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1. 发明授权

EP0343357B1 Hollow fiber bioreactor culture system and method 失效转让
标题翻译：中空纤维生物反应器文化系统与方法
公开(公告)号：EP0343357B1
公开(公告)日：1993-03-24
申请号：EP89106379.4
申请日：1989-04-11
申请人： W.R. Grace & Co.-Conn.
发明人： Wolfe, Richard Alan , Heifetz, Aaron Herman , Braatz, James Anthony , Donofrio, David M.
IPC分类号： C12M3/00 , C12M1/34
CPC分类号： C12M25/10 , C12M29/16 , C12M41/14 , C12M41/26 , Y10S435/813

2. 发明公开

EP0367362A3 Chemically modified hydrophilic prepolymers and polymers 失效
标题翻译：化学改性的亲水性聚合物和聚合物
公开(公告)号：EP0367362A3
公开(公告)日：1990-10-03
申请号：EP89250066.1
申请日：1989-10-27
申请人： W.R. Grace & Co.-Conn.
发明人： Braatz, James Anthony , Heifetz, Aaron Herman , Wolfe, Richard Alan , Luthra, Narender Pal
IPC分类号： C08G18/10 , C08G18/32 , C08G18/38 , C08G18/28
CPC分类号： C08G18/4837 , A61K47/59 , A61K47/60 , C08G18/10 , C08G18/283 , C08G18/4833 , C08G2210/00 , Y10S521/905 , Y10S528/904 , C08G18/388 , C08G18/3821 , C08G18/3271 , C08G18/3863 , C08G18/3855 , C08G18/3876
摘要： A class of modified hydrophilic prepolymers and polymers is disclosed which are characterized by their specific reactivity. Isocyanate-capped oxyethylene-based prepolymers are modified by reacting with a compound having an isocyanate-reactive group which is a sulfhydryl group, an amino group, a hydroxyl group or a carboxyl group, and a non-isocyanate-reactive group, in quantities sufficient to modify at least a portion of the isocyanate groups of the prepolymer. Where said first functional group is an amino group contained in a diamine or polyamine compound or is a carboxyl group, the modifying compound is present in quantities sufficient to modify all or substantially all of the isocyanate groups of the prepolymer.

3. 发明公开

EP0367362A2 Chemically modified hydrophilic prepolymers and polymers 失效
标题翻译： Chemisch modifizierte亲水性Prepolymere und Polymere。
公开(公告)号：EP0367362A2
公开(公告)日：1990-05-09
申请号：EP89250066.1
申请日：1989-10-27
申请人： W.R. Grace & Co.-Conn.
发明人： Braatz, James Anthony , Heifetz, Aaron Herman , Wolfe, Richard Alan , Luthra, Narender Pal
IPC分类号： C08G18/10 , C08G18/32 , C08G18/38 , C08G18/28
CPC分类号： C08G18/4837 , A61K47/59 , A61K47/60 , C08G18/10 , C08G18/283 , C08G18/4833 , C08G2210/00 , Y10S521/905 , Y10S528/904 , C08G18/388 , C08G18/3821 , C08G18/3271 , C08G18/3863 , C08G18/3855 , C08G18/3876
摘要： A class of modified hydrophilic prepolymers and polymers is disclosed which are characterized by their specific reactivity. Isocyanate-capped oxyethylene-based prepolymers are modified by reacting with a compound having an isocyanate-reactive group which is a sulfhydryl group, an amino group, a hydroxyl group or a carboxyl group, and a non-isocyanate-reactive group, in quantities sufficient to modify at least a portion of the isocyanate groups of the prepolymer. Where said first functional group is an amino group contained in a diamine or polyamine compound or is a carboxyl group, the modifying compound is present in quantities sufficient to modify all or substantially all of the isocyanate groups of the prepolymer.
摘要翻译：公开了一类改性的亲水性预聚物和聚合物，其特征在于它们的具体反应性。通过与具有巯基，氨基，羟基或羧基的异氰酸酯反应性基团和非异氰酸酯反应性基团的化合物反应来改性异氰酸酯封端的氧化乙烯基预聚物，其量足够以修饰预聚物的至少一部分异氰酸酯基团。当所述第一官能团是二胺或多胺化合物中所含的氨基或羧基时，所述改性化合物的存在量足以改变所述预聚物的所有或基本上所有的异氰酸酯基团。

4. 发明授权

EP0367362B1 Chemically modified hydrophilic prepolymers and polymers 失效
标题翻译：化学改性的亲水性预聚物和聚合物。
公开(公告)号：EP0367362B1
公开(公告)日：1994-06-15
申请号：EP89250066.1
申请日：1989-10-27
申请人： W.R. Grace & Co.-Conn.
发明人： Braatz, James Anthony , Heifetz, Aaron Herman , Wolfe, Richard Alan , Luthra, Narender Pal
IPC分类号： C08G18/10 , C08G18/32 , C08G18/38 , C08G18/28
CPC分类号： C08G18/4837 , A61K47/59 , A61K47/60 , C08G18/10 , C08G18/283 , C08G18/4833 , C08G2210/00 , Y10S521/905 , Y10S528/904 , C08G18/388 , C08G18/3821 , C08G18/3271 , C08G18/3863 , C08G18/3855 , C08G18/3876

5. 发明公开

EP0343357A1 Hollow fiber bioreactor culture system and method 失效转让
标题翻译： Einrichtung und Verfahren zur Kultur在einem Hohlfaserbioreaktor。
公开(公告)号：EP0343357A1
公开(公告)日：1989-11-29
申请号：EP89106379.4
申请日：1989-04-11
申请人： W.R. Grace & Co.-Conn.
发明人： Wolfe, Richard Alan , Heifetz, Aaron Herman , Braatz, James Anthony , Donofrio, David M.
IPC分类号： C12M3/00 , C12M1/34
CPC分类号： C12M25/10 , C12M29/16 , C12M41/14 , C12M41/26 , Y10S435/813
摘要： The cell culturing system of the present invention includes a tubular membrane, e.g. hollow fiber, cartridge. Provision is made for the continuous circulation of a nutrient-containing medium through the tube side of the cartridge by pumping the nutrient-containing medium in an endless loop. The cells to be cultured are placed within the cartridge on the shell side where the desired extracellular products are accumulated. Nutrients are assimilated into the cell culture through the semipermeable tubular membranes and waste products are removed by passing through the semipermeable membranes into the recirculating nutrient-containing medium. Within the endless loop (20) are located a circulating pump (24), an oxygenator (26) and a pH probe. The system additionally includes a variable delivery feed pump (22) for continuously injecting fresh nutrient-containing solution into the loop, which feed pump is operated at a rate responsive to the measured pH. A portion of the stream exiting the cartridge is continuously split off at a rate identical to that for the introduction for fresh nutrient-containing solution in order to maintain cellular waste products at a suitably low level. The conventional nutrient-solution preparation reservoir has been eliminated from the loop in order to simplify the system and reduce the potential points of entry for contaminating microorganisms. The membrane cartridge is mounted with its longitudinal axis at approximately 60° with respect to the horizontal.
摘要翻译：本发明的细胞培养系统包括管状膜，例如，中空纤维，墨盒。规定通过在无限循环中泵送含营养物质介质，使含营养物质的介质通过筒的管侧连续循环。待培养的细胞被放置在所需细胞外产物积累的壳侧上的筒内。通过半透性管状膜吸收营养物质进入细胞培养物，并通过将半透膜通入含循环营养物质的介质中除去废物。无环回路（20）内设有循环泵（24），氧合器（26）和pH探头。该系统还包括用于将新鲜的含营养物溶液连续注入环中的可变输送进料泵（22），该进料泵以响应于测量的pH的速率运行。离开料筒的一部分流以与用于新鲜营养液的溶液的引入相同的速率连续分离，以便将细胞废物保持在适当的低水平。已经从循环中消除了常规营养液制备储存器，以简化系统并减少污染微生物的潜在进入点。膜片盒的纵轴相对于水平面大约为60度。

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