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1. 发明授权

EP2648772B1 CROSSLINKED POLYMERS INCLUDING ONE OR MORE ANTIOXIDANTS, METHODS FOR MAKING SAME AND METHODS FOR SELECTING ANTIOXIDANTS 有权转让
公开(公告)号：EP2648772B1
公开(公告)日：2019-04-17
申请号：EP11806015.1
申请日：2011-12-05
申请人： Zimmer, Inc.
发明人： THOMAS, Brian , ACKER, Dean , GSELL, Ray , STARK, Norman
IPC分类号： C08L23/06 , A61L2/16 , A61L27/50 , A61L27/16

2. 发明公开

EP2635623A1 MODIFIED POLYMERIC MATERIALS AND METHODS MODIFYING POLYMERIC MATERIALS 失效
标题翻译：改性聚合物材料与方法进行修改高分子材料
公开(公告)号：EP2635623A1
公开(公告)日：2013-09-11
申请号：EP11788643.2
申请日：2011-11-02
申请人： Zimmer, Inc.
发明人： THOMAS, Brian , YAKIMICKI, Donald , POPOOLA, Oludele , WALLICK, Michael
IPC分类号： C08J3/12 , A61L27/14
CPC分类号： A61L27/16 , A61L27/50 , B29C43/02 , C08J3/28 , C08L23/06
摘要： Methods of forming polymeric articles using plasma treated polymer resins, and orthopedic implants comprising a polymeric article wherein the polymeric article has reactive groups bonded to polymer molecules in an interior region of the polymeric article.

3. 发明授权

EP2648772B8 CROSSLINKED POLYMERS INCLUDING ONE OR MORE ANTIOXIDANTS, METHODS FOR MAKING SAME AND METHODS FOR SELECTING ANTIOXIDANTS 有权转让
公开(公告)号：EP2648772B8
公开(公告)日：2019-06-12
申请号：EP11806015.1
申请日：2011-12-05
申请人： Zimmer, Inc.
发明人： THOMAS, Brian , ACKER, Dean , GSELL, Ray , STARK, Norman
IPC分类号： C08L23/06 , A61L2/16 , A61L27/50 , A61L27/16

4. 发明授权

EP2173792B1 MULTI-POLYMER HYDROGELS 失效
标题翻译：水凝胶多种聚合物
公开(公告)号：EP2173792B1
公开(公告)日：2011-12-14
申请号：EP08796762.6
申请日：2008-07-29
申请人： ZIMMER INC.
发明人： THOMAS, Brian , ZHANG, Kai
IPC分类号： C08J3/075
CPC分类号： A61L27/52 , C08J3/075 , C08J2300/00 , C08J2329/04
摘要： The invention provides a multi-polymer hydrogel article having a first polymeric, water-swellable material and a second polymeric material, organized such that a first region substantially comprises the first polymeric, water-swellable material, a second region adjacent the first region comprises a mixture of the first polymeric, water-swellable material and the second polymeric material, and a third region adjacent the second region substantially comprises the second polymeric material. The article exhibits an increasing concentration gradient of the second polymeric material moving from the first region, through the second region, to the third region. The invention also provides methods for forming a multi-polymer hydrogel article by (a) forming a hydrogel structure using a first polymeric, water-swellable material, (b) creating an aerogel structure having a plurality of open pores by dehydrating the hydrogel structure, (c) contacting the aerogel structure with a second polymeric material to incorporate the second polymeric material into at least a portion of the plurality of open pores to form the multi-polymer hydrogel article, and (d) rehydrating the multi-polymer hydrogel article.

5. 发明授权

EP2635623B1 MODIFIED POLYMERIC MATERIALS AND METHODS MODIFYING POLYMERIC MATERIALS 失效
标题翻译：改性聚合物材料与方法进行修改高分子材料
公开(公告)号：EP2635623B1
公开(公告)日：2015-01-21
申请号：EP11788643.2
申请日：2011-11-02
申请人： Zimmer, Inc.
发明人： THOMAS, Brian , YAKIMICKI, Donald , POPOOLA, Oludele , WALLICK, Michael
IPC分类号： C08J3/12 , A61L27/14 , A61L27/16 , C08L23/06 , A61L27/50 , B29C43/02 , C08J3/28
CPC分类号： A61L27/16 , A61L27/50 , B29C43/02 , C08J3/28 , C08L23/06

6. 发明公开

EP2648772A1 CROSSLINKED POLYMERS INCLUDING ONE OR MORE ANTIOXIDANTS, METHODS FOR MAKING SAME AND METHODS FOR SELECTING ANTIOXIDANTS 有权转让
标题翻译：与一个或更多的抗氧化剂，法交联聚合物用于生产和抗氧化剂的选择
公开(公告)号：EP2648772A1
公开(公告)日：2013-10-16
申请号：EP11806015.1
申请日：2011-12-05
申请人： Zimmer, Inc.
发明人： THOMAS, Brian , ACKER, Dean , GSELL, Ray , STARK, Norman
IPC分类号： A61L27/16 , A61L27/50
CPC分类号： A61L27/16 , A61L2/16 , A61L27/50 , A61L27/505 , C08L23/06
摘要： The present disclosure is directed to polymer compositions having one or more antioxidants providing high crosslink density and improved oxidation resistance to the polymer composition and methods for making same. Such polymer compositions can be advantageously used to make orthopedic implants. The disclosure also provides methods for selecting antioxidants providing desirable properties to the polymer composition. In one embodiment, a measure of OIT can be used to select the antioxidant and antioxidant blend. In another embodiment, measurements of OIT and OI-rate can be used to select the one or more antioxidants. In an other embodiment, the product of OIT and crosslink density can be calculated to predict wear resistance and oxidation resistance of a polymer composition including one or more antioxidants.

7. 发明公开

EP2635316A1 POLYMER ARTICLES HAVING CHEMICALLY BONDED AGENTS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：与结合化学药剂及其制造方法的聚合物制品
公开(公告)号：EP2635316A1
公开(公告)日：2013-09-11
申请号：EP11788644.0
申请日：2011-11-02
申请人： Zimmer, Inc.
发明人： THOMAS, Brian , PLETCHER, Dirk , YAKIMICKI, Donald
IPC分类号： A61L27/16
CPC分类号： A61L31/048 , A61L27/16 , C08L23/06 , C08L23/12
摘要： Modified polymeric articles having modifying agents dispersed within and bonded to an interior region of the article. Methods of modifying polymer materials used to form polymeric articles, and methods of making polymeric articles from polymer particles having modifying agents bonded thereto.

8. 发明公开

EP2598153A1 SYNTHETIC SYNOVIAL FLUID COMPOSITIONS AND METHODS FOR MAKING THE SAME 有权
标题翻译：合成SYNOVIAZUSAMMENSETZUNGEN及其制备方法
公开(公告)号：EP2598153A1
公开(公告)日：2013-06-05
申请号：EP11746459.4
申请日：2011-07-27
申请人： Zimmer, Inc.
发明人： STARK, Norman , STRECKENBACH, Maria , GILCHRIST, Seth , SCHWENKE, Thorsten , THOMAS, Brian
IPC分类号： A61K35/16
CPC分类号： A61K35/16 , A61K31/685 , A61K31/728 , A61K38/1722 , A61K38/38 , A61K45/06 , A61K2300/00
摘要： Artificial or synthetic synovial fluids and methods for making such fluids are disclosed. The fluid includes selected proteins, phospholipids and hyaluronic acid and mimics the properties of human synovial fluid.

9. 发明授权

EP2598153B1 SYNTHETIC SYNOVIAL FLUID COMPOSITIONS AND METHODS FOR MAKING THE SAME 有权
标题翻译：合成SYNOVIAZUSAMMENSETZUNGEN及其制备方法
公开(公告)号：EP2598153B1
公开(公告)日：2014-05-14
申请号：EP11746459.4
申请日：2011-07-27
申请人： Zimmer, Inc.
发明人： STARK, Norman , STRECKENBACH, Maria , GILCHRIST, Seth , SCHWENKE, Thorsten , THOMAS, Brian
IPC分类号： C10M125/24 , A61K31/728 , A61K35/16 , A61K38/38 , A61K38/17 , A61K45/06 , A61K31/685
CPC分类号： A61K35/16 , A61K31/685 , A61K31/728 , A61K38/1722 , A61K38/38 , A61K45/06 , A61K2300/00
摘要： Artificial or synthetic synovial fluids and methods for making such fluids are disclosed. The fluid includes selected proteins, phospholipids and hyaluronic acid and mimics the properties of human synovial fluid.

10. 发明公开

EP2185210A2 HYDROGELS WITH GRADIENT 审中-公开
标题翻译：水凝胶与梯度
公开(公告)号：EP2185210A2
公开(公告)日：2010-05-19
申请号：EP08796828.5
申请日：2008-07-30
申请人： ZIMMER INC.
发明人： LIU, Kaifeng , THOMAS, Brian , CHARLEBOIS, Steven
IPC分类号： A61L27/52 , A61L27/56 , B32B7/02 , B32B27/30
CPC分类号： B32B7/02 , A61L27/50 , A61L27/52 , B32B27/08 , B32B27/30 , Y10T428/24942
摘要： The present invention provides a hydrogel article having a multi-layered structure and exhibiting a gradient in polymer molecular weight. The invention also provides a method of forming a hydrogel article having a multi-layered structure and exhibiting a gradient in polymer molecular weight.

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