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2. 发明公开

EP2536744A1 CHIMERIC SURFACE ACTIVE PROTEINS 审中-公开
标题翻译： CHIMÄREOBERFLÄCHENAKTIVEPROTEINE
公开(公告)号：EP2536744A1
公开(公告)日：2012-12-26
申请号：EP11706789.2
申请日：2011-02-18
申请人： B.R.A.I.N. Biotechnology Research And Information Network AG
发明人： MEURER, Guido , GABOR, Esther , BACHERT, Anke , ECK, Jürgen
IPC分类号： C07K14/37 , A61K47/42 , C09D189/00
CPC分类号： C07K14/37 , A61K9/286 , A61K9/2873 , C09D189/00 , C12N15/62
摘要： The present invention relates to a nucleic acid molecule encoding a chimeric protein having the biochemical activity of a surface active protein, wherein said chimeric protein comprises: (a) an N-terminal portion of a first surface active protein, wherein the N-terminal portion is devoid of between 0 and 10 of the most N-terminal amino acids of the mature first surface active protein; and, C-terminally thereof, (b) a C-terminal portion of a second surface active protein, wherein the C-terminal portion is devoid of between 0 and 10 of the most C-terminal amino acids of the mature second surface active protein. The present invention further relates to a vector, a non-human host and a method for the production of a chimeric protein having the biochemical activity of a surface active protein. In addition, the present invention relates to a chimeric protein encoded by the nucleic acid molecule of the invention and a composition comprising the chimeric protein. The chimeric protein may only consist of the above mentioned core of (a) and (b), but may also be flanked by additional components of the core, i.e. (a) or (b) or by (an) additional complete core(s) (a) and (b). The present invention furthermore relates to a method of coating and/or impregnating a material, comprising contacting the material with the chimeric protein or the composition of the invention.
摘要翻译：本发明涉及编码具有表面活性蛋白的生化活性的嵌合蛋白质的核酸分子，其中所述嵌合蛋白质包含：（a）第一表面活性蛋白质的N末端部分，其中所述N-末端部分没有成熟的第一表面活性蛋白的最多N末端氨基酸的0和10之间; 并且其C末端，（b）第二表面活性蛋白质的C末端部分，其中C末端部分缺乏成熟第二表面活性蛋白质的最C端氨基酸的0至10个。本发明还涉及载体，非人宿主和生产具有表面活性蛋白的生化活性的嵌合蛋白的方法。此外，本发明涉及由本发明的核酸分子编码的嵌合蛋白质和包含该嵌合蛋白质的组合物。嵌合蛋白质只能由上述（a）和（b）的核心组成，但也可以由核心的另外的成分，即（a）或（b）或（a）另外的完整核心）（a）和（b）。本发明还涉及一种涂覆和/或浸渍材料的方法，包括使材料与本发明的嵌合蛋白或组合物接触。

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