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1. 发明公开

EP3417778A1 AUTOMATISIERTES VERFAHREN ZUR VERRINGERUNG DES STÖRSIGNALEINFLUSSES BEI DER ANALYSE VON EVOZIERTEN POTENZIAL-SIGNALEN ODER EREIGNISKORRELIERTEN POTENZIAL-SIGNALEN EINER NEURONALEN AKTIVITÄT 审中-公开
公开(公告)号：EP3417778A1
公开(公告)日：2018-12-26
申请号：EP18000549.8
申请日：2018-06-21
申请人： Universität des Saarlandes , Hochschule RheinMain
发明人： Hecker, Dietmar , Metzler, Patrick , Schick, Bernhard , Schorn, Bianca
IPC分类号： A61B5/12 , A61B5/0484 , A61B5/00 , A61B5/16
CPC分类号： A61B5/125 , A61B5/04845 , A61B5/128 , A61B5/168 , A61B5/7267 , A61B2503/06
摘要： Automatisiertes Verfahren zur Verringerung des Störsignaleinflusses bei der Analyse von evozierten Potenzial-Signalen oder ereigniskorrelierten Potenzial-Signalen einer neuronalen Aktivität
Die Erfindung gibt ein automatisiertes Verfahren zur Verringerung eines Störeinflusses bei der Analyse von evozierten Potenzial-Signalen oder ereigniskorrelierten Potenzial-Signalen einer neuronalen Aktivität an. Es weist auf:
- Darbieten von physiologischen Reizen einem Testsubjekt (2), wobei der physiologische Reiz durch mindestens einen Parameter (RP) beschreibbar ist,
- Ermitteln von abgeleiteten zeitabhängigen Potenzial-Signalen,
- Definieren einer ersten und/oder zweiten Klasse,
- Zuordnen der Potenzial-Signale oder Teilabschnitten der Potenzial-Signale zu der ersten Klasse oder der zweiten Klasse durch eine Klassierungseinheit,
- Ermitteln von Häufigkeiten der der ersten Klasse zugeordneten und/oder der zweiten Klasse zugeordneten Potenzial-Signale oder zugehörigen

Eine zugehörige Anordnung und ein zugehöriges computerlesbares Speichermedium werden ebenfalls angegeben.

2. 发明公开

EP3311738A1 EVALUATION OF INHIBITORY CIRCUIT AND USE THEREOF 有权
标题翻译：阻碍电路的评估及其使用
公开(公告)号：EP3311738A1
公开(公告)日：2018-04-25
申请号：EP16811756.2
申请日：2016-06-17
申请人： Inter-University Research Institute Corporation National Institutes of Natural Sciences , Tokai Optical Co., Ltd.
发明人： INUI Koji , TAKESHIMA Yasuyuki , SUZUKI Masaya , KUMAGAI Naoya
IPC分类号： A61B5/0484 , A61B5/05
CPC分类号： A61B5/04842 , A61B5/04001 , A61B5/0484 , A61B5/04845 , A61B5/05
摘要： Provided are a more practical method for evaluating an inhibitory circuit applicable to a living body, and the use thereof. Herein the action of an inhibitory circuit on an excitatory circuit is evaluated on the basis of attenuation of the brain activity produced by activation of an excitatory circuit by the input of an inhibitory circuit by performing a step for inputting an inhibitory circuit by applying a second trigger in advance of a first trigger to an excitatory circuit activated by a first trigger which is a stimulus or challenge.
摘要翻译：提供了用于评估适用于活体的抑制电路的更实用的方法及其用途。在此，基于通过执行通过应用第二触发器输入抑制电路的步骤通过抑制电路的输入激活兴奋性电路而产生的脑活动的衰减来评估抑制电路在兴奋性电路上的动作在第一次触发之前到由作为刺激或挑战的第一触发激活的兴奋电路。

3. 发明公开

EP3256042A1 METHODS AND SYSTEMS FOR THERAPEUTIC NEUROMODULATION 审中-公开
标题翻译：用于治疗性神经调节的方法和系统
公开(公告)号：EP3256042A1
公开(公告)日：2017-12-20
申请号：EP16749907.8
申请日：2016-02-11
申请人： Biosensor, Inc.
发明人： IZVARINA, Natalia
IPC分类号： A61B5/04 , A61B5/0476 , A61M21/02
CPC分类号： A61B5/04845 , A61B5/0006 , A61B5/024 , A61B2018/00839 , A61M21/00 , A61M2021/0027 , A61M2205/3553 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/502 , A61M2230/04 , A61M2230/06 , A61M2230/10 , A61M2230/205 , A61N1/0551 , A61N1/36031 , A61N1/36085 , A61N1/36096 , A61N1/37211 , A61M2230/005
摘要： Systems, methods and computer-readable media are disclosed for providing therapeutic auditory stimulation. Consistent with disclosed embodiments, a system for providing therapeutic auditory stimulation may comprise a diagnostic unit that computes an EEG spectral density of a patient and a heart rate spectral density of a patient and provides values for one or more EEG frequency bands and one or more heart rate frequency bands. The system may also comprise a therapy unit that generates, based on the provided values, one or more stimulation waveforms corresponding to one or more of the EEG frequency bands and provides the stimulation waveforms for therapeutic auditory stimulation. The stimulation waveforms may comprise audible carrier frequencies modulated by signals with frequencies that vary exponentially with time. The EEG frequency bands may comprise the delta, theta, alpha, beta 1, beta 2, and gamma EEG frequency hands.

4. 发明授权

EP1948014B1 SYSTEM FOR PREDICTION OF COGNITIVE DECLINE 有权
标题翻译：预测认知衰退的系统
公开(公告)号：EP1948014B1
公开(公告)日：2017-12-20
申请号：EP06816494.6
申请日：2006-10-06
申请人： New York University
发明人： PRICHEP, Leslie, S.
IPC分类号： A61B5/04
CPC分类号： A61B5/04009 , A61B5/04845 , A61B5/4064 , A61B5/4088 , A61B5/7264 , G06F19/00 , G16H50/50
摘要： A system and method for prediction of cognitive decline, comprises an input receiving input data corresponding to brain activity of an individual and a processor coupled to the input for analyzing the input data to obtain a selected set of features, the processor comparing the selected set of features to at least a portion of entries in a database corresponding to brain activity of a plurality of individuals, wherein entries in the database have been separated into a plurality of categories corresponding to one of a degree of cognitive decline and a propensity for future cognitive decline of individuals relating to the entries, the processor determining, based on the comparison, a category most closely corresponding to the selected set of features.

5. 发明授权

EP2581038B1 Automatic real-time hearing aid fitting based on auditory evoked potentials 有权
标题翻译：基于听觉诱发电位的自动实时助听器验配
公开(公告)号：EP2581038B1
公开(公告)日：2017-12-13
申请号：EP11185225.7
申请日：2011-10-14
申请人： Oticon A/S
发明人： Lunner, Thomas , Neher, Tobias
IPC分类号： G06F3/01 , A61B5/00 , A61B5/12 , H04R25/00 , A61B5/0484
CPC分类号： H04R25/30 , A61B5/04845 , A61B5/121 , A61B5/6815 , G06F3/015 , H04R25/552 , H04R25/554 , H04R25/558 , H04R25/70
摘要： The application relates to a hearing aid comprising at least one electrode located at a surface of a housing of the hearing aid to allow said electrodes to contact the skin of a user during use of the hearing aid, at least one electrode being adapted to pick up a low voltage signal from the user's brain, the hearing aid further comprising an amplifier unit operationally connected to said electrode(s) and adapted for amplifying said low voltage signal(s) to provide amplified brain signal(s), and a signal processing unit adapted to process said amplified brain signal(s) to provide a processed brain signal as well as to apply a time and frequency dependent gain to an input audio signal and to provide a processed audio output signal. The application further relates to a method of operating a hearing aid and to its use and to a hearing aid system. The object of the present application is to provide a hearing aid capable of monitoring a user's hearing ability over time. The problem is solved in that the hearing aid further comprises a signal generator for generating an electric test signal specifically adapted to be used in an auditory evoked potential (AEP) measurement, the signal generator being operationally connected to said output transducer allowing said electric test signal to be converted to an auditory test stimulus for being presented to a user together with said processed acoustic signal during use of the hearing aid. This has the advantage of providing a hearing aid wherein at least a part of the fitting process of a hearing aid to a particular user can be automated and/or continuously updated. The invention may e.g. be used for the hearing aids or hearing aid systems where a continuous evaluation of a user's hearing thresholds is needed.

6. 发明公开

EP3223695A1 DISPOSITIF ET PROCEDE DE STIMULATION DES ONDES LENTES CEREBRALES 无效转让
公开(公告)号：EP3223695A1
公开(公告)日：2017-10-04
申请号：EP15801824.2
申请日：2015-11-27
申请人： DREEM
发明人： SOULET DE BRUGIERE, Quentin , MERCIER, Hugo , GALTIER, Mathieu
IPC分类号： A61B5/0484 , A61B5/00 , A61M21/02
CPC分类号： A61M21/02 , A61B5/0478 , A61B5/04845 , A61B5/0488 , A61B5/0496 , A61B5/4812 , A61B5/4836 , A61B5/6814 , A61M2021/0005 , A61M2021/0027 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/8206 , A61M2209/088 , A61M2210/06 , A61M2230/04 , A61M2230/10 , A61M2230/14 , A61M2230/60 , A61M2230/005
摘要： The invention relates to a self-contained device (1) for stimulating slow brain waves, capable of being worn by a person (P), in particular during a period of time when said person is sleeping. The device (1) comprises a supporting element (2), capable of surrounding the head of a person, and on which electrodes (3) are mounted in contact with the person in order to acquire a measurement signal that represents a physiological electrical signal of the person; an acoustic transducer (4) for emitting an acoustic signal (A) stimulating the inner ear of the person; and on-board conditioning and control electronics (5) for, in flexible real time, receiving the measurement signal and controlling the emission of an acoustic signal (A) synchronised with a predefined slow brain wave time pattern.
摘要翻译：本发明涉及一种用于刺激能够由人（P）穿戴的慢脑波的自足式装置（1），特别是在所述人睡觉的时间段期间。该装置（1）包括能够围绕人的头部的支撑元件（2），并且电极（3）安装在该支撑元件上以与人接触以便获取表示生理电信号的测量信号，该测量信号为此人; 用于发出刺激人的内耳的声信号（A）的声学换能器（4）和车载调节和控制电子器件（5），用于以灵活实时的方式接收测量信号并控制与预定义的慢脑电波时间模式同步的声信号（A）的发射。

7. 发明公开

EP3223694A1 SYSTEM AND METHOD FOR ADJUSTING DURATION OF SENSORY STIMULATION DURING SLEEP TO ENHANCE SLOW WAVE ACTIVITY 审中-公开
标题翻译：用于调整睡眠期间的感觉刺激持续时间以增强慢波活动的系统和方法
公开(公告)号：EP3223694A1
公开(公告)日：2017-10-04
申请号：EP15797457.7
申请日：2015-11-11
申请人： Koninklijke Philips N.V.
发明人： GEERLINGS, Alexander Cornelis , GARCIA MOLINA, Gary Nelson , PFUNDTNER, Stefan
IPC分类号： A61B5/0484 , A61B5/00 , A61M21/02 , A61M21/00
CPC分类号： A61M21/02 , A61B5/04845 , A61B5/4812 , A61B5/4836 , A61M2021/0027 , A61M2205/18 , A61M2205/3375 , A61M2205/505 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2230/10 , A61M2230/005
摘要： The present disclosure describes a system configured to adjust the duration of individual sensory stimuli provided to a subject. The system is configured to determine a current amount of slow wave activity in the subject, responsive to the subject being presently in slow wave sleep, control one or more sensory stimulators to provide the individual sensory stimuli to the subject, determine habituation of the subject to the individual sensory stimuli and, responsive to the slow wave activity in the subject for a period of time following the providing of the individual sensory stimuli showing habituation, adjust the duration of the individual sensory stimuli.
摘要翻译：本公开描述了一种配置成调节提供给对象的单独感官刺激的持续时间的系统。该系统被配置成响应于目标目前处于慢波睡眠中来确定当前的对象中的慢波活动量，控制一个或多个感官刺激器以向对象提供个体感官刺激，确定对象的习惯在提供显示习惯性的个体感觉刺激之后的一段时间内，响应个体中的慢波活动，调整个体感觉刺激的持续时间。

8. 发明公开

EP3166481A1 SYSTEM AND METHOD FOR ADJUSTING THE INTENSITY OF SENSORY STIMULATION DURING SLEEP BASED ON SLEEP SPINDLES 有权转让
标题翻译：系统和方法用于设置感官刺激的最强时段睡在睡眠纺锤波的BASIS
公开(公告)号：EP3166481A1
公开(公告)日：2017-05-17
申请号：EP15750117.2
申请日：2015-07-06
申请人： Koninklijke Philips N.V. , Wisconsin Alumni Research Foundation
发明人： GARCIA MOLINA, Gary Nelson , BELLESI, Michele , PFUNDTNER, Stefan , RIEDNER, Brady Alexander , TONONI, Giulio
IPC分类号： A61B5/04 , A61B5/0476 , A61B5/048
CPC分类号： A61B5/04845 , A61B5/048 , A61B5/4812 , A61B5/6803 , A61B5/6831
摘要： The present disclosure pertains to a system configured to adjust an intensity of sensory stimulation delivered to a subject during a sleep session based on sleep spindles in the subject during the sleep session. The system is configured to adjust the intensity of the stimulation based on a sleep spindle frequency and/or a sleep spindle density. The system is configured to determine a recent spindle density and/or a recent spindle frequency for a recent period of time during the sleep session based on detected sleep spindles, and to determine a previous spindle density and/or a previous spindle frequency for a previous period of time during the sleep session based on the detected sleep spindles. The system controls the intensity of sensory stimulation provided to the subject based on a comparison of the previous spindle density to the recent spindle density and/or the previous spindle frequency to the recent spindle frequency.
摘要翻译：本公开涉及被配置为调整到基于睡眠纺锤在睡眠会话期间所述受试者的睡眠会话期间递送至受试者的感官刺激的强度的系统。该系统被配置成基于一个睡眠主轴频率和/或睡眠主轴密度的刺激的强度。该系统被配置以确定矿针对先前最近的主轴密度和/或基于所检测的睡眠纺锤的时间的睡眠会话期间最近一个时期最近主轴频率，而确定性矿先前主轴密度和/或先前的主轴频率根据检测到的睡眠纺锤波睡眠时期期间的时间段。该系统控制提供给基于前一主轴密度与最近主轴密度和/或先前频率主轴最近频率主轴比较所述受试者的感官刺激的强度。

9. 发明公开

EP2967484A4 SYSTEM AND SIGNATURES FOR THE MULTI-MODAL PHYSIOLOGICAL STIMULATION AND ASSESSMENT OF BRAIN HEALTH 审中-公开
标题翻译：系统和多式联运生理性起搏签字和大脑健康评估
公开(公告)号：EP2967484A4
公开(公告)日：2016-11-09
申请号：EP14762521
申请日：2014-03-14
申请人： SIMON ADAM J
发明人： SIMON ADAM J
IPC分类号： A61B8/00 , A61B5/00 , A61B5/024 , A61B5/0484 , A61B5/05 , G06F15/00 , G10L13/00 , G10L21/00
CPC分类号： A61B5/04842 , A61B5/024 , A61B5/02405 , A61B5/0478 , A61B5/04845 , A61B5/04847 , A61B5/0533 , A61B5/1118 , A61B5/14542 , A61B5/16 , A61B5/4064 , A61B5/4088 , A61B5/6803
摘要： A system and diagnostic signatures which are derived from the data collected in the system captures multiple streams of biological sensor data for assessing brain health and functionality of a user. The system includes a plurality of biological sensors adapted to collect biological sensor data from the user as well as the ability to stimulate the brain in a variety of sensory, cognitive, physical, and chemical challenges. Several of the biological sensors are accommodated in an electronics module mounted on the user's head.

10. 发明公开

EP3060110A1 METHODE ELECTROPHYSIOLOGIQUE D'EVALUATION DE L'EFFICACITE D'UNE PROTHESE AUDITIVE 有权
标题翻译： ELECTRO生理的方法来评估助听器的效果
公开(公告)号：EP3060110A1
公开(公告)日：2016-08-31
申请号：EP14824890.9
申请日：2014-10-24
申请人： Hospices Civils De Lyon , Université Claude Bernard Lyon I
发明人： THAI-VAN, Hung , CACLIN, Anne , BELLIER, Ludovic , VESSON, Jean-François , VEUILLET, Evelyne
IPC分类号： A61B5/04 , A61B5/0484 , A61B5/12 , A61B5/00 , H04R25/00
CPC分类号： A61B5/04845 , A61B5/0006 , A61B5/04009 , A61B5/04012 , A61B5/048 , A61B5/125 , A61B5/4836 , A61B5/4851 , A61B5/7246 , H04R25/70
摘要： A method for assessing the effectiveness of a hearing aid. Said method involves: transmitting out a stimulus via a hearing aid, thereby supplying an auditory stimulus to the auditory nervous system of a person provided with said hearing aid; receiving the neurophysiological signals emitted by said auditory nervous system in response to the auditory stimulus by means of an electro- or magneto-encephalography system; processing the received signals; sending out a stimulus consisting of at least one pair of linguistic units selected from a phonetic confusion matrix; separately receiving a neurophysiological signal in response for each linguistic unit; and comparing the signals such as to assess the effectiveness of the hearing aid.

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