专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2596799B1 Methods and compositions related to inhibition of viral entry 有权
标题翻译：与抑制病毒进入有关的方法和组合物
公开(公告)号：EP2596799B1
公开(公告)日：2016-11-23
申请号：EP13156450.2
申请日：2008-02-08
申请人： University of Utah Research Foundation
发明人： Kay, Michael, S. , Welch, Brett, D.
IPC分类号： A61K38/10 , C07K7/08 , C07K14/00 , G01N33/569
CPC分类号： A61K38/10 , A61K45/06 , A61K47/481 , A61K47/48215 , A61K47/48253 , A61K47/55 , A61K47/60 , A61K47/641 , C07K5/1024 , C07K7/06 , G01N33/5008 , G01N33/56983 , G01N2333/005 , G01N2333/162 , G01N2500/00

2. 发明公开

EP2257280A4 ENGINEERED TUNABLE NANOPARTICLES FOR DELIVERY OF THERAPEUTICS, DIAGNOSTICS, AND EXPERIMENTAL COMPOUNDS AND RELATED COMPOSITIONS FOR THERAPEUTIC USE 审中-公开
标题翻译：技术操作的可调谐纳米粒子治疗，诊断和实验化合物用于治疗目的的运载工具和相关组合物
公开(公告)号：EP2257280A4
公开(公告)日：2015-09-09
申请号：EP09714125
申请日：2009-02-26
申请人： APARNA BIOSCIENCES
发明人： BERNINGER MARK , SCARIA PUTHUPPARAMPIL , WOODLE MARTIN
IPC分类号： A61K9/50 , A61K39/07 , A61K39/39 , A61K47/48 , B82Y5/00
CPC分类号： B82Y5/00 , A61K39/07 , A61K39/39 , A61K47/60 , A61K47/641 , A61K47/6911 , A61K2039/55555 , A61K2039/6031 , C07K2317/21 , C07K2317/52

3. 发明公开

EP2908849A1 A METHOD TO IMPROVE PHARMACOKINETICS OF DRUGS 审中-公开
标题翻译：方法提高药物的药代动力学
公开(公告)号：EP2908849A1
公开(公告)日：2015-08-26
申请号：EP13832975.0
申请日：2013-08-30
申请人： Board of Regents, The University of Texas System
发明人： HARGREAVES, Kenneth M.
IPC分类号： A61K38/46 , A61K38/18 , A61K39/395 , A61P35/00
CPC分类号： A61K47/48246 , A61K38/00 , A61K39/39533 , A61K45/06 , A61K47/64 , A61K47/641 , A61K47/643 , C07K14/46 , C07K16/44 , C07K2319/31
摘要： A compound comprises a pharmacologically active agent coupled to a plasma protein binding agent. The pharmacologically active agent, in some embodiments, may be an OLAM inhibitor. The plasma protein binding agent, in some embodiments, is a compound that is pharmacologically active in inflamed/injured tissue. A pharmaceutical composition that includes these compounds may be used to treat pain, shock, inflammatory conditions, or combinations thereof in a subject comprising administering to a subject who would benefit from such treatment a therapeutically effective amount of the pharmaceutical composition.

4. 发明公开

EP2852619A1 TRANSLOCATION OF NON-NATURAL CHEMICAL ENTITIES THROUGH ANTHRAX PROTECTIVE ANTIGEN PORE 审中-公开
标题翻译：易位不是化学天然物质，通过对炭疽保护抗原孔隙
公开(公告)号：EP2852619A1
公开(公告)日：2015-04-01
申请号：EP13793070.7
申请日：2013-05-21
申请人： Massachusetts Institute of Technology
发明人： LIAO, Xiaoli , RABIDEAU, Amy, E. , PENTELUTE, Bradley, L. , LING, Jingjing , AKÇAY, Gizem
IPC分类号： C07K19/00 , C07K1/107 , C07K1/36 , C07K7/06 , C07K17/06 , C12N15/12 , C12N15/63 , C12P21/04 , A61K38/03 , A61K38/17 , B82Y5/00
CPC分类号： A61K47/6811 , A61K31/7056 , A61K39/395 , A61K47/64 , A61K47/641 , A61K47/6415 , C07K1/047 , C07K1/107 , C07K2/00 , C12P21/06
摘要： Disclosed is a new approach for delivering compounds and drugs to the cytosol of living cells through the use of engineered protein transporters. The engineered protein transporters include a pore and a pore specific delivery protein, wherein a reagent such as a drug is attached to one or more of the engineered protein transporters.

5. 发明公开

EP2391215A4 BINDING-SITE MODIFIED LECTINS AND USES THEREOF 审中-公开
标题翻译： BINDUNGSSTELLENMODIFIZIERTE LECTINE UND IHRE VERWENDUNG
公开(公告)号：EP2391215A4
公开(公告)日：2013-10-30
申请号：EP10736332
申请日：2010-01-27
申请人： SMARTCELLS INC
发明人： ZION TODD C , LANCASTER THOMAS M
IPC分类号： C07K14/62 , A61K38/28 , A61K47/48
CPC分类号： C07K14/42 , A61K38/28 , A61K47/61 , A61K47/641 , A61K47/6415 , C07K14/4726 , G01N33/66 , G01N2333/4724
摘要： In one aspect, the disclosure provides cross-linked materials that include multivalent lectins with at least two binding sites for glucose, wherein the lectins include at least one covalently linked affinity ligand which is capable of competing with glucose for binding with at least one of said binding sites; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with glucose for binding with the lectins at said binding sites and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between lectins and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of glucose. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label.
摘要翻译：在一个方面，本公开提供了交联材料，其包括具有至少两个葡萄糖结合位点的多价凝集素，其中所述凝集素包括至少一种共价连接的亲和配体，其能够与葡萄糖竞争与至少一个所述结合位点; 和缀合物，其包含与缀合物框架结合的两个或更多个分离的亲和配体，其中两个或更多个亲和配体与葡萄糖竞争与所述结合位点处的凝集素结合，并且其中缀合物在材料内交联，在不同共轭物上的凝集素和亲和配体之间的共价相互作用。这些材料被设计成响应于所需浓度的葡萄糖释放结合物的量。根据最终应用，在各种实施方案中，缀合物还可以包括药物和/或可检测标记。

6. 发明公开

EP1812016A4 HIGHLY BRANCHED HK PEPTIDES AS EFFECTIVE CARRIERS OF siRNA 审中-公开
标题翻译：高支HK肽的siRNA AS有效载体
公开(公告)号：EP1812016A4
公开(公告)日：2010-07-14
申请号：EP05851791
申请日：2005-11-17
申请人： UNIV MARYLAND
发明人： MIXSON ARCHIBALD
IPC分类号： A61K31/70 , C12N15/11
CPC分类号： C12N15/111 , A61K47/641 , A61K47/645 , A61K47/6455 , C12N2320/32

7. 发明公开

EP2117601A2 MACROMOLECULAR CONJUGATES OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORS AND USES THEREOF 审中-公开
标题翻译：囊性纤维化跨膜电导调节器蛋白抑制剂大分子结合物及其用途
公开(公告)号：EP2117601A2
公开(公告)日：2009-11-18
申请号：EP07869565.7
申请日：2007-12-19
申请人： The Regents of the University of California
发明人： VERKMAN, Alan, S. , SONAWANE, Natin, D.
IPC分类号： A61K47/48 , A61P43/00 , A61P1/00
CPC分类号： A61K31/74 , A61K47/549 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/64 , A61K47/641 , A61K47/645 , A61K47/65 , A61K47/6803 , A61K47/6849 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/491
摘要： Provided herein are bioactive agents comprising a compound that inhibits the ion transport activity of a cystic fibrosis transmembrane conductance regulator (CFTR) and that is linked to a macromolecule that interacts with a cell that expresses CFTR. The bioactive agents described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea.

8. 发明公开

EP2117576A1 METHODS AND COMPOSITIONS RELATED TO INHIBITION OF VIRAL ENTRY 有权转让
标题翻译：与病毒入侵抑制有关的方法和组合物
公开(公告)号：EP2117576A1
公开(公告)日：2009-11-18
申请号：EP08729413.8
申请日：2008-02-08
申请人： University of Utah Research Foundation
发明人： KAY, Michael, S. , WELCH, Brett, D.
IPC分类号： A61K38/10
CPC分类号： A61K38/10 , A61K45/06 , A61K47/481 , A61K47/48215 , A61K47/48253 , A61K47/55 , A61K47/60 , A61K47/641 , C07K5/1024 , C07K7/06 , G01N33/5008 , G01N33/56983 , G01N2333/005 , G01N2333/162 , G01N2500/00
摘要： Disclosed are compositions and methods for inhibiting viral entry.
摘要翻译：公开了用于抑制病毒进入的组合物和方法。

9. 发明授权

EP1115428B1 CATIONIC DENDRIMERIC COMPOUNDS AND THEIR USE AS OLIGONUCLEOTIDE/POLYNUCLEOTIDE CARRIERS 有权
标题翻译：阳离子型树形化合物及其AS寡核苷酸/多核苷酸载体
公开(公告)号：EP1115428B1
公开(公告)日：2005-11-30
申请号：EP99947667.4
申请日：1999-09-23
申请人： SCHOOL OF PHARMACY, UNIVERSITY OF LONDON
发明人： FLORENCE, Alexander T., School of Pharmacy , WILDERSPIN, Andrew, F., School of Pharmacy , TOTH, Istvan, Steele Building , SAKTHIVEL, Thiagarajan, School of Pharmacy , BAYELE, Henry, K., Dept. Biochem. Molecular Bio.
IPC分类号： A61K47/48 , A61P43/00
CPC分类号： C08G83/003 , A61K47/641 , A61K47/645 , C12N15/87
摘要： Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C6-24-alkyl group containing alpha -amino acyl groups, preferably joined to the focal group, are used to assist transfection of cells in vitro and in vivo by DNA. The complex of dendrimer and DNA may be used in gene therapy, for instance to delivery clotting factor genes to cells.

10. 发明公开

EP1400550A1 BRANCHED POLYALKYLENE GLYCOLS 有权
标题翻译： VERZWEIGTE POLYALKYLENGLYKOLE
公开(公告)号：EP1400550A1
公开(公告)日：2004-03-24
申请号：EP02712277.9
申请日：2002-01-30
申请人： Kyowa Hakko Kogyo Co., Ltd
发明人： YAMASAKI, Motoo, c/o Tokyo Research Laboratories , SUZAWA, Toshiyuki, c/o Tokyo Research Laboratories , MURAKAMI, Tatsuya, c/o Tokyo Research Laboratories , SAKURAI, Noriko, c/o Head Office , YAMASHITA, Kinya, c/o Pharmaceutical Res. Inst. , MUKAI, Mayumi, c/o Pharmaceutical Res. Inst. , KUWABARA, Takashi, c/o Pharmaceutical Res. Inst.
IPC分类号： C08G65/329 , C07K14/535 , C07K14/56 , C07K14/565 , C07K16/18 , A61K38/02 , A61K38/43 , A61K38/19 , A61K38/22 , A61K47/34 , A61K47/48 , C12N9/02
CPC分类号： C08G65/3311 , A61K38/00 , A61K47/60 , A61K47/62 , A61K47/641 , A61K47/642 , C08G65/329 , C08L2203/02
摘要： The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity are bound; and a physiologically active polypeptide modified with the branched polyalkylene glycol.
摘要翻译：本发明提供一种支链聚亚烷基二醇，其中三个或更多个单链聚亚烷基二醇和与多肽或可转化为多肽的基团中的氨基酸侧链，N-末端氨基或C-末端羧基具有反应性的基团具有反应性的基团被结合; 和用支链聚亚烷基二醇改性的生理活性多肽。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式