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1. 发明公开

EP3370548A1 NUTRITIONAL COMPOSITIONS FOR PROMOTING GUT BARRIER FUNCTION AND AMELIORATING VISCERAL PAIN 审中-公开
公开(公告)号：EP3370548A1
公开(公告)日：2018-09-12
申请号：EP16785637.6
申请日：2016-10-10
申请人： MJN U.S. Holdings LLC
发明人： ZHONG, Yan , LAMBERS, Teartse Tim , GROSS, Gabriele , MANURUNG, Sarmauli , VAN TOL, Eric A.F. , WAWORUNTU, Rosaline
IPC分类号： A23L33/00 , A61K35/747 , A23L33/135
CPC分类号： A61K35/747 , A23L29/065 , A23L33/135 , A23L33/40 , A23V2002/00 , A23Y2220/73 , A61K38/40 , A61K2035/115 , A61K2300/00
摘要： The present disclosure is directed to methods for i) promoting gut regeneration, ii) promoting gut maturation and/or adaptation, iii) supporting gut barrier resistance and/or iv) protecting gut barrier function in a pediatric subject comprising administering to the pediatric subject a composition comprising an effective amount of a soluble mediator preparation derived from a late-exponential growth phase of a probiotic batch-cultivation process, such as Lactobacillus rhamnosus GG (LGG). The present methods advantageously provide the gut-protection benefits of LGG soluble mediators without introducing live bacterial culture to individuals with impaired gut barrier function. In some embodiments, the pediatric subject has impaired gut barrier function and/or short bowel syndrome. The present disclosure in other embodiments, directed methods for reducing visceral pain in a pediatric subject comprising administering to the pediatric subject a composition comprising an effective amount of a soluble mediator preparation from a late-exponential growth phase of a probiotic batch-cultivation process, such as LGG.

2. 发明授权

EP2477638B1 PROBIOTIC STABILIZATION 有权转让
公开(公告)号：EP2477638B1
公开(公告)日：2018-07-25
申请号：EP10817876.5
申请日：2010-09-17
申请人： MJN U.S. Holdings LLC
发明人： RANGAVAJLA, Nagendra , CEVALLOS, Bolivar
IPC分类号： A61K35/74 , C12N1/20 , A23C9/152
CPC分类号： A61K35/747 , A23L33/10 , A23L33/115 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/19 , A23L33/40 , A23V2002/00 , A23Y2220/73 , A61K9/0053 , A61K9/08 , A61K31/202 , A61K47/26 , A61K47/36 , A61K47/42 , A61K2035/11 , A23V2200/3204 , A23V2250/54246 , A23V2250/55
摘要： An ingestible composition including a probiotic contained in a mixture of hydrolyzed mammalian protein, one or more carbohydrates and a compound binder useful for nutrition of infants and children.

3. 发明公开

EP3344052A1 LACTOBACILLUS FERMENTUM BACTERIA INHIBITING POST-ACIDIFICATION 有权
公开(公告)号：EP3344052A1
公开(公告)日：2018-07-11
申请号：EP16760689.6
申请日：2016-08-30
申请人： Chr. Hansen A/S
发明人： NIELSEN, Cecilie Lykke Marvig , HORNBAEK, Tina , RASMUSSEN, Pia , POULSEN, Lone
IPC分类号： A23C9/123 , C12R1/225
CPC分类号： A23C9/1234 , A23K10/18 , A23L33/135 , A23Y2220/15 , A23Y2220/35 , A23Y2220/63 , A23Y2220/73 , A23Y2240/75 , A61K35/747 , C12N1/20 , C12R1/225
摘要： The present invention relates to a bacterium of the species Lactobacillus fermentum, wherein the bacterium is characterized in that it increases the pH of a fermented milk product comprising the Lactobacillus fermentum during storage after fermentation in comparison to a milk product fermented with the same starter culture not containing the Lactobacillus fermentum. In a related embodiment the present invention provides a bacterium of the species Lactobacillus fermentum characterized in that a fermented milk product comprising the Lactobacillus fermentum maintains a pH above 4.0 when stored for at least 14 days at 25° C., wherein the fermented milk product is obtained by a method comprising incubating a milk with the Lactobacillus fermentum in a concentration of at least 107 CFU/g and with a starter culture, fermenting until a pH of 4.6 is reached, shaking the fermented product and cooling. The invention further relates to compositions comprising the bacteria, methods for producing fermented milk products using the bacteria and the products thus obtained.

4. 发明公开

EP3214953A1 NUTRITIONAL SUPPLEMENTS CONTAINING A PEPTIDE COMPONENT AND USES THEREOF 审中-公开
标题翻译：含有肽组分的营养补充剂及其用途
公开(公告)号：EP3214953A1
公开(公告)日：2017-09-13
申请号：EP15784224.6
申请日：2015-10-07
申请人： MJN U.S. Holdings, LLC
发明人： VAN TOL, Eric A.F. , SCHOEMAKER, Marieke H. , GROSS, Gabriele , LAMBERS, Teartse Tim , WIELINGA, Peter , KLEEMANN, Robert
IPC分类号： A23L33/18 , A23L33/135 , A23L33/115
CPC分类号： A61K38/08 , A23L33/115 , A23L33/12 , A23L33/135 , A23L33/18 , A23V2002/00 , A23Y2220/73 , A61K31/202 , A61K35/747 , A61K38/06 , A61K2035/115 , A23V2200/328 , A23V2200/332 , A23V2250/186 , A23V2250/1862 , A23V2250/1868 , A23V2250/1882 , A23V2250/54 , A23V2250/55
摘要： The present disclosure relates to nutritional supplement including a peptide component. The nutritional supplement further includes a source of long-chain polyunsaturated fatty acids and
Lactobacillus rhamnosus GG. The disclosure further relates to methods of protecting against obesity and its related metabolic disorders and inflammatory diseases in a target subject by providing the nutritional supplement(s) disclosed herein to a target subject, which includes a pediatric subject.
摘要翻译：本公开涉及包含肽组分的营养补充剂。营养补充剂还包括长链多不饱和脂肪酸和鼠李糖乳杆菌GG的来源。本公开还涉及通过将本文公开的营养补充剂提供给包括儿科对象的靶标对象来防止靶标对象中的肥胖症及其相关代谢紊乱和炎性疾病的方法。

5. 发明授权

EP2455095B1 PROPHYLACTIC, AMELIORATING OR THERAPEUTIC AGENT FOR ORAL DISEASES 有权
标题翻译：用于口腔疾病的预防，美容或治疗剂
公开(公告)号：EP2455095B1
公开(公告)日：2017-06-07
申请号：EP10799648.0
申请日：2010-07-16
申请人： Hiroshima University
发明人： NIKAWA, Hiroki
IPC分类号： A61K35/74 , A61P1/02
CPC分类号： A61K35/747 , A23C9/123 , A23Y2220/73
摘要： To provide a novel lactic acid bacterium strain having a broad antibacterial spectrum against bacteria that cause oral diseases, from which a fermented product having good flavor and being excellent in palatability can be produced, and a prophylactic, ameliorating or therapeutic agent for oral diseases using the same. A prophylactic, ameliorating or therapeutic agent for an oral disease, which contains a lactic acid bacterial cell of one or more kinds selected from the group consisting of Lactobacillus rhamnosus strain KO3, Lactobacillus casei strain YU3 and Lactobacillus paracasei strain YU4 or a culture of the cell, or an extract thereof, as an active ingredient.
摘要翻译：本发明提供一种能够制造口腔疾病的细菌的广谱抗菌性的新型乳酸菌菌株，该乳酸菌菌株能够制造风味良好且适口性优异的发酵物，以及使用该制剂的口腔疾病的预防，改善或治疗剂相同。含有选自鼠李糖乳杆菌菌株KO3，干酪乳杆菌菌株YU3和副干酪乳杆菌菌株YU4中的一种或多种的乳酸菌细胞或细胞培养物的口腔疾病预防，改善或治疗剂或其提取物作为活性成分。

6. 发明公开

EP3141254A1 LACTOBACILLUS RHAMNOSUS RHT-3201 CONJUGATED TO POLYSACCHARIDE POLYMER BINDER, AND USE THEREOF FOR PREVENTION OR TREATMENT OF ATOPIC DISEASES 有权
标题翻译： AN OLYSACCHARIDPOLYMERBINDEMITTEL缀合鼠李糖乳杆菌RHT-3201及其用于特异反应性疾病的预防和治疗
公开(公告)号：EP3141254A1
公开(公告)日：2017-03-15
申请号：EP15788586.4
申请日：2015-04-20
申请人： Ildong Pharmaceutical Co., Ltd.
发明人： LEE, Seung-Hun , KANG, Dae-Jung , KANG, Jae-Hoon
IPC分类号： A61K35/74 , A61P17/00 , A23L33/00
CPC分类号： C12N1/20 , A23L2/52 , A23L33/00 , A23L33/10 , A23V2002/00 , A23Y2220/73 , A61K35/74
摘要： The present invention relates to heat-killed Lactobacillus rhamnosus conjugated to a polysaccharide polymer binder, a preparation method therefor and a use thereof. The heat-killed Lactobacillus rhamnosus conjugated to a polysaccharide polymer binder of the present invention has an excellent therapeutic effect for atopic diseases, and particularly has high industrial applicability because membrane adhesion competitiveness, which is an advantage of existing lactic acid bacteria, is significantly improved, thereby exhibiting dermatitis preventing, alleviating and treating effects of the same level as steroid-based drugs.
摘要翻译：本发明涉及缀合的多糖聚合物粘合剂，用于其的制备方法和它们的用途，以热灭活鼠李糖乳杆菌。缀合至本发明的多糖类聚合物粘合剂热灭活鼠李糖乳杆菌具有特异反应性疾病的优异的治疗效果，特别是具有高的工业适用性由于膜粘附竞争力，所有这些是在利用现有的乳酸菌，显着提高，由此呈现皮炎预防，缓解和治疗相同的水平基于类固醇药物的效果。

7. 发明公开

EP3139772A1 METHODS OF USE FOR PROBIOTICS AND PREBIOTICS 审中-公开
标题翻译： VERFAHREN ZUR VERWENDUNG VON PROBIOTIKA UNDPRÄBIOTIKA
公开(公告)号：EP3139772A1
公开(公告)日：2017-03-15
申请号：EP15713270.5
申请日：2015-03-10
申请人： MJN U.S. Holdings, LLC
发明人： CHICHLOWSKI, Maciej , BERG, Brian, , RUDOLPH, Colin, , MCMAHON, Robert J. , WAWORUNTU, Rosaline
IPC分类号： A23L33/00 , A23L33/10 , A61K35/747 , C12N1/00
CPC分类号： A61K35/747 , A23L33/10 , A23L33/135 , A23L33/26 , A23L33/40 , A23V2002/00 , A23Y2220/73 , A61K31/702 , A61K31/716 , A61K2035/115 , C12N1/20
摘要： The present disclosure relates to method(s) for reducing the risk of visceral pain hypersensitivity, modulating the gut-brain axis, or reducing the local inflammatory response in a subject. The method(s) include providing a nutritional composition that includes Lactobacillus rhamnosus GG (LGG), galacto-oligosaccharide(s) (GOS) and polydextrose (PDX) to the subject. The combination of LGG, GOS, and PDX may exhibit additive or synergistic beneficial health effects when consumed. The nutritional compositions herein are suitable for administration to children and infants.
摘要翻译：本公开涉及用于降低内脏痛过敏风险，调节肠 - 脑轴线或减少受试者局部炎症反应的方法。该方法包括向受试者提供包括鼠李糖乳杆菌GG（LGG），半乳寡糖（GOS）和聚右旋糖（PDX））的营养组合物。当消费时，LGG，GOS和PDX的组合可能表现出增加的或协同的有益的健康影响。本发明的营养组合物适用于给予儿童和婴儿。

8. 发明授权

EP2945494B1 BABY FOOD COMPOSITION COMPRISING VIABLE PROPIONIC ACID-PRODUCING BACTERIA AND VIABLE LACTIC ACID-PRODUCING BACTERIA 有权
标题翻译：婴儿食物组合物含启用Live丙酸生产菌的生活资格MILK产酸菌
公开(公告)号：EP2945494B1
公开(公告)日：2017-03-08
申请号：EP14700426.1
申请日：2014-01-14
申请人： ETH Zürich , Universität Zürich
发明人： CHASSARD, Christophe , LACROIX, Christophe , BRAEGGER, Christian
IPC分类号： A61P1/12 , A61K35/74 , A23L33/00 , A23L33/135
CPC分类号： A61K9/0095 , A23L33/135 , A23L33/21 , A23L33/40 , A23V2002/00 , A23Y2220/73 , A23Y2300/49 , A23Y2320/25 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747 , A61K45/06 , Y02A50/481
摘要： The present invention relates to compositions, particularly baby food compositions, comprising living lactate-utilizing propionic acid-producing bacteria, as well as viable lactic-acid producing bacteria, its manufacture and use in the treatment of digestive diseases, particularly for treatment of infantile colic, intestinal discomfort, intestinalpain, visceral sensitivity, and intestinal cramp.

9. 发明授权

EP2593570B1 FERMENTED SOY-BASED MIXTURE COMPRISING ISOFLAVONES-AGLYCONES, EQUOL AND LUNASIL, PROCESS FOR THE PREPARATION AND USES THEREOF IN FOOD, MEDICAL AND COSMETIC FIELDS 有权
标题翻译：发酵的大豆混合异黄酮苷元，雌马酚LUNASIL，其制造方法相同，它们在食品技术，医药和化妆品范围
公开(公告)号：EP2593570B1
公开(公告)日：2017-03-01
申请号：EP11754750.5
申请日：2011-07-11
申请人： Giuliani S.p.A.
发明人： GIULIANI, Giammaria , BENEDUSI, Anna , GOBBETTI, Marco , DI CAGNO, Raffaella , BARONI, Sergio , RIZZELLO, Carlo Giuseppe
IPC分类号： C12N1/20 , A23C11/10 , A23L11/00 , A23L33/105 , A23L33/135 , A61K8/64 , A61K8/97 , A61K31/352 , A61K31/353 , A61K35/747 , A61K36/48 , A61K38/16 , A61P1/00 , A61P17/14 , A61Q7/00 , A61Q19/00 , C12R1/25 , C12R1/225
CPC分类号： A23L1/2008 , A23C11/106 , A23L11/09 , A23L33/105 , A23L33/135 , A23V2002/00 , A23Y2220/35 , A23Y2220/67 , A23Y2220/73 , A61K8/645 , A61K8/97 , A61K31/352 , A61K31/353 , A61K35/747 , A61K36/48 , A61K38/168 , A61Q7/00 , A61Q19/00 , C12N1/20 , C12P21/00 , C12R1/225 , C12R1/25 , A61K2300/00 , A23V2200/318 , A23V2200/32 , A23V2200/324

10. 发明授权

EP2429546B1 INFANT CEREAL COMPRISING NON-REPLICATING PROBIOTIC MICROORGANISMS 无效
标题翻译：非复制性益生菌微生物含谷物的婴儿
公开(公告)号：EP2429546B1
公开(公告)日：2016-08-31
申请号：EP10719341.9
申请日：2010-05-11
申请人： Nestec S.A.
发明人： MERCENIER, Annick , NUTTEN, Sophie , PRIOULT, Guénolée
IPC分类号： A61K35/745 , A23L7/10 , A23L33/135 , A61P37/04 , A61P29/00 , A61K35/747
CPC分类号： A61K35/745 , A23K10/18 , A23L33/135 , A23L33/40 , A23V2002/00 , A23Y2220/03 , A23Y2220/15 , A23Y2220/17 , A23Y2220/43 , A23Y2220/63 , A23Y2220/71 , A23Y2220/73 , A23Y2240/41 , A23Y2240/75 , A23Y2300/29 , A23Y2300/49 , A23Y2300/55 , A61K35/747 , C12N1/36 , Y02A50/473
摘要： The present invention relates to the field of nutrition for infants and young children. In particular, the present invention relates to growing-up milks comprising probiotic micro-organisms to be administered to infants and young children older than 10 months. These probiotic micro-organisms may be non-replicating probiotic micro-organisms such as bioactive heat treated probiotic micro-organisms, for example.

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