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1. 发明授权

EP2385109B1 A group of esterases for the enantioselective production of fine and speciality chemicals 有权
标题翻译：一组用于精细和特种化学品对映选择性生产的酯酶
公开(公告)号：EP2385109B1
公开(公告)日：2015-12-02
申请号：EP11002834.7
申请日：2007-05-03
申请人： B.R.A.I.N. Biotechnology Research And Information Network AG
发明人： Liebeton, Klaus , Eck, Jürgen , Bornscheuer, Uwe , Böttcher, Dominique , Langer, Peter , Bellur, Esen
IPC分类号： C12N9/18 , C12N15/55 , C07K16/40 , C12N5/10
CPC分类号： C12N9/18

2. 发明公开

EP2885317A1 A NOVEL CALCIUM-ACTIVATED CHLORIDE CHANNEL INVOLVED IN HUMAN SWEAT FORMATION 有权
标题翻译：小说人类焊接教学参与，钙激活氯离子通道
公开(公告)号：EP2885317A1
公开(公告)日：2015-06-24
申请号：EP13750054.2
申请日：2013-08-14
申请人： B.R.A.I.N. Biotechnology Research And Information Network AG
发明人： ERTONGUR-FAUTH, Torsten , HOCHHEIMER, Andreas , KROHN, Michael
IPC分类号： C07K14/705
CPC分类号： C12Q1/6876 , C07K14/705 , C12Q2600/106
摘要： Accordingly, the present invention relates to a nucleic acid molecule encoding a protein capable of forming a calcium-activated chloride channel, wherein said nucleic acid molecule comprises or consists of (a) a nucleic acid molecule encoding a protein having the amino acid sequence of SEQ ID NO:1; (b) a nucleic acid molecule having the DNA sequence of SEQ ID NO:2; (c) a nucleic acid molecule having the sequence of SEQ ID NO:2, wherein each thymine is replaced by uracil; (d) a nucleic acid molecule that hybridizes under stringent conditions to the complementary strand of a nucleic acid molecule of (a), (b) or (c); (e) a nucleic acid molecule encoding a protein having at least 97% sequence identity to the protein of (a); or (f) a nucleic acid molecule that is degenerate with respect to the nucleic acid molecule of (b), (c) or (d). The present invention further relates to a protein capable of forming a calcium-activated chloride channel, the use of the nucleic acid molecule of or the protein of the invention for identifying an inhibitor of sweat formation as well as an in vitro method of identifying an inhibitor of sweat formation.

3. 发明授权

EP2530148B1 Novel beta-galactosidases useful for the production of lactose depleted milk products 有权
标题翻译：新β-半乳糖苷酶用于生产乳制品lactoseverarmten的
公开(公告)号：EP2530148B1
公开(公告)日：2015-04-29
申请号：EP11004424.5
申请日：2011-05-30
申请人： B.R.A.I.N. Biotechnology Research And Information Network AG
发明人： Niehaus, Frank , Eck, Jürgen
IPC分类号： C12N9/38 , A23C9/12
CPC分类号： C12Y302/01023 , A23C9/1203 , A23C9/1206 , A23C9/123 , A23C13/16 , A23C19/032 , A23C19/0328 , A23C2220/202 , C12N9/2471

4. 发明公开

EP2813585A1 Process of isolating rare earth elements 审中-公开
标题翻译： Verfahren zur Isolierung von Seltenerden
公开(公告)号：EP2813585A1
公开(公告)日：2014-12-17
申请号：EP13003058.8
申请日：2013-06-14
申请人： B.R.A.I.N. Biotechnology Research And Information Network AG
发明人： The designation of the inventor has not yet been filed
IPC分类号： C22B3/18 , C22B59/00
CPC分类号： C22B59/00 , C12P3/00 , C22B3/18 , C22B3/20 , Y02P10/234
摘要： A process of isolating a REE or a group of REE from a solution or dispersion containing said REE or said group of REEs comprising the following steps: (i) preparing a mixture comprising said solution or dispersion and biomass comprising at least one organism selected from any one of the following organism classes: eubacteria, archaea, algae, and fungi, whereby the at least one organism is capable of adsorbing or accumulating said REE or said group of REEs; (ii) incubating said mixture of step (i) for allowing the adsorption or accumulation of said REE or said group of REEs by said biomass; (iii) separating the biomass having adsorbed or accumulated REE(s) from the mixture of step (ii); and (iv) isolating said REE or said group of REEs from said biomass separated in step (iii).
摘要翻译：从包含所述REE或所述REE组的溶液或分散体中分离REE或一组REE的方法包括以下步骤：（i）制备包含所述溶液或分散体的混合物和包含至少一种选自任何以下有机体之一：真细菌，古细菌，藻类和真菌，由此所述至少一种生物体能够吸附或积累所述REE或所述REE组; （ii）将所述步骤（i）的混合物温育以允许所述生物质吸收或积累所述REE或所述REE组; （iii）从步骤（ii）的混合物中分离具有吸附或累积的REE的生物质; 和（iv）从步骤（iii）中分离的所述生物质中分离所述REE或所述REE组。

5. 发明公开

EP2706995A2 SMALL MOLECULE INHIBITORS OF TRPA1 有权
标题翻译： KLEINMOLEKULARE TRPA1-HEMMER
公开(公告)号：EP2706995A2
公开(公告)日：2014-03-19
申请号：EP12719772.1
申请日：2012-05-11
申请人： B.R.A.I.N. Biotechnology Research and Information Network AG
发明人： KROHN, Michael , SOMBROEK, Dirk
IPC分类号： A61K31/235 , A61K8/00 , A61Q19/00 , A61P17/00 , A23L1/00 , A61P29/00
CPC分类号： C07C62/30 , A23L27/86 , A23L27/88 , A61K8/36 , A61K8/37 , A61K8/49 , A61K8/496 , A61K8/69 , A61K31/192 , A61K31/235 , A61K2800/782 , A61Q19/00 , C07C69/78 , C07C255/44 , C07D249/08 , C07D513/04
摘要： The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be caused, enter alia, by ingredients of cosmetic or pharmaceutical compositions and/or environmental irritants. In particular, the present invention relates to compounds having the property of antagonizing the activation of the transient receptor potential (TRP) ankyrin 1 (TRPA1) ion channel and the use of said compounds as soothing agents. Such compounds can be used in many fields, particularly in personal-care products, cosmetics, textile and packaging products, pharmaceutical compositions, medical devices, and foodstuffs. The present invention further relates to products and/or pharmaceutical compositions containing said compounds. The present invention also relates to the use of the compounds described herein for the modulation of the taste of a food product.
摘要翻译：本发明涉及当它们施用于皮肤时能够减轻皮肤刺激的化合物的用途。特别是由化妆品或药物组合物和/或环境刺激物的成分引起皮肤刺激。特别地，本发明涉及具有拮抗瞬时受体电位（TRP）锚蛋白1（TRPA1）离子通道的活化的作用的化合物以及所述化合物作为舒缓剂的用途。这些化合物可用于许多领域，特别是在个人护理产品，化妆品，纺织和包装产品，药物组合物，医疗装置和食品中。本发明还涉及含有所述化合物的产品和/或药物组合物。本发明还涉及本文所述的化合物用于调节食品味道的用途。

6. 发明公开

EP2683352A2 SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8 有权
标题翻译： KLEINMOLEKÜLIGEMODULATOREN DESKÄLTE-UND MENTHOLREZEPTORS TRPM8
公开(公告)号：EP2683352A2
公开(公告)日：2014-01-15
申请号：EP12707363.3
申请日：2012-03-08
申请人： B.R.A.I.N. Biotechnology Research And Information Network AG
发明人： KROHN, Michael , ZINKE, Holger
IPC分类号： A61K8/41 , A61K8/49 , A61K31/00 , A61Q11/00 , A61Q17/02 , A61Q19/00
CPC分类号： A61K31/352 , A23L27/204 , A23L27/2052 , A23L27/2054 , A23L27/2056 , A23L27/88 , A23V2002/00 , A61K8/41 , A61K8/411 , A61K8/49 , A61K8/4933 , A61K8/498 , A61K31/00 , A61K31/136 , A61K31/137 , A61K31/35 , A61K31/351 , A61K31/353 , A61K31/4439 , A61K31/496 , A61K31/513 , A61K2800/244 , A61K2800/782 , A61Q5/00 , A61Q11/00 , A61Q17/02 , A61Q19/00 , C07D311/36 , Y10T428/249921
摘要： The present invention relates to the use of compounds which are capable of producing a cooling sensation when they are brought into contact with the human body. In particular, the present invention relates to the use of compounds modulating TRPM8, and optionally to the use of compounds selectively exhibiting agonist activity at the TRPM8 channel. Such compounds have applications in many fields, particularly in oral and personal hygiene products and foodstuffs, but also in pharmaceutical composition products, cosmetics, textile products and packaging products. The present invention further relates to products containing such compounds and to the medical use of such compounds.
摘要翻译：本发明涉及当与人体接触时能够产生冷却感的化合物的用途。特别地，本发明涉及调节TRPM8的化合物的用途，并且任选地涉及使用在TRPM8通道选择性显示激动剂活性的化合物。这些化合物在许多领域中尤其在口腔和个人卫生产品和食品中也有应用，而且在药物组合物产品，化妆品，纺织产品和包装产品中也有应用。本发明还涉及含有这些化合物的产品和这些化合物的医疗用途。

7. 发明公开

EP2530148A1 Novel beta-galactosidases useful for the production of lactose depleted milk products 有权
标题翻译： Neue beta-Galactosidasen zur Herstellung von lactoseverarmten Milchprodukten
公开(公告)号：EP2530148A1
公开(公告)日：2012-12-05
申请号：EP11004424.5
申请日：2011-05-30
申请人： B.R.A.I.N. Biotechnology Research And Information Network AG
发明人： Niehaus, Frank , Eck, Jürgen
IPC分类号： C12N9/38 , A23C9/12
CPC分类号： C12Y302/01023 , A23C9/1203 , A23C9/1206 , A23C9/123 , A23C13/16 , A23C19/032 , A23C19/0328 , A23C2220/202 , C12N9/2471
摘要： The invention relates to a nucleic acid molecule encoding (I) a polypeptide having the activity of a beta-galactosidase (EC 3.2.1.23), which is (a) a nucleic acid molecule encoding a polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 1; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 2; (c) a nucleic acid molecule encoding a beta-galactosidase the amino acid sequence of which is at least 64% identical to the amino acid sequence of SEQ ID NO: 1, (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 63% identical to the nucleotide sequence of SEQ ID NO: 2, (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (e) wherein T is replaced by U; (II) a fragment of the polypeptide of (I) having the activity of a beta-galactosidase.
摘要翻译：本发明涉及编码（I）具有β-半乳糖苷酶活性的多肽的核酸分子（EC 3.2.1.23），其是（a）编码多肽的核酸分子，所述多肽包含或由其组成的氨基酸序列 SEQ ID NO：1; （b）包含SEQ ID NO：2的核苷酸序列或由其组成的核酸分子; （c）编码其氨基酸序列与SEQ ID NO：1的氨基酸序列至少64％相同的β-半乳糖苷酶的核酸分子，（d）包含核苷酸序列或由其组成的核酸分子其与SEQ ID NO：2的核苷酸序列至少63％相同，（e）相对于（d）的核酸分子简并的核酸分子; 或（f）对应于（a）〜（e）中任一项所述的核酸分子的核酸分子，其中T被U代替; （II）具有β-半乳糖苷酶活性的（I）多肽的片段。

8. 发明公开

EP2385109A3 A group of esterases for the enantioselective production of fine and speciality chemicals 有权
标题翻译：酯酶集团不对称生产精细和专用化学品
公开(公告)号：EP2385109A3
公开(公告)日：2012-02-15
申请号：EP11002834.7
申请日：2007-05-03
申请人： B.R.A.I.N. Biotechnology Research And Information Network AG
发明人： Liebeton, Klaus , Eck, Jürgen , Bornscheuer, Uwe , Böttcher, Dominique , Langer, Peter , Bellur, Esen
IPC分类号： C12N9/18 , C12N15/55 , C07K16/40 , C12N5/10
CPC分类号： C12N9/18
摘要： The present invention relates to a polynucleotide consisting of more than 30 nucleotides encoding an enzyme having carboxylesterase [E.C. 3.1.1.1] activity, wherein the coding sequence is selected from the group consisting of (a) a polynucleotide encoding an amino acid sequence as depicted in any one of SEQ ID NOs: 10, 4; 8, and 12; (b) a polynucleotide consisting of or comprising a nucleotide sequence, wherein the nucleic acid sequence is as shown in any one of SEQ ID NOs: 9, 3, 7 and 11; (c) a polynucleotide consisting of or comprising a nucleotide sequence encoding a fragment or derivative of an enzyme encoded by a polynucleotide of (a) or (b), wherein in said derivative one amino acid residue is conservatively substituted compared to the amino acid sequence of (a); (d) a polynucleotide encoding an enzyme having carboxylesterase activity which polynucleotide is at least 66% identical to a polynucleotide encoding an enzyme as shown in any one of SEQ ID NOs: 10, 4, 8 and 12; (e) a polynucleotide consisting of or comprising a nucleotide sequence the complementary strand of which hybridizes under stringent conditions to a polynucleotide as defined in any one of (a) to (b); and (f) a polynucleotide consisting of or comprising a nucleotide sequence being degenerate to the nucleotide sequence of the polynucleotide of (e); or the complementary strand of such a polynucleotide of (a) to (f).

9. 发明授权

EP2139347B1 VERWENDUNG VON WASSERDISPERGIERBAREN CAROTINOID-NANOPARTIKELN ALS GESCHMACKSMODULATOREN, GESCHMACKSMODULATOREN, ENTHALTEND WASSERDISPERGIERBARE CAROTINOID-NANOPARTIKEL, UND VERFAHREN ZUR GESCHMACKSMODULATION 有权
标题翻译：使用水分散性类胡萝卜素纳米粒子口味调节剂，口感调节剂含有水分散性类胡萝卜素纳米粒子和方法味道调制
公开(公告)号：EP2139347B1
公开(公告)日：2011-01-12
申请号：EP08717107.0
申请日：2008-02-25
申请人： B.R.A.I.N. Biotechnology Research And Information Network AG
发明人： MATUSCHEK, Markus , ERNST, Andreas , KÖPSEL, Christian , JAGER, Martin, B. , KLEBER, Alice , KROHN, Michael , ZINKE, Holger
IPC分类号： A23L1/22 , A23L1/275
CPC分类号： A23L2/56 , A23L2/58 , A23L2/60 , A23L5/44 , A23L5/47 , A23L27/204 , A23L27/30 , A23L27/86 , A23P10/30 , A23V2002/00 , A23V2200/25 , A23V2200/16 , A23V2200/132 , A23V2200/044 , A23V2200/224 , A23V2250/211 , A23V2250/213 , A23V2250/242
摘要： The invention relates to the use of at least one type of water-dispersible carotinoid nanoparticles as taste modulators in material compositions; to a method for taste modulation of material compositions, according to which at least one type of water-dispersible carotinoid nanoparticles is added to material compositions; and to taste modulators for material compositions, containing (A) at least one type of water-dispersible carotinoid nanoparticles, and (B) at least one azo compound containing at least one azo group.

10. 发明授权

EP2536744B1 CHIMERIC SURFACE ACTIVE PROTEINS 有权
公开(公告)号：EP2536744B1
公开(公告)日：2018-10-17
申请号：EP11706789.2
申请日：2011-02-18
申请人： B.R.A.I.N. Biotechnology Research And Information Network AG
发明人： MEURER, Guido , GABOR, Esther , BACHERT, Anke , ECK, Jürgen
IPC分类号： C07K14/37 , C09D189/00 , A61K9/28
CPC分类号： C07K14/37 , A61K9/286 , A61K9/2873 , C09D189/00 , C12N15/62
摘要： The present invention relates to a nucleic acid molecule encoding a chimeric protein having the biochemical activity of a surface active protein, wherein said chimeric protein comprises: (a) an N-terminal portion of a first surface active protein, wherein the N-terminal portion is devoid of between 0 and 10 of the most N-terminal amino acids of the mature first surface active protein; and, C-terminally thereof, (b) a C-terminal portion of a second surface active protein, wherein the C-terminal portion is devoid of between 0 and 10 of the most C-terminal amino acids of the mature second surface active protein. The present invention further relates to a vector, a non-human host and a method for the production of a chimeric protein having the biochemical activity of a surface active protein. In addition, the present invention relates to a chimeric protein encoded by the nucleic acid molecule of the invention and a composition comprising the chimeric protein. The chimeric protein may only consist of the above mentioned core of (a) and (b), but may also be flanked by additional components of the core, i.e. (a) or (b) or by (an) additional complete core(s) (a) and (b). The present invention furthermore relates to a method of coating and/or impregnating a material, comprising contacting the material with the chimeric protein or the composition of the invention.

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