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1. 发明公开

EP3294344A1 COMPOSITIONS FOR CIRCULATORY SYSTEM VISUALIZATION 无效转让
公开(公告)号：EP3294344A1
公开(公告)日：2018-03-21
申请号：EP16722179
申请日：2016-05-10
申请人： ETH ZUERICH
发明人： LEROUX JEAN CHRISTOPHE , DETMAR MICHAEL , BRAMBILLA DAVIDE , PROULX STEVEN
IPC分类号： A61K49/00 , A61K9/16
CPC分类号： A61K49/0034 , A61K9/0021 , A61K9/1635 , A61K47/32 , A61K49/0069 , A61K49/0073
摘要： This invention describes compositions comprising indocyanine green and poly(N-vinylpyrrolidone) and methods of making the same as well as applications thereof for diagnostic and therapeutic uses. One of those applications is the structural and functional assessment of the lymphatic system by fluorescence imaging.

2. 发明公开

EP3277268A1 SELF ASSEMBLING MOLECULES FOR TARGETED DRUG DELIVERY 审中-公开
标题翻译：用于靶向药物递送的自组装分子
公开(公告)号：EP3277268A1
公开(公告)日：2018-02-07
申请号：EP16774208.9
申请日：2016-03-31
申请人： The General Hospital Corporation
发明人： ELMALEH, David, R. , TAKAHASHI, Kazue
IPC分类号： A61K9/51 , A61K47/48 , A61P35/00
CPC分类号： A61K47/6949 , A61K9/5052 , A61K9/5169 , A61K31/337 , A61K31/473 , A61K31/7068 , A61K39/39 , A61K47/62 , A61K47/6849 , A61K47/6925 , A61K49/0069 , A61K49/0091 , A61K49/1821 , A61K49/189 , A61K51/1251 , A61K51/1268 , A61P35/00
摘要： Described herein are self-assembling protein molecules for delivering a payload, for example, a toxic anti-cancer agent, a cancer immunotherapy, a toxic anti-cancer agent and a cancer immunotherapy, or an imaging agent, to specific tissues. Examples of self-assembled proteins include clathrin and derivatives of clathrin.

3. 发明公开

EP2682131A4 SWITCHING-TYPE FLUORESCENT NANOPARTICLE PROBE, AND FLUORESCENT MOLECULAR IMAGING METHOD USING SAME 有权
标题翻译：具有荧光纳米粒子的可切换探针及其插图荧光分子的方法
公开(公告)号：EP2682131A4
公开(公告)日：2014-09-17
申请号：EP12751966
申请日：2012-03-01
申请人： UNIV KYOTO , SHIMADZU CORP
发明人： SAJI HIDEO , KIMURA SHUNSAKU , ONO MASAHIRO , TEMMA TAKASHI , HARA ISAO , OZEKI EIICHI
IPC分类号： A61K49/00
CPC分类号： A61K49/0054 , A61K49/0032 , A61K49/0034 , A61K49/0069 , A61K49/0093
摘要： [Abstract] [Problem] To provide a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye in a blood component and emit fluorescence in a tumor or an inflamed site to be imaged). [Solution] A fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a polylactic acid-bound cyanine compound comprising: a fluorescent group represented by the formula (I):[Chemical and a polylactic acid group having 5 to 50 lactic acid units, and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly. [Selected Figure] Fig.1

4. 发明公开

EP3177326A1 SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS 审中-公开
标题翻译：自组装在酸性肿瘤微环境中的分子
公开(公告)号：EP3177326A1
公开(公告)日：2017-06-14
申请号：EP15830109.3
申请日：2015-08-07
申请人： The Ohio State Innovation Foundation
发明人： GOLDBERGER, Joshua E. , TWEEDLE, Michael F.
IPC分类号： A61K47/50 , A61K49/22 , A61K51/12
CPC分类号： A61K49/0069 , A61K49/0019 , A61K49/0056 , A61K49/14 , A61K49/18
摘要： Disclosed are compositions that contain a plurality of biocompatible self-assembling molecules that transform from isolated molecules or spherical micelles while in blood serum into cylindrical nanofibers in the acidic extracellular environment of tumors, which can be used to achieve a higher relative concentration of imaging drug delivery, or radiotherapeutic agents at the tumor site compared to non-tumor tissues. This transition is rapid and reversible, indicating the system is in thermodynamic equilibrium.
摘要翻译：公开了含有多种生物相容性自组装分子的组合物，所述自组装分子从血清中的分离的分子或球形胶束转变成肿瘤的酸性细胞外环境中的圆柱形纳米纤维，其可用于实现更高的相对成像浓度与非肿瘤组织相比，在肿瘤部位递送或放射治疗剂。这种转变是快速且可逆的，表明系统处于热力学平衡状态。

5. 发明公开

EP2682131A1 SWITCHING-TYPE FLUORESCENT NANOPARTICLE PROBE, AND FLUORESCENT MOLECULAR IMAGING METHOD USING SAME 有权
标题翻译：与荧光纳米粒子和可逆的探针法用于说明荧光分子
公开(公告)号：EP2682131A1
公开(公告)日：2014-01-08
申请号：EP12751966.8
申请日：2012-03-01
申请人： Kyoto University , Shimadzu Corporation
发明人： SAJI, Hideo , KIMURA, Shunsaku , ONO, Masahiro , TEMMA, Takashi , HARA, Isao , OZEKI, Eiichi
IPC分类号： A61K49/00
CPC分类号： A61K49/0054 , A61K49/0032 , A61K49/0034 , A61K49/0069 , A61K49/0093
摘要： [Abstract] [Problem] To provide a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye in a blood component and emit fluorescence in a tumor or an inflamed site to be imaged).
[Solution] A fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a polylactic acid-bound cyanine compound comprising: a fluorescent group represented by the formula (I):[Chemical

and a polylactic acid group having 5 to 50 lactic acid units, and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly. [Selected Figure] Fig.1
摘要翻译： [摘要] [问题]提供一种具有切换功能（以淬灭在血液成分的荧光染料和在肿瘤或炎症部位要被成像发出荧光的函数）的新型荧光纳米颗粒成像探针。 [解决方法]一种荧光纳米颗粒探针，包括：具有亲水性嵌段链和疏水性嵌段链的两亲性嵌段聚合物组成的分子组件; 和封装在组件上的荧光染料，worin（a）所述亲水性嵌段链包含，作为基本亲水性结构单元，从一个肌氨酸单元选择的单元和烯化氧单元，（B）疏水性嵌段链包含，如在基本疏水性结构单元，选自一种氨基酸单元和羟基羧酸单元，和（c）的荧光染料为聚乳酸结合的花青化合物，包含的选择的单元：由式（I）表示的荧光基团：[化学和具有5至50乳酸单元，和荧光染料的两个或多个分子的聚乳酸组被封装在单个分子组装。 [选定图]图1

6. 发明公开

EP3177326A4 SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS 审中-公开
公开(公告)号：EP3177326A4
公开(公告)日：2018-02-28
申请号：EP15830109
申请日：2015-08-07
申请人： OHIO STATE INNOVATION FOUNDATION
发明人： GOLDBERGER JOSHUA E , TWEEDLE MICHAEL F
IPC分类号： A61K47/50 , A61K49/22 , A61K51/12
CPC分类号： A61K49/0069 , A61K49/0019 , A61K49/0056 , A61K49/14 , A61K49/18
摘要： Disclosed are compositions that contain a plurality of biocompatible self-assembling molecules that transform from isolated molecules or spherical micelles while in blood serum into cylindrical nanofibers in the acidic extracellular environment of tumors, which can be used to achieve a higher relative concentration of imaging drug delivery, or radiotherapeutic agents at the tumor site compared to non-tumor tissues. This transition is rapid and reversible, indicating the system is in thermodynamic equilibrium.

7. 发明授权

EP2823050B1 DIAGNOSTIC CHEWING GUM FOR PATHOGENS 有权
标题翻译：嚼口香糖诊断的病原体
公开(公告)号：EP2823050B1
公开(公告)日：2017-03-01
申请号：EP13710333.9
申请日：2013-03-08
申请人： Julius-Maximilians-Universität Würzburg
发明人： MEINEL, Lorenz , SCHNABELRAUCH, Matthias , SCHLOTTIG, Falko
IPC分类号： A61K49/00 , C12Q1/04
CPC分类号： A61K49/0004 , A23G4/14 , A61C2201/002 , A61K9/0058 , A61K49/00 , A61K49/0069 , C12Q1/04 , C12Q1/37 , C12Q2304/00 , G01N33/528 , G01N33/68 , G01N33/6893 , Y02A50/54 , Y02A50/58
摘要： Described herein is a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular pathogens residing in nasal, oropharyngeal, laryngeal, oesophageal, ocular and/or pulmonal tissue of a user, more particularly pathogens selected from among a virus, bacterium, protozoa, prion, fungus or a combination thereof. The inventive diagnostic chewing gum includes a base material or particles (3) embedded and/or attached to the base material and an element (1, 5-7), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user, wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4) which is released by the pathogens, or, in case of a virus or prion, by the cellular structure hosting it.

8. 发明公开

EP2823050A1 DIAGNOSTIC CHEWING GUM FOR PATHOGENS 有权
标题翻译： KAUGUMMI ZUR DIAGNOSE VON KRANKHEITSERREGER
公开(公告)号：EP2823050A1
公开(公告)日：2015-01-14
申请号：EP13710333.9
申请日：2013-03-08
申请人： Julius-Maximilians-Universität Würzburg
发明人： MEINEL, Lorenz , SCHNABELRAUCH, Matthias , SCHLOTTIG, Falko
IPC分类号： C12Q1/04 , A61K9/00
CPC分类号： A61K49/0004 , A23G4/14 , A61C2201/002 , A61K9/0058 , A61K49/00 , A61K49/0069 , C12Q1/04 , C12Q1/37 , C12Q2304/00 , G01N33/528 , G01N33/68 , G01N33/6893 , Y02A50/54 , Y02A50/58
摘要： Described herein is a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular pathogens residing in nasal, oropharyngeal, laryngeal, oesophageal, ocular and/or pulmonal tissue of a user, more particularly pathogens selected from among a virus, bacterium, protozoa, prion, fungus or a combination thereof. The inventive diagnostic chewing gum includes a base material or particles (3) embedded and/or attached to the base material and an element (1, 5-7), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user, wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4) which is released by the pathogens, or, in case of a virus or prion, by the cellular structure hosting it.
摘要翻译：本文描述的是用于鉴定通过口可检测的病原体的存在的诊断性口香糖，特别是存在于使用者的鼻，口咽，喉，食管，眼和/或肺组织中的病原体，特别是选自病毒，细菌，原生动物，朊病毒，真菌或其组合。本发明的诊断口香糖包括嵌入和/或附着到基底材料的基底材料或颗粒（3）和元件（1,5-7）连接到基材和/或颗粒上的可释放风味分子，用于产生用户可直接检测的口香糖的变化，其中元件（1,5-7）在直接或间接接触时产生变化具有由病原体释放的标记物（4），或者在病毒或朊病毒的情况下由宿主的细胞结构产生。

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