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1. 发明授权

EP2163255B1 Tuberculosis vaccines comprising antigens expressed during the latent infection phase 有权
标题翻译：包含在潜伏感染期期间表达的抗原的结核疫苗
公开(公告)号：EP2163255B1
公开(公告)日：2017-08-09
申请号：EP09172905.3
申请日：2006-06-20
申请人： Statens Serum Institut
发明人： Vingsbo-Lundberg, Carina , Aagaard, Claus , Andersen, Peter
IPC分类号： A61K39/04 , C07K14/35 , A61P31/06
CPC分类号： C07K19/00 , A61K39/00 , A61K39/04 , C07K14/35 , C07K2319/00

2. 发明公开

EP3193924A1 ALPHA-TOCOPHEROL-BASED ADJUVANTED SOLVENT FOR DNA VACCINES 审中-公开
标题翻译：用于DNA疫苗的α-生育酚基辅助溶剂
公开(公告)号：EP3193924A1
公开(公告)日：2017-07-26
申请号：EP15784559.5
申请日：2015-09-17
申请人： Statens Serum Institut
发明人： FOMSGAARD, Anders
IPC分类号： A61K39/39 , A61K31/355 , C07D311/72 , A61K39/00 , A61P31/16
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/107 , A61K31/355 , A61K39/145 , A61K45/06 , A61K47/22 , A61K2039/53 , A61K2039/54 , A61K2039/55511 , A61K2039/55566 , C07D311/72 , C12N7/00 , C12N2760/16134
摘要： The present invention discloses a delivery system for nucleic acid vaccines comprising an emulsion of tocol and esters hereof. Vaccines and new ways of administration of DNA vaccines are disclosed.
摘要翻译：本发明公开了用于核酸疫苗的递送系统，其包含母育酚及其酯的乳液。公开了DNA疫苗的疫苗和新的施用方式。

3. 发明公开

EP3134116A1 NEW M.TUBERCULOSIS VACCINES 审中-公开
标题翻译： NEUE M. TUBERKULOSEIMPFSTOFFE
公开(公告)号：EP3134116A1
公开(公告)日：2017-03-01
申请号：EP15722435.3
申请日：2015-04-09
申请人： Statens Serum Institut
发明人： AAGAARD, Claus , ROSENKRANDS, Ida , HOANG, Truc Thi Kim Thanh , ANDERSEN, Peter Lawætz
IPC分类号： A61K39/04 , C07K14/35
CPC分类号： A61K39/04 , A61K39/39 , A61K2039/5254 , A61K2039/55555 , A61K2039/575 , A61K2039/70 , C07K14/35 , C07K2319/00
摘要： The present invention is directed to a fusion protein, antigen cocktails and immunological compositions such as vaccines against infections caused by virulent mycobacteria, e.g. by Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis, Mycobacterium microti, Mycobacterium canettii, Mycobacterium pinnipedii or Mycobacterium mungi. The fusion protein, antigen cocktails and immunological compositions are based on proteins secreted by the ESAT-6 secretion system 1 (ESX-1) and are among the most immunodominant M. tuberculosis (MTB) antigens.
摘要翻译：本发明涉及融合蛋白，抗原鸡尾酒和免疫组合物，例如针对由毒性分枝杆菌引起的感染的疫苗，例如，结核分枝杆菌，非洲分枝杆菌，牛分枝杆菌，微枝枝杆菌，分枝杆菌，分枝杆菌或粘液分枝杆菌。融合蛋白，抗原鸡尾酒和免疫组成基于ESAT-6分泌系统1（ESX-1）分泌的蛋白质，是最具免疫优势的结核分枝杆菌（MTB）抗原之一。

4. 发明公开

EP2763694A1 PRODUCTION OF A CYSTEINE RICH PROTEIN 有权
标题翻译： HERSTELLUNG EINES CYSTEINREICHEN蛋白质
公开(公告)号：EP2763694A1
公开(公告)日：2014-08-13
申请号：EP12784427.2
申请日：2012-10-03
申请人： Statens Serum Institut
发明人： THEISEN, Michael , ANDERSEN, Gorm
IPC分类号： A61K39/015 , C07K14/445 , C12N15/30
CPC分类号： C07K14/445 , A61K39/015 , C07K14/4718 , C07K2319/055 , C12N15/62 , C12N15/746 , C12P21/02 , Y02A50/412
摘要： The present invention relates to a method for the production of correctly folded Pfs48/45. This is achieved in the lactococcus lactis when Pfs48/45 or fractions thereof are fused genetically to a glutamate rich protein, e.g. GLURP from Plasmodium falciparum.
摘要翻译：本发明涉及生产正确折叠的Pfs48 / 45的方法。当Pfs48 / 45或其部分在遗传上与富含谷氨酸的蛋白质融合时，这在乳酸乳球菌中实现。来自恶性疟原虫的GLURP。

5. 发明公开

EP2729127A2 METHODS FOR PRODUCING LIPOSOMES 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON LIPOSOMEN
公开(公告)号：EP2729127A2
公开(公告)日：2014-05-14
申请号：EP12746008.7
申请日：2012-07-03
申请人： Statens Serum Institut
发明人： ANDREASEN, Lars, Vibe , WOOD, Grith, Krøyer , CHRISTENSEN, Dennis
IPC分类号： A61K9/127
CPC分类号： A61K47/48815 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K39/04 , A61K39/118 , A61K39/12 , A61K39/39 , A61K2039/55555 , C12N2740/16234 , C12N2760/16134
摘要： The invention discloses a method for the formation of liposomes by using high shear mixing of aqueous solution of lipid powder; the lipid powder can be produced by any known technique. Components of the liposomes include but are not limited to cationic lipids, immunostimulatory/immunopotentiators and macromolecules as components for the liposome formation. The disclosed method describes the formulation of stable liposomes solitary or complexing high concentrations of macromolecules such as proteins, DNA and RNA having opposite charge of the liposomes by high shear mixing where aggregation is avoided due to the formulation method.
摘要翻译：本发明公开了通过使用脂质粉末水溶液的高剪切混合形成脂质体的方法; 脂质粉末可以通过任何已知的技术生产。脂质体的组分包括但不限于阳离子脂质，免疫刺激/免疫增强剂和大分子作为脂质体形成的组分。所公开的方法描述了通过高剪切混合，通过制备方法避免聚集，单独或络合高浓度大分子的蛋白质，DNA和RNA与脂质体相反电荷的稳定脂质体的制剂。

6. 发明公开

EP2402024A1 Expanding the t cell repertoire to include subdominant epitopes by vaccination with antigens delivered as protein fragments or peptide cocktails 审中-公开
标题翻译： T细胞组库的膨胀为包括通过接种亚优势表位与输送抗原蛋白质片段或肽的鸡尾酒
公开(公告)号：EP2402024A1
公开(公告)日：2012-01-04
申请号：EP11182885.1
申请日：2007-06-26
申请人： Statens Serum Institut
发明人： Aagaard, Claus , Dietrich, Jes , Andersen, Peter
IPC分类号： A61K39/04 , A61K39/02 , A61K39/12 , A61K39/002
CPC分类号： A61K39/00 , A61K39/04 , A61K2039/55511 , A61K2039/5555 , Y02A50/412
摘要： The present invention teaches a way of inducing a broad recognition of dominant and subdominant responses to epitopes of any given antigen of importance for prophylaxis or treatment of a chronic disease by immunizing with pools of overlapping fragments (synthetic peptides e.g. 10-30 mers with 2-20 aa overlap) of the desired antigen in appropriate adjuvants. The T cell repertoire is primed to include not only the immunodominant epitope recognized when the intact molecule is used for immunization and induced by the chronic infection itself, but induce a much broader and balanced response to a number of the subdominant epitopes as well. The resulting T-cell response to subdominant epitopes is important for protection against chronic diseases that on their own induces a response focused only towards immunodominant epitopes. The present invention requires no prior knowledge of the precise localisation and identity of the subdominant epitopes and their recognition in a human population, but expands the T-cell repertoire and thereby the total number of epitopes recognized by specific T cells primed by vaccination from a few immunodominant epitopes to multiple of epitopes of vaccine relevance. For chronic disease controlled by humoral immunity the T helper cell response primed by the peptide mix may be boosted by the full size protein for maximum induction of an antibody response as well.
摘要翻译：本发明通过用重叠片段的池进行免疫（合成肽，例如10-30聚体与2-教导诱导的显性和亚优势响应的广泛认识到用于预防或治疗慢性疾病的重要性的任何给定的抗原表位的一种方式在适当的佐剂所需抗原的20个氨基酸重叠）。的T细胞库被起动为不仅包括识别当完整的分子被用于免疫和由慢性感染本身引起的，但诱导了许多的优势表位的更广泛的和平衡的反应以及免疫优势表位。亚优势抗原表位所产生的T细胞反应是针对慢性疾病对她们自己做了保护重要的诱导只注重对免疫表位的响应。本发明要求的优势表位以及它们在人类群体识别的精确定位和身份的先验知识，但扩展T细胞所有组成成分，并通过从数由疫苗接种引发特异性T细胞识别的表位的从而总数免疫抗原表位疫苗相关的多个表位。对于慢性疾病由体液免疫控制由所述肽混合引发T辅助细胞应答可以通过全尺寸为蛋白质的抗体应答的诱导最大被升压为好。

7. 发明公开

EP2314314A2 Chlamydia trachomatis antigens for vaccine and diagnostic use 审中-公开
标题翻译：衣原体Rrachomatis Antigene zur Impfung und diagnische Verwendung
公开(公告)号：EP2314314A2
公开(公告)日：2011-04-27
申请号：EP10185754.8
申请日：2005-10-11
申请人： Statens Serum Institut
发明人： Theisen, Michael , Olsen, Anja , Leah, Robert , Follmann, Frank , Jensen, Klaus , Andersen, Peter
IPC分类号： A61K39/118 , C07K14/295 , C12Q1/68 , G01N33/569 , C07K16/12
CPC分类号： C07K14/295 , A61K39/118
摘要： The present invention is related to antigens from Chlamydia trachomatis which are recognized by specific antibodies from individuals infected with Chlamydia or which can induce T cells from the same individuals to secrete gamma-interferon. The T cell reactive antigens are present in a whole-cell lysate and have apparent molecular weights of 5-12, 16-20, 25-35 and 58-74 kDa as determined by SDS-PAGE. The antigens of the invention are believed to be useful in vaccines but also as diagnostic compositions.
摘要翻译：本发明涉及来自沙眼衣原体的抗原，其被来自感染衣原体的个体的特异性抗体识别或可以诱导来自相同个体的T细胞分泌γ-干扰素。 T细胞反应性抗原存在于全细胞裂解物中，并且通过SDS-PAGE测定具有5-12,16-20,25-35和58-74kDa的表观分子量。据信本发明的抗原可用于疫苗，但也可用作诊断组合物。

8. 发明公开

EP2261658A2 IP-10 based infection diagnosis 有权转让
标题翻译：适用于IP-10 basierende Infektionsdiagnose
公开(公告)号：EP2261658A2
公开(公告)日：2010-12-15
申请号：EP10180905.1
申请日：2007-09-05
申请人： Hvidovre Hospital
发明人： Ruhwald, Morten , Ravn, Pernille , Eugen-Olsen, Jesper
IPC分类号： G01N33/50 , G01N33/68 , G01N33/569
CPC分类号： G01N33/6863 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/505 , G01N33/56911 , G01N33/56927 , G01N2333/02 , G01N2333/16 , G01N2333/295 , G01N2333/35 , G01N2333/44 , Y02A50/451 , Y02A50/55
摘要： The present invention relates to an immunological method and, more particularly, a method for measuring cell-mediated immune reactivity (CMI) in mammals based on the production of IP-10.The invention further discloses an assay and a kit for measuring CMI to an antigen using whole blood or other suitable biological samples. The methods of the present invention are useful in therapeutic and diagnostic protocols for livestock and veterinary and wild life applications, thus the invention further relates to a method for diagnosing an infection in a mammal.
摘要翻译：本发明涉及一种基于IP-10生产的免疫学方法，更具体地说涉及一种用于测量哺乳动物细胞介导的免疫反应性（CMI）的方法。本发明还公开了一种用于测量CMI至使用全血或其他合适的生物样品的抗原。本发明的方法可用于家畜和兽医和野生生物应用的治疗和诊断方案，因此本发明还涉及用于诊断哺乳动物感染的方法。

9. 发明公开

EP2087348A1 SCREENING METHOD USING SAMPLE ADSORPTION ON FILTER PAPER 有权
标题翻译：与样品吸附滤纸筛选过程
公开(公告)号：EP2087348A1
公开(公告)日：2009-08-12
申请号：EP07817923.1
申请日：2007-11-30
申请人： Statens Serum Institut
发明人： HOUEN, Gunnar , HOUGAARD, David M. , SKOGSTRAND, Kristin , JØRGENSEN, Charlotte Sværke
IPC分类号： G01N33/50
CPC分类号： G01N33/521 , G01N33/48 , G01N33/66 , G01N33/68 , G01N33/92 , Y10T436/143333
摘要： The present invention discloses a diagnostic test and method comprising mixing blood or another biological fluid sample with' a test compound and spotting the blood or the biological fluid on filter paper for subsequent analysis of the effect of the test compound on the blood or on the biological fluid. The biological fluid can be a cerebrospinal fluid, a peritoneal fluid, a cyst fluid, an amniotic fluid, a lavage fluid, a saliva, a. cell extract or a tissue extract. The test compound is chosen among an amino acid, a peptide, a protein, a carbohydrate, an oligosaccharide, a polysaccharide, a glycoprotein, a lipid, a lipoprotein, a glycosa- minoglycan, a hormone, a steroid, a vitamin, a low molecular weight synthetic or natural compound which influences the blood or the biological fluid to cause an alteration of its composition e.g. a toxin, allergen, autoantigen, bacterial protein or polysaccharide, viral protein, fungal protein or polysaccharide, parasitic protein or polysaccharide, bacterial lipopolysaccharide or any other compound relevant to diseases.

10. 发明公开

EP1891232A2 PCR DIAGNOSTICS OF DERMATOPHYTES AND OTHER PATHOGENIC FUNGI 有权转让
标题翻译：皮肤癣菌等致病真菌的PCR诊断
公开(公告)号：EP1891232A2
公开(公告)日：2008-02-27
申请号：EP06753306.7
申请日：2006-06-13
申请人： Statens Serum Institut
发明人： BRILLOWSKA-DABROWSKA, Anna, H.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , C12N15/1003 , C12Q2600/16
摘要： Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic procedures consist of microscopy and culture, but due to the slow growth rate of dermatophytes typically two to four weeks are needed before a final diagnosis is obtained. The present invention is a rapid DNA extraction method extracting nucleic acids from fungi (e.g. dermatophytes and other pathogenic fungi) which can be performed from directly on hair, nail or skin specimens from humans, from naturally or experimentally infected animals or from cultured fungal colonies for the use in PCR amplification and detection assays. The present invention also includes specific primer sets for detection of any dermatophyte and for species specific detection of Trichophyton rubrum and Epidermophyton floccosum by PCR and a kit for diagnosing fungal infections.

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