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1. 发明公开

EP2380973A4 DRUG MADE FROM STEM CELLS WITH REPROGRAMMED CELL SIGNALING, METHOD FOR PRODUCING SAID PREPARATION AND THE USE THEREOF 审中-公开
标题翻译：药物从细胞信号NEUPROGRAMMIERTER，方法干细胞生产这种制备及其用途
公开(公告)号：EP2380973A4
公开(公告)日：2013-08-21
申请号：EP09836446
申请日：2009-08-20
申请人： BRYUKHOVETSKIY ANDREY STEPANOVICH
发明人： SEVASTIANOV VIKTOR IVANOVICH
IPC分类号： C12N5/071 , A61K9/107 , A61K9/127 , A61K9/51 , A61K35/12 , A61K47/48 , A61P35/00
CPC分类号： A61K9/5153 , A61K9/1075 , A61K9/127 , A61K9/1272 , A61K47/6925 , A61K2035/126 , C12N5/0623
摘要： The invention is applied in the therapy of brain and spinal cord tumors, degenerative, hypoxic, ischemic diseases and traumatic injuries of the central nervous system (CNS) and other diseases of humans and animals. Object of invention is to provide target delivery of signaling substance to the pathological area of an organism, triggering in due time and long-time support of active signaling intercellular action of specific therapeutic character of a healthy and well controlled stem cell (SC) onto controlling system of defective cells. The preparation of SC with reprogrammed cell signaling comprises the basic preparation of SC, the membrane, and/or nucleus, and/or cytoplasm of which contains implanted protein or pharmaceutical able to regulate signaling pathways of SC and cells of pathological focus in a mammal organism, provisionally encapsulated in nanocontainers of less than 100nm size, obtained from biodegradable material, intact for organelles and compartments of SC of the basic preparation. The material has a set biodegradation period in a mammal organism to provide programmed exit of protein or pharmaceutical in intra-or intercellular space thus reprogramming signal transduction of key genes in the desired therapeutic orientation of physiologic events in the cell cycle directly in the pathological area or tissue of an organism.

2. 发明公开

EP2347763A1 AN IMPLANTABLE NEUROENDOPROSTHESIS SYSTEM, A METHOD FOR PREPARING SAME AND A PROCEDURE FOR PERFORMING OF A RECONSTRUCTIVE NEUROSURGICAL OPERATION 审中-公开
标题翻译：植入神经根神经系统，VERFAHREN ZU SEINER HERSTELLUNG UND VERFAHRENFÜREINE REKONSTRUKTIVE NEUROCHIRURGISCHE OPERATION
公开(公告)号：EP2347763A1
公开(公告)日：2011-07-27
申请号：EP09816502.0
申请日：2009-02-13
申请人： Bryukhovetskiy, Andrey Stepanovich
发明人： SEVASTIANOV, Viktor Ivanovich
IPC分类号： A61K38/39 , A61K35/12 , A61K35/14 , A61P25/00
CPC分类号： A61K35/28 , A61K35/30 , A61K35/44 , A61K38/185 , A61K38/1866 , A61L27/24 , A61L27/3878 , A61L2430/32 , A61K2300/00
摘要： The invention is used in neurosurgery and tissue engineering of organs to replace defects of nervous tissue of a mammal brain and spinal cord in reconstructive neurosurgical operations. The object of invention is to develop a tissue-replaceable artificial cell-biopolymer neuroendoprosthetic system (ACBP NEPS) for surgical plasty of defects of nervous tissue of brain and spinal cord that will stimulate regeneration and growth of damaged axons of neural cells, as well as to develop a production method of the ACBP NEPS and a method of reconstructive neurosurgical operation using the ACBP NEPS. The ACBP NEPS is an elastic cell-biopolymer biologically active mass produced from a heterogeneous collagen-containing matrix for implantation and a biocomposition of cell preparations of various types of autologous cells of a patient. The biocomposition comprises, in a NaCl solution, neural stem cells (NSC), neuroglial ensheathing cells (NGEC), endothelial cells with CD34+ marker (EC) and purified mononuclears (MN) in the following ratios (in parts according to numbers of the cells): 0.8 to 1.2 of NSC; 1.6 to 2.4 of NGEC; 4 to 6 of EC; 4000 to 6000 of MN. The method of production of the ACBP NEPS comprises perfusion of the biocomposition of the cell preparations of various types of autologous cells of a patient into the heterogeneous collagen-containing matrix for implantation to obtain the elastic cell-biopolymer biologically active mass. The method of the reconstructive neurosurgical operation to replace the defects of a mammal brain and/or spinal cord and/or vegetative nervous system comprises implantation of the ACBP NEPS into the defect of neural tissue.
摘要翻译：本发明用于神经外科和器官组织工程，以在重建神经外科手术中替代哺乳动物脑和脊髓神经组织的缺陷。本发明的目的是开发一种组织可替代的人造细胞 - 生物聚合物神经内假体系统（ACBP NEPS），用于手术成形脑和脊髓神经组织缺陷的刺激神经细胞损伤的轴突的再生和生长，以及开发ACBP NEPS的生产方法和使用ACBP NEPS重建神经外科手术的方法。 ACBP NEPS是由用于植入的异质胶原基质和患者的各种类型的自体细胞的细胞制剂的生物组合产生的弹性细胞 - 生物聚合物生物活性物质。该生物组合物在NaCl溶液中包含神经干细胞（NSC），神经胶质细胞鞘细胞（NGEC），具有CD34 +标记物（EC）和纯化单核细胞（MN）的内皮细胞，按以下比例（按照细胞数量）：NSC 0.8〜1.2; 1.6到2.4的NGEC; EC的4到6; 4000到6000的MN。 ACBP NEPS的生产方法包括将患者的各种类型的自体细胞的细胞制剂的生物组合物灌注到用于植入的含异质胶原的基质中以获得弹性细胞 - 生物聚合物生物活性物质。用于替代哺乳动物脑和/或脊髓和/或营养性神经系统的缺陷的重建神经外科手术的方法包括将ACBP NEPS植入神经组织的缺陷中。

3. 发明公开

EP2347763A4 AN IMPLANTABLE NEUROENDOPROSTHESIS SYSTEM, A METHOD FOR PREPARING SAME AND A PROCEDURE FOR PERFORMING OF A RECONSTRUCTIVE NEUROSURGICAL OPERATION 审中-公开
标题翻译：植入NEUROENDOPROSTHESENSYSTEM，工艺用于为重建操作神经外科PRODUCING和方法
公开(公告)号：EP2347763A4
公开(公告)日：2013-01-09
申请号：EP09816502
申请日：2009-02-13
申请人： BRYUKHOVETSKIY ANDREY STEPANOVICH
发明人： SEVASTIANOV VIKTOR IVANOVICH
IPC分类号： A61K38/39 , A61K35/14 , A61K35/30 , A61L27/24 , A61L27/36 , A61L27/38 , A61P25/00
CPC分类号： A61K35/28 , A61K35/30 , A61K35/44 , A61K38/185 , A61K38/1866 , A61L27/24 , A61L27/3878 , A61L2430/32 , A61K2300/00
摘要： The invention is used in neurosurgery and tissue engineering of organs to replace defects of nervous tissue of a mammal brain and spinal cord in reconstructive neurosurgical operations. The object of invention is to develop a tissue-replaceable artificial cell-biopolymer neuroendoprosthetic system (ACBP NEPS) for surgical plasty of defects of nervous tissue of brain and spinal cord that will stimulate regeneration and growth of damaged axons of neural cells, as well as to develop a production method of the ACBP NEPS and a method of reconstructive neurosurgical operation using the ACBP NEPS. The ACBP NEPS is an elastic cell-biopolymer biologically active mass produced from a heterogeneous collagen-containing matrix for implantation and a biocomposition of cell preparations of various types of autologous cells of a patient. The biocomposition comprises, in a NaCl solution, neural stem cells (NSC), neuroglial ensheathing cells (NGEC), endothelial cells with CD34+ marker (EC) and purified mononuclears (MN) in the following ratios (in parts according to numbers of the cells): 0.8 to 1.2 of NSC; 1.6 to 2.4 of NGEC; 4 to 6 of EC; 4000 to 6000 of MN. The method of production of the ACBP NEPS comprises perfusion of the biocomposition of the cell preparations of various types of autologous cells of a patient into the heterogeneous collagen-containing matrix for implantation to obtain the elastic cell-biopolymer biologically active mass. The method of the reconstructive neurosurgical operation to replace the defects of a mammal brain and/or spinal cord and/or vegetative nervous system comprises implantation of the ACBP NEPS into the defect of neural tissue.

4. 发明公开

EP2380973A1 DRUG MADE FROM STEM CELLS WITH REPROGRAMMED CELL SIGNALING, METHOD FOR PRODUCING SAID PREPARATION AND THE USE THEREOF 审中-公开
标题翻译：药物从细胞信号NEUPROGRAMMIERTER，方法干细胞生产这种制备及其用途
公开(公告)号：EP2380973A1
公开(公告)日：2011-10-26
申请号：EP09836446.6
申请日：2009-08-20
申请人： Bryukhovetskiy, Andrey Stepanovich
发明人： SEVASTIANOV, Viktor Ivanovich
IPC分类号： C12N5/095 , C12N5/10 , A61K9/51 , A61P35/00
CPC分类号： A61K9/5153 , A61K9/1075 , A61K9/127 , A61K9/1272 , A61K47/6925 , A61K2035/126 , C12N5/0623
摘要： The invention is applied in the therapy of brain and spinal cord tumors, degenerative, hypoxic, ischemic diseases and traumatic injuries of the central nervous system (CNS) and other diseases of humans and animals. Object of invention is to provide target delivery of signaling substance to the pathological area of an organism, triggering in due time and long-time support of active signaling intercellular action of specific therapeutic character of a healthy and well controlled stem cell (SC) onto controlling system of defective cells. The preparation of SC with reprogrammed cell signaling comprises the basic preparation of SC, the membrane, and/or nucleus, and/or cytoplasm of which contains implanted protein or pharmaceutical able to regulate signaling pathways of SC and cells of pathological focus in a mammal organism, provisionally encapsulated in nanocontainers of less than 100nm size, obtained from biodegradable material, intact for organelles and compartments of SC of the basic preparation. The material has a set biodegradation period in a mammal organism to provide programmed exit of protein or pharmaceutical in intra-or intercellular space thus reprogramming signal transduction of key genes in the desired therapeutic orientation of physiologic events in the cell cycle directly in the pathological area or tissue of an organism.
摘要翻译：本发明是在脑和脊髓肿瘤，变性，缺氧，局部缺血性疾病和中枢神经系统（CNS）和人类和动物的其它疾病的创伤性损伤的治疗中的应用。本发明的目的在于，走上控制提供信令物质对生物体的病理区域的目标传递，在适当的时间和长期的支持健康和良好控制的干细胞（SC）的特定治疗性质的活性信令间动作的触发有缺陷的细胞的系统。与重编程细胞信号SC的制备包括SC，膜，和/或核的基本制剂，和/或细胞质都包含植入的蛋白质或药物能够调节信号SC的途径和病理焦点的细胞在哺乳动物生物体的临时封装在小于100nm尺寸的纳米容器，由可生物降解材料获得，完整的细胞器和基本制备的SC的隔室。该材料具有在哺乳动物生物体的一组生物降解时期，以提供蛋白质或药物的编程出口在帧内或细胞间隙中的细胞周期的生理事件的期望的治疗取向的关键基因。因此重新编程的信号转导直接在病变区域或生物体组织。

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