专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3743519A1 BIODIFFUSION CHAMBER 审中-实审
公开(公告)号：EP3743519A1
公开(公告)日：2020-12-02
申请号：EP19744113.2
申请日：2019-01-24
申请人： Thomas Jefferson University , Imvax, Inc. , Laurenzi, Brendan
发明人： LAURENZI, Brendan , ANDREWS, David , HITCHINGS, William , VENTURA, Dominic , PIGOTT, Kara , HOOPER, Douglas Craig
IPC分类号： C12N15/113 , A61K35/13 , A61K39/00

2. 发明公开

EP3628055A1 SYSTEMS-LEVEL ANALYSIS OF TCGA CANCERS REVEALS DISEASE TRNA FRAGMENTATION PATTERNS AND ASSOCIATIONS WITH MESSENGER RNAS AND REPEAT 审中-公开
公开(公告)号：EP3628055A1
公开(公告)日：2020-04-01
申请号：EP18794729.6
申请日：2018-05-01
申请人： Thomas Jefferson University
发明人： RIGOUTSOS, Isidore , TELONIS, Aristeidis G.
IPC分类号： C12N15/113 , C12Q1/68 , G01N33/50

3. 发明公开

EP3628003A1 P-ETHOXY NUCLEIC ACIDS FOR IGF-1R INHIBITION 审中-实审转让
公开(公告)号：EP3628003A1
公开(公告)日：2020-04-01
申请号：EP18788289.9
申请日：2018-04-19
申请人： Bio-Path Holdings, Inc. , Thomas Jefferson University
发明人： ASHIZAWA, Ana , HOOPER, Douglas Craig , ANDREWS, David W.
IPC分类号： A61K9/127 , A61K31/7125 , A61K47/54 , A61K47/69 , A61P35/00 , C07H21/02

4. 发明公开

EP3592841A1 METHODS AND COMPOSITIONS FOR TREATING CANCERS USING ANTISENSE 有权
公开(公告)号：EP3592841A1
公开(公告)日：2020-01-15
申请号：EP18764973.6
申请日：2018-03-09
申请人： Thomas Jefferson University
发明人： ANDREWS, David, W. , HOOPER, Douglas, C.
IPC分类号： C12N5/02 , C12N5/10 , C12N15/09 , C12N15/11 , C12N15/52 , C12N15/113 , C12P19/34 , C07H21/04 , C12Q1/68

5. 发明公开

EP3280806A1 METHODS AND COMPOSITIONS FOR TREATING CANCERS AND ENHANCING THERAPEUTIC IMMUNITY BY SELECTIVELY REDUCING IMMUNOMODULATORY M2 MONOCYTES 审中-公开
标题翻译：通过选择性减少免疫调节性M2单克隆抗体治疗癌症和增强治疗性免疫的方法和组合物
公开(公告)号：EP3280806A1
公开(公告)日：2018-02-14
申请号：EP16777497.5
申请日：2016-04-11
申请人： THOMAS JEFFERSON UNIVERSITY , Andrews, David W. , Hooper, Douglas C.
发明人： ANDREWS, David W. , HOOPER, Douglas C.
IPC分类号： C12N15/113 , C12N15/11 , A61K31/7088 , A61P35/00
CPC分类号： A61K31/713 , A61K31/7125 , A61K45/06 , C12N15/1138 , C12N2310/11 , C12N2310/315
摘要： The present disclosure provides pharmaceutical compositions comprising nucleic acids capable of targeting IGF-1R expression in M2 cells. The present disclosure also provides methods for the selective reduction of M2 cells by targeting expression of IGF-1R in these cells. The present disclosure further provides methods for treating cancer and enhancing therapeutic by targeting expression of IGF-1R in M2 cells in patients. The pharmaceutical composition of the present invention is effective when administered systemically to subjects in need thereof. The ease of administration of the pharmaceutical composition facilitates treatment and enhances patient compliance.

6. 发明公开

EP3280315A1 IMPLANTABLE VITAL SIGN SENSOR 有权
标题翻译：可植入生命体征传感器
公开(公告)号：EP3280315A1
公开(公告)日：2018-02-14
申请号：EP16714727.1
申请日：2016-03-29
申请人： Thomas Jefferson University
发明人： JOSEPH, Jeffrey I.
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/1455
摘要： An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.

7. 发明授权

EP2417259B1 NEURON GENERATION, REGENERATION AND PROTECTION 有权
标题翻译：神经生成，再生和保护
公开(公告)号：EP2417259B1
公开(公告)日：2017-06-28
申请号：EP10717225.6
申请日：2010-04-02
申请人： Institut Pasteur , Thomas Jefferson University
发明人： PREHAUD, Christophe , LAFON, Monique , SCHNELL, Matthias, Johannes
IPC分类号： C12N15/47 , C12N15/86 , C07K14/145 , A61K38/17 , A61K48/00
CPC分类号： C07K14/005 , A61K35/13 , A61K35/766 , A61K38/00 , A61K38/162 , C12N2760/20122 , Y02A50/465
摘要： The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of said non-apoptotic rabies virus G proteins, more particularly to their PDZ-BS, which shows a single-point mutation compared to the one of apoptotic rabies virus G proteins. The invention provides means for inducing and/or stimulating neurite outgrowth, which are useful in inducing neuron differentiation, for example for the treatment of a neoplasm of the nervous system, as well as in regenerating impaired neurons, for example for the treatment of a neurodegenerative disease, disorder or condition or in the treatment of a microbial infection, or in protecting neurons from neurotoxic agents or oxidative stress.
摘要翻译：本发明证明，与凋亡狂犬病病毒G蛋白相反，某些非凋亡狂犬病病毒G蛋白如CVS-NIV株的G蛋白具有神经突生长促进作用。本发明进一步表明，这种神经突生长促进作用是由于所述非凋亡狂犬病病毒G蛋白的细胞质尾部，更具体地是由于它们的PDZ-BS，其与凋亡狂犬病病毒G相比表现出单点突变蛋白质。本发明提供用于诱导和/或刺激神经突生长的手段，其可用于诱导神经元分化，例如用于治疗神经系统肿瘤以及再生受损神经元，例如用于治疗神经变性疾病，病症或病症或用于治疗微生物感染，或用于保护神经元免受神经毒剂或氧化应激。

8. 发明公开

EP3180065A2 LONG-TERM IMPLANTABLE MONITORING SYSTEM & METHODS OF USE 审中-公开
标题翻译：佛罗伦萨兰德维尔
公开(公告)号：EP3180065A2
公开(公告)日：2017-06-21
申请号：EP15825386.4
申请日：2015-07-24
申请人： THOMAS JEFFERSON UNIVERSITY
发明人： JOSEPH, Jeffrey I. , JOSEPH, Amanda L.
IPC分类号： A61M37/00 , A61N1/372 , A61B34/00
CPC分类号： A61B5/14528 , A61B5/0031 , A61B5/1451 , A61B5/14532 , A61B5/14552 , A61B5/14556 , A61B5/1459 , A61B5/1473 , A61B5/1495 , A61B5/6852 , A61B5/6876 , A61B5/7282 , A61B5/742 , A61B5/746 , A61B2560/0214 , A61M5/14 , A61M5/14276 , A61M5/1723 , A61M27/002 , A61M2005/1726 , A61M2205/0244 , A61M2205/04
摘要： Methods and systems include a long-term implantable ultra-filtrate monitoring system that uses micro-porous membranes to produce an ultra-filtrate of tissue interstitial fluid or blood plasma. The ultra-filtrate is transported through a sensor to detect a level of analyte in the ultra-filtrate. The long-term implantable fluid monitoring system thus includes a first porous catheter, a second porous catheter, a sensor configured to measure an amount of analyte in fluid, and a pump configured to move fluid through the first porous catheter to the sensor and from the sensor through the second porous catheter.
摘要翻译：方法和系统包括使用微孔膜产生组织间质液或血浆的超滤液的长期可植入超滤液监测系统。超滤液通过传感器传输，以检测超滤液中的分析物水平。因此，长期可植入液体监测系统包括第一多孔导管，第二多孔导管，被配置为测量流体中分析物的量的传感器，以及构造成将流体通过第一多孔导管移动到传感器并从传感器通过第二个多孔导管。

9. 发明公开

EP3054936A4 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES AS 12-LIPOXYGENASE INHIBITORS 有权转让
标题翻译： 4 - （（2-羟基-3-甲氧基苄基）氨基）苯磺酰胺衍生物作为12脂氧合酶抑制剂
公开(公告)号：EP3054936A4
公开(公告)日：2017-03-29
申请号：EP14852765
申请日：2014-10-10
申请人： EASTERN VIRGINIA MEDICAL SCHOOL , THE REGENTS OF THE UNIV OF CALIFORNIA SANTA CRUZ , THE UNITED STATES OF AMERICA DEPT OF HEALTH AND HUMAN SERVICES , UNIV JEFFERSON
发明人： MALONEY DAVID J , LUCI DIANE K , JADHAV AJIT , HOLMAN THEODORE , NADLER JERRY L , HOLINSTAT MICHAEL , TAYLOR-FISHWICK DAVID , SIMEONOV ANTON , YASGAR ADAM , MCKENZIE STEVEN E
IPC分类号： A61K31/045 , A61K31/10 , A61K31/18 , A61P3/00 , A61P7/00 , A61P35/00 , C07C311/44 , C07D211/28 , C07D213/76 , C07D217/02 , C07D217/22 , C07D235/30 , C07D239/69 , C07D261/16 , C07D263/58 , C07D277/52 , C07D277/82 , C07D295/135 , C07D333/36 , C07D417/12 , C12Q1/26
CPC分类号： C07C311/44 , C07D211/28 , C07D213/76 , C07D217/02 , C07D217/22 , C07D235/30 , C07D239/69 , C07D261/16 , C07D263/58 , C07D277/52 , C07D277/82 , C07D295/135 , C07D333/36 , C07D417/12
摘要： Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Platelet-type 12-(S)-LOX (12-LOX) is of particular interest because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer. Disclosed herein is the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide-based scaffold. The compounds display nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. In addition to possessing favorable ADME properties, the compounds also inhibit PAR-4 induced aggregation and calcium mobilization in human platelets, and reduce 12-HETE in mouse/human beta cells. The compounds can also be used in methods for treating or preventing a 12-lipoxygenase mediated disease or disorder.

10. 发明授权

EP2152865B1 METHODS OF TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES AND DISORDERS 有权
标题翻译：方法用于治疗和预防神经变性疾病和病症
公开(公告)号：EP2152865B1
公开(公告)日：2015-04-15
申请号：EP07776985.9
申请日：2007-05-11
申请人： THOMAS JEFFERSON UNIVERSITY , Rowan University
发明人： SHI, Yi , NAGELE, Robert
IPC分类号： C12N9/20
CPC分类号： C12N9/20 , A61K31/4545 , A61K31/4709 , A61K31/517 , A61K31/519

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式