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1. 发明公开

EP3251682A1 COMPOSITIONS FOR TREATING INFECTIONS CAUSED BY THE MITE DEMODEX SPP 有权
标题翻译：用于治疗由MITE DEMODEX SPP引起的感染的组合物
公开(公告)号：EP3251682A1
公开(公告)日：2017-12-06
申请号：EP14909573.9
申请日：2014-12-30
申请人： Procaps S.A.
发明人： EGEA BERMEJO, Eduardo , GARAVITO DE EGEA, Gloria , ABELLO LLANOS, Raimundo , MENDOZA MEZA, Dary Luz , LIZARAZO CARREÑO, Martha , ESCAFF JARABA, Luis , ESCAFF SALES, Luis Carlos
IPC分类号： A61K36/31 , A61K36/9068 , A61K36/9062 , A61P31/02 , A61P27/02
CPC分类号： A61K36/31 , A61K36/9062 , A61K36/9068 , A61K2300/00
摘要： The invention relates to compositions and kits for treating infections caused by the mite Demodex Spp, said compositions comprising essential oils selected from the group consisting of Eruca sativa oil, Zingiber officinale oil, and Alpinia officinarum oil and mixtures thereof incorporated into solvents and vehicles, and presented in a kit in the form of a solution, a suspension, an emulsion or a dispersion. The compositions are topically applied for the treatment of infections and disorders caused by Demodex Spp in humans.
摘要翻译：本发明涉及用于治疗由螨蠕形螨引起的感染的组合物和试剂盒，所述组合物包含选自由Eruca sativa油，姜officinle油和高良姜（Alpinia officinarum）油及其混合物组成的组中的精油，并且其混入溶剂和媒介物中，以及以溶液，悬浮液，乳液或分散液的形式呈现在试剂盒中。该组合物局部用于治疗由人类蠕形螨引起的感染和病症。

2. 发明公开

EP1941893A3 Compositions containing an extract of a primula denticulata and use thereof 审中-公开
标题翻译：与球花报春和使用的提取物组合物
公开(公告)号：EP1941893A3
公开(公告)日：2008-09-10
申请号：EP08250040.6
申请日：2008-01-07
申请人： Johnson and Johnson Consumer Companies, Inc.
发明人： Saliou, Claude , Boddupalli, Sekhar , Mahmood, Khalid , Anthonavage, Michael , Huang, Kelly
IPC分类号： A61K36/45 , A61K36/82 , A61K36/9062 , A61K36/8965 , A61K36/48 , A61P17/10 , A61P17/08
CPC分类号： A61K36/45 , A61K36/185 , A61K36/82 , A61K36/9062 , A61K2300/00
摘要： The present invention features composition comprising an extract of a primula denticulata and the use thereof for treating acne and reducing the appearance of oil or pores on the skin, hair and scalp.

3. 发明公开

EP1503778A4 FORMULATION OF A MIXTURE OF FREE-B-RING FLAVONOIDS AND FLAVANS AS A THERAPEUTIC AGENT 有权
标题翻译：配方类黄酮和黄烷WITH FREE B环的混合物作为治疗剂
公开(公告)号：EP1503778A4
公开(公告)日：2007-01-03
申请号：EP03726548
申请日：2003-04-30
申请人： UNIGEN PHARMACEUTICALS INC
发明人： JIA QI
IPC分类号： A61K31/353 , A01N31/08 , A61K31/05 , A61K31/35 , A61K31/352 , A61K31/7048 , A61K36/00 , A61K36/18 , A61K36/47 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00
CPC分类号： A61K36/539 , A61K31/35 , A61K31/353 , A61K31/7048 , A61K36/11 , A61K36/15 , A61K36/185 , A61K36/28 , A61K36/47 , A61K36/48 , A61K36/484 , A61K36/486 , A61K36/53 , A61K36/54 , A61K36/60 , A61K36/74 , A61K36/906 , A61K36/9062
摘要： The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.; This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.

4. 发明公开

EP1071440A1 NOVEL SYNERGISTIC COMPOSITIONS CONTAINING AROMATIC COMPOUNDS AND TERPENOIDS PRESENT IN ALPINIA GALANGA 有权
标题翻译：新的协同组合物芳香族化合物和现有的高良姜萜类化合物CONTAIN
公开(公告)号：EP1071440A1
公开(公告)日：2001-01-31
申请号：EP99913123.8
申请日：1999-04-16
申请人： Ida Development A/S
发明人： WEIDNER, Morten, Sloth , PETERSEN, Morten, Just , JENSEN, Nina Worm
IPC分类号： A61K35/78
CPC分类号： A61K8/97 , A61K36/48 , A61K36/9062 , A61K36/9068 , A61Q19/00 , A61K2300/00
摘要： Novel compositions of matter containing aromatic compounds and terpenoids which are present in and may preferably be derived from the plant Alipinia galanga (Zingiberaceae) show synergistic effects with respect to immunomodulation, and they significantly suppress hypersensitivity reactions. Thus they are used for preparing medicaments for these purposes and, more specifically, for the treatement or prevention of IgE mediated allergic reactions and conditions, such as asthma, allergic rhinitis, atopic eczema or anaphylaxis, and autoimmune disorders, such as Crohn's disease, ulcerative colitis, rheumatoid arthritis or psoriasis, as well as for the alleviation of pain. They can for example be formulated into pharmaceuticals, cosmetics or dietary supplements. A method of preparing such compositions from Alpinia galanga is also described.

5. 发明授权

EP2952201B1 Compositions of Alpinia galanga or Alpinia conchigera with high content of 1'S-1'-acetoxychavicol acetate suitable for pharmaceutical use 有权
标题翻译：从高良姜或节鞭山姜成分与医疗用1'S -1'-乙酰氧基含量高
公开(公告)号：EP2952201B1
公开(公告)日：2017-06-21
申请号：EP14196552.5
申请日：2014-12-05
申请人： Nerthus ApS
发明人： Jakobsen, Henrik Byrial , Giversen, Ina
IPC分类号： A61K36/9062 , A61K36/18
CPC分类号： A61K36/9062 , A23L33/105 , A23P10/20 , A61K36/185 , A61K2236/00 , A61K2300/00

6. 发明公开

EP2138054A1 Extrait de plante pour la prévention ou le traitement du ronflement et/ou de l'apnée du sommeil 审中-公开
标题翻译：打鼾和/或睡眠呼吸暂停的预防或治疗植物提取物
公开(公告)号：EP2138054A1
公开(公告)日：2009-12-30
申请号：EP09163948.4
申请日：2009-06-26
申请人： Cariel, Léon , Rabhi, Chérif
发明人： Cariel, Léon , Rabhi, Chérif
IPC分类号： A23L1/29 , A61K31/035 , A61K36/9068 , A61K36/9062 , A61P11/00
CPC分类号： A61K31/035 , A23L33/105 , A61K36/9062 , A61K36/9068
摘要： La présente invention concerne un nouvel extrait de plante et les compositions contenant cet extrait pour la prévention, la diminution ou la suppression du ronflement et/ou de l'apnée du sommeil. L'invention concerne plus particulièrement une composition comprenant au moins un terpène ou un terpénoïde et un extrait d'une plante de la famille des Zingiberaceae, de préférence choisie parmi les espèces Alpinia galanga, Alpinia officinarum, Zingiber officinalis, Zingiber cassumunar et Zingiber zerumbet, de préférence Alpinia galanga, l'extrait contenant des dérivés de phénylpropène et étant exempt de dérivés de type chavicol. Elle concerne aussi un procédé d'obtention d'un tel extrait comprenant une étape de macération en présence d'un solvant, puis une seconde étape dans laquelle l'extrait issu de la macération est soumis au reflux d'une solution aqueuse.
摘要翻译：组合物包含至少一种萜或萜，并提取姜科族的植物，优选物种，包括高良姜，高良姜，姜巴戟，姜cassumunarand红球姜，优选高良姜，其中该提取物包含phenylpropenes衍生物和不含胡椒酚衍生物。独立权利要求中包括了：（1）药物产品或食品补充剂，其包含所述组合物; （2），用于获得从姜科的植物材料提取物，其包含在溶剂中，其中该提取物通过浸渍获得的存在浸泡提取物，以及对所述提取物的方法，以在经过一段wässrige溶液回流中并在一定温度，以获得提取游离胡椒酚衍生物和含有10至40，优选20至40重量二乙酸酯衍生物和/或phenylpropenes乙酸盐和/或5-20％，优选10-20重量。phenylpropenol衍生物％ ; （3）用于制备所述组合物包含通过在提取工艺包括在溶剂的存在下浸泡获得的提取物，将提取物从浸渍导致wässrige溶液至回流，然后加入萜烯或萜类化合物，优选的精油的过程; （4）以提取由实施该方法获得高良姜的。活动：合成; CNS基因。作用机理：没有给出。

7. 发明公开

EP2108370A1 Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent 审中-公开
标题翻译： Formulierung einer Mischung aus Flavonoiden mit freiem B-Ring und Flavanen als Therapiemittel
公开(公告)号：EP2108370A1
公开(公告)日：2009-10-14
申请号：EP09167112.3
申请日：2003-04-30
申请人： Unigen Pharmaceuticals, Inc.
发明人： Jia, Qi
IPC分类号： A61K31/35 , A61K31/352
CPC分类号： A61K36/539 , A61K31/35 , A61K31/353 , A61K31/7048 , A61K36/11 , A61K36/15 , A61K36/185 , A61K36/28 , A61K36/47 , A61K36/48 , A61K36/484 , A61K36/486 , A61K36/53 , A61K36/54 , A61K36/60 , A61K36/74 , A61K36/906 , A61K36/9062
摘要： The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.; This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.
摘要翻译：本发明提供了由两种特定类别的化合物的混合物组成的物质的新组合物 - 自由B环黄酮和黄烷 - 用于预防和治疗COX-2和5介导的疾病和病症 -LO途径。本发明还提供了一种同时抑制环氧合酶-2（COX-2）和5-脂氧合酶（5-LO）酶并降低cox-2 mRNA产生的新方法。最后，本发明包括减肥和血糖控制的方法。本发明的方法包括向有需要的宿主施用有效量的本发明组合物和药学上可接受的载体。本发明一般涉及由环氧合酶-2（COX-2）和5-脂氧合酶（5-LO）途径介导的疾病和病症的预防和治疗，所述途径包括但不限于缓解关节的不适和与诸如作为骨关节炎，类风湿性关节炎以及过度使用引起的其他损伤。

8. 发明公开

EP1631304A4 FORMULATION OF DUAL CYCLOXYGENASE (COX) AND LIPOXYGENASE (LOX) INHIBITORS FOR MAMMAL SKIN CARE 审中-公开
标题翻译：双环氧化酶制剂（COX）和脂氧合酶（LOX）抑制剂对哺乳动物皮肤护理
公开(公告)号：EP1631304A4
公开(公告)日：2007-03-21
申请号：EP04758816
申请日：2004-04-02
申请人： UNIGEN PHARMACEUTICALS INC
发明人： JIA QI
IPC分类号： A61K36/00 , A61K8/49 , A61K31/352 , A61K31/353 , A61K31/7048 , A61K36/11 , A61K36/15 , A61K36/185 , A61K36/28 , A61K36/47 , A61K36/48 , A61K36/484 , A61K36/486 , A61K36/53 , A61K36/539 , A61K36/54 , A61K36/60 , A61K36/906 , A61K36/9062 , A61K45/06 , A61Q19/00 , A61Q19/08
CPC分类号： A61K8/97 , A61K8/498 , A61K8/67 , A61K31/352 , A61K31/353 , A61K31/7048 , A61K36/11 , A61K36/15 , A61K36/185 , A61K36/28 , A61K36/47 , A61K36/48 , A61K36/484 , A61K36/486 , A61K36/53 , A61K36/539 , A61K36/54 , A61K36/60 , A61K36/906 , A61K36/9062 , A61K45/06 , A61K2800/782 , A61Q19/00 , A61Q19/004 , A61Q19/08 , A61K2300/00
摘要： The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds-Free-B-Ring flavonoids and flavans-for use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity in normal, aged and damaged dermal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the skin mediated by cyclooxygenase (COX) and lipoxygenase (LOX). The method for preventing and treating COX and LOX mediated diseases and conditions of the skin is comprised of topically administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria and Acacia genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of COX and LOX mediated diseases and conditions, including but not limited to sun burns, thermal burns, acne, topical wounds, minor inflammatory conditions caused by fungal, microbial and viral infections, vitilago, systemic lupus erythromatosus, psoriasis, carcinoma, melanoma, as well as other mammal skin cancers, skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, wind and dry environments, wrinkles, saggy skin, lines and dark circles around the eyes, dermatitis and other allergy related conditions of the skin. Use of the composition described herein also affords the benefit of smooth and youthful skin with improved elasticity, reduced and delayed aging, enhanced youthful appearance and texture, and increased flexibility, firmness, smoothness and suppleness.

9. 发明公开

EP1581237A1 DEVELOPMENT OF AN ANTI-COUGH, ANTI-TUSSIVE AND THROAT SOOTHING HERBAL FORMULATION 有权
标题翻译：的一个草本咳嗽母乳喂养和复仇镇痛制剂开发
公开(公告)号：EP1581237A1
公开(公告)日：2005-10-05
申请号：EP02788439.4
申请日：2002-12-30
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
发明人： PALPU, PushpangadanNat. Botanical Research Inst. , RAGHAVAN, GovindarajanNat. Botanical Res. Inst. , MADHAVAN, VijayakumarNat. Botanical Res. Inst. , MEHROTRA, ShantaNat. Botanical Research Inst. , SINGH, Rawat Ajay KumarNat. Botanical Res. Inst. , RAO, Chandana V.Nat. Botanical Research Inst.
IPC分类号： A61K35/78 , A61P11/14
CPC分类号： A61K36/484 , A61K36/67 , A61K36/882 , A61K36/9062 , A61K36/9068 , A61K2300/00
摘要： An anti-cough, anti-tussive, and throat soothing synergistic herbal formulation comprising of an extract of Piper cubeba, Glycyrrhiza glabra, Acorus calamus Alpinia galanga, Zingiber officinale and pharmaceutically acceptable additives as a syrup, lozenges or chewable tablets for preventing cracking of voice, dryness of mouth and toning of voice, vocal cord; the present invention also provides a method of preparation of this formulation.

10. 发明公开

EP0514508A1 EXTRAKT AUS TROPISCHEN PFLANZEN, EIN VERFAHREN ZU DESSEN HERSTELLUNG SOWIE DESSEN VERWENDUNG ALS HEILMITTEL 失效
标题翻译： EXTRACT热带植物，其制造方法相同，其作为医学研究。
公开(公告)号：EP0514508A1
公开(公告)日：1992-11-25
申请号：EP91920013.0
申请日：1991-11-27
申请人： MRAK, Magdalena
发明人： MRAK, Magdalena
IPC分类号： A61K36 , C07G99
CPC分类号： A61K36/906 , A61K36/185 , A61K36/27 , A61K36/88 , A61K36/888 , A61K36/9062 , A61K2300/00
摘要： On produit un extrait de plantes tropicales, dont les parties individuelles, telles que racines, tiges, graines, fleurs et feuilles, sont administrées à la personne à traiter selon son âge, son origine et le stade de la maladie. Les parties utilisées de la plante sont découpées, mélangées avec de l'éthanol ou de l'alcool et macérées à la température ambiante pendant une semaine. Le rapport de la quantité de matière végétale à la quantité du liquide ajouté se situe entre 1:4 et 1:9 et dépend de la partie ou des parties de la plante qui sont utilisées. L'extrait est utile pour traiter la syphilis congénitale, bien que l'on puisse supposer qu'il soit possible de traiter également d'autres maladies tropicales avec les mêmes produits.

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