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1. 发明公开

EP4407046A3 COMPOSITIONS AND METHODS FOR DETECTING GROUP A STREPTOCOCCUS 审中-公开
公开(公告)号：EP4407046A3
公开(公告)日：2024-10-16
申请号：EP24172440.0
申请日：2020-03-20
申请人： Gen-Probe Incorporated
发明人： PANUGANTI, Sree Divya , SHAH, Ankur
IPC分类号： C12Q1/689
CPC分类号： C12Q1/689
摘要： There is described a composition or kit comprising at least first and second amplification oligomers, wherein:(a) the first amplification oligomer and second amplification oligomer are configured to amplify a Group A Streptococcus amplicon; (b) the first amplification oligomer: (i) comprises a first sequence which is SEQ ID NO: 4; (ii) comprises a sequence with 0, 1, or 2 mismatches to a first sequence which is SEQ ID NO: 4; (iii) competes for hybridization to a Group A Streptococcus (GAS) nucleic acid under stringent conditions with an amplification oligomer whose sequence consists of a first sequence which is SEQ ID NO: 4; or (iv) comprises at least 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 contiguous nucleotides of a first sequence which is SEQ ID NO: 4; and (c) the second amplification oligomer: (i) comprises a second sequence which is SEQ ID NO: 6; (ii) comprises a sequence with 0, 1, or 2 mismatches to a second sequence which is SEQ ID NO: 6; (iii) competes for hybridization to a Group A Streptococcus (GAS) nucleic acid under stringent conditions with an amplification oligomer whose sequence consists of a second sequence which is SEQ ID NO: 6; or (iv) comprises at least 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 contiguous nucleotides of a second sequence which is SEQ ID NO: 6.

2. 发明公开

EP4382622A3 COMPOSITIONS AND METHODS FOR DETECTING SHIGELLA AND AT LEAST ONE OF SALMONELLA, C. JEJUNI, C. COLI, AND STEC 审中-实审
公开(公告)号：EP4382622A3
公开(公告)日：2024-08-21
申请号：EP24165401.1
申请日：2022-07-26
申请人： Gen-Probe Incorporated
发明人： PANUGANTI, Sree Divya
IPC分类号： C12Q1/689
CPC分类号： C12Q1/689 , C12Q1/686 , Y02A50/30 , C12Q2600/1620130101
摘要： There is described a set of oligonucleotides for determining the presence or absence of at least two enteric pathogens, said set of oligonucleotides comprising (a) and at least one of (b)-(e): (a) a Shigella-specific amplification oligomer set comprising first and second oligomers respectively comprising target-hybridizing sequences consisting of the nucleotide sequences of: (i) SEQ ID NO:15 and SEQ ID NO:17; (ii) SEQ ID NO:34 and SEQ ID NO:22; or (iii) SEQ ID NO:32 and SEQ ID NO:33; (b) a Salmonella-specific amplification oligomer set comprising first and second oligomers respectively comprising target-hybridizing sequences consisting of the nucleotide sequences of: (i) SEQ ID NO:12 and SEQ ID NO:14; (ii) SEQ ID NO:21 and SEQ ID NO:47; (iii) SEQ ID NO:38 and SEQ ID NO:36; (iv) SEQ ID NO:35 and SEQ ID NO:40; (v) SEQ ID NO:12 and SEQ ID NO:28; (vi) SEQ ID NO:42 and SEQ ID NO:31; or (vii) SEQ ID NO:41 and SEQ ID NO:27; (c)a C. jejuni-specific amplification oligomer set comprising first and second oligomers respectively comprising target-hybridizing sequences consisting of the nucleotide sequences of: SEQ ID NO:11 and SEQ ID NO: 19; (d) a C. coli-specific amplification oligomer set comprising first and second oligomers respectively comprising target-hybridizing sequences consisting of the nucleotide sequences of: (i) SEQ ID NO:8 and SEQ ID NO:10; and (e) a Shigatoxigenic E. coli (STEC)-specific amplification oligomer set comprising first and second oligomers respectively comprising target-hybridizing sequences consisting of the nucleotide sequences of: (i) SEQ ID NO:20 and SEQ ID NO:3; (ii) SEQ ID NO:49 and SEQ ID NO:3; or (iii) SEQ ID NO:4 and SEQ ID NO:7.

3. 发明公开

EP4382619A3 COMPOSITIONS, METHODS AND KITS TO DETECT ADENOVIRUS AND AT LEAST ONE OF METAPNEUMOVIRUS AND RHINOVIRUS NUCLEIC ACIDS 审中-实审
公开(公告)号：EP4382619A3
公开(公告)日：2024-08-21
申请号：EP24168848.0
申请日：2018-03-23
申请人： Gen-Probe Incorporated
发明人： MAJLESSI, Mehrdad R. , SHAH, Ankur , DOUGLASS, Pamela , KOLK, Daniel P. , HILLIUS, Amber
IPC分类号： C12Q1/70 , C12Q1/6888
CPC分类号： C12Q1/701 , C12Q2600/1620130101 , C12Q1/6888
摘要： There is disclosed a composition comprising a combination of amplification oligomers configured for amplification of an Adenovirus target nucleic acid and at least one additional target nucleic acid selected from the group consisting of a Metapneumovirus target nucleic acid and a Rhinovirus target nucleic acid, wherein: (A) for the Adenovirus target nucleic acid, a first Adenovirus amplification oligomer and a second Adenovirus amplification oligomer are configured to amplify an Adenovirus amplicon of at least about 50 nucleotides in length comprising at least one Adenovirus position located in the range of nucleotide positions 52 to 74 of SEQ ID NO:47, nucleotide positions 76 to 99 of SEQ ID NO:47, nucleotide positions 40 to 56 of SEQ ID NO:47, nucleotide positions 65 to 87 of SEQ ID NO:47, nucleotide positions 1 to 18 of SEQ ID NO:47, nucleotide positions 7 to 23 of SEQ ID NO:47, nucleotide positions 28 to 45 of SEQ ID NO:47, nucleotide positions 27 to 45 of SEQ ID NO:47, nucleotide positions 26 to 45 of SEQ ID NO:47, nucleotide positions 139 to 155 of SEQ ID NO:47, nucleotide positions 103 to 123 of SEQ ID NO:47, nucleotide positions 159 to 175 of SEQ ID NO:47, nucleotide positions 83 to 99 of SEQ ID NO:47, and/or nucleotide positions 83 to 98 of SEQ ID NO:47; and (B) for the at least one additional target nucleic acid, (1) a first Metapneumovirus amplification oligomer and a second Metapneumovirus amplification oligomer are configured to amplify a Metapneumovirus amplicon of at least about 50 nucleotides in length comprising at least one Metapneumovirus position located in the range of nucleotide positions 966 to 1147 of SEQ ID NO:150, nucleotides 844 to 1027 of SEQ ID NO:159, nucleotide positions 1000 to 1040 of SEQ ID NO:150, nucleotide positions 880 to 915 of SEQ ID NO:159, nucleotide positions 1027 to 1080 of SEQ ID NO:150, nucleotide positions 913 to 958 of SEQ ID NO:159, nucleotide positions 1073 to 1115 of SEQ ID NO:150, and/or nucleotide positions 953 to 995 of SEQ ID NO:159; and/or (2) a first Rhinovirus amplification oligomer and a second Rhinovirus amplification oligomer are configured to amplify a Rhinovirus amplicon of at least 50 nucleotides in length comprising at least one Rhinovirus position located in the range of nucleotide positions 230 to 556 of SEQ ID NO:120, nucleotide positions 199 to 525 of SEQ ID NO:101, nucleotide positions 80 to 410 of SEQ ID NO:76, nucleotide positions 263 to 303 of SEQ ID NO:120, nucleotide positions 231 to 264 of SEQ ID NO:101, nucleotide positions 106 to 156 of SEQ ID NO:76, nucleotide positions 312 to 346 of SEQ ID NO:120, nucleotide positions 279 to 314 of SEQ ID NO:101, nucleotide positions 455 to 506 of SEQ ID NO:76, nucleotide positions 480 to 533 of SEQ ID NO:120, nucleotide positions 455 to 506 of SEQ ID NO:101, and/or nucleotide positions 338 to 397 of SEQ ID NO:76.

4. 发明公开

EP4414712A2 AUTOMATED SYSTEMS AND METHODS FOR LOADING SOLID REAGENT PELLETS INTO WELLS OF A CARTRIDGE 审中-实审
公开(公告)号：EP4414712A2
公开(公告)日：2024-08-14
申请号：EP24184641.9
申请日：2022-07-28
申请人： Gen-Probe Incorporated
发明人： SILBERT, Rolf
IPC分类号： G01N35/10
CPC分类号： G01N35/0099 , G01N35/1002 , G01N35/109 , G01N35/00584 , G01N35/1074 , G01N2035/0005920130101 , G01N2035/0057420130101
摘要： There is described a method for automatically supplying a dried reagent pellet (102) to each well of a cartridge comprising a plurality of wells, wherein the method comprises: (A) automatically positioning a pellet transfer head above a pellet supply reservoir containing a supply of dried reagent pellets, wherein the pellet transfer head comprises (i) a plurality of vacuum nozzles, wherein each vacuum nozzle comprises a downwardly-facing vacuum port in selective communication with a vacuum source and wherein the number and arrangement of the vacuum nozzles corresponds to the number and arrangement of wells of the cartridge and (ii) one or more downwardly-facing pressure ports in selective communication with a pressure source; (B) after step (A), automatically lowering the pellet transfer head to a pellet pickup position with respect to the pellet supply reservoir; (C) with the pellet transfer head in the pellet pickup position, activating the pressure source to supply gas flow at the one or more pressure ports of the pellet transfer head to fluidize the supply of pellets within the pellet supply reservoir and activating the vacuum source to create a vacuum at each vacuum port to draw a pellet from the pellet supply reservoir to each vacuum port; (D) after step (C), automatically raising the pellet transfer head from the pellet pickup position with respect to the pellet supply reservoir; (E) after step (D), automatically positioning the pellet transfer head within a field of view of a vision sensor camera; (F) after step (E), activating the vision sensor camera and a vision sensor system to detect whether a dried reagent pellet is disposed at each of the vacuum nozzles; (G) after step (F), automatically positioning the pellet transfer head above the cartridge so that each vacuum nozzle is aligned with a corresponding well of the cartridge; (H) after step (G), automatically lowering the pellet transfer head to a pellet dispensing position with respect to the cartridge; and (I) after step (H), deactivating the vacuum source to terminate the vacuum at each vacuum port to release the pellet from each vacuum nozzle into the corresponding well of the cartridge.

5. 发明公开

EP4328592A3 LABORATORY AUTOMATED INSTRUMENTS, SYSTEMS, AND METHODS 审中-实审
公开(公告)号：EP4328592A3
公开(公告)日：2024-06-19
申请号：EP23218659.3
申请日：2017-02-16
申请人： Gen-Probe Incorporated
发明人： WALKER, George T. , MERTEN, Matthias , LAIR, Gary D.
IPC分类号： G01N35/04 , G01N35/00
CPC分类号： G01N35/04 , G01N2035/0078220130101 , G01N2035/040620130101 , G01N2035/046220130101 , G01N2035/046720130101 , B65G47/46
摘要： A laboratory automated system can include a host conveyor assembly configured to transport a plurality of carriers and receptacles coupled thereto between at least a sample processing instrument and at least one assay instrument. The system includes an intermediate conveyor assembly configured to transport a plurality of carriers and receptacles coupled thereto from within sample processing instrument to the host conveyor assembly. The system also includes an intermediate conveyor assembly for each assay instrument configured to transport a plurality of carriers from host conveyor assembly to a respective processing position within the assay instrument. The intermediate conveyor assembly coupled to the assay instrument can include a buffer conveyor subassembly configured to receive carriers from the host conveyor assembly, and a spur conveyor assembly configured to transport a carrier to the processing position of the assay instrument.

6. 发明公开

EP4377481A1 COMPOSITIONS AND METHODS FOR DETECTING GASTROINTESTINAL PATHOGENS 审中-实审
公开(公告)号：EP4377481A1
公开(公告)日：2024-06-05
申请号：EP22755052.2
申请日：2022-07-26
申请人： Gen-Probe Incorporated
发明人： PANUGANTI, Sree Divya
IPC分类号： C12Q1/689
CPC分类号： C12Q1/689 , C12Q1/686 , Y02A50/30

7. 发明授权

EP3601617B3 COMPOSITIONS AND METHODS FOR DETECTING OR QUANTIFYING PARAINFLUENZA VIRUS 有权
公开(公告)号：EP3601617B3
公开(公告)日：2024-03-20
申请号：EP18716844.8
申请日：2018-03-23
发明人： MAJLESSI, Mehrdad R. , DOUGLASS, Pamela , KOLK, Daniel P.
IPC分类号： C12Q1/6888 , C12Q1/70

8. 发明授权

EP3411499B1 DRIED AMPLIFICATION COMPOSITIONS 有权
公开(公告)号：EP3411499B1
公开(公告)日：2023-11-08
申请号：EP17704979.8
申请日：2017-02-03
发明人： FILIPOWSKY, Mark , MARTIN, Donald , JOST, Matthias , NODELMAN, Vladislav , DICKSON, Robert Stephen , CROWELL, Cheryl Lynn , MAUCH, Steven
IPC分类号： C12Q1/68

9. 发明授权

EP3739062B1 RED BLOOD CELL LYSIS SOLUTION 有权
公开(公告)号：EP3739062B1
公开(公告)日：2023-08-16
申请号：EP20181919.0
申请日：2015-10-20
发明人： CHELLISERRY, Jijumon , GAO, Kui , LINNEN, Jeffrey M
IPC分类号： C12Q1/6809 , G01N33/483 , C12Q1/6806 , C12N1/06

10. 发明授权

EP3764079B1 SYSTEM AND METHOD FOR MONITORING THE PERFORMANCE OF AN OPTICAL SIGNAL DETECTOR 有权
公开(公告)号：EP3764079B1
公开(公告)日：2023-08-09
申请号：EP20171886.3
申请日：2016-12-22
发明人： OPALSKY, David , RAGHUWANSHI, Srajan , BUI, James
IPC分类号： G01N21/03 , G01N21/64 , G01N21/75 , G01N21/27

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