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1. 发明授权

EP3052125B1 ELASTIN-LIKE POLYPEPTIDE COUPLED TO THERAPEUTIC AGENT FOR DELIVERY DURING PREGNANCY 有权
公开(公告)号：EP3052125B1
公开(公告)日：2020-09-30
申请号：EP14851017.5
申请日：2014-10-01
申请人： University of Mississippi Medical Center
发明人： BIDWELL III, Gene L. , GEORGE, Eric M.
IPC分类号： A61K38/18 , A61K47/64 , C07K14/78 , A61P43/00

2. 发明公开

EP3052125A2 COMPOSITION AND METHOD FOR THERAPEUTIC AGENT DELIVERY DURING PREGNANCY 有权
标题翻译：组合物和方法对于治疗性活化怀孕期间发布
公开(公告)号：EP3052125A2
公开(公告)日：2016-08-10
申请号：EP14851017.5
申请日：2014-10-01
申请人： University of Mississippi Medical Center
发明人： BIDWELL III, Gene L. , GEORGE, Eric M.
IPC分类号： A61K39/00 , A61K38/17
CPC分类号： C07K14/78 , A61K38/005 , A61K38/1866 , A61K47/6435 , C07K7/08 , C07K14/4703 , C07K14/49 , C07K2319/00 , C07K2319/33
摘要： A composition including an elastin-like polypeptide (ELP) coupled to a therapeutic agent is provided. The ELP comprises at least about 5 repeats of the amino acid sequence VPGXG. Further provided is a method of using the composition for therapeutic agent delivery during pregnancy to reduce the amount of the therapeutic agent crossing a placenta in a pregnant subject. The method includes administering to the pregnant subject an effective amount of the composition comprising the ELP coupled to the therapeutic agent.
摘要翻译：提供了一种包括在耦合到治疗剂弹性蛋白样多肽（ELP）的组合物。所述ELP包含至少约5个重复的氨基酸序列的VPGXG。进一步提供的是使用在怀孕期间用于治疗剂递送组合物，以减少交叉在怀孕检测对象胎盘的治疗剂的量的方法。该方法包括给予所述受试者怀孕至有效量的组合物，其包括耦合到所述治疗剂的ELP的。

3. 发明公开

EP3217947A1 KIDNEY-TARGETED DRUG DELIVERY SYSTEMS 有权
标题翻译： KIDNEY-TARGETED药物输送系统
公开(公告)号：EP3217947A1
公开(公告)日：2017-09-20
申请号：EP15859214.7
申请日：2015-11-12
申请人： University of Mississippi Medical Center
发明人： CHADE, Alejandro R. , BIDWELL III, Gene L.
IPC分类号： A61K8/04
CPC分类号： A61K47/64 , A61K38/1866 , A61K38/39 , A61K47/6435 , A61P13/12 , A61K2300/00
摘要： A composition including an elastin-like polypeptide (ELP) coupled to a kidney targeting peptide and. a therapeutic agent is provided. A method of delivering a therapeutic agent to a subject in need thereof comprising: administering to the subject an effective amount of a composition comprising: an elastin-like polypeptide (ELP), a kidney targeting agent coupled to the ELP and a targeting agent and/or a drug binding domain coupled to the ELP, wherein the ELP includes an amino acid sequence having at least about repeats of the amino acid sequence GVPGX (SEQ ID NO: 1), and wherein the composition enhances the deposition and retention of the therapeutic agent in the kidney relative to the non-conjugated therapeutic.
摘要翻译：包含与肾靶向肽偶联的弹性蛋白样多肽（ELP）的组合物。提供治疗剂。向有需要的受试者递送治疗剂的方法，其包括：给受试者施用有效量的组合物，所述组合物包含：弹性蛋白样多肽（ELP），与ELP偶联的肾靶向剂和靶向剂，以及 /或与所述ELP偶联的药物结合结构域，其中所述ELP包含具有至少约氨基酸序列GVPGX（SEQ ID NO：1）的重复序列的氨基酸序列，并且其中所述组合物增强所述治疗剂的沉积和保留相对于非共轭治疗剂而言，在肾中的药物。

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