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1. 发明授权

EP2264175B1 Fibroblast growth factor homologs 失效
标题翻译：成纤维细胞生长因子同源
公开(公告)号：EP2264175B1
公开(公告)日：2012-11-21
申请号：EP10176653.3
申请日：1997-10-16
申请人： ZymoGenetics, Inc.
发明人： Deisher, Theresa A. , Conklin, Darrell C. , Raymond, Fenella C. , Bukowski, Thomas R. , Julien, Susan D. , Hansen, Brigit , Sheppard, Paul O.
IPC分类号： C12N15/18 , C07K14/50 , C07K16/22 , C07K19/00 , C12N5/10 , A61K38/18
CPC分类号： C12N5/0657 , A61K38/00 , A61K47/62 , A61K47/6835 , C07K14/50 , C07K16/22 , C07K2319/00 , C12N2501/119

2. 发明授权

EP2105446B1 Cytokine receptor zalpha11 有权
标题翻译：细胞因子受体zalpha11
公开(公告)号：EP2105446B1
公开(公告)日：2013-08-14
申请号：EP09165460.8
申请日：1999-09-23
申请人： ZymoGenetics, Inc.
发明人： Presnell, Scott R. , Conklin, Darrell C. , Novak, Julia E , Hammond, Angela K.
IPC分类号： C12N15/12 , C07K14/715 , C07K16/28
CPC分类号： C07K16/2866 , C07K14/715

3. 发明授权

EP1632574B1 Fibroblast growth factor homologs 失效
标题翻译：成纤维细胞生长因子同系物
公开(公告)号：EP1632574B1
公开(公告)日：2010-12-08
申请号：EP05021714.0
申请日：1997-10-16
申请人： ZymoGenetics, Inc.
发明人： Deisher, Theresa A. , Conklin, Darrell C. , Raymond, Fenella C. , Bukowski, Thomas R. , Julien, Susan D. , Hansen, Brigit , Sheppard, Paul O.
IPC分类号： C12N15/18 , C07K14/50 , C07K16/22 , C07K19/00 , C12N5/10 , A61K38/18
CPC分类号： C12N5/0657 , A61K38/00 , A61K47/62 , A61K47/6835 , C07K14/50 , C07K16/22 , C07K2319/00 , C12N2501/119

4. 发明公开

EP1424393A2 Mammalian cytokine-like polypeptide-10 审中-公开
标题翻译：哺乳动物细胞因子样多肽-10
公开(公告)号：EP1424393A2
公开(公告)日：2004-06-02
申请号：EP04002769.0
申请日：1998-11-25
申请人： Zymogenetics Inc
发明人： Conklin, Darrell C. , Haldeman, Betty A. , Grossmann, Angelika
IPC分类号： C12N15/12 , C07K14/52 , C07K16/24 , A61K38/19 , G01N33/53
CPC分类号： C07K14/54 , A01K67/027 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/52 , C12N2799/021
摘要： Use of a mammalian cytokine-like polypeptide, called Zcyto10, and polynucleotides encoding the same, for the manufacture of a medicament for the prevention or treatment of an autoimmune disease or condition. In a preferred embodiment, said use is for treating a disease or condition selected from the group consisting of immune dependent diabetes mellitus (IDDM), multiple sclerosis, rheumatoid arthritis, cancer cell growth or proliferation, asthma, bronchitis, thrombocytopenia in cancer patients due to chemotherapy or radiation therapy, psoriasis, eczema, and dry skin conditions.
摘要翻译：称为Zcyto10的哺乳动物细胞因子样多肽和编码它的多核苷酸用于制备用于预防或治疗自身免疫疾病或病症的药物的用途。在一个优选的实施方案中，所述用途是用于治疗癌症患者中选自由免疫依赖性糖尿病（IDDM），多发性硬化症，类风湿性关节炎，癌细胞生长或增殖，哮喘，支气管炎，血小板减少症组成的组的疾病或病症，化疗或放疗，牛皮癣，湿疹和皮肤干燥症。

5. 发明公开

EP2339002A1 Fibroblast growth factor homologs 失效
标题翻译： Homologe des Fibroblasten-Wachstumsfaktors
公开(公告)号：EP2339002A1
公开(公告)日：2011-06-29
申请号：EP10185113.7
申请日：1997-10-16
申请人： ZymoGenetics, Inc.
发明人： Deisher, Theresa A. , Conklin, Darrell C. , Raymond, Fenella C. , Bukowski, Thomas R. , Julien, Susan D. , Hansen, Brigit , Sheppard, Paul O.
IPC分类号： C12N15/18 , C07K14/50 , C07K16/22 , C07K19/00 , C12N5/10 , A61K38/18
CPC分类号： C12N5/0657 , A61K38/00 , A61K47/62 , A61K47/6835 , C07K14/50 , C07K16/22 , C07K2319/00 , C12N2501/119
摘要： There is provided an isolated polynucleotide molecule encoding a fibroblast growth factor (FGF) homolog polypeptide selected from the group consisting of: a) a polynucleotide molecule comprising a nucleotide sequence as shown in SEQ ID. NO:1 from nucleotide 82 to nucleotide 621; b) allelic variants of (a); c) a polynucleotide molecule that encode a polypeptide that is at least 60% identical to the amino acid sequence of SEQ ID. NO:2 from amino acid residue 28 (Glu) to amino acid residue 207 (Ala); and d) a polynucleotide molecule comprising a nucleotide sequence as shown in SEQ ID. NO:6 from nucleotide 82 to nucleotide 621.
摘要翻译：提供了编码选自以下的成纤维细胞生长因子（FGF）同源多肽的分离的多核苷酸分子：a）包含SEQ ID NO：1所示的核苷酸序列的多核苷酸分子。 NO：1从核苷酸82到核苷酸621; b）（a）的等位基因变体; c）编码与SEQ ID中氨基酸序列至少60％相同的多肽的多核苷酸分子。从氨基酸残基28（Glu）到氨基酸残基207（Ala）的NO：2; 和d）包含SEQ ID NO：1所示的核苷酸序列的多核苷酸分子。 NO：6从核苷酸82到核苷酸621。

6. 发明公开

EP1719780A3 Mammalian cytokine-like polypeptide-10 审中-公开
标题翻译：哺乳动物细胞因子样多肽-10
公开(公告)号：EP1719780A3
公开(公告)日：2006-12-20
申请号：EP06006241.1
申请日：1998-11-25
申请人： ZymoGenetics, Inc.
发明人： Conklin, Darrell C. , Haldeman, Betty A. , Grossmann, Angelika
IPC分类号： C07K16/24 , A61K38/00 , A61P37/00
CPC分类号： C07K14/54 , A01K67/027 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/52 , C12N2799/021
摘要： There is provided the use of an antibody, antibody fragment or single chain antibody that selectively binds to a polypeptide comprising an amino acid sequence having at least 80% identity to an IL-20 polypeptide selected from the group consisting of SEQ ID NOs: 2, 4, 12, 13, 19, 20, 25, 26, 34 and 35 for the manufacture of a medicament for the prevention or treatment of an autoimmune disease or condition, or for the prevention or treatment of conditions characterised by improper cell proliferation, cell differentiation or cytokine production.
摘要翻译：提供选择性结合多肽的抗体，抗体片段或单链抗体的用途，所述多肽包含与选自SEQ ID NO：2，SEQ ID NO：2，SEQ ID NO： 4,12,13,19,20,25,26,34和35的化合物在制备用于预防或治疗自身免疫性疾病或病症，或用于预防或治疗以不正常细胞增殖为特征的病症的药物中的应用，细胞分化或细胞因子产生。

7. 发明公开

EP1632574A1 Fibroblast growth factor homologs 失效
标题翻译： Fibroblasten-Wachstumsfaktoren-Homologe
公开(公告)号：EP1632574A1
公开(公告)日：2006-03-08
申请号：EP05021714.0
申请日：1997-10-16
申请人： ZymoGenetics, Inc.
发明人： Deisher, Theresa A. , Conklin, Darrell C. , Raymond, Fenella C. , Bukowski, Thomas R. , Holderman, Susan D. , Hansen, Brigit , Sheppard, Paul O.
IPC分类号： C12N15/18 , C07K14/50 , C07K16/22 , C07K19/00 , C12N5/10 , A61K38/18
CPC分类号： C12N5/0657 , A61K38/00 , A61K47/62 , A61K47/6835 , C07K14/50 , C07K16/22 , C07K2319/00 , C12N2501/119
摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF-5, a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
摘要翻译：本发明涉及用于zFGF-5（FGF家族的新成员）的多核苷酸和多肽分子。多肽和编码它们的多核苷酸对于肌肉细胞是增殖性的，并且可以用于重建心脏组织和改善心脏功能。本发明还包括对zFGF-5多肽的抗体。

8. 发明公开

EP1424393A3 Mammalian cytokine-like polypeptide-10 审中-公开
标题翻译：来自哺乳动物Cytokinähnliches多肽 - 10
公开(公告)号：EP1424393A3
公开(公告)日：2004-06-09
申请号：EP04002769.0
申请日：1998-11-25
申请人： Zymogenetics Inc
发明人： Conklin, Darrell C. , Haldeman, Betty A. , Grossmann, Angelika
IPC分类号： C12N15/12 , C07K14/52 , C07K16/24 , A61K38/19 , G01N33/53
CPC分类号： C07K14/54 , A01K67/027 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/52 , C12N2799/021
摘要： Use of a mammalian cytokine-like polypeptide, called Zcyto10, and polynucleotides encoding the same, for the manufacture of a medicament for the prevention or treatment of an autoimmune disease or condition. In a preferred embodiment, said use is for treating a disease or condition selected from the group consisting of immune dependent diabetes mellitus (IDDM), multiple sclerosis, rheumatoid arthritis, cancer cell growth or proliferation, asthma, bronchitis, thrombocytopenia in cancer patients due to chemotherapy or radiation therapy, psoriasis, eczema, and dry skin conditions.

9. 发明公开

EP2105446A3 Cytokine receptor zalpha11 有权
标题翻译：细胞因子受体zalpha11
公开(公告)号：EP2105446A3
公开(公告)日：2010-07-07
申请号：EP09165460.8
申请日：1999-09-23
申请人： ZymoGenetics, Inc.
发明人： Presnell, Scott R. , Conklin, Darrell C. , Novak, Julia E , Hammond, Angela K.
IPC分类号： C12N15/12 , C07K14/715 , C07K16/28
CPC分类号： C07K16/2866 , C07K14/715
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo . Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo . The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefore and antibodies thereto.

10. 发明公开

EP2105446A2 Cytokine receptor zalpha11 有权
标题翻译： Zytokinrezeptor Zalpha11
公开(公告)号：EP2105446A2
公开(公告)日：2009-09-30
申请号：EP09165460.8
申请日：1999-09-23
申请人： ZymoGenetics, Inc.
发明人： Presnell, Scott R. , Conklin, Darrell C. , Novak, Julia E , Hammond, Angela K.
IPC分类号： C07K14/715 , C07K16/28
CPC分类号： C07K16/2866 , C07K14/715
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo . Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo . The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefore and antibodies thereto.
摘要翻译：公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zalpha11，一种新的细胞因子受体。多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞的增殖和/或发育的配体的方法。配体结合受体多肽也可用于在体外和体内阻断配体活性。编码zalpha11的多核苷酸位于染色体16上，可用于鉴定与人类疾病状态相关的基因组区域。本发明还包括用于生产蛋白质的方法，因此使用它们及其抗体。

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