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1. 发明公开

EP2444814A4 BIOMARKER FOR MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS, AND METHOD USING SAID BIOMARKER TO DETECT MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS 失效
标题翻译：对精神障碍的生物标志物包括认知障碍和方法，使用这些生物标记物用于识别精神障碍，包括认知障碍
公开(公告)号：EP2444814A4
公开(公告)日：2013-03-20
申请号：EP10777546
申请日：2010-05-17
申请人： MCBI INC
发明人： UCHIDA KAZUHIKO , ISHII TAKASHI , MENO KOHJI , SUZUKI HIDEAKI
IPC分类号： G01N33/68 , C07K14/47 , G01N21/78 , G01N27/62 , G01N33/53 , G01N33/543
CPC分类号： G01N33/6896 , C07K14/47 , G01N2333/705 , G01N2333/974 , G01N2560/00 , G01N2800/2814 , G01N2800/2828

2. 发明公开

EP3422009A1 NOVEL BIOMARKERS FOR COGNITIVE IMPAIRMENT AND METHODS FOR DETECTING COGNITIVE IMPAIRMENT USING SUCH BIOMARKERS 审中-公开
公开(公告)号：EP3422009A1
公开(公告)日：2019-01-02
申请号：EP18163418.9
申请日：2011-12-21
申请人： MCBI INC.
发明人： UCHIDA, Kazuhiko , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N27/62 , G01N33/53
摘要： The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including Alzheimer disease or mild cognitive impairment.
Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by Sequence Nos. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, and 25 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by Sequence Nos. 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, and 27. And further aims to provide diagnostic method using these biomarker.

3. 发明授权

EP2444814B1 BIOMARKER FOR MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS, AND METHOD USING SAID BIOMARKER TO DETECT MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS 失效
标题翻译：对精神障碍的生物标志物包括认知障碍和方法，使用这些生物标记物用于识别精神障碍，包括认知障碍
公开(公告)号：EP2444814B1
公开(公告)日：2016-12-28
申请号：EP10777546.2
申请日：2010-05-17
申请人： Mcbi Inc.
发明人： UCHIDA, Kazuhiko , ISHII, Takashi , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N21/78 , G01N27/62 , G01N33/53 , G01N33/543 , C07K14/47
CPC分类号： G01N33/6896 , C07K14/47 , G01N2333/705 , G01N2333/974 , G01N2560/00 , G01N2800/2814 , G01N2800/2828

4. 发明公开

EP3015865A1 BIOMARKERS FOR COGNITIVE DYSFUNCTION DISEASES AND METHOD FOR DETECTING COGNITIVE DYSFUNCTION DISEASE USING BIOMARKERS 有权转让
标题翻译：生物标记于检测的认知功能障碍疾病生物标志物使用认知功能障碍疾病及方法
公开(公告)号：EP3015865A1
公开(公告)日：2016-05-04
申请号：EP13888380.6
申请日：2013-06-28
申请人： Mcbi Inc. , University of Tsukuba
发明人： UCHIDA, Kazuhiko , MENO Kohji , SUZUKI, Hideaki , NISHIMURA, Yoshinori
IPC分类号： G01N33/68
摘要： Biomarkers for detecting cognitive dysfunction diseases and methods for detecting cognitive dysfunction diseases using the biomarkers are provided. A method for detecting cognitive dysfunction diseases comprising measuring one or more biomarkers for detecting cognitive dysfunction diseases selected from the following (a), (b), and (c) in a biological sample simultaneously or separately: (a) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of apolipoprotein A1 comprising the amino acid sequence represented by SEQ ID NO:1 or a partial peptide thereof; (b) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of transthyretin comprising the amino acid sequence represented by SEQ ID NO:2 or a partial peptide thereof; and (c) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of complement C3 comprising the amino acid sequence represented by SEQ ID NO:3 or a partial peptide thereof.
摘要翻译：提供了检测认知功能障碍疾病，以及用于检测使用的生物标志物的认知功能障碍疾病的方法生物标志物。（a）中的生物标志物用于检测认知：一种用于检测认知功能障碍的疾病，其包括测量一种或多种生物标志物用于检测生物样品中从下列（a），（b）和（c）中选择的认知功能障碍的疾病同时或分开方法功能障碍的疾病由...组成的载脂蛋白A1的包含由SEQ ID NO所代表的氨基酸序列的完整蛋白质：1或其部分肽; （b）用于检测的认知功能障碍的疾病由...组成运甲状腺素蛋白的包含由SEQ ID NO所代表的氨基酸序列的完整蛋白质的生物标志物：2或其部分肽; 和（c）用于检测的认知功能障碍的疾病由...组成补体C3的包含由SEQ ID NO所代表的氨基酸序列的完整蛋白质的生物标志物：3或其部分肽。

5. 发明授权

EP3015865B1 BIOMARKERS FOR COGNITIVE DYSFUNCTION DISEASES AND METHOD FOR DETECTING COGNITIVE DYSFUNCTION DISEASE USING BIOMARKERS 有权转让
公开(公告)号：EP3015865B1
公开(公告)日：2020-03-25
申请号：EP13888380.6
申请日：2013-06-28
申请人： MCBI INC. , University of Tsukuba
发明人： UCHIDA, Kazuhiko , MENO Kohji , SUZUKI, Hideaki , NISHIMURA, Yoshinori
IPC分类号： G01N33/68

6. 发明公开

EP3422010A1 NOVEL BIOMARKERS FOR COGNITIVE IMPAIRMENT AND METHODS FOR DETECTING COGNITIVE IMPAIRMENT USING SUCH BIOMARKERS 审中-公开
公开(公告)号：EP3422010A1
公开(公告)日：2019-01-02
申请号：EP18163419.7
申请日：2011-12-21
申请人： MCBI INC.
发明人： UCHIDA, Kazuhiko , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N27/62 , G01N33/53
摘要： The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including Alzheimer disease or mild cognitive impairment.
Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by Sequence Nos. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, and 25 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by Sequence Nos. 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, and 27. And further aims to provide diagnostic method using these biomarker.

7. 发明授权

EP3088899B1 BIOMARKERS FOR PSYCHIATRIC DISEASES INCLUDING COGNITIVE IMPAIRMENT AND METHODS FOR DETECTING PSYCHIATRIC DISEASES INCLUDING COGNITIVE IMPAIRMENT USING THE BIOMARKERS 有权
标题翻译：用于精神疾病的生物标志物，包括认知性减退和使用生物标志物检测精神疾病包括认知性减退的方法
公开(公告)号：EP3088899B1
公开(公告)日：2018-01-17
申请号：EP16171946.3
申请日：2010-05-17
申请人： Mcbi Inc.
发明人： UCHIDA, Kazuhiko , ISHII, Takashi , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N21/78 , G01N27/62 , G01N33/53 , G01N33/543 , C07K14/47
CPC分类号： G01N33/6896 , C07K14/47 , G01N2333/705 , G01N2333/974 , G01N2560/00 , G01N2800/2814 , G01N2800/2828
摘要： The present invention aims to present methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including mild cognitive impairment and Alzheimer disease. Simultaneously, the present invention aims to present novel biomarkers for cognitive impairment and non-psychiatry disease and methods for detecting cognitive impairment using such biomarkers. Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by SEQ ID NO: 1, 3, 6, 8, 10, 13, 15, 18, and 20 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by SEQ ID NO: 2, 4, 5, 7, 9, 11, 12, 14, 16, 17, 19, and 21. And further aims to present diagnostic method using these biomarker, and further aims to present synthesis antigen peptide expressed by SEQ ID NO: 22 for preparation of peptide specific antibody for use in diagnostic method.

8. 发明授权

EP2444814B9 BIOMARKER FOR MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS, AND METHOD USING SAID BIOMARKER TO DETECT MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS 失效
标题翻译：用于精神病的生物标志物，包括认知障碍，以及使用所述生物标志物来检测包括认知障碍在内的精神病的方法
公开(公告)号：EP2444814B9
公开(公告)日：2017-08-09
申请号：EP10777546.2
申请日：2010-05-17
申请人： Mcbi Inc.
发明人： UCHIDA, Kazuhiko , ISHII, Takashi , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N21/78 , G01N27/62 , G01N33/53 , G01N33/543 , C07K14/47
CPC分类号： G01N33/6896 , C07K14/47 , G01N2333/705 , G01N2333/974 , G01N2560/00 , G01N2800/2814 , G01N2800/2828

9. 发明公开

EP2333552A4 NOVEL BIOMARKERS FOR NONALCOHOLIC FATTY LIVER DISEASE AND METHODS FOR DETECTING NONALCOHOLIC FATTY LIVER DISEASE USING BIOMARKER 有权
标题翻译：用于非酒精性脂肪性肝病和方法的新的生物标志物非酒精性脂肪肝WITH A生物标志物检测
公开(公告)号：EP2333552A4
公开(公告)日：2013-03-20
申请号：EP09814303
申请日：2009-09-16
申请人： MCBI INC
发明人： MENO KOHJI , SUZUKI HIDEAKI
IPC分类号： G01N33/68 , C07K14/81 , G01N33/53
CPC分类号： G01N33/6893 , C07K14/8114 , G01N2333/811 , G01N2800/085
摘要： The present invention aims to present methods to detect nonalcoholic fatty liver disease including nonalcoholic steatohepatitis by using a protein or its partial peptide that differs in presence or absence, or in quantity between healthy human subjects and patients with nonalcoholic fatty liver disease or nonalcoholic steatohepatitis or between patients with fatty liver and nonalcoholic steatohepatitis and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect nonalcoholic fatty liver disease including nonalcoholic steatohepatitis. Specifically, 35 kDa protein fragment consisting of amino acid sequence expressed by Sequence No. 2 and its partial peptide consisting of amino acid sequence expressed by Sequence No. 3 (including its glycated form) of inter-alpha-trypsin inhibitor heavy chain H4 precursor consisting of amino acid sequence expressed by Sequence No. 1 could be used as biomarkers to detect nonalcoholic fatty liver disease including nonalcoholic steatohepatitis.

10. 发明公开

EP3422007A1 NOVEL BIOMARKERS FOR COGNITIVE IMPAIRMENT AND METHODS FOR DETECTING COGNITIVE IMPAIRMENT USING SUCH BIOMARKERS 审中-公开
公开(公告)号：EP3422007A1
公开(公告)日：2019-01-02
申请号：EP18163414.8
申请日：2011-12-21
申请人： MCBI INC.
发明人： UCHIDA, Kazuhiko , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N27/62 , G01N33/53
摘要： The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including Alzheimer disease or mild cognitive impairment.
Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by Sequence Nos. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, and 25 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by Sequence Nos. 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, and 27. And further aims to provide diagnostic method using these biomarker.

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