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1. 发明公开

EP1545607A1 ALLERGY VACCINES 有权
标题翻译：疫苗抵抗过敏症状
公开(公告)号：EP1545607A1
公开(公告)日：2005-06-29
申请号：EP03740967.9
申请日：2003-06-02
申请人： Resistentia Pharmaceuticals AB
发明人： HELLMAN, Lars, T. , PERSSON, Stephen , JANSSON, Asa
IPC分类号： A61K39/395 , A61K39/39
CPC分类号： A61K39/39566 , A61K38/00 , A61K39/00 , C07K14/705 , C07K16/00 , C07K16/4291 , C07K2317/24 , C07K2317/52
摘要： The invention provides methods and materials related to vaccines against self IgE polypeptides. Compositions are described comprising a chimeric self IgE polypeptide and an adjuvant, which is either an aluminium compound or MN51, i.e. Montanide Incomplete Adjuvant (ISA) 51, which is mannide oleate in mineral oil solution. Administration of said composition should elicit an anti-self response and thereby reduce the level of detectable free IgE.

2. 发明授权

EP1569958B1 METHODS AND MATERIALS FOR TREATING INFLAMMATORY CONDITIONS USING A POLYPEPTIDE COMPRISING A SELF-C5 AMINO ACID SEGMENT AND A NON-SELF AMINO ACID SEGMENT 有权
标题翻译：的方法和材料治疗炎症USING的多肽的OWN-C5AMINOSAÜRESEGMENT和非OWNAMINOSAÜRESEGMENTCONTAINS
公开(公告)号：EP1569958B1
公开(公告)日：2009-02-18
申请号：EP03780546.2
申请日：2003-12-01
申请人： Resistentia Pharmaceuticals AB
发明人： HELLMAN, Lars, T. , HOLMDAHL, Rikard
IPC分类号： C07K14/47 , C07K19/00 , C12N15/62 , C07K14/195 , A61K38/17 , A61P29/00
CPC分类号： C07K14/472 , A61K39/0008 , A61K39/001 , C07K2319/24 , C07K2319/50 , Y10S530/806

3. 发明授权

EP0666760B2 VACCINE COMPRISING PART OF CONSTANT REGION OF IgE FOR TREATMENT OF IgE-MEDIATED ALLERGIC REACTIONS 有权转让
标题翻译： IGE含疫苗的恒定区，用于治疗IGE诱发过敏反应PART
公开(公告)号：EP0666760B2
公开(公告)日：2007-10-10
申请号：EP92920757.9
申请日：1992-09-25
申请人： Resistentia Pharmaceuticals AB
发明人： Hellmann, Lars
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/4291 , A61K39/00 , C07K17/02 , Y10S424/80 , Y10S424/801 , Y10S424/805 , Y10S424/809 , Y10S424/81 , Y10S530/862 , Y10S530/867 , Y10S530/868
摘要： The invention relates to a vaccine, preferably for human use, against IgE-mediated allergic reactions. The vaccine contains a protein having the entire amino acid sequence of the constant CH2-CH3 domains of the epsilon chain of the IgE molecule or a structurally stable unit of said amino acid sequence, the protein optionally being coupled to one or more heterologous carrier proteins, and optionally containing an adjuvant. The vaccine is injected, with or without adjuvant, to raise the concentration of endogenous anti-IgE antibodies in the plasma of allergy subjects. In practice, the vaccine can be used against all types of IgE-mediated allergies since the antibodies are not dependent of the antigen specificity of the IgE molecule but will reduce the total IgE pool of the subject. Therefore, the vaccine is aimed at being used for treatment of subjects having different types of IgE-mediated allergies. The increased concentrations of anti-IgE antibodies reduces the free pool of antigen-specific IgE, which thereby strongly reduces the risk for an allergen-mediated release of the physiologically highly active substances which are stored or produced in connection with granula release from mast cells and basophilic leucocytes.

4. 发明公开

EP1621209A3 Vaccines based on domains of chimeric immunoglobulin E peptides 审中-公开
标题翻译：基于嵌合免疫球蛋白E肽疫苗领域
公开(公告)号：EP1621209A3
公开(公告)日：2006-04-19
申请号：EP05017841.7
申请日：1999-10-21
申请人： Resistentia Pharmaceuticals AB
发明人： Hellman, Lars T.
IPC分类号： A61K39/395 , C07K16/42
CPC分类号： C07K16/4291 , A61K2039/505 , C07K16/00 , C07K2317/52
摘要： The invention relates to methods and materials involved in the treatment and prevention of various diseases such as infections and IgE-related diseases. Specifically, the invention relates to methods and materials that can be used to vaccinate a mammal against specific self or non-self antigens. For example, the methods and materials described herein can be used to reduce the effects of IgE antibodies within a mammal by reducing the amount of total and receptor bound IgE antibodies in the mammal. In addition, the invention provides vaccine conjugates, immunogenic polypeptides, nucleic acid molecules that encode immunogenic polypeptides, host cells containing the nucleic acid molecules, that encode immunogenic polypeptides, and methods for making vaccine conjugates and immunogenic polypeptides as well as nucleic acid molecules that encode immunogenic polypeptides based on the use of IgE domains from non-placental mammals. Further, the invention provides an IgE vaccine that induces an anti-self IgE response in a mammal.

5. 发明公开

EP1621209A2 Vaccines based on domains of chimeric immunoglobulin E peptides 审中-公开
标题翻译：基于嵌合免疫球蛋白E肽域的疫苗
公开(公告)号：EP1621209A2
公开(公告)日：2006-02-01
申请号：EP05017841.7
申请日：1999-10-21
申请人： Resistentia Pharmaceuticals AB
发明人： Hellman, Lars T.
IPC分类号： A61K39/395 , C07K16/42
CPC分类号： C07K16/4291 , A61K2039/505 , C07K16/00 , C07K2317/52
摘要： The invention relates to methods and materials involved in the treatment and prevention of various diseases such as infections and IgE-related diseases. Specifically, the invention relates to methods and materials that can be used to vaccinate a mammal against specific self or non-self antigens. For example, the methods and materials described herein can be used to reduce the effects of IgE antibodies within a mammal by reducing the amount of total and receptor bound IgE antibodies in the mammal. In addition, the invention provides vaccine conjugates, immunogenic polypeptides, nucleic acid molecules that encode immunogenic polypeptides, host cells containing the nucleic acid molecules, that encode immunogenic polypeptides, and methods for making vaccine conjugates and immunogenic polypeptides as well as nucleic acid molecules that encode immunogenic polypeptides based on the use of IgE domains from non-placental mammals. Further, the invention provides an IgE vaccine that induces an anti-self IgE response in a mammal.
摘要翻译：本发明涉及涉及治疗和预防各种疾病例如感染和IgE相关疾病的方法和材料。具体而言，本发明涉及可用于针对特定自身或非自身抗原给哺乳动物接种疫苗的方法和材料。例如，本文所述的方法和材料可以用于通过减少哺乳动物中总体和受体结合的IgE抗体的量来减少哺乳动物体内IgE抗体的作用。此外，本发明提供了疫苗缀合物，免疫原性多肽，编码免疫原性多肽的核酸分子，含有该核酸分子的宿主细胞，编码免疫原性多肽，以及制备疫苗缀合物和免疫原性多肽的方法以及编码基于使用来自非胎盘哺乳动物的IgE结构域的免疫原性多肽。此外，本发明提供了在哺乳动物中诱导抗自身IgE应答的IgE疫苗。

6. 发明公开

EP1569958A2 METHODS AND MATERIALS FOR TREATING INFLAMMATORY CONDITIONS USING A POLYPEPTIDE COMPRISING A SELF-C5 AMINO ACID SEGMENT AND A NON-SELF AMINO ACID SEGMENT 有权
标题翻译：的方法和材料治疗炎症USING的多肽的OWN-C5AMINOSAÜRESEGMENT和非OWNAMINOSAÜRESEGMENTCONTAINS
公开(公告)号：EP1569958A2
公开(公告)日：2005-09-07
申请号：EP03780546.2
申请日：2003-12-01
申请人： Resistentia Pharmaceuticals AB
发明人： HELLMAN, Lars, T. , HOLMDAHL, Rikard
IPC分类号： C07K14/47 , C07K19/00 , C12N15/62 , C07K14/195 , A61K38/17 , A61P29/00
CPC分类号： C07K14/472 , A61K39/0008 , A61K39/001 , C07K2319/24 , C07K2319/50 , Y10S530/806
摘要： The invention provides methods and materials for treating inflammatory conditions. Specifically, the invention provides polypeptides, isolated nucleic acids, host cells, and methods that can be used to induce an antibody response in a mammal against an antigen such as C5 or C5a. For example, the methods and materials described herein can be used to reduce the effects of C5a within a mammal by reducing the amount of total and receptor bound C5a in the mammal.

7. 发明授权

EP0666760B1 VACCINE COMPRISING PART OF CONSTANT REGION OF IgE FOR TREATMENT OF IgE-MEDIATED ALLERGIC REACTIONS 有权转让
标题翻译： IGE含疫苗的恒定区，用于治疗IGE诱发过敏反应PART
公开(公告)号：EP0666760B1
公开(公告)日：2000-03-01
申请号：EP92920757.9
申请日：1992-09-25
申请人： HELLMAN, Lars T.
发明人： HELLMAN, Lars T.
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/4291 , A61K39/00 , C07K17/02 , Y10S424/80 , Y10S424/801 , Y10S424/805 , Y10S424/809 , Y10S424/81 , Y10S530/862 , Y10S530/867 , Y10S530/868
摘要： The invention relates to a vaccine, preferably for human use, against IgE-mediated allergic reactions. The vaccine contains a protein having the entire amino acid sequence of the constant CH2-CH3 domains of the epsilon chain of the IgE molecule or a structurally stable unit of said amino acid sequence, the protein optionally being coupled to one or more heterologous carrier proteins, and optionally containing an adjuvant. The vaccine is injected, with or without adjuvant, to raise the concentration of endogenous anti-IgE antibodies in the plasma of allergy subjects. In practice, the vaccine can be used against all types of IgE-mediated allergies since the antibodies are not dependent of the antigen specificity of the IgE molecule but will reduce the total IgE pool of the subject. Therefore, the vaccine is aimed at being used for treatment of subjects having different types of IgE-mediated allergies. The increased concentrations of anti-IgE antibodies reduces the free pool of antigen-specific IgE, which thereby strongly reduces the risk for an allergen-mediated release of the physiologically highly active substances which are stored or produced in connection with granula release from mast cells and basophilic leucocytes.

8. 发明授权

EP1545607B1 ALLERGY VACCINES 有权
标题翻译：疫苗抵抗过敏症状
公开(公告)号：EP1545607B1
公开(公告)日：2008-11-19
申请号：EP03740967.9
申请日：2003-06-02
申请人： Resistentia Pharmaceuticals AB
发明人： HELLMAN, Lars, T. , PERSSON, Stephen , JANSSON, Asa
IPC分类号： A61K39/395 , A61K39/39
CPC分类号： A61K39/39566 , A61K38/00 , A61K39/00 , C07K14/705 , C07K16/00 , C07K16/4291 , C07K2317/24 , C07K2317/52

9. 发明授权

EP1135158B1 ENHANCED VACCINES BASED ON CHIMERIC IMMUNOGLOBULIN E PEPTIDES 有权
标题翻译：基于嵌合免疫球蛋白E肽的研究采取更多行动疫苗
公开(公告)号：EP1135158B1
公开(公告)日：2005-12-28
申请号：EP99963705.1
申请日：1999-10-21
申请人： Resistentia Pharmaceuticals AB
发明人： HELLMAN, Lars, T.
IPC分类号： A61K39/00 , C07K16/46
CPC分类号： C07K16/4291 , A61K39/395 , A61K2039/505 , A61K2300/00
摘要： The invention relates to methods and materials involved in the treatment and prevention of various diseases such as infections and IgE-related diseases. Specifically the invention relates to methods and materials that can be used to vaccinate a mammal against specific self or non-self antigens. The material comprises e.g. a complex of a self and an immunogenic non-self part of an antigen e.g. the Fc part of IgE. Also claimed are complexes of polypeptides having at least a stretch of five amino acids of similar structure in common. The effects of IgE within a mammal can be reduced by reducing the amount of total and receptor bound IgE in the mammal. In addition, the invention provides vaccine conjugates, immunogenic polypeptides and corresponding nucleic acid molecules and host cells and methods for making these conjugates, polypeptides and nucleic acid. Further, the invention provides an IgE vaccine that induces an anti-self IgE response in a mammal.

10. 发明公开

EP1504102A2 CHIMERIC IGE POLYPEPTIDES AND HOST CELLS 审中-公开
标题翻译： CHIMERA -IgE多肽和宿主细胞
公开(公告)号：EP1504102A2
公开(公告)日：2005-02-09
申请号：EP03752877.5
申请日：2003-05-15
申请人： Resistentia Pharmaceuticals AB
发明人： LUNDGREN, Mats , FUENTES, Alexis , MAGNUSSON, Ann-Christin
IPC分类号： C12N15/63 , C12N15/11
CPC分类号： C07K16/00 , C07K2317/24
摘要： The invention provides methods and materials related to expressing chimeric IgE proteins. The chimeric IgE proteins have combinations of IgE constant heavy chains from different species. Specifically, the invention provides nucleic acid vectors, host cells, and methods for producing chimeric IgE polypeptides.

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