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1. 发明公开

EP4344695A3 COMBINATORIAL DRUG DELIVERY DEVICE 审中-实审
公开(公告)号：EP4344695A3
公开(公告)日：2024-06-05
申请号：EP24157510.9
申请日：2019-05-10
申请人： Bristol-Myers Squibb Company
发明人： MCLOUGHLIN, Martin, John , LARROW, Chester , MUMPOWER, Mariano
IPC分类号： A61J1/20 , A61M5/14 , A61J3/00 , A61J1/16
CPC分类号： A61J1/20 , A61J1/2058 , A61J1/2068 , A61J1/2089 , A61J3/002 , A61M5/1408 , A61M5/1409 , A61J1/16 , A61M5/14248 , A61M2005/1426820130101 , A61M2209/04520130101 , A61M5/1413
摘要： In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.

2. 发明公开

EP3386863A1 METHOD FOR PROTECTING AND UNPROTECTING THE FLUID PATH IN A CONTROLLED ENVIRONMENT ENCLOSURE 审中-实审
公开(公告)号：EP3386863A1
公开(公告)日：2018-10-17
申请号：EP16872486.2
申请日：2016-12-09
申请人： VANRX Pharmasystems Inc.
发明人： PROCYSHYN, Chris , CICHY, Marcin
IPC分类号： B65B3/04 , A61J1/14 , A61J1/20 , B25J9/18 , B65B55/12
CPC分类号： G01N35/10 , A61J1/12 , A61J1/14 , A61J1/20 , B01L1/04 , B01L3/02 , B01L2200/026 , B01L2200/0689 , B01L2200/141 , B01L2300/0609 , B01L2400/0487 , B65B3/003 , B65B3/04 , B65B55/12 , G01N35/00029 , G01N35/0099 , G01N2035/00148 , G01N2035/00277
摘要： A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection molded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.

3. 发明授权

EP3082854B1 METHOD FOR EMULSIFYING A TRIEPITOPE PEPTIDE WITH MONTANIDE AND KITS FOR PERFORMING THE SAME 有权转让
公开(公告)号：EP3082854B1
公开(公告)日：2018-10-17
申请号：EP14833390.9
申请日：2014-12-18
申请人： Vaxon Biotech
发明人： MENEZ-JAMET, Jeanne
IPC分类号： A61K39/00 , A61K39/39
CPC分类号： A61K39/0011 , A61J1/20 , A61K9/1075 , A61K39/39 , A61K2039/55566 , A61K2039/645 , A61M5/19
摘要： The present invention relates to a method for preparing a vaccine formulation with an optimized polypeptide comprising three epitopes and Montanide as adjuvant, for use in anti-cancer immunotherapy for administration to a human subject.

4. 发明授权

EP2476446B1 Drug delivery devices and related systems and methods 有权
公开(公告)号：EP2476446B1
公开(公告)日：2018-08-15
申请号：EP12161821.9
申请日：2010-06-30
申请人： Fresenius Medical Care Holdings, Inc.
发明人： Beiriger, Michael James , Kaintz, Ryan
IPC分类号： A61G7/05 , A61M5/14 , A61M5/142 , A61M5/19 , A61J1/20 , G06F19/00 , A61M39/26 , A61M5/32 , A61M5/162 , A61M5/168 , A61M5/36 , A61M1/34 , A61M1/36 , A61M39/14 , A61J3/00
CPC分类号： A61J1/20 , A61G7/0503 , A61J1/201 , A61J1/2013 , A61J1/2089 , A61J1/2096 , A61J3/002 , A61M1/342 , A61M1/3462 , A61M5/14 , A61M5/1408 , A61M5/1415 , A61M5/142 , A61M5/162 , A61M5/16827 , A61M5/16831 , A61M5/19 , A61M5/36 , A61M39/14 , A61M2005/3267 , A61M2039/267 , A61M2205/12 , A61M2205/14 , A61M2205/18 , A61M2205/583 , A61M2205/6018 , A61M2205/6054 , G06F19/00 , G06F19/3468 , Y02A90/26
摘要： Drug delivery device (703) with a pump (732) extending from a surface of the drug delivery device, and a door (704) comprising a spring-loaded member defining a recess (718) for receiving a portion of the pump and of a fluid line when the door is closed.

5. 发明授权

EP3027162B1 COMPOUNDING SYSTEMS AND METHODS FOR SAFE MEDICAMENT TRANSPORT 有权转让
公开(公告)号：EP3027162B1
公开(公告)日：2018-07-18
申请号：EP14833089.7
申请日：2014-08-04
申请人： J&J Solutions, Inc. D.B.A Corvida Medical , Garfield, Jared , Lyon, Gregory
发明人： GARFIELD, Jared , LYON, Gregory
IPC分类号： A61J3/00 , A61J1/20
CPC分类号： A61J1/2096 , A61J1/20 , A61J1/2003 , A61J1/201 , A61J1/2072 , A61J1/2089 , A61M5/31 , A61M2005/3114 , B65B3/003 , B65B3/12 , B65B3/28 , B65B63/08
摘要： An automatic or semi-automatic preparation system and process is provided for forming a medicament solution from a vial containing one of a liquid and a non-liquid material.

6. 发明公开

EP3280471A2 COMBINED MEDICAMENT FILL AND CANNULA INSERTION DEVICE 无效
标题翻译：组合药物填充物和套管插入装置
公开(公告)号：EP3280471A2
公开(公告)日：2018-02-14
申请号：EP16727831.6
申请日：2016-04-08
申请人： Cequr SA
发明人： HASSMAN, Michael , LAWRENCE, Douglas , FREED, David , MCDERMOTT, Patrick , PUTNAM, Stephen , DALL, Mads , GRAVESEN, Peter , ERIKSEN, Christian, Brunn , ARNDT, Heiko
IPC分类号： A61M5/158 , A61M25/02 , A61M25/06 , A61M5/142
CPC分类号： A61M5/158 , A61J1/20 , A61M5/14248 , A61M2005/14252 , A61M2005/1583 , A61M2005/1585 , A61M2205/18 , A61M2205/33 , A61M2209/045
摘要： A device for filling a medicament delivery device (e.g., a patch pump) with medicament or fluid and inserting a cannula subcutaneously enables improved results and user safety, while simplifying the set up process for a user. The device can include a housing with a first chamber portion having a first deployment mechanism and a second chamber portion having a second deployment mechanism. The device can also include a trigger mounted to the housing to activate at least one of the first deployment mechanism and the second deployment mechanism and an interface adapted to mate releasably with the medicament delivery device. The filling of the device with medicament and the insertion of the cannula may occur sequentially or simultaneously, and both actions can be initiated by a single user step or a limited number of user steps, as compared to conventional approaches.

7. 发明授权

EP3167866B1 LIQUID DRUG TRANSFER DEVICES 有权转让
标题翻译：液体药物转移装置
公开(公告)号：EP3167866B1
公开(公告)日：2017-11-22
申请号：EP16200458.4
申请日：2013-08-20
申请人： Medimop Medical Projects Ltd
发明人： LEV, Nimrod , BEN SHALOM, Niv
IPC分类号： A61J1/20 , A61J1/10 , A61J1/14
CPC分类号： A61J1/20 , A61J1/10 , A61J1/1406 , A61J1/201 , A61J1/2013 , A61J1/2048 , A61J1/2051 , A61J1/2055 , A61J1/2089 , A61J1/2096
摘要： Liquid drug transfer device 160 for use with an infusion bag 40 containing an infusion liquid and having an injection port 41 , the injection port 41 terminating in an injection port tip 44 containing a self-sealing plug 46 with an exposed plug surface 47 , the injection port tip 44 having a trailing injection port rim 48 , the liquid drug transfer device 160 comprising an open ended housing 161 having a longitudinal housing axis 162 and including a universal injection port connector 250 , said universal injection port connector 250 having a longitudinal connector axis 251 co-directional with said longitudinal housing axis 162 and a closed support ring 252 defining a horizontal plane 253 transverse to said longitudinal connector axis 251 , said support ring 252 having a multitude of curved connector members 254 resiliently flexibly mounted thereon and a free connector member end 256 converging towards a connector aperture 257 underlying said support ring 252 from a direction of said open ended housing 161 such that said universal injection port connector 160 assumes an overall bowl like shape,the arrangement being such that on forced sliding insertion of the injection port tip 44 through said connector aperture 257 into said open ended housing 161 , the injection port tip 44 outwardly flexes said multitude of connector members 254 from their non-flexed position relative to said connector axis 251 for snapping behind the trailing injection port rim 48 , thereby precluding outward sliding withdrawal of the injection port tip 44 from said open ended housing 161 in a reverse direction to said forced sliding insertion.

8. 发明公开

EP2495010A4 CONNECTOR ASSEMBLY 审中-公开
公开(公告)号：EP2495010A4
公开(公告)日：2017-11-22
申请号：EP10826613
申请日：2010-10-21
申请人： TERUMO CORP
发明人： TAKEMOTO MASAFUMI , SHIMAZAKI TAKAYASU
IPC分类号： A61M39/02 , A61J1/10 , A61J1/20 , A61M5/162 , A61M39/06 , A61M39/10 , A61M39/22
CPC分类号： A61J1/20 , A61J1/10 , A61J1/2051 , A61J1/2055 , A61J1/2065 , A61J1/2089 , A61M5/162 , A61M5/1626 , A61M39/10 , A61M39/1011 , A61M39/221 , A61M2039/066 , A61M2039/1066 , A61M2039/1072
摘要： Disclosed is a connector assembly provided with a first connector having a tubular first connector body, a hollow needle supported inside the first connector body and a first sealing component that can be pierced by the hollow needle, and a second connector having a tubular second connector body and a second sealing component. The second sealing component is disposed in the second connector body, is attached to a first piercing section when inserted into the first connector body, and, in that state, is pierced by the hollow needle together with the first piercing section. The connector assembly is further provided with an operation restricting means which, when the second connector is inserted into the first connector, temporarily interrupts and restricts the insertion operation, but allows resumption of the insertion operation when the restriction is removed, and which, when the second connector is withdrawn from the first connector, temporarily interrupts and restricts the withdrawing operation, but allows resumption of the withdrawing operation when the restriction is removed.

9. 发明授权

EP3072494B1 PRESSURE EQUALIZING DEVICE AND RECEPTACLE 有权
标题翻译：压力均衡装置和接收器
公开(公告)号：EP3072494B1
公开(公告)日：2017-10-18
申请号：EP16168854.4
申请日：2013-03-01
申请人： Becton, Dickinson and Company Ltd.
发明人： Cederschiöld, Alexander
IPC分类号： A61J1/20
CPC分类号： F16K17/00 , A61J1/20 , A61J1/201 , A61J1/2055 , A61J1/2072 , A61J1/2096 , Y10T137/7784
摘要： Provided is an assembly for reconstitution of a substance comprising: a fluid injector (110) comprising a fluid reservoir and having a longitudinal axis; a receptacle (22) defining an interior volume and having a longitudinal axis; and a pressure equalizing device (10) connected between the fluid injector (110) and the receptacle (22) having a longitudinal axis, the pressure equalizing device (10) comprising: a container (12) for attachment to the receptacle (22), to permit pressure equalization between the container (12) and the receptacle (22), the container (12) comprising a first chamber (16) and a second chamber (14); and a fluid transfer member (24) having an access channel (30), connected between the fluid injector (110) and the interior volume of the receptacle (22), and a vent channel (28), connected between the interior volume of the receptacle (22) and the first chamber (16), wherein when the receptacle (22) is connected to the pressure equalizing device (10), the vent channel (28) establishes direct fluid communication between the first chamber (16) and the receptacle (22), and wherein the longitudinal axis of the pressure equalizing device (10), the longitudinal axis of the receptacle (22), and the longitudinal axis of the fluid injector (110) are aligned with or parallel to each other.

10. 发明公开

EP3167866A1 LIQUID DRUG TRANSFER DEVICES 有权转让
标题翻译：转让弗吉尼亚州弗吉尼亚州ARZNEIMITTEL
公开(公告)号：EP3167866A1
公开(公告)日：2017-05-17
申请号：EP16200458.4
申请日：2013-08-20
申请人： Medimop Medical Projects Ltd
发明人： LEV, Nimrod , BEN SHALOM, Niv
IPC分类号： A61J1/20 , A61J1/10 , A61J1/14
CPC分类号： A61J1/20 , A61J1/10 , A61J1/1406 , A61J1/201 , A61J1/2013 , A61J1/2048 , A61J1/2051 , A61J1/2055 , A61J1/2089 , A61J1/2096
摘要： Liquid drug transfer device 160 for use with an infusion bag 40 containing an infusion liquid and having an injection port 41 , the injection port 41 terminating in an injection port tip 44 containing a self-sealing plug 46 with an exposed plug surface 47 , the injection port tip 44 having a trailing injection port rim 48 , the liquid drug transfer device 160 comprising an open ended housing 161 having a longitudinal housing axis 162 and including a universal injection port connector 250 , said universal injection port connector 250 having a longitudinal connector axis 251 co-directional with said longitudinal housing axis 162 and a closed support ring 252 defining a horizontal plane 253 transverse to said longitudinal connector axis 251 , said support ring 252 having a multitude of curved connector members 254 resiliently flexibly mounted thereon and a free connector member end 256 converging towards a connector aperture 257 underlying said support ring 252 from a direction of said open ended housing 161 such that said universal injection port connector 160 assumes an overall bowl like shape,the arrangement being such that on forced sliding insertion of the injection port tip 44 through said connector aperture 257 into said open ended housing 161 , the injection port tip 44 outwardly flexes said multitude of connector members 254 from their non-flexed position relative to said connector axis 251 for snapping behind the trailing injection port rim 48 , thereby precluding outward sliding withdrawal of the injection port tip 44 from said open ended housing 161 in a reverse direction to said forced sliding insertion.
摘要翻译：液体药物转移装置160，用于含有输注液体并具有注射口41的输液袋40，注射口41终止于注射口尖端44，注射口尖端44包含具有暴露插塞表面47的自密封塞46，注射端口尖端44具有尾部注入口边缘48，液体药物转移装置160包括具有纵向外壳轴线162并且包括通用注射端口连接器250的开口端壳体161，所述通用注射端口连接器250具有纵向连接器轴线251 与所述纵向壳体轴线162共同定向，并且限定横向于所述纵向连接器轴线251的水平平面253的闭合支撑环252，所述支撑环252具有弹性地柔性地安装在其上的多个弯曲连接器构件254，以及自由连接构件端部 256从所述op的方向朝着所述支撑环252下方的连接器孔257会聚使得所述通用注入端口连接器160呈现整体碗状形状，该布置使得在将注射端口44通过所述连接器孔257强制滑动插入到所述开放端壳体161中时，注入端口 44将所述多个连接器构件254从其相对于所述连接器轴线251的不弯曲位置向外弯曲，以便在后部喷射口边缘48的后面卡扣，从而阻止注射口尖端44从开口端壳体161向外滑动与所述强制滑动插入相反的方向。

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