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    • 9. 发明公开
    • VORRICHTUNG UND VERFAHREN ZUM HERSTELLEN VON DISPERSIONEN UND FESTSTOFFEN
    • EP2978515A1
    • 2016-02-03
    • EP14735837.8
    • 2014-03-28
    • Instillo GmbH
    • PENTH, BerndPENTH, FelixBAUMSTÜMMLER, BerndTÜRELI, Akif Emre
    • B01D1/14B01D1/18B01J2/04F26B3/12
    • B01J13/0095B01D9/0027B01D9/0054B01F5/0256B01J2/04F26B3/12F26B2210/12
    • The invention relates to an apparatus and a method for producing dispersions and solids by controlled precipitation, coprecipitation and self-organising processes in a microjet reactor, wherein a jet of a solvent (2) containing at least one target molecule collides with a jet of a non-solvent (3) at defined pressures and flow rates at a collision point (K) in the reactor chamber of the microjet reactor, and wherein the microjet reactor has a gas inlet (5) for admitting gas to the reactor chamber (1) and a reactant outlet (6) for discharging the reactants in a gas stream. This results in very rapid precipitation, coprecipitation or a chemical reaction in which microparticles or nanonparticles are produced. In order to provide an apparatus that can perform solvent/non-solvent precipitation in such a way as to produce particles that are as small as possible and are largely unaffected by Ostwald ripening in the resulting dispersion, the invention proposes connecting a spray-drying unit (7) to the reactant outlet and providing a control circuit (11) to optimise and maintain the operating parameters of the spray-drying unit (7).
    • 本发明涉及通过微喷射反应器中的受控沉淀,共沉淀和自组装方法生产分散体和固体的装置和方法,含有至少一种靶分子的溶剂射流和非溶剂射流碰撞 在特定压力和流速下,在微喷射反应器的反应器室中的碰撞点处,并且具有用于将气体引入反应器室的气体入口的微喷射反应器和用于将流体排放到流体中的喷射出口 的气体。 这导致非常快速的沉淀,共沉淀或化学反应,在其中形成微米或纳米颗粒。 为了产生可以进行溶剂/非溶剂沉淀的装置,以便产生尽可能小的颗粒,并且在形成的分散体中基本上不含Ostwald熟化,根据本发明建议 喷射出口之后是喷雾干燥器单元,并且提供反馈控制系统以优化和保持喷雾干燥器单元的操作参数。