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3. 发明公开

EP1724265A4 ANTICANCER AGENT 审中-公开
标题翻译： KREBSMITTEL
公开(公告)号：EP1724265A4
公开(公告)日：2008-11-26
申请号：EP04772348
申请日：2004-08-27
申请人： WAN STATION CO LTD
发明人： ONO NOBUFUMI
IPC分类号： C07D257/10 , A61K31/395 , A61P35/00
CPC分类号： C07D257/10 , A61K31/395
摘要： A new anticancer agent which is less apt to be discharged from cancer cells and is suitable for use in a local treatment of cancer cells. The anticancer agent contains a catenane compound represented by the chemical formula (I): [Chemical formula 1] (I) as an active ingredient. This catenane compound is a kind of compound called amide type [2]catenane, and consists of two molecular rings fitted into each other like a chain and not linked to each other by covalent bonding. Because of this, the molecular shape is apt to change and incorporation through a receptor is relatively difficult. However, once the compound is introduced into cancer cells, cancer cell proliferation is inhibited.
摘要翻译：一种新型的抗癌剂，不易从癌细胞中排出，适用于局部治疗癌细胞。抗癌剂含有由化学式（I）表示的c系化合物：[化学式1]（I）作为有效成分。该c化合物是一种称为酰胺型[2] c化合物的化合物，由两个彼此嵌合的分子环组成，并且不通过共价键相互连接。因此，分子形状易于改变，并且通过受体结合相对困难。但是，一旦将化合物引入癌细胞中，癌细胞增殖受到抑制。

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