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1. 发明公开

EP2745850A1 NANO-PARTICLES FOR INTERNAL RADIATION THERAPY OF INVOLVED AREA, AND THERAPY SYSTEM 失效
标题翻译： NANOPARTIKEL ZUR INTERNEN STRAHLAPHERAPIE EINES BETRIFENEN BEREICHS UND THERAPIESYSTEM
公开(公告)号：EP2745850A1
公开(公告)日：2014-06-25
申请号：EP12832548.7
申请日：2012-09-12
申请人： Shimadzu Corporation , Kyoto University
发明人： TAKEUCHI, Eri , HARA, Isao , YAMAHARA, Ryo , OZEKI, Eiichi , KIMURA, Shunsaku , KURIHARA, Kensuke
IPC分类号： A61K51/00 , A61B1/00 , A61B5/055 , A61B6/03 , A61B8/08 , A61K31/765 , A61N5/10 , A61P35/00 , G01T1/161
CPC分类号： A61K51/1244 , A61B5/055 , A61B5/061 , A61B5/0813 , A61B6/037 , A61B6/12 , A61B6/4258 , A61B6/485 , A61B6/508 , A61B8/085 , A61B18/0218 , A61B18/1477 , A61B18/1815 , A61B2018/0293 , A61B2018/1869 , A61K49/0054 , A61K49/0086 , A61K51/06 , A61K51/12 , A61K51/1237 , A61K2123/00 , A61N5/10 , A61N2005/1011 , A61N2005/1021 , A61N2005/1052 , A61N2005/1098
摘要： The present invention provides a therapeutic system that is widely applicable to general solid cancers, can achieve both a reduction in side effects of cancer therapy and suppression of cancer recurrence and metastasis, and requires no expensive drug such as an antibody; and a nanoparticle for internal radiation therapy. A system for internal radiation therapy of a vascular lesion site comprising: a device comprising a means for acquiring image data showing a position of a vascular lesion site, and a means for positioning a needle, which should be punctured into the vascular lesion site, at the vascular lesion site based on the image data; and a nanoparticle comprising an amphiphilic block polymer comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit, and a substance labeled with a β-ray emitting nuclide. The nanoparticle for internal radiation therapy.
摘要翻译：本发明提供广泛适用于一般实体癌症的治疗系统，可以实现癌症治疗的副作用降低和癌症复发和转移的抑制，并且不需要昂贵的药物如抗体; 和用于内部放射治疗的纳米颗粒。一种用于血管损伤部位的内部放射治疗的系统，包括：装置，其包括用于获取显示血管病变部位的位置的图像数据的装置，以及用于定位应该穿刺到血管损伤部位的针的装置，基于图像数据的血管病变部位; 以及包含两亲性嵌段聚合物的纳米颗粒，所述两亲性嵌段聚合物包含具有肌氨酸单元的亲水性嵌段和具有乳酸单元的疏水性嵌段，以及用2号放射性核素标记的物质。用于内部放射治疗的纳米颗粒。

2. 发明公开

EP2745850A4 NANO-PARTICLES FOR INTERNAL RADIATION THERAPY OF INVOLVED AREA, AND THERAPY SYSTEM 失效
标题翻译：内部放射治疗设备纳米疫区和
公开(公告)号：EP2745850A4
公开(公告)日：2015-04-29
申请号：EP12832548
申请日：2012-09-12
申请人： SHIMADZU CORP , UNIV KYOTO
发明人： TAKEUCHI ERI , HARA ISAO , YAMAHARA RYO , OZEKI EIICHI , KIMURA SHUNSAKU , KURIHARA KENSUKE
IPC分类号： A61K51/00 , A61B1/00 , A61B5/055 , A61B6/03 , A61B8/08 , A61K31/765 , A61N5/10 , A61P35/00 , G01T1/161
CPC分类号： A61K51/1244 , A61B5/055 , A61B5/061 , A61B5/0813 , A61B6/037 , A61B6/12 , A61B6/4258 , A61B6/485 , A61B6/508 , A61B8/085 , A61B18/0218 , A61B18/1477 , A61B18/1815 , A61B2018/0293 , A61B2018/1869 , A61K49/0054 , A61K49/0086 , A61K51/06 , A61K51/12 , A61K51/1237 , A61K2123/00 , A61N5/10 , A61N2005/1011 , A61N2005/1021 , A61N2005/1052 , A61N2005/1098
摘要： The present invention provides a therapeutic system that is widely applicable to general solid cancers, can achieve both a reduction in side effects of cancer therapy and suppression of cancer recurrence and metastasis, and requires no expensive drug such as an antibody; and a nanoparticle for internal radiation therapy. A system for internal radiation therapy of a vascular lesion site comprising: a device comprising a means for acquiring image data showing a position of a vascular lesion site, and a means for positioning a needle, which should be punctured into the vascular lesion site, at the vascular lesion site based on the image data; and a nanoparticle comprising an amphiphilic block polymer comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit, and a substance labeled with a ²-ray emitting nuclide. The nanoparticle for internal radiation therapy.

3. 发明授权

EP2745850B1 NANO-PARTICLES FOR INTERNAL RADIATION THERAPY OF INVOLVED AREA, AND THERAPY SYSTEM 失效
标题翻译：用于内照射区域的内部辐射治疗的纳米颗粒和治疗系统
公开(公告)号：EP2745850B1
公开(公告)日：2018-05-16
申请号：EP12832548.7
申请日：2012-09-12
申请人： Shimadzu Corporation , Kyoto University
发明人： TAKEUCHI, Eri , HARA, Isao , YAMAHARA, Ryo , OZEKI, Eiichi , KIMURA, Shunsaku , KURIHARA, Kensuke
IPC分类号： A61K51/00 , A61B1/00 , A61B5/055 , A61B6/03 , A61B8/08 , A61K31/765 , A61N5/10 , A61P35/00 , G01T1/161 , A61K49/00 , A61B6/12 , A61B6/00 , A61B18/14 , A61B18/18 , A61K51/06 , A61B5/08 , A61B5/06 , A61B18/02 , A61K51/12
CPC分类号： A61K51/1244 , A61B5/055 , A61B5/061 , A61B5/0813 , A61B6/037 , A61B6/12 , A61B6/4258 , A61B6/485 , A61B6/508 , A61B8/085 , A61B18/0218 , A61B18/1477 , A61B18/1815 , A61B2018/0293 , A61B2018/1869 , A61K49/0054 , A61K49/0086 , A61K51/06 , A61K51/12 , A61K51/1237 , A61K2123/00 , A61N5/10 , A61N2005/1011 , A61N2005/1021 , A61N2005/1052 , A61N2005/1098
摘要： The present invention provides a therapeutic system that is widely applicable to general solid cancers, can achieve both a reduction in side effects of cancer therapy and suppression of cancer recurrence and metastasis, and requires no expensive drug such as an antibody; and a nanoparticle for internal radiation therapy. A system for internal radiation therapy of a vascular lesion site comprising: a device comprising a means for acquiring image data showing a position of a vascular lesion site, and a means for positioning a needle, which should be punctured into the vascular lesion site, at the vascular lesion site based on the image data; and a nanoparticle comprising an amphiphilic block polymer comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit, and a substance labeled with a ²-ray emitting nuclide. The nanoparticle for internal radiation therapy.

4. 发明公开

EP3251659A1 NANOVESICLES DERIVED FROM CELL MEMBRANE, AND USE THEREOF 有权转让
标题翻译：来源于细胞膜的纳米材料及其应用
公开(公告)号：EP3251659A1
公开(公告)日：2017-12-06
申请号：EP15882787.3
申请日：2015-08-24
申请人： Postech Academy-Industry Foundation
发明人： GHO, Yong Song , CHOI, Dong-Sic , GO, Gyeongyun
IPC分类号： A61K9/127 , A61K47/50 , A61K48/00 , A61K49/00
CPC分类号： A61K9/1273 , A61K9/5068 , A61K9/5089 , A61K9/5192 , A61K31/704 , A61K31/713 , A61K33/26 , A61K38/465 , A61K47/50 , A61K48/00 , A61K49/00 , A61K49/0067 , A61K49/0086 , C12Y301/27005
摘要： The present invention relates to cell membrane-derived nanovesicles, a method of preparing the same, and a pharmaceutical composition and a diagnostic kit using the nanovesicles. The cell membrane-derived nanovesicles according to the present invention may prevent the occurrence of potential side effects because intracellular materials (e.g., genetic materials and cytosolic proteins) unnecessary for delivery of therapeutic or diagnostic substances are removed from the nanovesicles. In addition, since the nanovesicles may be targeted to the specific types of cells or tissues, therapeutic or diagnostic substances may be predominantly delivered to the targeted cells or tissues while delivery of therapeutic or diagnostic substances to untargeted sites may be inhibited. Therefore, when the cell membrane-derived nanovesicles are applied to disease treatment, the side effects of therapeutic substances such as drugs may be reduced, so that suffering and inconvenience of patients may be alleviated during the course of treating diseases, and therapeutic efficacy may be improved. In addition, the cell membrane-derived nanovesicles of the present invention, in which substances for the treatment or diagnosis of diseases are loaded, and a method of preparing the nanovesicles may be used in vitro or in vivo for therapeutic or diagnostic purposes, or for experimental use.
摘要翻译：本发明涉及细胞膜衍生的纳米囊泡及其制备方法，以及使用该纳米囊泡的药物组合物和诊断试剂盒。根据本发明的细胞膜衍生纳米囊泡可防止潜在副作用的发生，因为从纳米囊泡中去除了用于递送治疗或诊断物质的细胞内物质（例如，遗传物质和胞质蛋白）。另外，由于纳米囊泡可以靶向特定类型的细胞或组织，所以治疗或诊断物质可以主要递送至靶细胞或组织，而治疗或诊断物质向非靶向位点的递送可以被抑制。因此，将细胞膜来源的纳米囊泡应用于疾病治疗时，可以减少药物等治疗物质的副作用，从而可以在治疗疾病的过程中减轻患者的痛苦和不便，并且治疗效果可能是改进。另外，本发明的细胞膜衍生纳米囊泡，其中加载用于治疗或诊断疾病的物质，以及制备纳米囊泡的方法可以体外或体内用于治疗或诊断目的，或用于实验使用。

5. 发明公开

EP2722058A1 Solid oral composition containing dyes for use in endoscopic diagnosis 审中-公开
标题翻译：与在内镜诊断染料使用口服固体组合物
公开(公告)号：EP2722058A1
公开(公告)日：2014-04-23
申请号：EP12189206.1
申请日：2012-10-19
申请人： Cosmo Technologies Ltd
发明人： Moro, Luigi , Repici, Alessandro
IPC分类号： A61K49/00 , A61K9/16 , A61K9/20 , A61K9/00 , A61K9/28
CPC分类号： A61K49/006 , A61K9/2018 , A61K9/2054 , A61K9/2846 , A61K49/003 , A61K49/0086 , A61K49/0089
摘要： Herein described are solid oral compositions of dyes for use in diagnostic endoscopy, preferably colon endoscopy.
摘要翻译：快来描述的是染料用于诊断内窥镜，优选结肠内窥镜检查用途的固体口服组合物。

6. 发明公开

EP2908866A1 SOLID ORAL COMPOSITION CONTAINING DYES FOR USE IN ENDOSCOPIC DIAGNOSIS 有权转让
标题翻译：用染料口服固体组合物用于本内镜诊断
公开(公告)号：EP2908866A1
公开(公告)日：2015-08-26
申请号：EP13774382.9
申请日：2013-09-26
申请人： Cosmo Technologies Ltd.
发明人： MORO, Luigi , REPICI, Alessandro
IPC分类号： A61K49/00 , A61K9/16 , A61K9/20 , A61K9/00 , A61K9/28
CPC分类号： A61K49/006 , A61K9/2018 , A61K9/2054 , A61K9/2846 , A61K49/003 , A61K49/0086 , A61K49/0089
摘要： Herein described are solid oral compositions of dyes for use in diagnostic endoscopy, preferably colon endoscopy.
摘要翻译：快来描述的是染料用于诊断内窥镜，优选结肠内窥镜检查用途的固体口服组合物。

7. 发明公开

EP1659938A4 POLYMERSOMES INCORPORATING HIGHLY EMISSIVE PROBES 审中-公开
标题翻译：与某些HOCHEMISSIVEN探头聚合物
公开(公告)号：EP1659938A4
公开(公告)日：2010-03-24
申请号：EP04786113
申请日：2004-07-26
申请人： UNIV PENNSYLVANIA
发明人： HAMMER DANIEL A , THERIEN MICHAEL J , GHOROGHCHIAN PAIMAN PETER
IPC分类号： A61K49/00 , A61K9/00
CPC分类号： A61K49/0036 , A61K49/0021 , A61K49/0041 , A61K49/0086

8. 发明公开

EP1659938A2 POLYMERSOMES INCORPORATING HIGHLY EMISSIVE PROBES 审中-公开
标题翻译：与某些HOCHEMISSIVEN探头聚合物
公开(公告)号：EP1659938A2
公开(公告)日：2006-05-31
申请号：EP04786113.3
申请日：2004-07-26
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： HAMMER, Daniel, A. , THERIEN, Michael, J. , GHOROGHCHIAN, Paiman, Peter
IPC分类号： A61B5/055 , A61K9/14
CPC分类号： A61K49/0036 , A61K49/0021 , A61K49/0041 , A61K49/0086
摘要： The instant invention concerns compositions comprising polymersomes, visible or near infrared emissive agents, and optionally a targeting moiety associated with a surface of the polymersome. The invention also relates to use of these compositions in the treatment of disease and in imaging methodology.

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