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1. 发明授权

EP2648772B1 CROSSLINKED POLYMERS INCLUDING ONE OR MORE ANTIOXIDANTS, METHODS FOR MAKING SAME AND METHODS FOR SELECTING ANTIOXIDANTS 有权转让
公开(公告)号：EP2648772B1
公开(公告)日：2019-04-17
申请号：EP11806015.1
申请日：2011-12-05
申请人： Zimmer, Inc.
发明人： THOMAS, Brian , ACKER, Dean , GSELL, Ray , STARK, Norman
IPC分类号： C08L23/06 , A61L2/16 , A61L27/50 , A61L27/16

2. 发明公开

EP2635623A1 MODIFIED POLYMERIC MATERIALS AND METHODS MODIFYING POLYMERIC MATERIALS 失效
标题翻译：改性聚合物材料与方法进行修改高分子材料
公开(公告)号：EP2635623A1
公开(公告)日：2013-09-11
申请号：EP11788643.2
申请日：2011-11-02
申请人： Zimmer, Inc.
发明人： THOMAS, Brian , YAKIMICKI, Donald , POPOOLA, Oludele , WALLICK, Michael
IPC分类号： C08J3/12 , A61L27/14
CPC分类号： A61L27/16 , A61L27/50 , B29C43/02 , C08J3/28 , C08L23/06
摘要： Methods of forming polymeric articles using plasma treated polymer resins, and orthopedic implants comprising a polymeric article wherein the polymeric article has reactive groups bonded to polymer molecules in an interior region of the polymeric article.

3. 发明授权

EP2648772B8 CROSSLINKED POLYMERS INCLUDING ONE OR MORE ANTIOXIDANTS, METHODS FOR MAKING SAME AND METHODS FOR SELECTING ANTIOXIDANTS 有权转让
公开(公告)号：EP2648772B8
公开(公告)日：2019-06-12
申请号：EP11806015.1
申请日：2011-12-05
申请人： Zimmer, Inc.
发明人： THOMAS, Brian , ACKER, Dean , GSELL, Ray , STARK, Norman
IPC分类号： C08L23/06 , A61L2/16 , A61L27/50 , A61L27/16

4. 发明授权

EP2173792B1 MULTI-POLYMER HYDROGELS 失效
标题翻译：水凝胶多种聚合物
公开(公告)号：EP2173792B1
公开(公告)日：2011-12-14
申请号：EP08796762.6
申请日：2008-07-29
申请人： ZIMMER INC.
发明人： THOMAS, Brian , ZHANG, Kai
IPC分类号： C08J3/075
CPC分类号： A61L27/52 , C08J3/075 , C08J2300/00 , C08J2329/04
摘要： The invention provides a multi-polymer hydrogel article having a first polymeric, water-swellable material and a second polymeric material, organized such that a first region substantially comprises the first polymeric, water-swellable material, a second region adjacent the first region comprises a mixture of the first polymeric, water-swellable material and the second polymeric material, and a third region adjacent the second region substantially comprises the second polymeric material. The article exhibits an increasing concentration gradient of the second polymeric material moving from the first region, through the second region, to the third region. The invention also provides methods for forming a multi-polymer hydrogel article by (a) forming a hydrogel structure using a first polymeric, water-swellable material, (b) creating an aerogel structure having a plurality of open pores by dehydrating the hydrogel structure, (c) contacting the aerogel structure with a second polymeric material to incorporate the second polymeric material into at least a portion of the plurality of open pores to form the multi-polymer hydrogel article, and (d) rehydrating the multi-polymer hydrogel article.

5. 发明授权

EP2598153B1 SYNTHETIC SYNOVIAL FLUID COMPOSITIONS AND METHODS FOR MAKING THE SAME 有权
标题翻译：合成SYNOVIAZUSAMMENSETZUNGEN及其制备方法
公开(公告)号：EP2598153B1
公开(公告)日：2014-05-14
申请号：EP11746459.4
申请日：2011-07-27
申请人： Zimmer, Inc.
发明人： STARK, Norman , STRECKENBACH, Maria , GILCHRIST, Seth , SCHWENKE, Thorsten , THOMAS, Brian
IPC分类号： C10M125/24 , A61K31/728 , A61K35/16 , A61K38/38 , A61K38/17 , A61K45/06 , A61K31/685
CPC分类号： A61K35/16 , A61K31/685 , A61K31/728 , A61K38/1722 , A61K38/38 , A61K45/06 , A61K2300/00
摘要： Artificial or synthetic synovial fluids and methods for making such fluids are disclosed. The fluid includes selected proteins, phospholipids and hyaluronic acid and mimics the properties of human synovial fluid.

6. 发明公开

EP2185210A2 HYDROGELS WITH GRADIENT 审中-公开
标题翻译：水凝胶与梯度
公开(公告)号：EP2185210A2
公开(公告)日：2010-05-19
申请号：EP08796828.5
申请日：2008-07-30
申请人： ZIMMER INC.
发明人： LIU, Kaifeng , THOMAS, Brian , CHARLEBOIS, Steven
IPC分类号： A61L27/52 , A61L27/56 , B32B7/02 , B32B27/30
CPC分类号： B32B7/02 , A61L27/50 , A61L27/52 , B32B27/08 , B32B27/30 , Y10T428/24942
摘要： The present invention provides a hydrogel article having a multi-layered structure and exhibiting a gradient in polymer molecular weight. The invention also provides a method of forming a hydrogel article having a multi-layered structure and exhibiting a gradient in polymer molecular weight.

7. 发明公开

EP2173792A2 MULTI-POLYMER HYDROGELS 失效
标题翻译：水凝胶多种聚合物
公开(公告)号：EP2173792A2
公开(公告)日：2010-04-14
申请号：EP08796762.6
申请日：2008-07-29
申请人： ZIMMER INC.
发明人： THOMAS, Brian , ZHANG, Kai
IPC分类号： C08J3/075
CPC分类号： A61L27/52 , C08J3/075 , C08J2300/00 , C08J2329/04
摘要： The invention provides a multi-polymer hydrogel article having a first polymeric, water-swellable material and a second polymeric material, organized such that a first region substantially comprises the first polymeric, water-swellable material, a second region adjacent the first region comprises a mixture of the first polymeric, water-swellable material and the second polymeric material, and a third region adjacent the second region substantially comprises the second polymeric material. The article exhibits an increasing concentration gradient of the second polymeric material moving from the first region, through the second region, to the third region. The invention also provides methods for forming a multi-polymer hydrogel article by (a) forming a hydrogel structure using a first polymeric, water-swellable material, (b) creating an aerogel structure having a plurality of open pores by dehydrating the hydrogel structure, (c) contacting the aerogel structure with a second polymeric material to incorporate the second polymeric material into at least a portion of the plurality of open pores to form the multi-polymer hydrogel article, and (d) rehydrating the multi-polymer hydrogel article.

8. 发明公开

EP1998823A2 METHODS OF PREPARING HYDROGEL COATINGS 审中-公开
标题翻译：用于生产水凝胶涂层
公开(公告)号：EP1998823A2
公开(公告)日：2008-12-10
申请号：EP07759243.4
申请日：2007-03-23
申请人： Zimmer, Inc.
发明人： HAWKINS, Michael, E. , PLETCHER, Dirk, L. , THOMAS, Brian , ZHANG, Kai , BRINKERHUFF, Hallie, E.
IPC分类号： A61L27/34 , A61L27/50 , A61L27/52
CPC分类号： A61L27/52 , A61L27/28 , A61L27/50 , A61L2420/02 , A61L2430/24 , Y10T428/31536 , Y10T428/31678
摘要： The present invention provides hydrogel coated, implantable medical devices and 10 methods of coating hydrogels onto implantable medical devices. In one embodiment, a hydrogel coated medical device is formed by 12 physically treating a surface of the medical device, 14 chemically treating the surface, 16 applying a hydrogel precursor and then 18 crosslmking the hydrogel precursor to form a hydrogel coating on the surface of the medical device. The present invention may be particularly applicable for coating articulating surfaces on implantable medical devices such as artificial joints.

9. 发明公开

EP1957124A2 METHODS OF BONDING OR MODIFYING HYDROGELS USING IRRADIATION 审中-公开
标题翻译：方法进行结合或修改水凝胶的辐射
公开(公告)号：EP1957124A2
公开(公告)日：2008-08-20
申请号：EP06839157.2
申请日：2006-12-07
申请人： ZIMMER INC.
发明人： THOMAS, Brian , ZHANG, Kai , HUDGINS, Garryl , HODOREK, Robert
IPC分类号： A61L27/00
CPC分类号： A61L24/06 , A61L24/0031 , A61L27/16 , A61L27/52 , C08L29/04
摘要： This invention provides methods and processes to attach or bond hydrogels to suitable surfaces using irradiation techniques and also provides methods and processes to create crosslinked regions in hydrogel articles using these irradiation techniques. Specifically, lasers at wavelengths tuned to the irradiation absorption bands of hydroxyl groups, carboxylic acid groups or water may be used to attach or bond hydrogels to surfaces such as soft tissue and hydrogel surfaces or to crosslink regions in hydrogel articles.

10. 发明授权

EP2640430B1 CERAMIC MONOBLOCK IMPLANTS WITH OSSEOINTEGRATION FIXATION SURFACES 失效转让
标题翻译：具有OSSEOINTEGRATION固定表面的陶瓷单块植入物
公开(公告)号：EP2640430B1
公开(公告)日：2016-03-09
申请号：EP11793584.1
申请日：2011-11-16
申请人： Zimmer, Inc.
发明人： POPOOLA, Oludele , MILLER, David , ANDERSON, Jeffrey , THOMAS, Brian
IPC分类号： A61F2/28 , A61L27/06 , A61L27/10 , A61L27/30 , A61L27/56
CPC分类号： A61F2/28 , A61L27/06 , A61L27/10 , A61L27/306

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