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1. 发明公开

EP1576112A3 CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS 审中-公开
标题翻译：细胞因子受体ZCYTOR17多体
公开(公告)号：EP1576112A3
公开(公告)日：2005-10-26
申请号：EP03761891.5
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , GAO, Zeren , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , PRESNELL, Scott, R. , WHITMORE, Theodore, E. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C12N1/00

2. 发明授权

EP1115862B1 CYTOKINE RECEPTOR ZALPHA11 有权
标题翻译：细胞因子受体ZALPHA11
公开(公告)号：EP1115862B1
公开(公告)日：2009-07-15
申请号：EP99952948.0
申请日：1999-09-23
申请人： ZymoGenetics, Inc.
发明人： PRESNELL, Scott, R. , CONKLIN, Darrell, C. , NOVAK, Julia, E. , HAMMOND, Angela, K.
IPC分类号： C12N15/12 , C07K14/715 , C07K16/28
CPC分类号： C07K16/2866 , C07K14/715

3. 发明公开

EP1115862A2 CYTOKINE RECEPTOR ZALPHA11 有权
标题翻译：细胞因子受体ZALPHA11
公开(公告)号：EP1115862A2
公开(公告)日：2001-07-18
申请号：EP99952948.0
申请日：1999-09-23
申请人： ZymoGenetics, Inc.
发明人： PRESNELL, Scott, R. , CONKLIN, Darrell, C. , NOVAK, Julia, E. , HAMMOND, Angela, K.
IPC分类号： C12N15/12 , C07K14/715 , C07K16/28
CPC分类号： C07K16/2866 , C07K14/715
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译：新型多肽，编码多肽的多核苷酸以及相关的组合物和方法公开用于zalpha11，一种新的细胞因子受体。所述多肽可用于检测刺激造血细胞，淋巴细胞和骨髓细胞体外和体内增殖和/或发育的配体的方法中。配体结合受体多肽也可用于在体外和体内阻断配体活性。编码zalpha11的多核苷酸位于染色体16上，并可用于鉴定与人类疾病状态相关的基因组区域。本发明还包括生产蛋白质的方法，其用途和抗体。

4. 发明公开

EP1576112A2 CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS 有权
标题翻译：多聚CYTOKINREZEPTORS zcytoR17的
公开(公告)号：EP1576112A2
公开(公告)日：2005-09-21
申请号：EP03761891.5
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , GAO, Zeren , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , PRESNELL, Scott, R. , WHITMORE, Theodore, E. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C12N1/00
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： There is provided an isolated multimeric or heterodimeric cytokine receptor comprising: a first polypeptide, wherein the first polypeptide comprises an amino acid sequence having at least 90 percent sequence identity with residues 20-732 of SEQ ID NO:111 or an amino acid sequence having at least 90 percent sequence identity with residues 20-649 of SEQ ID NO:109; and a second polypeptide comprising residues 28-429 of SEQ IDNO:7; wherein the multimeric or heterodimeric cytokine receptor binds a ligand comprising residues 27-164 of SEQ ID NO:2.

5. 发明公开

EP1476541A2 NOVEL CYTOKINE ZCYTOR17 LIGAND 有权
标题翻译：细胞因子（ZCYTOR17配体）
公开(公告)号：EP1476541A2
公开(公告)日：2004-11-17
申请号：EP03729693.6
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C12N5/10 , C12N15/19 , C12N15/62 , C12N15/63 , C07K14/52 , C07K16/24 , G01N33/53 , G01N33/567 , A61K38/19 , A61K39/395
CPC分类号： C07K16/24 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/52 , C07K2317/24
摘要： The present invention relates to zcytor171ig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor171ig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

6. 发明公开

EP1165791A2 HUMAN CYTOKINE AS LIGAND OF THE ZALPHA RECEPTOR AND USES THEREOF 失效
标题翻译：人细胞因子作为配体ZALPHA受体和及其用途
公开(公告)号：EP1165791A2
公开(公告)日：2002-01-02
申请号：EP00916164.7
申请日：2000-03-09
申请人： ZymoGenetics, Inc.
发明人： NOVAK, Julia, E. , PRESNELL, Scott, R. , SPRECHER, Cindy, A. , FOSTER, Donald, C. , HOLLY, Richard, D. , GROSS, Jane, A. , JOHNSTON, Janet, V. , NELSON, Andrew, J. , DILLON, Stacey, R. , HAMMOND, Angela, K.
IPC分类号： C12N15/19 , C07K14/52 , C12N15/62 , C12N15/85 , C07K16/24 , C12Q1/68 , G01N33/68 , A61K38/19
CPC分类号： C07K14/52 , A61K38/00 , C07K2319/00 , C07K2319/55
摘要： The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

7. 发明授权

EP1576112B1 CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS 有权
标题翻译：细胞因子受体ZCYTOR17的多聚体
公开(公告)号：EP1576112B1
公开(公告)日：2012-02-29
申请号：EP03761891.5
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , GAO, Zeren , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , PRESNELL, Scott, R. , WHITMORE, Theodore, E. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C07K14/715
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： There is provided an isolated multimeric or heterodimeric cytokine receptor comprising: a first polypeptide, wherein the first polypeptide comprises an amino acid sequence having at least 90 percent sequence identity with residues 20-732 of SEQ ID NO:111 or an amino acid sequence having at least 90 percent sequence identity with residues 20-649 of SEQ ID NO:109; and a second polypeptide comprising residues 28-429 of SEQ IDNO:7; wherein the multimeric or heterodimeric cytokine receptor binds a ligand comprising residues 27-164 of SEQ ID NO:2.

8. 发明授权

EP1165791B1 HUMAN CYTOKINE AS LIGAND OF THE ZALPHA RECEPTOR AND USES THEREOF 失效
标题翻译：人细胞因子作为配体ZALPHA受体和及其用途
公开(公告)号：EP1165791B1
公开(公告)日：2007-10-31
申请号：EP00916164.7
申请日：2000-03-09
申请人： ZymoGenetics, Inc.
发明人： NOVAK, Julie, E. , PRESNELL, Scott, R. , SPRECHER, Cindy, A. , FOSTER, Donald, C. , HOLLY, Richard, D. , GROSS, Jane, A. , JOHNSTON, Janet, V. , NELSON, Andrew, J. , DILLON, Stacey, R. , HAMMOND, Angela, K.
IPC分类号： C12N15/19 , C07K14/52 , C12N15/62 , C12N15/85 , C07K16/24 , C12Q1/68 , G01N33/68 , A61K38/19
CPC分类号： C07K14/52 , A61K38/00 , C07K2319/00 , C07K2319/55
摘要： The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

9. 发明公开

EP1185641A1 CYTOKINE RECEPTOR MOUSE ZCYTOR10 审中-公开
标题翻译：细胞因子ZCYTOR10 MOUSE
公开(公告)号：EP1185641A1
公开(公告)日：2002-03-13
申请号：EP00928962.0
申请日：2000-05-11
申请人： ZymoGenetics, Inc.
发明人： PRESNELL, Scott, R. , FOSTER, Donald, C. , HAMMOND, Angela, K. , LOK, Si
IPC分类号： C12N15/12 , C12N15/62 , C07K14/715 , C07K16/28 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/715 , C07K2319/00
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for mouse zcytor10, a novel mouse cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells. Ligand-binding receptor polypeptides can also be used to block ligand activity. The polynucleotides encoding mouse zcytor10 can be used to identify a human ortholog. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

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