , C07C35/14
CPC分类号： C07C29/12 , C07C29/56 , C07C29/78 , C07C29/92 , C07C2601/14 , C07C35/16
摘要： Methods of synthesis of scyllitol diborate and related compounds are provided, including methods that are performed in all-aqueous solutions. Also provided are methods in which the reaction products are recycled to increase the efficiency of the process. The methods include the steps of conversion of a solution of inositol to scyllitol, conversion of scyllitol in the solution to scyllitol diborate, and isolation of the scyllitol diborate from the solution. The scyllitol diborate is reacted to form substantially pure scyllitol diborate, and the remaining solution is efficiently recycled to scyllitol diborate, then to additional substantially pure scyllitol. This scyllitol diborate recycling step can be applied to a variety of processes to improve the yield of scyllitol. The methods are highly efficient and result in large scale reaction products of high purity.
摘要翻译：提供了合成辛二醇二硼酸盐和相关化合物的方法，包括在全水溶液中进行的方法。还提供了将反应产物再循环以提高该方法的效率的方法。所述方法包括将肌醇溶液转化成西欧糖醇的步骤，将溶液中的辛二醇溶液转化为青霉烷醇二硼酸酯，并从该溶液中分离出来的二水合二环己糖醇盐。反应所述的青霉醇二硼酸酯形成基本上纯的鲨烯糖醇二硼酸盐，并将剩余的溶液有效地再循环至雪利醇醇二硼酸盐，然后再添加至另外基本上纯的鲨烯醇。该Scyllitol二硼酸盐回收步骤可以应用于各种工艺以提高石蜡醇的产率。该方法高效，高纯度的大规模反应产物。

10. 发明公开

EP1928853A2 PROCESS FOR PRODUCTION OF DELTA-9-TETRAHYDROCANNABINOL 审中-公开
标题翻译：于制备DELTA-9-四氢
公开(公告)号：EP1928853A2
公开(公告)日：2008-06-11
申请号：EP06804207.6
申请日：2006-09-28
申请人： AMR Technology, Inc.
发明人： BURDICK, David, C. , COLLIER, Steven, J. , JOS, Frederic , BIOLATTO, Betina , PAUL, Bernhard, J. , MECKLER, Harold , HELLE, Mark, A. , HABERSHAW, Alicia, J.
IPC分类号： C07D311/78
CPC分类号： C07C29/00 , C07C37/16 , C07C67/343 , C07C2601/16 , C07C35/16 , C07C39/23 , C07C69/94
摘要： The present invention relates to a process for preparation of a delta-9- tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula (I): where R8, R9, and R10 are the same or different and independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or halo, with R1, R2, and R3 defined herein.

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