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1. 发明公开

EP2090354A2 Enhanced drop mixing using magnetic actuation 审中-公开
标题翻译： Verbesserte Tropfenmischung unter Verwendung vonMagnetbetätigung
公开(公告)号：EP2090354A2
公开(公告)日：2009-08-19
申请号：EP09152403.3
申请日：2009-02-09
申请人： Palo Alto Research Center Incorporated
发明人： Debruyker, Dirk , Bhagat, Ali Asgar , Bell, Alan G , Recht, Michael I , Torres, Francisco E
IPC分类号： B01F13/08 , B01F13/00 , G01N25/48 , H01F41/02
CPC分类号： B01F13/0818 , B01F13/0071 , B01F13/0076 , B01F13/0077 , B01F2015/0221 , G01N25/48 , Y10T137/0318 , Y10T137/87652 , Y10T436/25 , Y10T436/2575
摘要： A method and device for merging and mixing at least two separate and distinct fluid drops on a substrate, includes a drop merging area on the surface, where a first magnetic material (32) is placed at a first location. A first drop of fluid (20) is then placed at the first location on the surface, resulting in the first magnetic material being at least partially positioned within the first drop of fluid. A second drop of fluid (18) is then placed at a second location on the surface of the drop merging area. A magnetic field is applied by a varying magnetic field generator (34) to at least a portion of the drop merge area of the substrate, which includes at least the first location on the substrate. The varying magnetic field will act on the first magnetic material (32) to move the first magnetic material within the first drop of fluid, causing a stirring of the fluid. A drop merging force from a drop merging mechanism is applied to at least one of the first drop of fluid and the second drop of fluid within the drop merge area. This causes at least one of the first drop of fluid and the second drop of fluid to move toward the other and make contact. The internal stirring of the fluid in the first drop of fluid by the movement of the magnetic material enhances the mixing of the constituents of the first drop of fluid and the constituents of the second drop of fluid.
摘要翻译：一种用于在衬底上合并和混合至少两个独立且不同的液滴的方法和装置，包括在表面上的液滴合并区域，其中第一磁性材料（32）被放置在第一位置。然后将第一滴流体（20）放置在表面上的第一位置处，导致第一磁性材料至少部分地定位在第一液滴内。然后将第二滴流体（18）放置在滴液合并区域的表面上的第二位置。通过变化的磁场发生器（34）将磁场施加到衬底的下落合并区域的至少一部分，其至少包括衬底上的第一位置。变化的磁场将作用在第一磁性材料（32）上，以移动第一液体流中的第一磁性材料，引起流体的搅拌。来自液滴合并机构的液滴合并力被施加到液滴合并区域中的第一滴流体和第二液体流中的至少一个。这使得第一液体流体和第二液体流中的至少一个向另一方移动并进行接触。通过磁性材料的运动在第一滴流体中的流体的内部搅拌增强了第一滴流体的组分和第二滴流体的组分的混合。

2. 发明公开

EP1306674A1 Dispositif d'injection parallelisée et synchronisée pour injections séquentielles de réactifs differents 审中-公开
标题翻译：一种用于各种试剂的并行和串行synkronisierten注射
公开(公告)号：EP1306674A1
公开(公告)日：2003-05-02
申请号：EP02292613.3
申请日：2002-10-22
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE
发明人： Fouillet, Yves , Sarrut, Nicolas , Gruss, Antoine
IPC分类号： G01N35/08
CPC分类号： B01F13/0071 , B01F13/0076 , B01F13/0077 , B01F15/00123 , B01F15/00344 , B01J19/0093 , B01J2219/00286 , B01J2219/00306 , B01J2219/00353 , B01J2219/00389 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00657 , B01J2219/00659 , B01J2219/0068 , B01L3/502784 , B01L3/563 , B01L2200/027 , B01L2200/0605 , B01L2300/1822 , B01L2400/0403 , B01L2400/0475 , B01L2400/06 , C40B60/14 , G01N35/08 , G01N35/085 , G01N2035/00237
摘要： L'invention concerne un dispositif microfluidique d'injection de trains de chambres mobiles de réaction (102, 103) avec séparateurs (101) non miscibles dans des micro-canaux (21 à 26), comprenant :

des moyens d'injection (10) pour injecter en alternance et en parallèle dans les micro-canaux du liquide pour former les chambres mobiles de réaction et du liquide pour former les séparateurs,
des moyens de contrôle de la progression de l'un des deux liquides, disposés pour intervenir sur une zone (31) de chaque micro-canal délimitant un volume à injecter de ce liquide, les moyens de contrôle étant aptes à provoquer l'arrêt ou le ralentissement de la progression de ce liquide sur la zone de chaque micro-canal en exerçant une action basée sur une propriété physico-chimique de ce liquide, cette action n'ayant pas d'effet direct sur l'autre liquide.
摘要翻译：适合于高通量筛选的生物微反应器，是新的。的喷射系统（10）介绍交替两个单独的液体，进入微通道。一种液体的喷射形成的移动反应室中。的其他形式分隔注射。一种液体的进展被控制在每个微通道，在介入的一个区域。一种用于液体注射体积限定。控制逮捕或减速在微通道中的液体，利用与所述液体相关联的物理或化学性质。这个动作对其他液体没有直接的影响。一种独立claimsoft包括用于对应的方法，该方法形成由第二非混溶的液体中分离流动液体反应室。样品被注入同时反应室。

3. 发明公开

EP1202802A1 MICROFLUIDIC DEVICES FOR THE CONTROLLED MANIPULATION OF SMALL VOLUMES 有权
标题翻译：微型器件的微型体积控制的流体处理
公开(公告)号：EP1202802A1
公开(公告)日：2002-05-08
申请号：EP00967377.3
申请日：2000-08-10
申请人： UT-Battelle, LLC
发明人： RAMSEY, J., Michael , JACOBSON, Stephen, C.
IPC分类号： B01L3/00 , B01J19/00
CPC分类号： B01F13/0071 , B01F5/0471 , B01F13/0076 , B01F13/0077 , B01J19/0093 , B01J2219/00853 , B01J2219/00891 , B01L3/502761 , B01L3/502784 , B01L2200/0605 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2400/0415 , B01L2400/049 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K99/0042 , F16K99/0051 , F16K99/0059 , F16K2099/0084 , G01N35/08 , G11C19/00 , G11C25/00 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/2575
摘要： A method for conducting a broad range of biochemical analyses or manipulations on a series of nano- to subnanoliter reaction volumes and an apparatus for carrying out the same are disclosed. The method and apparatus are implemented on a fluidic microchip to provide high serial throughput. The method and device of the invention also lend themselves to multiple parallel analyses and manipulation to provide greater throughput for the generation of biochemical information. In particular, the disclosed device is a microfabricated channel device that can manipulate nanoliter or subnanoliter biochemical reaction volumes in a controlled manner to produce results at rates of 1 to 10 Hz per channel. The individual reaction volumes are manipulated in serial fashion analogous to a digital shift register. The method and apparatus according to this invention have application to such problems as screening molecular or cellular targets using single beads from split-synthesis combinatorial libraries, screening single cells for RNA or protein expression, genetic diagnostic screening at the single cell level, or performing single cell signal transduction studies.

4. 发明公开

EP0990148A1 ELECTROKINETIC PUMPING 失效
标题翻译：电动泵
公开(公告)号：EP0990148A1
公开(公告)日：2000-04-05
申请号：EP97923614.8
申请日：1997-05-12
申请人： Sarnoff Corporation
发明人： ZANZUCCHI, Peter, John , BURTON, Charlotte, Anna , McBRIDE, Sterling, Edward , LEVINE, Aaron, William , CHIANG, William , CHERUKURI, Satyam, Choudary
IPC分类号： G01N27/26
CPC分类号： C07C17/263 , B01F5/0601 , B01F13/0077 , B01F15/0264 , B01J4/02 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00351 , B01J2219/00353 , B01J2219/00358 , B01J2219/00369 , B01J2219/00389 , B01J2219/00488 , B01J2219/00495 , B01J2219/005 , B01J2219/00536 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/0068 , B01J2219/00686 , B01J2219/00698 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00783 , B01J2219/00835 , B01J2219/00853 , B01J2219/00873 , B01J2219/00891 , B01J2219/00952 , B01J2219/00961 , B01J2219/00995 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/1827 , B01L2400/0415 , B01L2400/0688 , B01L2400/084 , C07C17/25 , C07C45/46 , C07C45/68 , C07C45/69 , C07C45/72 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , F04B17/00 , F04B19/006 , G01N33/54366 , H02N11/006
摘要： The invention provides methods of performing a synthetic process in a liquid distribution system (300, 310 and 320) having reaction cells (in 320), by pumping at least one reagent into a reaction cell using an electrode-based pump (360).
摘要翻译：本发明提供了通过使用基于电极的泵（360）将至少一种试剂泵入反应池中而在具有反应池（320）的液体分配系统（300,310和320）中执行合成过程的方法。

5. 发明公开

EP1666136A4 MICROREACTOR INCLUDING MAGNETIC BARRIER 有权
标题翻译： MIKROREAKTOR MIT MAGNETSPERRE
公开(公告)号：EP1666136A4
公开(公告)日：2006-09-06
申请号：EP03770124
申请日：2003-11-04
申请人： AOGAKI RYOICHI , ITO EIKO
发明人： AOGAKI RYOICHI , ITO EIKO , OGATA MIKIO
IPC分类号： B01J19/00 , B01F13/00 , B01L3/00 , C23F1/08 , C25D5/00 , C25D5/34 , C25D7/12
CPC分类号： B01F13/0077 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00853 , B01J2219/0086 , B01J2219/00889 , B01J2219/00918 , B01J2219/00921 , B01J2219/0093 , B01J2219/00952 , B01J2219/0097 , B01L3/502707 , B01L3/502746 , B01L2300/0816 , B01L2400/043 , B01L2400/084 , C23F1/08 , C25D5/34
摘要： Means for enabling plating on sites of complex configuration, etching for fine complex pattern, etc. through reduction of the viscosity resistance brought about by walls of fine liquid channel of microreactor. In particular, a microreactor comprising a liquid inlet, a fine liquid channel and a liquid discharge zone characterized in that the liquid channel is formed of a magnetic barrier of band ferromagnet so that a magnetic liquid introduced through the inlet undergoes at least one operation of chemical reaction, mixing, extraction and absorption in the liquid channel. Further, there is provided means for plating or etching performed by causing a plating solution or an etching solution to flow through the liquid channel.
摘要翻译：用于在复杂构造的位置进行电镀的方法，精细复合图案的蚀刻等。真空降低由微反应器的细液体通道壁引起的粘度阻力。特别地，微反应器包括液体入口，细液体通道和液体排放区，其特征在于，液体通道由磁带铁磁体的磁屏障形成，使得通过入口引入的磁性液体经历至少一种化学操作液体通道中的反应，混合，萃取和吸附。此外，提供通过使电镀溶液或蚀刻溶液流过液体通道进行的电镀或蚀刻的装置。

6. 发明授权

EP1089823B1 ELEKTRODENANORDNUNGEN ZUR ERZEUGUNG FUNKTIONELLER FELDBARRIEREN IN MIKROSYSTEMEN 有权
标题翻译：电极装置，用于产生微系统功能现场安全栅
公开(公告)号：EP1089823B1
公开(公告)日：2003-11-12
申请号：EP99929320.2
申请日：1999-06-28
申请人： Evotec OAI AG
发明人： FUHR, Günter , SCHNELLE, Thomas , HAGEDORN, Rolf , MÜLLER, Torsten
IPC分类号： B03C5/02 , G01N15/04
CPC分类号： B01F13/0076 , B01F13/0077 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , B01L2400/0415 , B03C5/026 , C12M33/00 , C12M47/04
摘要： The invention relates to an electrode arrangement in a microsystem which is installed in a channel for dielectrophoretically manipulating particles in a suspension liquid. At least one microelectrode is located on a side wall of the channel in order to generate a field barrier along a reference surface, said reference surface passing through the channel at least partially. The microelectrode has a predetermined curvature or predetermined angle in relation to the direction of flow in the channel so that the reference surface has a predetermined curvature in relation to the direction of flow. According to one embodiment, the particles move in the microsystem due to the effect of the centrifugal and/or gravitational forces.

7. 发明授权

EP0555252B1 VERFAHREN ZUR HANDHABUNG MIKROSKOPISCH KLEINER, DIELEKTRISCHER TEILCHEN UND VORRICHTUNG ZUR DURCHFÜHRUNG DES VERFAHRENS 失效转让
标题翻译：方法硫磷微观小，电介质粒子和装置实施过程
公开(公告)号：EP0555252B1
公开(公告)日：1996-02-07
申请号：EP91918107.3
申请日：1991-10-28
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
发明人： BENECKE, Wolfgang , WAGNER, Bernd , FUHR, Günter , HAGEDORN, Rolf , MÜLLER, Thorsten
IPC分类号： B03C5/00 , B03C5/02 , G01N15/00
CPC分类号： B03C5/005 , B01F13/0059 , B01F13/0076 , B01F13/0077 , B01J19/0093 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00853 , B01J2219/0093 , B03C5/026 , B03C5/028
摘要： The description relates to a process for manipulating microscopically small dielectric particles in which the particles are exposed to an electric field. In prior art processes the particles are exposed to non-uniform electric fields are polarised thereby. The polarised particles are moved towards higher field intensity. These processes do not permit the reversal of the direction of movement of the particles. The particles are enriched at the electrode and cannot therefore be held in free space. In the process of the invention the particles are exposed to one or more high-frequency fields moving in predeterminable directions whereby a force is exerted on the particles which puts them into a movement strongly asynchronous to the field. With the aid of a device for implementing the process of the invention it is possible very flexibly to manipulate particles. The particles can be moved by means of linearly or circularly arranged electrodes in any direction and through branched microstructures, they can be separated according to their dielectric properties and held contactlessly. The applications lie in the field of biotechnology and molecular separation, focussing and microtransport technology.

8. 发明公开

EP2090354A3 Enhanced drop mixing using magnetic actuation 审中-公开
标题翻译：使用磁致动改进降混合物
公开(公告)号：EP2090354A3
公开(公告)日：2009-11-18
申请号：EP09152403.3
申请日：2009-02-09
申请人： Palo Alto Research Center Incorporated
发明人： Debruyker, Dirk , Bhagat, Ali Asgar , Bell, Alan G , Recht, Michael I , Torres, Francisco E
IPC分类号： B01F13/08 , B01F13/00 , G01N25/48 , H01F41/02
CPC分类号： B01F13/0818 , B01F13/0071 , B01F13/0076 , B01F13/0077 , B01F2015/0221 , G01N25/48 , Y10T137/0318 , Y10T137/87652 , Y10T436/25 , Y10T436/2575
摘要： A method and device for merging and mixing at least two separate and distinct fluid drops on a substrate, includes a drop merging area on the surface, where a first magnetic material (32) is placed at a first location. A first drop of fluid (20) is then placed at the first location on the surface, resulting in the first magnetic material being at least partially positioned within the first drop of fluid. A second drop of fluid (18) is then placed at a second location on the surface of the drop merging area. A magnetic field is applied by a varying magnetic field generator (34) to at least a portion of the drop merge area of the substrate, which includes at least the first location on the substrate. The varying magnetic field will act on the first magnetic material (32) to move the first magnetic material within the first drop of fluid, causing a stirring of the fluid. A drop merging force from a drop merging mechanism is applied to at least one of the first drop of fluid and the second drop of fluid within the drop merge area. This causes at least one of the first drop of fluid and the second drop of fluid to move toward the other and make contact. The internal stirring of the fluid in the first drop of fluid by the movement of the magnetic material enhances the mixing of the constituents of the first drop of fluid and the constituents of the second drop of fluid.

9. 发明授权

EP1666136B1 MICROREACTOR INCLUDING MAGNETIC BARRIER 有权
标题翻译：带磁屏蔽微反
公开(公告)号：EP1666136B1
公开(公告)日：2008-10-15
申请号：EP03770124.0
申请日：2003-11-04
申请人： AOGAKI, Ryoichi , ITO, Eiko
发明人： AOGAKI, Ryoichi , ITO, Eiko , OGATA, Mikio
IPC分类号： B01J19/00 , C25D5/00 , C25D7/12 , C23F1/08
CPC分类号： B01F13/0077 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00853 , B01J2219/0086 , B01J2219/00889 , B01J2219/00918 , B01J2219/00921 , B01J2219/0093 , B01J2219/00952 , B01J2219/0097 , B01L3/502707 , B01L3/502746 , B01L2300/0816 , B01L2400/043 , B01L2400/084 , C23F1/08 , C25D5/34
摘要： Means for enabling plating on sites of complex configuration, etching for fine complex pattern, etc. through reduction of the viscosity resistance brought about by walls of fine liquid channel of microreactor. In particular, a microreactor comprising a liquid inlet, a fine liquid channel and a liquid discharge zone characterized in that the liquid channel is formed of a magnetic barrier of band ferromagnet so that a magnetic liquid introduced through the inlet undergoes at least one operation of chemical reaction, mixing, extraction and absorption in the liquid channel. Further, there is provided means for plating or etching performed by causing a plating solution or an etching solution to flow through the liquid channel.

10. 发明公开

EP1865322A1 BIOREACTION EXECUTION APPARATUS, METHOD OF BIOREACTION EXECUTION, DNA CHIP, INFORMATION PROCESSING UNIT, METHOD OF INFORMATION PROCESSING, PROGRAM AND RECORDING MEDIUM 审中-公开
标题翻译： DEVICE用于进行生物反应，METHOD用于进行生物反应，DNA芯片，信息处理单元，信息处理程序和记录介质
公开(公告)号：EP1865322A1
公开(公告)日：2007-12-12
申请号：EP06730434.5
申请日：2006-03-29
申请人： Sony Corporation
发明人： OHTO, Yasunori, SONY-KIHARA RESEARCH CENTER INC.
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , G01N27/447 , G01N37/00
CPC分类号： G01N27/44713 , B01F13/0077 , B01L3/502753 , B01L2300/0636 , B01L2300/0803 , B01L2300/0816 , B01L2300/0861 , B01L2400/0421 , C12Q2565/628
摘要： This invention relates to a bioreaction execution system and bioreaction execution method capable of producing electric fields in a flow channel, into which a solution with a target gene contained therein is dropped, on a DNA chip and causing the target gene to electrophoretically migrate, the DNA chip, an information processing system and information processing method, a program, and a recording medium. An AC supply unit 41 supplies an AC current to an electromagnetic induction generator unit 42, the electromagnetic induction generator unit 42 generates electromagnetic induction based on the thus-supplied AC current, and generates a magnetic field in adjacent to a flow channel which is formed on a mounted DNA chip 43 and into which a solution with a target gene contained therein is dropped. One of electric fields produced to negate the thus-generated magnetic field is canceled, while the other electric field is maintained. As the target gene is charged, it is caused to electrophoretically migrate by the electric field, which is maintained in only one direction, in the flow channel formed on the DNA chip 43.
摘要翻译：本发明涉及生物反应执行系统和生物反应能够在流动通道，在其中与其中所含的靶基因中的溶液滴生产电场，在DNA芯片上并且使所述靶基因的执行方法电泳迁移，所述DNA 芯片，信息处理系统和信息处理方法，程序，以及记录介质。 AC电源单元41只提供给AC电流在电磁感应产生器单元42的基础上，由此供给的交流电流的电磁感应产生器单元42基因率电磁感应，和基因率的磁场在邻近的流动通道的所有其形成在一个安装DNA芯片43并进入与其中所含的靶基因中的溶液被丢弃。之一产生否定由此产生的磁场的电场被解除，而另一电场得以维持。作为目标基因进行充电，它是由于以电泳通过电场迁移，所有这一切都被保持在形成于所述DNA芯片43在流动通道仅在一个方向

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