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1. 发明公开

EP1263503A2 USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS 有权
标题翻译：氰基喹啉可用于治疗或抑制结肠息肉USE
公开(公告)号：EP1263503A2
公开(公告)日：2002-12-11
申请号：EP01918367.2
申请日：2001-03-06
申请人： AMERICAN CYANAMID COMPANY
发明人： FROST, Philip , DISCAFANI-MARRO, Carolyn, M.
IPC分类号： A61P1/00 , A61K31/4706 , A61K31/4709
CPC分类号： A61K31/5377 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K31/4741 , A61K31/517 , Y02P20/582
摘要： This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula (1); wherein R1, R2, R3, R4, X, Y, and n are defined hereinbefore, or a pharmaceutically acceptable salt thereof.

2. 发明授权

EP1157024B1 ACETYLENIC ORTHO-SULFONAMIDO AND PHOSPHINIC ACID AMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS TACE INHIBITORS 有权
标题翻译：乙酰乙酸异硫氰酸酯 - 磷酸二铵 - 二氯环己烷甲基胆碱酯酶抑制剂
公开(公告)号：EP1157024B1
公开(公告)日：2002-11-06
申请号：EP00905788.6
申请日：2000-01-27
申请人： American Cyanamid Company
发明人： LEVIN, Jeremy, Ian , CHEN, James, Ming , DU, Xue-Mei , ALBRIGHT, Jay, Donald , ZASK, Arie
IPC分类号： C07D471/04 , C07D498/04 , C07D215/54 , C07D513/04 , C07F9/53 , A61K31/437 , A61K31/47 , A61P19/02 , A61P37/00 , C07C309/42 , C07C309/87
CPC分类号： C07D471/04 , C07C309/42 , C07C309/87 , C07D215/54 , C07D513/04

3. 发明公开

EP1202746A1 NSAID AND EFGR KINASE INHIBITOR CONTAINING COMPOSITION FOR THE TREATMENT OR INHIBITION OF COLONIC POLYPS AND COLORECTAL CANCER 有权
标题翻译： NSAID和EGFR激酶抑制剂的药物制剂治疗或抑制结肠息肉和肠癌
公开(公告)号：EP1202746A1
公开(公告)日：2002-05-08
申请号：EP00950930.8
申请日：2000-08-02
申请人： American Cyanamid Company
发明人： FROST, Philip , DISCAFANI-MARRO, Carolyn, Mary
IPC分类号： A61K45/06 , A61K31/505 , A61K31/47
CPC分类号： A61K45/06 , A61K31/47 , A61K31/505 , A61K31/19 , A61K2300/00
摘要： This invention provides a method of treating or inhibiting colonic polyps or treating or inhibiting colorectal cancer in a mammal in need thereof which comprises administering to said mammal an NSAID and an EFGR kinase inhibitor.

4. 发明公开

EP1197207A2 Stable compositions for parenteral administration 有权
标题翻译： Stabilisierte Arzneizusammensetzungen zur肠胃外Vearbreichung
公开(公告)号：EP1197207A2
公开(公告)日：2002-04-17
申请号：EP01308284.7
申请日：2001-09-28
申请人： American Cyanamid Company
发明人： Steber, William David
IPC分类号： A61K9/16 , A61K31/365
CPC分类号： A61K47/38 , A61K9/0019 , A61K9/1617 , A61K31/7048
摘要： This invention relates to certain stable microsphere compositions containing a fat, a wax or a mixture thereof; and an active ingredient selected from LL-F28249α-λ, compounds, 23-oxo or 23-imino derivatives of LL-F28249α-λ compounds, milbemycin compounds and avermectin compounds. The invention also relates to a method for introducing and maintaining levels of the active compound in the blood of warm-blooded animals for extended periods of time and for the prevention or treatment of infections and infestations caused by helminths, nematodes, acarids and endo- and ectoparasitic arthropods in warm-blooded animals by the parenteral administration of compositions of the invention.
摘要翻译：本发明涉及含有脂肪，蜡或其混合物的某些稳定的微球组合物; 和选自LL-F28249α-λ，LL-F28249α-λ化合物的23-氧代或23-亚氨基衍生物，米尔倍霉素化合物和除虫菌素化合物的活性成分。本发明还涉及一种用于在温血动物的血液中长时间引入和维持活性化合物的水平并用于预防或治疗由蠕虫，线虫，螨和内含物引起的感染和侵袭的方法通过肠胃外给药本发明的组合物在温血动物中的外寄生节肢动物。

5. 发明公开

EP1171440A1 SUBSTITUTED-3-CYANO-[1.7],[1.5], AND [1.8]-NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES 有权
标题翻译：酪氨酸激酶的取代基-3-氰基 - [1.7]，[1.5]和[1.8] - 氮TH IN IN IN IN IN TY
公开(公告)号：EP1171440A1
公开(公告)日：2002-01-16
申请号：EP00926043.1
申请日：2000-04-18
申请人： American Cyanamid Company
发明人： WISSNER, Allan , HAMANN, Philip, Ross , YAMASHITA, Ayako
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
CPC分类号： C07D471/04
摘要： This invention provides compounds of formula (I) having structure (a) wherein A'' is a diavalent moiety selected from the group (a, b, c) which are useful as inhibitors of protein tyrosine kinase.
摘要翻译：本发明提供了具有结构式（a）的式（I）化合物，其中A“是选自（a，b，c）的可用作蛋白酪氨酸激酶抑制剂的二价部分。

6. 发明授权

EP0591697B8 Cloning and characterization of the growth hormone releasing hormone receptor 失效
标题翻译：生长激素释放激素受体的克隆和表征
公开(公告)号：EP0591697B8
公开(公告)日：2001-11-14
申请号：EP93114519.7
申请日：1993-09-09
申请人： The University of Virginia Patent Foundation , American Cyanamid Company
发明人： Thorner, Michael Oliver , Gaylinn, Bruce David , Zysk, John Ronald , Lynch, Kevin R. , Harrison, Jeffrey K.
IPC分类号： C12N15/12 , C12P21/08 , A61K38/17 , C12Q1/68 , C12N5/10 , C12N1/21 , C07K14/00
CPC分类号： C07K14/60 , A61K38/00 , C07K14/723

7. 发明公开

EP1023833A3 Emulsifiable concentrate containing one or more pesticides and adjuvants 审中-公开
标题翻译：一种或多种农药和添加剂含有乳液浓缩物
公开(公告)号：EP1023833A3
公开(公告)日：2001-07-18
申请号：EP00300667.3
申请日：2000-01-28
申请人： American Cyanamid Company
发明人： Aven, Michael
IPC分类号： A01N25/30 , A01N25/02
CPC分类号： A01N25/02
摘要： The invention relates to a stable emulsifiable concentrate (EC) for crop protection active compounds which comprises (a) one or more crop protection active compounds, (b) 150 to 500 g/l of one or more adjuvants, (c) optionally one or more organic, non-polar solvents, (d) an emulsifying surfactant system forming an oil in water emulsion when the formulation is added to water, which essentially consists ofone or more non-ionic surfactants, andone or more anionic surfactants, (e) a water-miscible polar aprotic solvent or one or more dimethyl dicarboxylates, and (f) optionally an antifoam agent, and to the use of such a suspension as a pesticide.

8. 发明公开

EP1023837A3 Non-aqueous, emulsifiable concentrate formulation 有权
标题翻译：非水性悬浮液浓缩物
公开(公告)号：EP1023837A3
公开(公告)日：2001-05-30
申请号：EP00300666.5
申请日：2000-01-28
申请人： American Cyanamid Company
发明人： Aven, Michael
IPC分类号： A01N43/50 , A01N43/653 , A01N25/02
CPC分类号： A01N43/50 , A01N43/653 , A01N43/90 , A01N35/04 , A01N25/02 , A01N2300/00
摘要： The invention relates to a non-aqueous, emulsifiable concentrate (EC) formulation for crop protection active compounds which comprises (a1) 50 to 300 g/L of at least one azole derivative having a free hydroxy group or a salt or an adduct thereof, preferably a compound of formula I,wherein, R1 and R2 each independently represent hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or alkadienyl group;R3 represents a halogen atom or an optionally substituted alkyl, alkenyl, alkynyl, alkadienyl, alkoxy or aryl group;A represents a nitrogen atom or a CH group; andn represents an integer from 0 to 2; (a2) optionally, 50 to 500 g/L of at least one additional fungicidally active compound; (b) up to 700 g/L of one or more alkoxylates of an aliphatic alcohol, (c) up to 100 g/L of one or more non-ionic dispersants, (d) 10 to 100 g/L of one or more anionic dispersants, (e) 50 to 600 g/L of one or more polar aprotic organic solvents, and (f) 150 to 500 g/L of one or more non-polar organic solvents, any (g) up to 5 g/L of one or more defoamers, and to the use of such a emulsifiable concentrate as a fungicide.

9. 发明公开

EP1097937A1 N-acyl derivatives of the LL-E33288 antitumor antibiotics 失效
标题翻译： LL-E33288抗肿瘤抗生素的N-酰基衍生物
公开(公告)号：EP1097937A1
公开(公告)日：2001-05-09
申请号：EP00128100.5
申请日：1990-04-06
申请人： American Cyanamid Company
发明人： Lee, May Dean-Ming
IPC分类号： C07H15/203 , A61K31/704 , A61P31/04 , A61P35/00
CPC分类号： C07H15/203 , C12P19/60 , C12R1/29
摘要： The invention is N-acyl and dihydro-N-acyl analogs of the family of antibacterial and antitumor agents known collectively as the E33288 complex.
摘要翻译：本发明是统称为E33288复合物的抗菌剂和抗肿瘤剂家族的N-酰基和二氢-N-酰基类似物。

10. 发明授权

EP0661263B1 Process for the preparation of 2,4,5-tribromopyrrole-3-carbonitrile 失效
标题翻译：一种制备2,4,5-三溴吡咯-3-腈的过程
公开(公告)号：EP0661263B1
公开(公告)日：2001-04-25
申请号：EP94117385.8
申请日：1994-11-04
申请人： AMERICAN CYANAMID COMPANY
发明人： Kamhi, Victor Marc
IPC分类号： C07D207/34 , C07B41/08 , C07B39/00
CPC分类号： C07D207/34

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