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1. 发明公开

EP0630042A3 Method of high mass resolution scanning of an ion trap spectrometer 失效
标题翻译：一种用于在离子阱质谱仪扫描与高分辨率质谱法。
公开(公告)号：EP0630042A3
公开(公告)日：1997-05-14
申请号：EP94303845.5
申请日：1994-05-27
申请人： VARIAN ASSOCIATES, INC.
发明人： Wells, Gregory J. , Marquette, Edward G. , March, Raymond E. , Londry, Frank A.
IPC分类号： H01J49/42
CPC分类号： H01J49/0009 , H01J49/4275
摘要： A method of using a quadrupole ion trap mass spectrometer for high resolution mass spectroscopy is disclosed. High resolution of a mass spectrum of a desired species is achieved by first using a slow scanning rate and by first ridding the trap of unwanted ions. Accurate mass calibration is achieved by using a reference compound of known mass and using a second supplemental AC dipole voltage to eject the reference ions at nearly the same time as the sample ions of interest are ejected from the trap. This eliminates the need to scan the trap between the masses of the sample and reference ions. Space charge in the trap is held constant, thereby eliminating a major source of mass axis instability, by using the results of one scan to control the ionization time during the next scan. Preferably, during ionization a broadband supplemental dipole voltage is applied to the ion trap to rid it of unwanted ions. During a portion of the ionization time the broadband signal is constructed to retain only sample ions in the ion trap, and during the remainder of the ionization time the broadband signal is constructed to retain both sample and reference ions in the ion trap. By adjusting the relative lengths of the two portions of the ionization time the total space charge in the ion trap can be held constant notwithstanding variations in sample ion concentration.

2. 发明公开

EP0630041A2 Selective collisional dissociation 失效
标题翻译：消除毒素。
公开(公告)号：EP0630041A2
公开(公告)日：1994-12-21
申请号：EP94303818.2
申请日：1994-05-26
申请人： VARIAN ASSOCIATES, INC.
发明人： March, Raymond E. , Londry, Frank A. , Catinella, Silvia
IPC分类号： H01J49/42
CPC分类号： H01J49/4295 , H01J49/005 , H01J49/0468
摘要： A variable cooling time is imposed on ions in a quadrupole ion trap prior to excitation through border effect operation. Continuous variation of the cooling time brings about continuous variation of the selected ion internal energy when subjected to the boundary effect such that the boundary effect competes more favorably with ion loss in the trap, and fragmentation reaction channels having successively greater energies of activation can be accessed preferentially.
摘要翻译：在通过边界效应操作激发之前，在四极离子阱中对离子施加可变的冷却时间。当受到边界效应时，冷却时间的连续变化导致所选择的离子内部能量的连续变化，使得边界效应与陷阱中的离子损失更有利地竞争，并且可以访问具有连续更大的激活能量的碎裂反应通道优先。

3. 发明公开

EP0630041A3 Selective collisional dissociation 失效
标题翻译：选择性碰撞诱导解离。
公开(公告)号：EP0630041A3
公开(公告)日：1997-04-02
申请号：EP94303818.2
申请日：1994-05-26
申请人： VARIAN ASSOCIATES, INC.
发明人： March, Raymond E. , Londry, Frank A. , Catinella, Silvia
IPC分类号： H01J49/42
CPC分类号： H01J49/4295 , H01J49/005 , H01J49/0468
摘要： A variable cooling time is imposed on ions in a quadrupole ion trap prior to excitation through border effect operation. Continuous variation of the cooling time brings about continuous variation of the selected ion internal energy when subjected to the boundary effect such that the boundary effect competes more favorably with ion loss in the trap, and fragmentation reaction channels having successively greater energies of activation can be accessed preferentially.

4. 发明公开

EP0630042A2 Method of high mass resolution scanning of an ion trap spectrometer 失效
标题翻译：亚历山大·巴勒斯坦计算机公司（Massenauflösung）在einem Ionenfallemassenspektrometer。
公开(公告)号：EP0630042A2
公开(公告)日：1994-12-21
申请号：EP94303845.5
申请日：1994-05-27
申请人： VARIAN ASSOCIATES, INC.
发明人： Wells, Gregory J. , Marquette, Edward G. , March, Raymond E. , Londry, Frank A.
IPC分类号： H01J49/42
CPC分类号： H01J49/0009 , H01J49/4275
摘要： A method of using a quadrupole ion trap mass spectrometer for high resolution mass spectroscopy is disclosed. High resolution of a mass spectrum of a desired species is achieved by first using a slow scanning rate and by first ridding the trap of unwanted ions. Accurate mass calibration is achieved by using a reference compound of known mass and using a second supplemental AC dipole voltage to eject the reference ions at nearly the same time as the sample ions of interest are ejected from the trap. This eliminates the need to scan the trap between the masses of the sample and reference ions. Space charge in the trap is held constant, thereby eliminating a major source of mass axis instability, by using the results of one scan to control the ionization time during the next scan. Preferably, during ionization a broadband supplemental dipole voltage is applied to the ion trap to rid it of unwanted ions. During a portion of the ionization time the broadband signal is constructed to retain only sample ions in the ion trap, and during the remainder of the ionization time the broadband signal is constructed to retain both sample and reference ions in the ion trap. By adjusting the relative lengths of the two portions of the ionization time the total space charge in the ion trap can be held constant notwithstanding variations in sample ion concentration.
摘要翻译：公开了一种使用四极离子阱质谱仪进行高分辨率质谱的方法。通过首先使用慢速扫描速率和首先清除不想要的离子的阱来实现所需物质的质谱的高分辨率。通过使用已知质量的参考化合物和使用第二补充AC偶极子电压在与感兴趣的样品离子从捕集器中排出的几乎相同的时间喷射参考离子来实现精确的质量校准。这消除了在样品质量和参比离子之间扫描陷阱的需要。通过使用一次扫描的结果来控制下次扫描期间的电离时间，陷阱中的空间电荷保持恒定，从而消除了质量轴不稳定的主要来源。优选地，在电离期间，将宽带补充偶极电压施加到离子阱以将其除去不想要的离子。在离子化时间的一部分期间，构造宽带信号以仅将样品离子保留在离子阱中，并且在电离时间的剩余时间期间，构造宽带信号以将样品和参考离子保留在离子阱中。通过调整电离时间的两个部分的相对长度，离子阱中的总空间电荷可以保持恒定，尽管样品离子浓度的变化。

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