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1. 发明公开

EP1663359A1 DRY POWDER INHALER 有权
标题翻译：干粉吸入器
公开(公告)号：EP1663359A1
公开(公告)日：2006-06-07
申请号：EP04768486.5
申请日：2004-09-15
申请人： Vectura Limited
发明人： HARMER, Quentin , CLARKE, Roger, William 1a Winders Lane Histon , EASON, Stephen, William
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M11/001 , A61M15/003 , A61M15/0036 , A61M15/0045 , A61M15/0048 , A61M2202/064 , A61M2206/16
摘要： An Inhaler for delivering an aerosolised dose of a powdered drug for inhalation by a user is disclosed. The inhaler comprises a drug entreinment device to a receive a package having a piercable lid containing a dose to be delivered, the device including a drug outlet tube terminating with a primary piercing element to pierce an opening in said lid when a package is located in the inhaler, a secondary piercing member to pierce a plurality of peripheral openings in said lid and, an airflow path to enable the supply of a charge of gas into the package via said peripheral openings to scour the interior of a pierced package such that all or substantially all of the dose is entrained in the gas and flows out of the package via the drug outlet tube. A medicament pack is also disclosed.
摘要翻译：公开了一种用于递送雾化剂量的粉末药物以供用户吸入的吸入器。该吸入器包括用于容纳具有可穿透盖子的包装的药物夹带装置，该包装包含待递送的剂量，该装置包括药物出口管，该药物出口管终止于主要穿刺元件以在包装位于该主体中时刺穿该盖中的开口吸入器，用于刺穿所述盖中的多个周边开口的次要刺穿构件，以及气流路径，以使得能够经由所述周边开口向所述包装供给气体填充物以冲刷刺穿的包装的内部，使得全部或基本上所有剂量都夹带在气体中，并通过药物出口管流出包装。还公开了药物包装。

2. 发明公开

EP1684834A1 INHALER 有权转让
标题翻译：气雾
公开(公告)号：EP1684834A1
公开(公告)日：2006-08-02
申请号：EP04768942.7
申请日：2004-10-18
申请人： Vectura Limited
发明人： EASON, Stephen, William , CLARKE, Roger, William , HARMER, Quentin , EVANS, Peter, Alan , AHERN, David, Gregory
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0025 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0051 , A61M15/0078 , A61M15/0086 , A61M15/0091 , A61M2202/064
摘要： An inhaler (1) is disclosed. It comprises a housing (2) to receive a strip (6) of blisters (6a) each having a puncturable lid (6c) and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator (3) operable to sequentially move each blister into alignment with a blister piercing member (7, 9). The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway.
摘要翻译：公开了一种吸入器（1），其包括容纳多个泡罩（6a）的壳体（2），每个泡罩具有可刺穿的盖子（6c）并且包含一定剂量的用户吸入的药物。吸入器包括接口（5），用户吸入剂量的药剂（5），水泡延伸的分度轮（23）和可操作以使所述分度轮旋转的致动器（3），以顺序地将每个泡罩移动到对准具有泡罩穿孔构件（9）。致动器还可操作以使泡罩刺穿构件刺穿对准的泡罩的盖子，使得当使用者通过接口管吸入时，产生通过泡罩的气流以夹带其中所含的剂量并将其从泡罩中取出并通过喉舌进入使用者的气道。壳体包括一个室，其中使用的气泡由分度轮进给。

3. 发明公开

EP1663180A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING PREMATURE EJACULATION BY PULMONARY INHALATION 审中-公开
标题翻译：药物组合物早泄经肺吸入治疗
公开(公告)号：EP1663180A1
公开(公告)日：2006-06-07
申请号：EP04768481.6
申请日：2004-09-15
申请人： Vectura Limited
发明人： MORTON, David , STANIFORTH, John , TOBYN, Mike , EASON, Stephen , HARMER, Quentin , GANDERTON, David
IPC分类号： A61K9/72 , A61K31/55 , A61P15/00
CPC分类号： A61M15/0028 , A61K9/0075 , A61M11/001 , A61M15/0036 , A61M15/004 , A61M15/0091 , A61M15/0093 , A61M2202/064 , A61M2205/073
摘要： The present invention relates to improved formulations for the treatment of premature ejaculation and, in particular, relates to the administration of antidepressants by pulmonary inhalation for treating premature ejaculation. Various types of known antidepressants may be used, including tricyclic antidepressants, such as clomipramine.
摘要翻译：本发明涉及改进的式蒸发散早泄的治疗，特别是，通过肺吸入涉及抗抑郁药的给药治疗早泄。公知的各种抗抑郁药可以被使用，包括三环抗抑郁药，：如氯米帕明。

4. 发明公开

EP1670438A2 DRY POWDER COMPOSITION COMPRISING A BENZODIAZEPINE FOR PULMONARY INHALATION 审中-公开
标题翻译：与苯二氮卓肺部吸入干粉组合物
公开(公告)号：EP1670438A2
公开(公告)日：2006-06-21
申请号：EP04768488.1
申请日：2004-09-15
申请人： Vectura Limited
发明人： MORTON, David , GANDERTON, David , STANIFORTH, John , TOBYN, Mike , EASON, Stephen , HARMER, Quentin
IPC分类号： A61K9/14
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/16 , A61K9/1617 , A61K9/1623 , A61K9/1694 , A61K9/50 , A61K31/473 , A61K31/55 , A61K31/5513 , A61K31/727 , B02C19/06
摘要： The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.

5. 发明授权

EP1617820B1 DRY POWER INHALER DEVICES AND DRY POWER FORMULATIONS FOR ENHANCING DOSING EFFICIENCY 有权
标题翻译：干电力吸入器装置和干电力配方，以提高剂量效率
公开(公告)号：EP1617820B1
公开(公告)日：2018-03-21
申请号：EP04727320.6
申请日：2004-04-14
申请人： Vectura Limited
发明人： STANIFORTH, John , MORTON, David , TOBYN, Michael , EASON, Stephen , HARMER, Quentin , GANDERTON, David
IPC分类号： A61K9/16 , A61K47/18 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1682 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M16/207 , A61M2202/064 , A61M2205/073 , A61M2206/16
摘要： The present invention relates to enhancing the dosing efficiency of pharmaceutical dry powder formulations administered by pulmonary inhalation. In particular, the present invention relates to the provision of dry powder inhalers and dry powder compositions which reproducibly achieve a much higher delivered dose of the pharmaceutically active agent than currently achieved.

6. 发明公开

EP1617820A2 DRY POWER INHALER DEVICES AND DRY POWER FORMULATIONS FOR ENHANCING DOSING EFFICIENCY 有权
标题翻译：干粉吸入器和干粉制剂以提高加料器
公开(公告)号：EP1617820A2
公开(公告)日：2006-01-25
申请号：EP04727320.6
申请日：2004-04-14
申请人： Vectura Limited
发明人： STANIFORTH, John , MORTON, David , TOBYN, Michael , EASON, Stephen , HARMER, Quentin , GANDERTON, David
IPC分类号： A61K9/16 , A61K47/18 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1682 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M16/207 , A61M2202/064 , A61M2205/073 , A61M2206/16
摘要： The present invention relates to enhancing the dosing efficiency of pharmaceutical dry powder formulations administered by pulmonary inhalation. In particular, the present invention relates to the provision of dry powder inhalers and dry powder compositions which reproducibly achieve a much higher delivered dose of the pharmaceutically active agent than currently achieved.

7. 发明公开

EP1613323A1 PHARMACEUTICAL COMPOSITIONS COMPRISING APOMORHINE FOR PULMONARY INHALATION 审中-公开
标题翻译：筹备工作对于吸入阿扑吗啡
公开(公告)号：EP1613323A1
公开(公告)日：2006-01-11
申请号：EP04727312.3
申请日：2004-04-14
申请人： Vectura Limited
发明人： STANIFORTH, John Nicholas , MORTON, David , TOBYN, Michael , EASON, Stephen , HARMER, Quentin , GANDERTON, David
IPC分类号： A61K31/473 , A61K9/00 , A61P15/10
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/14 , A61K9/145 , A61K31/4745
摘要： The present invention relates to inhalable formulations of apomorphine or its pharmaceutically acceptable salts or esters for use in treating sexual dysfunction. The present invention also relates to methods for preparing the apomorphine formulations as well as to methods for treatment of sexual dysfunction using said formulations and inhalers including said formulations. The present invention further relates to the use of apomorphine in the manufacture of a medicament for treating sexual dysfunction.

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