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1. 发明授权

EP2707505B1 SPECTRAL IMAGING FOR MEASUREMENT OF NUCLEAR PATHOLOGY FEATURES IN CANCER CELLS PREPARED FOR IN SITU ANALYSIS 有权转让
标题翻译：测量核病理性的光谱成像特点在肿瘤细胞原位分析
公开(公告)号：EP2707505B1
公开(公告)日：2016-06-08
申请号：EP12725639.4
申请日：2012-05-07
申请人： Ventana Medical Systems, Inc. , Cornell University
发明人： DEMICHELIS, Francesca , GARSHA, Karl , MILLER, Phillip C , NAGLE, Ray B , OTTER, Michael , PESTANO, Gary Anthony , RUBIN, Mark A.
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q1/6841 , C12Q2600/156 , G01N33/57407 , G06F19/18 , H01H35/146 , H01M2/34 , H01M2/345 , H01M2/347 , H01M2/348 , H01M2220/20
摘要： In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.

2. 发明公开

EP2707505A2 SPECTRAL IMAGING FOR MEASUREMENT OF NUCLEAR PATHOLOGY FEATURES IN CANCER CELLS PREPARED FOR IN SITU ANALYSIS 有权转让
标题翻译：测量核病理性的光谱成像特点在肿瘤细胞原位分析
公开(公告)号：EP2707505A2
公开(公告)日：2014-03-19
申请号：EP12725639.4
申请日：2012-05-07
申请人： Ventana Medical Systems, Inc. , Cornell University
发明人： DEMICHELIS, Francesca , GARSHA, Karl , MILLER, Phillip C , NAGLE, Ray B , OTTER, Michael , PESTANO, Gary Anthony , RUBIN, Mark A.
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q1/6841 , C12Q2600/156 , G01N33/57407 , G06F19/18 , H01H35/146 , H01M2/34 , H01M2/345 , H01M2/347 , H01M2/348 , H01M2220/20
摘要： In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.

3. 发明公开

EP3865870A1 ACCURATELY CALCULATING ACOUSTIC TIME-OF-FLIGHT 审中-实审
公开(公告)号：EP3865870A1
公开(公告)日：2021-08-18
申请号：EP21156002.4
申请日：2015-12-17
申请人： Ventana Medical Systems, Inc.
发明人： OTTER, Michael , STEVENS, Benjamin , BAUER, Daniel
IPC分类号： G01N29/44 , G01N29/07 , G01N29/024
摘要： The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of-flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.

4. 发明授权

EP3368885B1 METHODS AND SYSTEMS FOR ANALYZING THE QUALITY OF TISSUE FIXATION USING MID-INFRARED SPECTROSCOPY 有权
公开(公告)号：EP3368885B1
公开(公告)日：2020-06-03
申请号：EP16790939.9
申请日：2016-10-28
申请人： Ventana Medical Systems, Inc. , F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： CHAFIN, David , OTTER, Michael , PETRICH, Wolfgang , BAUER, Daniel , KROEGER-LUI, Niels
IPC分类号： G01N21/35

5. 发明授权

EP2542883B1 PROCESSING SYSTEM FOR PROCESSING SPECIMENS USING ACOUSTIC ENERGY 有权
公开(公告)号：EP2542883B1
公开(公告)日：2019-10-02
申请号：EP11709549.7
申请日：2011-03-04
申请人： Ventana Medical Systems, Inc.
发明人： OTTER, Michael , CHAFIN, David , PIERSON, Abbey , TAFT, Jefferson, Curtis
IPC分类号： G01N29/024 , G01N29/44 , G01N1/30

6. 发明公开

EP2951543A2 SYSTEMS AND METHODS FOR CALIBRATING, CONFIGURING AND VALIDATING AN IMAGING DEVICE OR SYSTEM FOR MULTIPLEX TISSUE ASSAYS 有权
标题翻译：系统和校准，设定和验证MULTIPLEX面料测试的一个成像设备和系统的方法
公开(公告)号：EP2951543A2
公开(公告)日：2015-12-09
申请号：EP14702810.4
申请日：2014-01-31
申请人： Ventana Medical Systems, Inc.
发明人： GARSHA, Karl , OTTER, Michael , PESTANO, Gary Anthony , VENTURA, Frank
IPC分类号： G01J3/28 , G01J3/44 , G01N21/27 , G02B21/36 , G01J3/10
CPC分类号： G01J3/0297 , G01J3/10 , G01J3/28 , G01J3/2823 , G01J3/44 , G01J3/4406 , G01J2003/2826 , G01N21/274 , G02B21/365 , G06K9/0014 , G06T7/80
摘要： A system and method for characterization and/or calibration of performance of a multispectral imaging (MSI) system equipping the MSI system for use with a multitude of different fluorescent specimens while being independent on optical characteristics of a specified specimen and providing an integrated system level test for the MSI system. A system and method are adapted to additionally evaluate and express operational parameters performance of the MSI system in terms of standardized units and/or to determine the acceptable detection range of the MSI system.
摘要翻译：一种用于表征和/或的多光谱成像（MSI）系统装备使用的MSI系统用不同的荧光的标本，同时在指定的标本的光学特性是独立和集成的系统级测试提供的大量的性能校准系统和方法为MSI系统。一种系统和方法是angepasst额外评估和表示在标准化的单元和/或确定性矿井MSI系统的可接受的检测范围方面MSI系统的操作参数的性能。

7. 发明公开

EP2676118A1 METHOD FOR TISSUE SAMPLE FIXATION 有权
标题翻译： VERFAHREN ZUR FIXIERUNG VON GEWEBEPROBEN
公开(公告)号：EP2676118A1
公开(公告)日：2013-12-25
申请号：EP12706226.3
申请日：2012-02-17
申请人： Ventana Medical Systems, Inc.
发明人： OTTER, Michael , PIERSON, Abbey , CHAFIN, David , ROBERTS, Esteban
IPC分类号： G01N1/30
摘要： An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0° C. to at least 15° C. The second temperature typically is from greater than about 22° C. to about 55° C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.
摘要翻译：导致第一温度的醛固定溶液第一次接触组织样品，此外，在第二温度高于第一温度的第二温度下使醛固定液接触组织样品。第一时间段通常为约15分钟至约4小时，第一温度通常为大于0℃至至少15℃。第二温度通常为大于约22℃至约55℃，第二时间段为约1小时至约4小时。使用这个过程，改进的组织形态和IHC染色以及翻译后修饰信号的优异保存已经在大约4小时内完成，与室温方案相比，24小时，并且观察到更均匀的形态和抗原保存。

9. 发明授权

EP3250323B1 TRANSPORTER SYSTEMS, ASSEMBLIES AND ASSOCIATED METHODS FOR TRANSPORTING TISSUE SAMPLES 有权
公开(公告)号：EP3250323B1
公开(公告)日：2020-12-09
申请号：EP16703735.7
申请日：2016-01-26
申请人： Ventana Medical Systems, Inc.
发明人： CRUM, Nathan , KELLER, Timothy , LAING, Alastair , OTTER, Michael , PETRE, Marvin Arthur , PIGMAN, Elizabeth , SHINGLER, Taylor , STANISLAW, Stacey , STEVENS, Benjamin
IPC分类号： B01L3/00 , G01N1/30 , G01N1/31 , B01L7/04

10. 发明授权

EP3234581B1 OBTAINING A DIFFUSIVITY CONSTANT 有权转让
公开(公告)号：EP3234581B1
公开(公告)日：2020-09-23
申请号：EP15813403.1
申请日：2015-12-17
申请人： Ventana Medical Systems, Inc.
发明人： OTTER, Michael , STEVENS, Benjamin , BAUER, Daniel
IPC分类号： G01N29/024 , G01N29/07 , G01N29/44

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