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1. 发明公开

EP3227830A1 METHODS, SYSTEMS, AND APPARATUSES FOR QUANTITATIVE ANALYSIS OF HETEROGENEOUS BIOMARKER DISTRIBUTION 有权
标题翻译：用于定量分析非均匀生物标记分布的方法，系统和装置
公开(公告)号：EP3227830A1
公开(公告)日：2017-10-11
申请号：EP15813713.3
申请日：2015-12-03
申请人： Ventana Medical Systems, Inc. , Oregon Health & Science University
发明人： BARNES, Michael , CHAFIN, David , GARSHA, Karl , GROGAN, Thomas M. , ROBERTS, Esteban , STEVENS, Benjamin , VENTURA, Frank , CHEFD'HOTEL, Christophe , SHANMUGAM, Kandavel , GRAY, Joe , RAMUNNO-JOHNSON, Damien , VU, Tothu (Tania)
IPC分类号： G06K9/00 , G06K9/62 , G06T7/00 , G01N33/50 , G06T7/40
CPC分类号： G06T7/0012 , G06K9/00147 , G06K9/3233 , G06K9/4652 , G06K9/6222 , G06T7/11 , G06T7/90 , G06T2207/10036 , G06T2207/10056 , G06T2207/10064 , G06T2207/20032 , G06T2207/20104 , G06T2207/20152 , G06T2207/30024 , G06T2207/30096
摘要： Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.
摘要翻译：本文公开了用于检测和描述细胞样品中异质性的方法，系统和装置。针对细胞样品的图像内的一个或多个感兴趣区域（AOI）生成多个视场（FOV）。来自每个FOV的高光谱或多光谱数据组织成包含一个或多个z层的图像堆栈，每个z层包含FOV中每个像素处的单个标记的强度数据。将聚类分析应用于图像堆栈，其中聚类算法对具有跨越z轴的层的可检测标记强度的相似比率的像素进行分组，从而生成具有相似表达模式的多个聚类。

2. 发明公开

EP3839812A2 SYSTEMS AND METHODS FOR GENERATING REGIONS IN AN IMAGE ENCOMPASSING TUMOR CELLS 审中-实审
公开(公告)号：EP3839812A2
公开(公告)日：2021-06-23
申请号：EP20202876.7
申请日：2015-09-03
申请人： Ventana Medical Systems, Inc.
发明人： BARNES, Michael , CHEN, Ting , CHEFD'HOTEL, Christophe , TUBBS, Alisa , ASCIERTO, Paolo A.
IPC分类号： G06K9/00 , G01N33/50 , G06T7/00 , G06T7/11
摘要： Imaging systems, methods, and apparatuses for automatically identifying fields of view (FOVs) for regions in an image encompassing melanoma is disclosed. In embodiments and in further aspects of the present invention, a computer-implemented method is disclosed for a tumor region based immune score computation. The method, in accordance with the present invention, involves identifying regions, for example, tumor areas or regions around a tumor area, partitioning a whole slide image or portion of a whole slide image into multiple regions related to the tumor, selecting FOVs within each identified region, and computing a number of cells present in each FOV. An immune score and/or immune-related score is generated based on the cells counted in each FOV.

3. 发明公开

EP3345161A1 IMAGE PROCESSING SYSTEMS AND METHODS FOR DISPLAYING MULTIPLE IMAGES OF A BIOLOGICAL SPECIMEN 有权
公开(公告)号：EP3345161A1
公开(公告)日：2018-07-11
申请号：EP16757236.1
申请日：2016-08-25
申请人： Ventana Medical Systems, Inc. , Providence Health & Services - Oregon
发明人： BARNES, Michael , CHEN, Ting , CHEFD'HOTEL, Christophe , TUBBS, Alisa , BIFULCO, Carlo
IPC分类号： G06T11/60 , G06F19/26
CPC分类号： G06T7/0016 , G06F3/04817 , G06F3/04883 , G06F19/26 , G06K9/469 , G06T3/0006 , G06T7/11 , G06T11/005 , G06T11/60 , G06T2200/24 , G06T2207/20192
摘要： A system and method of displaying of multiple simultaneous views of a same region of a biological tissue sample. Logical instructions are executed by a processor to perform operations such as receiving a plurality of images of the biological tissue sample, converting the plurality of images to a common reference frame based on the individual metadata of each image, and arranging the plurality of images into a display pattern for simultaneous viewing of different aspects of the imaged biological tissue sample on a display screen. The plurality of images is produced by preprocessing images of the biological tissue sample. Each image shows a view mode of a same region of the biological tissue sample, and each image contains metadata that describe spatial orientation, such as the translation, rotation, and magnification, of the image to bring the plurality of images to a common view.

4. 发明公开

EP3839812A3 SYSTEMS AND METHODS FOR GENERATING REGIONS IN AN IMAGE ENCOMPASSING TUMOR CELLS 审中-实审
公开(公告)号：EP3839812A3
公开(公告)日：2021-09-01
申请号：EP20202876.7
申请日：2015-09-03
申请人： Ventana Medical Systems, Inc.
发明人： BARNES, Michael , CHEN, Ting , CHEFD'HOTEL, Christophe , TUBBS, Alisa , ASCIERTO, Paolo A.
IPC分类号： G06K9/00 , G01N33/50 , G06T7/00 , G06T7/11
摘要： Imaging systems, methods, and apparatuses for automatically identifying fields of view (FOVs) for regions in an image encompassing melanoma is disclosed. In embodiments and in further aspects of the present invention, a computer-implemented method is disclosed for a tumor region based immune score computation. The method, in accordance with the present invention, involves identifying regions, for example, tumor areas or regions around a tumor area, partitioning a whole slide image or portion of a whole slide image into multiple regions related to the tumor, selecting FOVs within each identified region, and computing a number of cells present in each FOV. An immune score and/or immune-related score is generated based on the cells counted in each FOV.

5. 发明公开

EP3729369A2 COMPUTATIONAL PATHOLOGY APPROACH FOR RETROSPECTIVE ANALYSIS OF TISSUE-BASED COMPANION DIAGNOSTIC DRIVEN CLINICAL TRIAL STUDIES 审中-公开
公开(公告)号：EP3729369A2
公开(公告)日：2020-10-28
申请号：EP18833184.7
申请日：2018-12-17
申请人： Ventana Medical Systems, Inc.
发明人： BARNES, Michael , CHEFD'HOTEL, Christophe , CHUKKA, Srinivas
IPC分类号： G06T7/00 , G16H50/30

6. 发明公开

EP3195191A2 SYSTEMS AND METHODS FOR CALCULATING IMMUNE SCORES 有权
标题翻译：用于计算免疫比例的系统和方法
公开(公告)号：EP3195191A2
公开(公告)日：2017-07-26
申请号：EP15767102.5
申请日：2015-09-03
申请人： Ventana Medical Systems, Inc.
发明人： BARNES, Michael , CHEN, Ting , CHEFD'HOTEL, Christophe , TUBBS, Alisa , ASCIERTO, Paolo A.
IPC分类号： G06K9/00 , G01N33/50 , G06T7/00
摘要： Embodiments disclosed herein are directed, among other things, to imaging systems, methods, and apparatuses for automatically identifying fields of view (FOVs) for regions in an image encompassing tumor are disclosed. In embodiments and in further aspects of the present invention, a computer-implemented method is disclosed for a tumor region based immune score computation. The method, in accordance with the present invention, involves identifying regions, for example, tumor areas or regions around a tumor area, partitioning a whole slide image or portion of a whole slide image into multiple regions related to the tumor, selecting FOVs within each identified region, and computing a number of cells present in each FOV. An immune score and/or immune-related score may be generated based on the cells counted in each FOV.
摘要翻译：公开了用于自动识别包含黑素瘤的图像中的区域的视野（FOV）的成像系统，方法和设备。在本发明的实施例和其他方面中，公开了一种用于基于肿瘤区域的免疫分数计算的计算机实现的方法。根据本发明，该方法涉及识别区域，例如肿瘤区域或肿瘤区域周围的区域，将整个载玻片图像或整个载玻片图像的一部分分成与肿瘤相关的多个区域，在每个区域内选择FOV 识别的区域，并计算每个FOV中存在的细胞的数量。基于在每个FOV中计数的细胞生成免疫分数和/或免疫相关分数。

7. 发明公开

EP3100205A1 ADAPTIVE CLASSIFICATION FOR WHOLE SLIDE TISSUE SEGMENTATION 有权
标题翻译：自适应KLASSIFIZIERUNG VON GEWEBESEGMENTIERUNG MITVOLLSTÄNDIGENOBJEKTTRGERN
公开(公告)号：EP3100205A1
公开(公告)日：2016-12-07
申请号：EP15703003.2
申请日：2015-01-23
申请人： Ventana Medical Systems, Inc.
发明人： BREDNO, Joerg , CHUKKA, Srinivas , CHEN, Ting , CHEFD'HOTEL, Christophe , NGUYEN, Kien
IPC分类号： G06K9/00 , G06K9/46 , G06K9/62 , G06K9/66
CPC分类号： G06K9/00147 , G06K9/4642 , G06K9/4652 , G06K9/623 , G06K9/66 , G06T7/0012 , G06T7/11 , G06T7/40 , G06T7/74 , G06T2207/20081 , G06T2207/30024
摘要： A method of segmenting images of biological specimens using adaptive classification to segment a biological specimen into different types of tissue regions. The segmentation is performed by, first, extracting features from the neighborhood of a grid of points (GPs) sampled on the whole-slide (WS) image and classifying them into different tissue types. Secondly, an adaptive classification procedure is performed where some or all of the GPs in a WS image are classified using a pre-built training database, and classification confidence scores for the GPs are generated. The classified GPs with high confidence scores are utilized to generate an adaptive training database, which is then used to re-classify the low confidence GPs. The motivation of the method is that the strong variation of tissue appearance makes the classification problem more challenging, while good classification results are obtained when the training and test data origin from the same slide.
摘要翻译：使用自适应分类将生物样本的图像分割成不同类型的组织区域的方法。通过以下步骤执行分割：首先，从全滑动（WS）图像上采样的点格网（GP）的邻域提取特征，并将其分类成不同的组织类型。其次，使用预先构建的训练数据库对WS图像中的一些或全部GP进行分类，并且生成GP的分类置信度得分，进行自适应分类过程。具有高置信度分数的分类GP用于生成适应性训练数据库，然后将其用于重新分类低置信度GP。该方法的动机是，组织外观的强烈变化使得分类问题更具挑战性，而当训练和测试数据来自同一幻灯片时，可以获得良好的分类结果。

8. 发明授权

EP3195191B1 SYSTEMS AND METHODS FOR CALCULATING IMMUNE SCORES 有权
公开(公告)号：EP3195191B1
公开(公告)日：2020-10-21
申请号：EP15767102.5
申请日：2015-09-03
申请人： Ventana Medical Systems, Inc.
发明人： BARNES, Michael , CHEN, Ting , CHEFD'HOTEL, Christophe , TUBBS, Alisa , ASCIERTO, Paolo A.
IPC分类号： G06K9/52 , G06K9/46 , G06T7/11 , G06K9/00 , G06T7/00

9. 发明授权

EP3389011B1 IMAGE ANALYSIS SYSTEM FOR DETECTING EDGES OF A NUCLEUS 有权
公开(公告)号：EP3389011B1
公开(公告)日：2019-06-12
申请号：EP18170775.3
申请日：2015-06-30
申请人： Ventana Medical Systems, Inc.
发明人： CHUKKA, Srinivas , CHEFD'HOTEL, Christophe , WANG, Xiuzhong
IPC分类号： G06T7/12 , G06T7/13 , G06T7/136 , G06T7/194

10. 发明公开

EP3345122A1 AUTOMATED ANALYSIS OF CELLULAR SAMPLES HAVING INTERMIXING OF ANALYTICALLY DISTINCT PATTERNS OF ANALYTE STAINING 有权
公开(公告)号：EP3345122A1
公开(公告)日：2018-07-11
申请号：EP16767160.1
申请日：2016-09-01
申请人： Ventana Medical Systems, Inc.
发明人： NGUYEN, Kien , CHEFD'HOTEL, Christophe
IPC分类号： G06K9/00
CPC分类号： G06K9/00147 , G06K9/0014 , G06K9/6269
摘要： Systems and methods discussed herein include, among other things, a method comprising quantifying analyte staining of a biological compartment in a region in which said staining is intermixed with analyte staining of an analytically-distinct distinct biological compartment. Disclosed systems and methods include, for example, a system and method for identifying membrane staining of an analyte of interest in regions where diffuse membrane staining is intermixed with cytoplasmic staining and/or punctate staining is disclosed. Disclosed systems and methods include, for example, a system and method for quantifying membrane staining of an analyte of interest in tissue or cytological samples having regions in which membrane staining is intermixed with cytoplasmic staining and/or punctate staining.

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