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1. 发明公开

EP4382507A1 COMPOUND, COATING COMPOSITION INCLUDING SAME, ORGANIC LIGHT-EMITTING DEVICE USING SAME, AND MANUFACTURING METHOD THEREFOR 审中-实审
公开(公告)号：EP4382507A1
公开(公告)日：2024-06-12
申请号：EP22867761.3
申请日：2022-09-13
申请人： LG Chem, Ltd.
发明人： JUNG, Sejin , SHIN, Hyeonah , LEE, Jiyoung , LIM, Dowon , JANG, Songrim , CHOI, Doowhan , LEE, Jaechol
IPC分类号： C07C211/61 , C07C211/54 , C07C217/44 , C07D307/91 , H10K99/00 , H10K50/00 , C09D5/00
CPC分类号： C07D307/91 , C07C211/54 , C07C217/44 , C09D7/40 , C09D5/00 , C07C211/61
摘要： The present specification relates to a compound of Chemical Formula 1, a coating composition including the compound, an organic light emitting device using the coating composition, and a manufacturing method thereof.

2. 发明公开

EP3103792A1 INTERMEDIATES FOR THE PREPARATION OF 6-(7-((1-AMINOCYCLOPROPYL)METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE 审中-公开
标题翻译： ZWISCHENPRODUKTEN ZUR HERSTELLUNG VON 6-（7 - （（1-氨基环戊基）甲氧基）-6-甲氧基喹啉-4-基）-N-甲基-1-萘甲酸
公开(公告)号：EP3103792A1
公开(公告)日：2016-12-14
申请号：EP16171791.3
申请日：2010-03-11
申请人： Clovis Oncology Italy S.r.l.
发明人： SPINELLI, Silvano , LIVI, Valeria
IPC分类号： C07C271/24 , C07C217/44
CPC分类号： C07D215/22 , C07C217/44 , C07C269/04 , C07C271/24 , C07C2601/02 , Y02P20/55
摘要： A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.
摘要翻译：制备式（I）的化合物6-（7 - （（1-氨基环丙基）甲氧基）-6-甲氧基喹啉-4-基氧基）-N-甲基-1-萘甲酰胺的高产率和纯度的方法和其药学上可接受的盐被描述。该方法相对于先前描述的方法具有各种优点，特别是避免了使用酰基叠氮化物中间体和它们的Curtius重排。还描述了可用于制备化合物（I）的新型中间体。

3. 发明公开

EP2038249A1 PROCESS FOR PREPARING GABAPENTIN 有权
标题翻译：用于生产加巴喷丁
公开(公告)号：EP2038249A1
公开(公告)日：2009-03-25
申请号：EP07766623.8
申请日：2007-06-29
申请人： ZaCh System S.p.A.
发明人： GHELFI, Franco , COTARCA, Livius , RONCAGLIA, Fabrizio , GIOVANETTI, Roberto , NICOLI, Andrea
IPC分类号： C07C217/44 , C07C227/18 , C07C229/28 , C07C253/30 , C07C255/46 , C07D317/28 , C07D317/30
CPC分类号： C07C227/18 , C07C217/44 , C07C253/30 , C07C255/46 , C07C2601/14 , C07D317/28 , C07D317/30 , C07C229/28
摘要： A process for preparing gabapentin of formula 1, which comprises Formula (I) converting 1-allyl-cyclohexanecarboxaldehyde into 1-allyl-cyclohexanecarbonitrile; ozonizing 1-allyl-cyclohexanecarbonitrile to obtain 1-cyano-cyclohexaneacetaldehyde; acetalizing 1-cyano-cyclohexaneacetaldehyde with a suitable acetalizing agent to give the corresponding acetal and converting the latter into gabapentin.

4. 发明公开

EP1263715A1 NOVEL PHENYLHETEROALKYLAMINE DERIVATIVES 有权
公开(公告)号：EP1263715A1
公开(公告)日：2002-12-11
申请号：EP01906491.4
申请日：2001-02-20
申请人： AstraZeneca AB
发明人： CHESHIRE, David,c/o AstraZeneca R & D Charnwood , CONNOLLY, Stephen,c/o AstraZeneca R & D Charnwood , COX, David,c/o AstraZeneca R & D Charnwood , METE, Antonio,c/o AstraZeneca R & D Charnwood
IPC分类号： C07C255/50 , C07C323/31 , C07C317/32 , C07C217/54 , C07C211/49 , C07D295/04 , A61K31/00 , A61P29/00
CPC分类号： C07C323/25 , C07C217/20 , C07C217/44 , C07C255/54 , C07C323/62 , C07C2601/02 , C07C2601/08
摘要： There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

5. 发明公开

EP0533056A2 Substituierte Aminopropane, Verfahren zu ihrer Herstellung und ihre Verwendung als Antimykutiku 失效
标题翻译： Substituierte Aminopropane，Verfahren zu ihrer Herstellung und ihre Verwendung als Antimykutiku。
公开(公告)号：EP0533056A2
公开(公告)日：1993-03-24
申请号：EP92115497.7
申请日：1992-09-10
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： Kirsch, Reinhard, Dr. , Hänel, Heinz, Dr. , Kottmann, Hariolf, Dr. , Linkies, Adolf Heinz, Dr. , Reuschling, Dieter Bernd, Dr. , Wehner, Volkmar, Dr.
IPC分类号： C07C217/34 , C07C217/32 , A61K31/13 , C07D211/58 , A61K31/44
CPC分类号： C07C217/32 , C07C217/34 , C07C217/44 , C07C217/48 , C07C217/58 , C07C2601/02 , C07C2601/14 , C07C2601/20 , C07C2603/74 , C07D209/14 , C07D211/58
摘要： Verbindungen der Formel I

dienen zur Behandlung und zur Prophylaxe von Pilzenkrankungen. Sie werden durch Umsetzung von II

zu IV

und Umsetzung mit einem Nucleophil M-NR(2)R(3) erhalten.
摘要翻译：式I的化合物用于治疗和预防真菌性疾病。它们通过II＆lt; IMAGE＆gt;与III＆lt; IMAGE＆gt;反应得到IV＆lt; IMAGE＆gt;并与亲核试剂M-NR（2）R（3）反应。

6. 发明授权

EP2575767B1 NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY 有权转让
标题翻译：用于寡核苷酸递送的新型低分子量阳离子脂质
公开(公告)号：EP2575767B1
公开(公告)日：2017-01-04
申请号：EP11790268.4
申请日：2011-05-31
申请人： Sirna Therapeutics, Inc.
发明人： BUDZIK, Brian, W. , COLLETTI, Steven, L. , DAVIS, Jennifer, R. , HILLS, Ivory, D. , SEIFRIED, Darla, D. , STANTON, Matthew, G.
IPC分类号： A61K9/127 , A61K47/18 , C07C217/46 , C12N15/87 , C07D317/28 , C07C43/15 , C07C217/44 , C07D205/04 , C07D295/084 , C07D207/08
CPC分类号： C07C217/46 , A61K9/1272 , A61K47/18 , C07C43/15 , C07C217/44 , C07D205/04 , C07D207/08 , C07D295/084 , C07D317/28 , C12N15/87

7. 发明公开

EP2832720A1 1,2-disubstituted cyclobutyl compounds 审中-公开
标题翻译： 1,2-二取代基环丁基二苯并噻吩
公开(公告)号：EP2832720A1
公开(公告)日：2015-02-04
申请号：EP13382310.4
申请日：2013-07-30
申请人： Laboratorios del. Dr. Esteve, S.A.
发明人： Torrens-Jover, Antoni , Ortuño-Mingarro, Rosa , Pericas-Cano, Àlex , Ferrer-Mallofrè, Èric
IPC分类号： C07C217/44 , C07D401/12 , C07D413/12 , C07D211/14 , C07D295/096 , A61K31/13 , A61K31/415 , A61K31/435 , A61P25/00
CPC分类号： C07D401/12 , C07C211/17 , C07C217/44 , C07C2601/04 , C07D207/06 , C07D211/14 , C07D231/22 , C07D295/03 , C07D295/096
摘要： The invention refers to compounds of general formula (I)

wherein the variables take various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.
摘要翻译：本发明涉及通式（I）的化合物，其中变量具有各种含义，含有它们的药物组合物及其在药物中的用途，特别是在疼痛疗法中。

8. 发明公开

EP2716630A1 PROCESS FOR PRODUCING ESTER COMPOUND 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG EINER ESTERVERBINDUNG
公开(公告)号：EP2716630A1
公开(公告)日：2014-04-09
申请号：EP12792034.6
申请日：2012-05-17
申请人： Sumitomo Chemical Company Limited
发明人： IKEMOTO, Tetsuya , LUTETE, Leopold Mpaka , AIKAWA, Toshiaki
IPC分类号： C07D209/52 , C07C205/29 , C07C217/44 , C07C271/16 , C07C271/18 , C07D317/16 , C07D317/28
CPC分类号： C07C223/02 , C07C201/12 , C07C205/29 , C07C213/02 , C07C213/08 , C07C217/44 , C07C269/04 , C07C271/16 , C07C271/18 , C07C2601/08 , C07D209/52 , C07D317/16 , C07D317/28 , C07C205/44
摘要： Compound (1) or a salt that is useful as an intermediate for the production of a medicine, an agrochemical or the like can be produced by a process comprising steps A to G as mentioned below:

[Step A] A step of reacting an aldehyde compound (2) with nitromethane to produce a nitroaldehyde compound (3);
[Step B] A step of reacting the nitroaldehyde compound (3) with an alcohol to produce a nitroacetal compound (4);
[Step C] A step of reducing the nitroacetal compound (4) to produce an aminoacetal compound (5);
[Step D] A step of protecting an amino group in the aminoacetal compound (5) to produce a protected aminoacetal compound (6);
[Step E] A step of treating the protected aminoacetal compound (6) with an acid and aubsequently with a base and then reacting the resultant product with a cyanating agent to produce a nitrile compound (7);
[Step F] A step of hydrolyzing the nitrile compound (7) to produce a protected amino acid compound (8); and
[Step G] A steep of substituting a group R 5 in the protected amino acid compound (8) by a hydrogen atom and protecting a carboxyl group therein.
摘要翻译：化合物（1）或可用作制备药物，农药等的中间体的盐可以通过包括如下所述的步骤A至G的方法制备：[步骤A]使醛化合物（2）与硝基甲烷反应生成硝基醛化合物（3）; [步骤B]使硝基醛化合物（3）与醇反应以制备硝基缩醛化合物（4）的步骤; [步骤C]还原硝基缩醛化合物（4）以产生氨基缩醛化合物（5）的步骤; [步骤D]保护氨基缩醛化合物（5）中的氨基以产生受保护的氨基缩醛化合物（6）的步骤; [步骤E]用酸和随后用碱处理受保护的氨基缩醛化合物（6），然后使所得产物与氰化剂反应以产生腈化合物（7）的步骤。 [步骤F]水解腈化合物（7）以产生受保护的氨基酸化合物（8）的步骤; 和[步骤G]通过氢原子将保护的氨基酸化合物（8）中的基团R 5取代并保护其中的羧基的陡峭。

9. 发明公开

EP2641897A2 A process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide and synthetic intermediates thereof 有权转让
标题翻译：（ - （（1-氨基环丙基）甲氧基）-6-甲氧基 - 喹啉-4-基氧基7）-N-甲基-1-萘甲酰胺和合成其中间体，一种制备6-过程
公开(公告)号：EP2641897A2
公开(公告)日：2013-09-25
申请号：EP13172499.9
申请日：2010-03-11
申请人： EOS Ethical Oncology Science S.p.A. in abbreviated form EOS S.p.A.
发明人： Spinelli, Silvano , Livi, Valeria
IPC分类号： C07C271/24 , C07D215/22 , C07C217/44
CPC分类号： C07D215/22 , C07C217/44 , C07C269/04 , C07C271/24 , C07C2601/02 , Y02P20/55
摘要： A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.

10. 发明授权

EP2408739B1 A PROCESS FOR THE PREPARATION OF 6-(7-((1-AMINOCYCLOPROPYL)METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND SYNTHETIC INTERMEDIATES THEREOF 有权转让
标题翻译： PROCESS FOR 6-的制备（7 - （（1- AMINOCYCLOPROPYL-）甲氧基）-6-甲氧基-4-基氧基）-N-甲基-1-萘甲酰胺和合成其中间体
公开(公告)号：EP2408739B1
公开(公告)日：2013-08-14
申请号：EP10712320.0
申请日：2010-03-11
申请人： EOS Ethical Oncology Science S.p.A. in abbreviated form EOS S.p.A.
发明人： SPINELLI, Silvano , LIVI, Valeria c/o EOS Ethical Oncology Science S.p.A.
IPC分类号： C07C271/24 , C07D215/22
CPC分类号： C07D215/22 , C07C217/44 , C07C269/04 , C07C271/24 , C07C2601/02 , Y02P20/55

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