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1. 发明授权

EP2501721B1 MULTIVALENT ANTIBODIES COMPRISING FAB-DSFV 有权
标题翻译：包含FAB-DSFV的多价抗体
公开(公告)号：EP2501721B1
公开(公告)日：2017-11-15
申请号：EP10796094.0
申请日：2010-11-17
申请人： UCB Biopharma SPRL
发明人： HUMPHREYS, David Paul , HEYWOOD, Sam Philip , LAWSON, Alastair David Griffiths
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K47/60 , C07K2317/522 , C07K2317/55 , C07K2317/60 , C07K2317/624

2. 发明授权

EP2935336B1 SINGLE LINKER FABFV ANTIBODIES AND METHODS OF PRODUCING SAME 有权转让
公开(公告)号：EP2935336B1
公开(公告)日：2018-07-04
申请号：EP13815506.4
申请日：2013-12-20
申请人： UCB Biopharma SPRL
发明人： DAVE, Emma , HEYWOOD, Sam Philip , HUMPHREYS, David Paul
IPC分类号： C07K16/46 , C07K16/28 , C07K16/18
CPC分类号： C07K16/468 , C07K16/18 , C07K16/2878 , C07K2317/55 , C07K2317/56 , C07K2317/624 , C07K2317/64 , C07K2317/92 , C07K2319/00
摘要： The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I): (Vxx)nVx-Cx-X—V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, n independently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.

3. 发明授权

EP2776466B1 ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 有权转让
标题翻译：白蛋白结合抗体及其结合片段
公开(公告)号：EP2776466B1
公开(公告)日：2017-08-23
申请号：EP12801467.7
申请日：2012-11-09
申请人： UCB Biopharma SPRL
发明人： ADAMS, Ralph , BHATTA, Pallavi , HEYWOOD, Sam Philip , HUMPHREYS, David Paul
IPC分类号： C07K16/18 , C07K16/46 , C07K16/28
CPC分类号： C07K16/18 , C07K16/2878 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/624 , C07K2317/92

4. 发明授权

EP1644412B1 MODIFIED ANTIBODY FAB FRAGMENTS 有权转让
标题翻译：变性Fab抗体片段
公开(公告)号：EP1644412B1
公开(公告)日：2015-09-09
申请号：EP04743158.0
申请日：2004-07-01
申请人： UCB Biopharma SPRL
发明人： HUMPHREYS, David Paul , HEYWOOD, Sam Philip
IPC分类号： A61K39/00 , C07K16/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K2317/55

5. 发明授权

EP2776469B1 ANTIBODY MOLECULES HAVING SPECIFICITY FOR HUMAN OX40 有权转让
公开(公告)号：EP2776469B1
公开(公告)日：2019-04-24
申请号：EP12803508.6
申请日：2012-11-09
申请人： UCB Biopharma SPRL
发明人： ADAMS, Ralph , BHATTA, Pallavi , HEYWOOD, Sam Philip , HUMPHREYS, David Paul
IPC分类号： C07K16/28 , C07K16/44 , C07K16/46 , A61K39/00 , C07K16/00 , A61K39/395

6. 发明公开

EP3390446A1 ANTIBODY MOLECULES WHICH BIND TNF ALPHA 审中-公开
公开(公告)号：EP3390446A1
公开(公告)日：2018-10-24
申请号：EP16822625.6
申请日：2016-12-14
申请人： UCB Biopharma SPRL
发明人： ADAMS, Ralph , BHATTA, Pallavi , DAVE, Emma , HEYWOOD, Sam Philip , HUMPHREYS, David Paul , MARSHALL, Diane
IPC分类号： C07K16/24 , C07K14/525 , A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K14/525 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

7. 发明公开

EP3390445A1 MULTI-SPECIFIC ANTIBODY MOLECULES HAVING SPECIFICITY FOR TNF-ALPHA, IL-17A AND IL-17F 审中-公开
公开(公告)号：EP3390445A1
公开(公告)日：2018-10-24
申请号：EP16822624.9
申请日：2016-12-14
申请人： UCB Biopharma SPRL
发明人： ADAMS, Ralph , BHATTA, Pallavi , DAVE, Emma , HEYWOOD, Sam Philip , HUMPHREYS, David Paul , MARSHALL, Diane , SHAW, Stevan Graham , LIGHTWOOD, Daniel, John
IPC分类号： C07K16/24 , C07K16/18
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/18 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/55 , C07K2317/60 , C07K2317/622 , C07K2317/624 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to multi-specific antibody molecules having specificity for TNF alpha, IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

8. 发明公开

EP2935336A1 SINGLE LINKER FABFV ANTIBODIES AND METHODS OF PRODUCING SAME 有权转让
标题翻译： EINZELLINKER-FABFV-ANTIKÖRPERUND VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP2935336A1
公开(公告)日：2015-10-28
申请号：EP13815506.4
申请日：2013-12-20
申请人： UCB Biopharma SPRL
发明人： DAVE, Emma , HEYWOOD, Sam Philip , HUMPHREYS, David Paul
IPC分类号： C07K16/46 , C07K16/28 , C07K16/18
CPC分类号： C07K16/468 , C07K16/18 , C07K16/2878 , C07K2317/55 , C07K2317/56 , C07K2317/624 , C07K2317/64 , C07K2317/92 , C07K2319/00
摘要： The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I): (Vxx)nVx-Cx-X—V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, n independently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.
摘要翻译：本公开涉及包含三种多肽或由以下三种多肽组成的多特异性抗体分子：a）式（I）的多肽链：（Vxx）nVx-Cx-X-V1; （II）的多肽链：（Vyy）nVy-Cy c）式（III）的多肽：V2其中Vx表示可变结构域，Vxx表示可变结构域，Cx表示恒定区，X表示接头，V表示可变结构域，Vy表示可变结构域，Vyy表示可变结构域，Cy表示恒定区，V2表示可变结构域，n独立地表示0或1，其中式（I）的多肽链和排列式（II）的多肽链使得恒定区Cx和Cy配对，并且可变结构域Vx和Vy配对形成结合结构域，并且任选地在V和V 2之间存在二硫键，特别是其中存在二硫键。本公开还延伸到包含构建体的药物制剂，编码构建体的DNA和包含其的载体。本公开进一步延伸到例如在宿主细胞中表达构建体的方法以及用于配制药物组合物的方法。本公开还涉及在治疗中使用构建体和制剂。

9. 发明授权

EP1644412B2 MODIFIED ANTIBODY FAB FRAGMENTS 有权转让
公开(公告)号：EP1644412B2
公开(公告)日：2018-08-08
申请号：EP04743158.0
申请日：2004-07-01
申请人： UCB Biopharma SPRL
发明人： HUMPHREYS, David Paul , HEYWOOD, Sam Philip
IPC分类号： A61K39/00 , C07K16/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K2317/55
摘要： The present invention provides antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1. Also provided are antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1 to which one or more effector molecules are attached.

10. 发明公开

EP3161007A1 MULTISPECIFIC ANTIBODY CONSTRUCTS 有权转让
标题翻译：多特异性抗体构建体
公开(公告)号：EP3161007A1
公开(公告)日：2017-05-03
申请号：EP15732228.0
申请日：2015-06-25
申请人： UCB Biopharma SPRL
发明人： BHATTA, Pallavi , DAVE, Emma , HEYWOOD, Sam Philip , HUMPHREYS, David Paul
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/94 , C07K2319/00
摘要： The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.
摘要翻译：本发明涉及包含以下或由以下组成的多特异性抗体分子：a）式（I）的多肽链：VH-CH 1 -X-V1; 和b）式（II）的多肽链：VL-CL-Y-V2和包含例如用于治疗的药物制剂。本公开还提供了编码所述多特异性抗体分子的多核苷酸序列，包含所述多核苷酸的载体和包含所述载体和/或多核苷酸序列的宿主细胞。提供了从宿主细胞表达本公开内容的多特异性抗体分子的方法。

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