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1. 发明授权

EP0861261B1 NUCLEOTIDE AND PROTEIN SEQUENCES OF VERTEBRATE DELTA GENES AND METHODS BASED THEREON 失效
标题翻译： NUARATID-UND PROTEINSEQUENZEN VON DELTA-GENEN VON VERTEBRATEN UND DARAUF BASIERENDE METHODEN
公开(公告)号：EP0861261B1
公开(公告)日：2009-09-09
申请号：EP96924334.4
申请日：1996-06-28
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LIMITED , Yale University
发明人： ISH-HOROWICZ, David , HENRIQUE, Domingo, M., P. , LEWIS, Julian, H. , ARTAVANIS-TSAKONAS, Spyridon , GRAY, Grace, E.
IPC分类号： C07H17/00 , C07K14/00 , C12P21/06 , C12N5/00 , C12N15/00 , C07K14/705
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , C07K2319/00
摘要： The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain amino-terminal to the DSL domain, transmembrane region, or one or more EGF-like repeats of a Delta protein, or any combination of the foregoing. Antobidies to Delta, its derivatives and analogs, are additionally provided. Methods of production of the Delta proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Delta genes, from Xenopus, chick, mouse, and human, are provided.
摘要翻译：本发明涉及脊椎动物Delta基因的核苷酸序列及其编码的蛋白质的氨基酸序列以及衍生物（例如片段）及其类似物。在具体实施方案中，脊椎动物Delta蛋白是人蛋白质。本发明还涉及包含Delta蛋白的一个或多个结构域的Delta的片段（及其衍生物和类似物），包括但不限于细胞内结构域，细胞外结构域，DSL结构域，DSL结构域的氨基末端，跨膜区域，或一种或多种Delta蛋白质的EGF样重复序列，或上述的任何组合。另外还提供了针对三角洲及其衍生物和类似物的抗体。还提供了通过重组方法生产Delta蛋白质，衍生物和类似物的方法。提供了治疗和诊断方法和药物组合物。在具体实例中，提供了来自爪蟾，小鸡，小鼠和人的孤立的Delta基因。

2. 发明授权

EP0861261B9 NUCLEOTIDE AND PROTEIN SEQUENCES OF VERTEBRATE DELTA GENES AND METHODS BASED THEREON 失效
标题翻译：核苷酸和DELTA基因的蛋白序列和基于事实的方法脊椎动物
公开(公告)号：EP0861261B9
公开(公告)日：2010-02-24
申请号：EP96924334.4
申请日：1996-06-28
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LIMITED , Yale University
发明人： ISH-HOROWICZ, David , HENRIQUE, Domingo, M., P. , LEWIS, Julian, H. , ARTAVANIS-TSAKONAS, Spyridon , GRAY, Grace, E.
IPC分类号： C07H17/00 , C07K14/00 , C12P21/06 , C12N5/00 , C12N15/00 , C07K14/705
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , C07K2319/00

3. 发明授权

EP0813545B1 NUCLEOTIDE AND PROTEIN SEQUENCES OF VERTEBRATE SERRATE GENES AND METHODS BASED THEREON 失效
标题翻译：锯齿基因从脊椎动物和基于事实的过程核苷酸和蛋白质序列
公开(公告)号：EP0813545B1
公开(公告)日：2009-09-09
申请号：EP96911262.2
申请日：1996-03-07
申请人： Yale University , IMPERIAL CANCER RESEARCH TECHNOLOGY LIMITED
发明人： ISH-HOROWICZ, David , HENRIQUE, Domingos, M., P. , LEWIS, Julian, H. , MYAT, Anna M., 4 Chawley Lane , ARTAVANIS-TSAKONAS, Spyridon , MANN, Robert, S. , GRAY, Grace E., Apartment 4
IPC分类号： C07K14/00 , A01N37/18 , A01N43/04 , C07H17/00 , C12N5/00 , C12P21/06
CPC分类号： C07K14/465 , A61K38/00 , C07K14/43504 , C07K14/43581 , C07K14/46 , C07K14/463 , C07K14/705
摘要： The present invention relates to nucleotide sequences of vertebrate Serrate genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the Serrate protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of a vertebrate Serrate which comprise one or more domains of the Serrate protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, cysteine rich domain, transmembrane region, membrane-associated region, or one or more EGF-like repeats of a Serrate protein, or any combination of the foregoing. Antibodies to vertebrate Serrate, its derivatives and analogs, are additionally provided. Methods of production of the vertebrate Serrate proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided.In specific examples, isolated Serrate genes, from chick, mouse, Xenopus and human, are provided.

4. 发明公开

EP0861261A1 NUCLEOTIDE AND PROTEIN SEQUENCES OF VERTEBRATE DELTA GENES AND METHODS BASED THEREON 失效
标题翻译：核苷酸和DELTA基因的蛋白序列和基于事实的方法脊椎动物
公开(公告)号：EP0861261A1
公开(公告)日：1998-09-02
申请号：EP96924334.0
申请日：1996-06-28
申请人： IMPERIAL CANCER RESEARCH TECHNOLOGY LIMITED , YALE UNIVERSITY
发明人： ISH-HOROWICZ, David , HENRIQUE, Domingo, M., P. , LEWIS, Julian, H. , ARTAVANIS-TSAKONAS, Spyridon , GRAY, Grace, E.
IPC分类号： C12N15 , A61K31 , A61K38 , A61K39 , A61K48 , A61P25 , A61P35 , C07K14 , C07K16 , C12N5 , C12P21 , C12R1
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , C07K2319/00
摘要： The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain amino-terminal to the DSL domain, transmembrane region, or one or more EGF-like repeats of a Delta protein, or any combination of the foregoing. Antobidies to Delta, its derivatives and analogs, are additionally provided. Methods of production of the Delta proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Delta genes, from Xenopus, chick, mouse, and human, are provided.

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