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1. 发明公开

EP3015865A1 BIOMARKERS FOR COGNITIVE DYSFUNCTION DISEASES AND METHOD FOR DETECTING COGNITIVE DYSFUNCTION DISEASE USING BIOMARKERS 有权转让
标题翻译：生物标记于检测的认知功能障碍疾病生物标志物使用认知功能障碍疾病及方法
公开(公告)号：EP3015865A1
公开(公告)日：2016-05-04
申请号：EP13888380.6
申请日：2013-06-28
申请人： Mcbi Inc. , University of Tsukuba
发明人： UCHIDA, Kazuhiko , MENO Kohji , SUZUKI, Hideaki , NISHIMURA, Yoshinori
IPC分类号： G01N33/68
摘要： Biomarkers for detecting cognitive dysfunction diseases and methods for detecting cognitive dysfunction diseases using the biomarkers are provided. A method for detecting cognitive dysfunction diseases comprising measuring one or more biomarkers for detecting cognitive dysfunction diseases selected from the following (a), (b), and (c) in a biological sample simultaneously or separately: (a) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of apolipoprotein A1 comprising the amino acid sequence represented by SEQ ID NO:1 or a partial peptide thereof; (b) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of transthyretin comprising the amino acid sequence represented by SEQ ID NO:2 or a partial peptide thereof; and (c) a biomarker for detecting cognitive dysfunction diseases consisting of an intact protein of complement C3 comprising the amino acid sequence represented by SEQ ID NO:3 or a partial peptide thereof.
摘要翻译：提供了检测认知功能障碍疾病，以及用于检测使用的生物标志物的认知功能障碍疾病的方法生物标志物。（a）中的生物标志物用于检测认知：一种用于检测认知功能障碍的疾病，其包括测量一种或多种生物标志物用于检测生物样品中从下列（a），（b）和（c）中选择的认知功能障碍的疾病同时或分开方法功能障碍的疾病由...组成的载脂蛋白A1的包含由SEQ ID NO所代表的氨基酸序列的完整蛋白质：1或其部分肽; （b）用于检测的认知功能障碍的疾病由...组成运甲状腺素蛋白的包含由SEQ ID NO所代表的氨基酸序列的完整蛋白质的生物标志物：2或其部分肽; 和（c）用于检测的认知功能障碍的疾病由...组成补体C3的包含由SEQ ID NO所代表的氨基酸序列的完整蛋白质的生物标志物：3或其部分肽。

2. 发明授权

EP3015865B1 BIOMARKERS FOR COGNITIVE DYSFUNCTION DISEASES AND METHOD FOR DETECTING COGNITIVE DYSFUNCTION DISEASE USING BIOMARKERS 有权转让
公开(公告)号：EP3015865B1
公开(公告)日：2020-03-25
申请号：EP13888380.6
申请日：2013-06-28
申请人： MCBI INC. , University of Tsukuba
发明人： UCHIDA, Kazuhiko , MENO Kohji , SUZUKI, Hideaki , NISHIMURA, Yoshinori
IPC分类号： G01N33/68

3. 发明公开

EP3422009A1 NOVEL BIOMARKERS FOR COGNITIVE IMPAIRMENT AND METHODS FOR DETECTING COGNITIVE IMPAIRMENT USING SUCH BIOMARKERS 审中-公开
公开(公告)号：EP3422009A1
公开(公告)日：2019-01-02
申请号：EP18163418.9
申请日：2011-12-21
申请人： MCBI INC.
发明人： UCHIDA, Kazuhiko , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N27/62 , G01N33/53
摘要： The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including Alzheimer disease or mild cognitive impairment.
Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by Sequence Nos. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, and 25 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by Sequence Nos. 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, and 27. And further aims to provide diagnostic method using these biomarker.

4. 发明授权

EP2444814B1 BIOMARKER FOR MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS, AND METHOD USING SAID BIOMARKER TO DETECT MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS 失效
标题翻译：对精神障碍的生物标志物包括认知障碍和方法，使用这些生物标记物用于识别精神障碍，包括认知障碍
公开(公告)号：EP2444814B1
公开(公告)日：2016-12-28
申请号：EP10777546.2
申请日：2010-05-17
申请人： Mcbi Inc.
发明人： UCHIDA, Kazuhiko , ISHII, Takashi , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N21/78 , G01N27/62 , G01N33/53 , G01N33/543 , C07K14/47
CPC分类号： G01N33/6896 , C07K14/47 , G01N2333/705 , G01N2333/974 , G01N2560/00 , G01N2800/2814 , G01N2800/2828

5. 发明公开

EP3422007A1 NOVEL BIOMARKERS FOR COGNITIVE IMPAIRMENT AND METHODS FOR DETECTING COGNITIVE IMPAIRMENT USING SUCH BIOMARKERS 审中-公开
公开(公告)号：EP3422007A1
公开(公告)日：2019-01-02
申请号：EP18163414.8
申请日：2011-12-21
申请人： MCBI INC.
发明人： UCHIDA, Kazuhiko , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N27/62 , G01N33/53
摘要： The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including Alzheimer disease or mild cognitive impairment.
Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by Sequence Nos. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, and 25 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by Sequence Nos. 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, and 27. And further aims to provide diagnostic method using these biomarker.

6. 发明授权

EP2657706B1 BIOMARKER FOR COGNITIVE DYSFUNCTION DISEASES, AND METHOD FOR DETECTION OF COGNITIVE DYSFUNCTION DISEASES USING THE BIOMARKER 有权
标题翻译：用于认知功能障碍疾病的生物标志物以及使用生物标志物检测认知功能障碍疾病的方法
公开(公告)号：EP2657706B1
公开(公告)日：2018-04-11
申请号：EP11851822.4
申请日：2011-12-21
申请人： Mcbi Inc.
发明人： UCHIDA, Kazuhiko , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N27/62 , G01N33/53
CPC分类号： G01N33/6896 , C07K16/40 , G01N2333/974 , G01N2800/2814 , G01N2800/2821 , G01N2800/60
摘要： The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including Alzheimer disease or mild cognitive impairment. Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by Sequence Nos. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, and 25 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by Sequence Nos. 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, and 27. And further aims to proviede diagnostic method using these biomarker.

7. 发明公开

EP3260866A1 NOVEL BIOMARKERS FOR COGNITIVE IMPAIRMENT AND METHODS FOR DETECTING COGNITIVE IMPAIRMENT USING SUCH BIOMARKERS 有权
标题翻译：用于认知障碍的新生物标记和使用此类生物标记检测认知障碍的方法
公开(公告)号：EP3260866A1
公开(公告)日：2017-12-27
申请号：EP17178674.2
申请日：2011-12-21
申请人： MCBI INC.
发明人： UCHIDA, Kazuhiko , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N27/62 , G01N33/53
CPC分类号： G01N33/6896 , C07K16/40 , G01N2333/974 , G01N2800/2814 , G01N2800/2821 , G01N2800/60
摘要： The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including Alzheimer disease or mild cognitive impairment.
Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by Sequence Nos. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, and 25 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by Sequence Nos. 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, and 27. And further aims to proviede diagnostic method using these biomarker.
摘要翻译：本发明旨在提供通过使用在非认知障碍和认知障碍患者之间存在或不存在或在数量上不同的蛋白质或其部分肽来检测包括轻度认知障碍和阿尔茨海默病的认知障碍的方法，并且进一步旨在包含所述蛋白质和所述部分肽的生物标志物用于检测包括阿尔茨海默病或轻度认知障碍的认知障碍。具体而言，涉及由选自由序列号1所表示的氨基酸序列组成的蛋白质群中的至少一种蛋白质或肽的至少5个氨基酸残基的蛋白质片段或肽组成的诊断精神病性疾病或认知障碍的生物标志物，3，5，7，9，11，13，15，17，19，21，23和25并且选自这些蛋白质中的部分肽的组，由序列号2,4和5表示的氨基酸序列组成。 6,8,10,12,14,16,18,20,22,24,26和27。并且进一步旨在提供使用这些生物标志物的诊断方法。

8. 发明公开

EP3422010A1 NOVEL BIOMARKERS FOR COGNITIVE IMPAIRMENT AND METHODS FOR DETECTING COGNITIVE IMPAIRMENT USING SUCH BIOMARKERS 审中-公开
公开(公告)号：EP3422010A1
公开(公告)日：2019-01-02
申请号：EP18163419.7
申请日：2011-12-21
申请人： MCBI INC.
发明人： UCHIDA, Kazuhiko , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N27/62 , G01N33/53
摘要： The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including Alzheimer disease or mild cognitive impairment.
Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by Sequence Nos. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, and 25 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by Sequence Nos. 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, and 27. And further aims to provide diagnostic method using these biomarker.

9. 发明授权

EP3088899B1 BIOMARKERS FOR PSYCHIATRIC DISEASES INCLUDING COGNITIVE IMPAIRMENT AND METHODS FOR DETECTING PSYCHIATRIC DISEASES INCLUDING COGNITIVE IMPAIRMENT USING THE BIOMARKERS 有权
标题翻译：用于精神疾病的生物标志物，包括认知性减退和使用生物标志物检测精神疾病包括认知性减退的方法
公开(公告)号：EP3088899B1
公开(公告)日：2018-01-17
申请号：EP16171946.3
申请日：2010-05-17
申请人： Mcbi Inc.
发明人： UCHIDA, Kazuhiko , ISHII, Takashi , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N21/78 , G01N27/62 , G01N33/53 , G01N33/543 , C07K14/47
CPC分类号： G01N33/6896 , C07K14/47 , G01N2333/705 , G01N2333/974 , G01N2560/00 , G01N2800/2814 , G01N2800/2828
摘要： The present invention aims to present methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including mild cognitive impairment and Alzheimer disease. Simultaneously, the present invention aims to present novel biomarkers for cognitive impairment and non-psychiatry disease and methods for detecting cognitive impairment using such biomarkers. Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by SEQ ID NO: 1, 3, 6, 8, 10, 13, 15, 18, and 20 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by SEQ ID NO: 2, 4, 5, 7, 9, 11, 12, 14, 16, 17, 19, and 21. And further aims to present diagnostic method using these biomarker, and further aims to present synthesis antigen peptide expressed by SEQ ID NO: 22 for preparation of peptide specific antibody for use in diagnostic method.

10. 发明授权

EP2444814B9 BIOMARKER FOR MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS, AND METHOD USING SAID BIOMARKER TO DETECT MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS 失效
标题翻译：用于精神病的生物标志物，包括认知障碍，以及使用所述生物标志物来检测包括认知障碍在内的精神病的方法
公开(公告)号：EP2444814B9
公开(公告)日：2017-08-09
申请号：EP10777546.2
申请日：2010-05-17
申请人： Mcbi Inc.
发明人： UCHIDA, Kazuhiko , ISHII, Takashi , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N21/78 , G01N27/62 , G01N33/53 , G01N33/543 , C07K14/47
CPC分类号： G01N33/6896 , C07K14/47 , G01N2333/705 , G01N2333/974 , G01N2560/00 , G01N2800/2814 , G01N2800/2828

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