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1. 发明公开

EP3448149A1 ORGAN PRESERVATION AND/OR PERFUSION SOLUTIONS 有权
公开(公告)号：EP3448149A1
公开(公告)日：2019-03-06
申请号：EP17700817.4
申请日：2017-01-17
申请人： XVIVO Perfusion AB
发明人： SJÖQVIST, Elin , SIGVARDSSON, Anne-Li
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/021 , A01N1/0221 , A01N1/0247 , A61K31/70 , A61K31/721 , A61M39/08 , A61M2210/12
摘要： An organ preservation and/or perfusion solution for an isolated tissue or organ is provided. The solution comprises dextran, glucose, calcium ions, a buffer, and water, has a pH of 6.6 to 7.8, and is sterile based on having been subjected to heat sterilization. A method of preparing the solution also is provided. The method comprises combining dextran, glucose, calcium ions, buffer, and water to obtain an initial solution, adjusting the pH of the initial solution to 7.0 to 7.8 if needed, and subjecting the initial solution to heat sterilization, thereby obtaining the organ preservation and/or perfusion solution. A method of preserving and/or perfusing an isolated tissue or organ also is provided. A method for flushing, storage, and/or transportation of an isolated lung after removal from a donor in preparation for eventual transplantation into a recipient also is provided.

2. 发明授权

EP3448149B1 ORGAN PRESERVATION AND/OR PERFUSION SOLUTIONS 有权
公开(公告)号：EP3448149B1
公开(公告)日：2019-08-21
申请号：EP17700817.4
申请日：2017-01-17
申请人： XVIVO Perfusion AB
发明人： SJÖQVIST, Elin , SIGVARDSSON, Anne-Li
IPC分类号： A01N1/02

3. 发明公开

EP2384112A1 A COMPOSITION COMPRISING NOR-ADRENALINE AND A NET INHIBITOR FOR ADMINISTERING TO A BRAIN-DEAD, HEART-BEATING POTENTIAL ORGAN DONOR. 失效转让
标题翻译：组合物去甲肾上腺素和净含抑制剂的施用至脑死亡的心跳潜在器官捐献者
公开(公告)号：EP2384112A1
公开(公告)日：2011-11-09
申请号：EP09836460.7
申请日：2009-12-30
申请人： Vivoline Medical AB
发明人： STEEN, Stig
IPC分类号： A01N1/02 , A61K31/135 , A61K31/46 , A61K31/55 , A61K31/137 , A61K31/198 , A61K31/573 , A61K38/11
CPC分类号： A61K31/46 , A01N1/0226 , A61K9/0019 , A61K31/135 , A61K31/137 , A61K31/198 , A61K31/55 , A61K31/573 , A61K38/11 , A61K45/06 , A61M5/142 , A61M5/172 , A61K2300/00
摘要： A composition, an infusion solution, a method for treatment, and a kit for intravascular administration for treatment of a brain-dead, heart-beating, respirated, potential organ donor. The composition includes a non-adrenaline and amphetamine or an amphetamine-like substance. The composition may in addition include adrenaline, hydrocortisone, thyroxin, insulin, triiodotyronine, dopamine, a vasopressor agent, such as desmopressin, and methylprednisolone. The composition may be dissolved in pure water, Ringer's acetate solution or physiological sodium chloride solution. The composition is infused in such an amount as to maintain a mean arterial pressure of about 60 mmHg.

4. 发明授权

EP2384112B1 A COMPOSITION COMPRISING NOR-ADRENALINE AND A NET INHIBITOR FOR ADMINISTERING TO A BRAIN-DEAD, HEART-BEATING POTENTIAL ORGAN DONOR. 失效转让
公开(公告)号：EP2384112B1
公开(公告)日：2019-02-27
申请号：EP09836460.7
申请日：2009-12-30
申请人： XVIVO Perfusion AB
发明人： STEEN, Stig
IPC分类号： A01N1/02 , A61K31/135 , A61K31/46 , A61K31/55 , A61K31/137 , A61K31/198 , A61K31/573 , A61K38/11 , A61P43/00

5. 发明授权

EP3071029B1 AN AFTERLOAD DEVICE FOR A BEATING HEART DURING EXAMINATION THEREOF 有权转让
公开(公告)号：EP3071029B1
公开(公告)日：2018-11-28
申请号：EP14856612.8
申请日：2014-10-24
申请人： Vivoline Medical AB
发明人： STEEN, Stig , PASKEVICIUS, Audrius , KING, Benjamin
IPC分类号： A01N1/02 , A61B5/02 , A61B5/0215 , A61B5/022 , A61B5/023
CPC分类号： A61B5/02028 , A01N1/0247 , A61B5/0215 , A61B5/02158 , A61B5/02233 , A61B5/023 , A61B5/6876 , A61B2505/05 , G09B23/306
摘要： An examination device for a heart. An afterload device connected to the aorta provides a counterpressure by an annular space delimited between a rigid cylinder and an elastic tube inserted in the rigid cylinder. The annular space comprises a compressible medium, such as air, nitrogen gas or carbon dioxide and is connected to a reservoir providing a predetermined pressure corresponding to a diastolic pressure. The reservoir is connected to the annular space via a restriction and a back-flow valve. During diastole, the annular space is inflated by the reservoir and provides a diastolic counter pressure for providing coronary flow. During systole, the ejected fluid from the heart ventricle displaces the medium inside the annular space through the restriction to the reservoir, thereby removing energy from the fluid. The compressible medium forms a compliance. In addition, there is a preload device comprising a vertical collapsible tube forming a fluid column for preload of the atrium with a desired preload pressure without introducing air into the fluid. A pump delivers fluid to the preload device and removes fluid from the afterload device.

6. 发明公开

EP3071029A1 AN AFTERLOAD DEVICE FOR A BEATING HEART DURING EXAMINATION THEREOF 有权转让
标题翻译： NACHLASTVORRICHTUNGFÜREINE HERZSCHLAGBEWEGUNGWÄHRENDDEREN UNTERSUCHUNG
公开(公告)号：EP3071029A1
公开(公告)日：2016-09-28
申请号：EP14856612.8
申请日：2014-10-24
申请人： Vivoline Medical AB
发明人： STEEN, Stig , PASKEVICIUS, Audrius , KING, Benjamin
IPC分类号： A01N1/02 , A61B5/02 , A61J1/00 , A61K35/34 , A61M1/00
CPC分类号： A61B5/02028 , A01N1/0247 , A61B5/0215 , A61B5/02158 , A61B5/02233 , A61B5/023 , A61B5/6876 , A61B2505/05 , G09B23/306
摘要： An examination device for a heart. An afterload device connected to the aorta provides a counterpressure by an annular space delimited between a rigid cylinder and an elastic tube inserted in the rigid cylinder. The annular space comprises a compressible medium, such as air, nitrogen gas or carbon dioxide and is connected to a reservoir providing a predetermined pressure corresponding to a diastolic pressure. The reservoir is connected to the annular space via a restriction and a back-flow valve. During diastole, the annular space is inflated by the reservoir and provides a diastolic counter pressure for providing coronary flow. During systole, the ejected fluid from the heart ventricle displaces the medium inside the annular space through the restriction to the reservoir, thereby removing energy from the fluid. The compressible medium forms a compliance. In addition, there is a preload device comprising a vertical collapsible tube forming a fluid column for preload of the atrium with a desired preload pressure without introducing air into the fluid. A pump delivers fluid to the preload device and removes fluid from the afterload device.
摘要翻译：心脏检查装置连接到主动脉的后负荷装置通过限定在刚性气缸和插入刚性气缸中的弹性管之间的环形空间提供反压力。环形空间包括诸如空气，氮气或二氧化碳的可压缩介质，并且连接到提供对应于舒张压的预定压力的储存器。储存器经由限制器和回流阀连接到环形空间。在舒张期间，环形空间被储存器充气，并提供用于提供冠状动脉血流的舒张压。在心脏收缩期间，来自心室的排出的液体将环形空间内的介质通过限制器移动到储存器，从而从流体中去除能量。可压缩介质形成顺应性。另外，还有一种预压装置，其包括垂直的可折叠管，该管可形成用于预充载心室的流体柱，并且不需要将空气引入到流体中。泵将流体输送到预载装置并从后负载装置中移除流体。

7. 发明公开

EP2568805A1 A MEDICAL FLUID, A METHOD OF TREATMENT AND USE OF THE FLUID 有权转让
标题翻译：药液，治疗和液体在其中使用的方法
公开(公告)号：EP2568805A1
公开(公告)日：2013-03-20
申请号：EP11780879.0
申请日：2011-05-13
申请人： Vivoline Medical AB
发明人： STEEN, Stig
IPC分类号： A01N1/02
CPC分类号： A01N1/0226
摘要： A medical fluid for a harvested organ, tissue or parts thereof, for evaluation and/or preservation. The fluid includes cocaine or a stimulating analogue thereof; nor-adrenalin; and/or adrenaline. In addition, the fluid includes an oncotic agent, such as dextran; hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium. In addition, the medical fluid further includes albumin in a concentration not exceeding 5.0%, and an oxygen carrier, such as erythrocytes. Further components may be dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. The cocaine; adrenalin; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM, for example in a ratio of 1:1:1.

8. 发明公开

EP2285211A1 APPARATUS FOR HOUSING AN ORGAN DURING EVALUATION AND PRESERVATION 有权转让
标题翻译： VORRICHTUNG ZUR AUFNAHME EINES ORGANSWÄHRENDBEWERTUNG UND KONSERVIERUNG
公开(公告)号：EP2285211A1
公开(公告)日：2011-02-23
申请号：EP09742920.3
申请日：2009-05-06
申请人： Vivoline Medical AB
发明人： STEEN, Stig , PASKEVICIUS, Audrius , KING, Benjamin Martin
IPC分类号： A01N1/02 , A61J1/00
CPC分类号： A01N1/02 , A01N1/0242 , A01N1/0247
摘要： A vessel for housing an organ such as lungs from a mammal ex-vivo, for evaluation or preservation. A liquid solution suitable for evaluation or preservation of the lungs surrounds the organ, at least partly. The solution is circulated via an outlet and an inlet. Two pressure chambers are arranged between the walls of the vessel and the organ. A gas is introducible to the pressure chamber in order to expand the pressure chamber for occupying the spaces surrounding the organ. Then, the pressure inside the pressure chambers is increased in order to push the solution to a higher level so that the organ is immersed in the solution without necessitating addition of further solution. Alternatively, the vessel is exposed to an under pressure and the pressure chambers are open to the atmosphere. In a further alternative embodiment, a solution collection space has variable volume.
摘要翻译：用于容纳来自哺乳动物的器官如肺的器官，用于评估或保存。适于评估或保存肺的液体溶液至少部分地包围器官。溶液通过出口和入口循环。在容器的壁和器官之间设置两个压力室。气体被引入压力室，以便扩大用于占据器官周围空间的压力室。然后，增加压力室内的压力以便将溶液推到更高的水平，使得器官浸入溶液中，而不需要添加另外的溶液。或者，容器暴露于低压下，并且压力室对大气开放。在另一替代实施例中，解决方案收集空间具有可变体积。

9. 发明授权

EP4152927B1 USE OF ACETYLATED SERUM ALBUMIN IN AN ORGAN PRESERVATION AND/OR PERFUSION SOLUTION 有权
公开(公告)号：EP4152927B1
公开(公告)日：2024-10-02
申请号：EP21742775.6
申请日：2021-07-05
IPC分类号： A01N1/02 , A61K31/00
CPC分类号： A01N1/0226 , A61K31/4709 , A61K31/137 , A61K31/661 , A61K31/203 , A61K31/593 , A61K31/355 , A61K31/122 , A61K31/573 , A61K31/4045 , A61K31/198

10. 发明授权

EP2568805B1 A MEDICAL FLUID, A METHOD OF TREATMENT AND USE OF THE FLUID 有权转让
公开(公告)号：EP2568805B1
公开(公告)日：2019-05-01
申请号：EP11780879.0
申请日：2011-05-13
申请人： XVIVO Perfusion AB
发明人： STEEN, Stig
IPC分类号： A01N1/02 , A61K31/135 , A61K31/46 , A61K31/55

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