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1. 发明公开

EP3231457A1 LAMINATED FILM AND SHEET FOR MEDICAL USE 审中-公开
标题翻译：用于医疗用途的层压薄膜和片材
公开(公告)号：EP3231457A1
公开(公告)日：2017-10-18
申请号：EP15867856.5
申请日：2015-12-04
申请人： Toray Industries, Inc. , Nanotheta Co, Ltd.
发明人： HOCHI, Motonori , SEKIDO, Yuki , SAITO, Akihiro , TAKEOKA, Shinji , OHTSUBO, Shinya , HINOKI, Akinari , KINOSHITA, Manabu
IPC分类号： A61L31/00 , A61L15/16 , B32B27/00
CPC分类号： A61L15/28 , A61L15/24 , A61L15/26 , A61L31/042 , A61L31/048 , A61L31/06 , B32B27/00 , B32B27/32 , C08L5/08 , C08L67/04
摘要： The purpose of the present invention is to provide a laminated film that is highly biocompatible and easy to handle, has good pasting ability and contact to an organ tissue and rarely induces infections. The laminated film provided by the present invention, which comprises a polylactic acid-based resin layer and one or more acetylated hyaluronic acid layers laminated on a side of the polylactic acid-based resin layer, is highly flexible and easy to handle, and, when stuck to an adherend with curved surface, the laminated film shows excellent followability, adhesiveness and coating properties to the adherend, since the acetylated hyaluronic acid layer(s) can be removed easily with an aqueous solution from the polylactic acid-based resin layer in a thin film shape. Moreover, the acetylated hyaluronic acid and the polylactic acid-based resin are biodegradable and, therefore, the laminated film is highly compatible with skin and organs such as visceral organs, etc. Thus, the laminated film is optimally usable as a dermal material for external application such as a wound coating material, an adhesion inhibitor and skin care articles.
摘要翻译：本发明的目的是提供一种生物相容性高，操作容易，粘贴性良好，与器官组织接触，极少引起感染的层压薄膜。由聚乳酸系树脂层和层压在聚乳酸系树脂层侧的一个或多个乙酰化透明质酸层构成的本发明提供的层压膜柔韧性高，易于处理，粘附到具有曲面的被粘物上时，由于乙酰化透明质酸层可以容易地用聚乳酸系树脂层中的水溶液除去，因此对被粘物显示优异的追随性，粘附性和涂布性，薄膜形状。此外，乙酰化透明质酸和聚乳酸类树脂是可生物降解的，因此，该层压膜与皮肤和器官如内脏器官等高度相容。因此，该层压膜最佳地可用作外用皮肤材料应用如伤口涂层材料，粘合抑制剂和皮肤护理制品。

2. 发明公开

EP3520825A1 ANTI-CONGLUTINATION MATERIAL 有权转让
公开(公告)号：EP3520825A1
公开(公告)日：2019-08-07
申请号：EP17856413.4
申请日：2017-09-29
申请人： Toray Industries, Inc. , Nanotheta Co., Ltd.
发明人： SAITO, Akihiro , NAKANISHI, Megumi , TANAHASHI, Kazuhiro , ARAKANE, Toru , HOCHI, Motonori , SUZUKI, Ai , OKABAYASHI, Koji , TAKEOKA, Shinji , FUJIE, Toshinori , ISHIDUKA, Yuya , OHTSUBO, Shinya
IPC分类号： A61L15/26 , A61L15/28 , A61L15/64 , A61L31/06 , A61L31/12 , A61L31/14 , A61P41/00
摘要： This invention provides a material for adhesion prevention that can be adhered to biological tissue with certainty and has improved tissue adhesiveness and biodegradability. Such material for adhesion prevention is composed of: a 1- to 1,000-µm-thick water-soluble support layer comprising a water-soluble polymer; and a 1- to 1,000-µm-thick adhesion prevention layer comprising a biodegradable polymer. The biodegradable polymer has a structure in which a branched polyalkylene glycol comprising 3 to 8 terminal hydroxyl groups per molecule is bound to a polyhydroxy alkanoic acid, and a mass ratio of the branched polyalkylene glycol relative to the total mass is 1% to 30%.

3. 发明公开

EP3295966A1 POLYMER FILM, AND LIQUID DISPERSION AND AGGLOMERATE USING SAME 有权
标题翻译：聚合物膜，液体分散体和使用相同的聚合物
公开(公告)号：EP3295966A1
公开(公告)日：2018-03-21
申请号：EP16792702.9
申请日：2016-05-11
申请人： Toray Industries, Inc. , Nanotheta Co, Ltd.
发明人： HOCHI, Motonori , SEKIDO, Yuki , ITAGAKI, Ichiro , ARAKANE, Toru , OHTSUBO, Shinya , TAKEOKA, Shinji , MURATA, Atsushi , FUJII, Mao , ISHIZUKA, Yuya , SHOJI, Shuichi , MIZUNO, Jun , KASAHARA, Takashi
IPC分类号： A61L15/22 , A61L31/00 , C08J5/18
CPC分类号： C08J5/18 , A61K8/04 , A61K8/8117 , A61K8/8152 , A61K8/8176 , A61K8/85 , A61K8/86 , A61L15/22 , A61L15/225 , A61L15/24 , A61L15/26 , A61L31/00 , A61L31/041 , A61L31/048 , A61L31/06 , A61Q19/00 , C08J2325/06 , C08J2333/12 , C08J2367/04 , C08J2467/04 , C08L25/06 , C08L33/12 , C08L67/04
摘要： Provided are: a polymer film characterized in that the average film thickness T 0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation Δ defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm ≤ T 0 ≤ 1000 nm, (b) 0.1 µm ≤ L ≤ 500 µm, (c) 0.01 GPa ≤ E ≤ 4.3 GPa, (d) Δ = 1 - T 1 /T 2 , (e) 0.346E x 10 -9 - 1.499 -9 + 0.316. According to the present invention, a polymer film which is easy to handle and has excellent followability, coatability, adhesiveness, and adherence with respect to organ tissues; and a dispersion liquid and an agglomerate using the same can be provided.
摘要翻译：本发明提供一种聚合物膜，其特征在于，沿着通过二维投影的重心的直线D使得聚合物膜的面积最大化的平均膜厚度T0满足方程（a），平均值从重心到边缘的距离1的值满足方程（b），杨氏模量E满足方程（c），并且由方程（d）定义的厚度偏差Δ满足方程（e）; 以及使用其的分散液和团块。（a）10nm≤T0≤1000nm，（b）0.1μm≤L≤500μm，（c）0.01GPa≤E≤4.3GPa，（d）Δ= 1 -T 1 / T 2，（e）0.346E x 10-9-1.499 <Δ<-0.073E×10-9 + 0.316。根据本发明，提供一种易于处理且具有优异的追随性，涂布性，粘附性和对器官组织的粘附性的聚合物膜; 并且可以提供分散液和使用其的分散液。

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