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3. 发明公开

EP2056801A1 RUTHENIUM II COMPOUNDS 审中-公开
标题翻译：钌II化合物
公开(公告)号：EP2056801A1
公开(公告)日：2009-05-13
申请号：EP07732895.3
申请日：2007-05-21
申请人： The University Court of the University of Edinburgh
发明人： HABTEMARIAM, Abraha , BUGARCIC, Tijana , SADLER, Peter John
IPC分类号： A61K31/00 , A61P35/00
CPC分类号： C07F17/02
摘要： A ruthenium (II) compound of formula (I), or a solvate form thereof for use in a method of therapy, wherein: R1 R2 R3 R4 R5 and R6 are independently selected from H, C1-7alkyl, C5-20aryl, C3-20heterocyclyl, halo, ester, amido, acyl, sulfo, sulfonamido, ether, thioether, azo and amino, or R1 and R2 together with the ring to which they are attached form a saturated or unsaturated carbocyclic or heterocyclic group containing up to three 3- to 8- membered carbocyclic or heterocyclic rings, wherein each carbocyclic or heterocyclic ring may be fused to one or more other carbocyclic or heterocyclic rings; X is halo or a neutral or negatively charged O, N- or S- donor ligand; m is -1, 0, 1 or 2; q is 1, 2 or 3; RC1 and RC2 independently represent one or more optional substituents selected from hydroxy, C1-7 alkoxy, C5-20 aryloxy, C1-7 alkyl, carboxy, C1-7 alkyl ester and C5-20 aryl ester; RN1 and RN2 are independently selected from hydroxy, C1-7 alkoxy, C5-20 aryloxy, C1-7 alkyl, carboxy, C1-7 alkyl ester and C5-20 aryl ester; or RN1 and RN2 together with the pyridine rings to which they are bound form an tricyclic heteraromatic moiety, where the ring formed by RN1 and RN2 together may be optionally substituted by one or more substituents represented by RC3 selected from: hydroxy, C1-7 alkoxy, C5-20 aryloxy, C1-7 alkyl, carboxy, C1-7 alkyl ester and C5-20 aryl ester.
摘要翻译：式（I）的钌（II）化合物或其溶剂化物形式用于治疗方法中，其中：R 1和R 2独立地选自H，C 1-7烷基，C 5-20芳基，杂环基，卤素，酯，酰胺基，酰基，磺基，亚磺酰氨基，醚，硫醚，偶氮和氨基，或者R1和R2与它们所连接的环一起形成饱和或不饱和的碳环或杂环基团， 8元碳环或杂环，其中每个碳环或杂环可以与一个或多个其它碳环或杂环稠合; X是卤素或中性或带负电的O，N-或S-供体配体; m是-1,0,1或2; q是1,2或3; RC 1和RC 2独立地表示选自羟基，C 1-7烷氧基，C 5-20芳氧基，C 1-7烷基，羧基，C 1-7烷基酯和C 5-20芳基酯的一个或多个任选取代基; RN1和RN2独立地选自羟基，C1-7烷氧基，C5-20芳氧基，C1-7烷基，羧基，C1-7烷基酯和C5-20芳基酯; 或RN1和RN2与它们所连接的吡啶环一起形成三环的杂芳族部分，其中由RN1和RN2一起形成的环可以任选地被RC3代表的一个或多个取代基取代，所述取代基选自：羟基，C1-7烷氧基，C 5-20芳氧基，C 1-7烷基，羧基，C 1-7烷基酯和C 5-20芳基酯。

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