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1. 发明公开

EP0913161A3 Diagnostic agent for diabetes 有权
标题翻译：对于糖尿病的诊断剂
公开(公告)号：EP0913161A3
公开(公告)日：2000-08-30
申请号：EP98308523.4
申请日：1998-10-19
申请人： Tokyo Gas Co., Ltd.
发明人： Kohno, Tadashi , Hosoi, Isaburo , Ohshima, Junko , Ito, Asuka , Shibata, Kunihiko
IPC分类号： A61K51/04
CPC分类号： A61K51/1206 , A61K49/1815
摘要： The present invention relates to a diagnostic agent for diabetes, comprising a compound labelled with 13 C at least at one specific position selected from the group consisting of the following (a) to (g): (a) galactose, fructose or xylose labelled with 13C at least at one specific position, or a starch composed of glucose units labelled with 13C at least at one specific position; (b) an amino acid labelled with 13C at least at one specific position; (c) lactic acid or citric acid labelled with 13C at least at one specific position; (d) a fatty acid labelled with 13C at least at one specific position; (e) a glyceride labelled with 13C at least at one specific position; (f) glycerol labelled with 13C at least at one specific position; and (g) aminopyrin of which the dimethylamino group at position 4 is labelled with 13C, phenacetin of which the ethoxy group is labelled with 13C at position 1, or methacetin of which the methoxy group is labelled with 13C.

2. 发明公开

EP0913161A2 Diagnostic agent for diabetes 有权
标题翻译：诊断糖尿病
公开(公告)号：EP0913161A2
公开(公告)日：1999-05-06
申请号：EP98308523.4
申请日：1998-10-19
申请人： Tokyo Gas Co., Ltd.
发明人： Kohno, Tadashi , Hosoi, Isaburo , Ohshima, Junko , Ito, Asuka , Shibata, Kunihiko
IPC分类号： A61K51/04
CPC分类号： A61K51/1206 , A61K49/1815
摘要： The present invention relates to a diagnostic agent for diabetes, comprising a compound labelled with 13 C at least at one specific position selected from the group consisting of the following (a) to (g):

(a) galactose, fructose or xylose labelled with 13 C at least at one specific position, or a starch composed of glucose units labelled with 13 C at least at one specific position;
(b) an amino acid labelled with 13 C at least at one specific position;
(c) lactic acid or citric acid labelled with 13 C at least at one specific position;
(d) a fatty acid labelled with 13 C at least at one specific position;
(e) a glyceride labelled with 13 C at least at one specific position;
(f) glycerol labelled with 13 C at least at one specific position; and
(g) aminopyrin of which the dimethylamino group at position 4 is labelled with 13 C, phenacetin of which the ethoxy group is labelled with 13 C at position 1, or methacetin of which the methoxy group is labelled with 13 C.
摘要翻译：本发明涉及糖尿病诊断剂，其包含至少在选自以下（a）至（g）中的至少一个特定位置标记的化合物：（a）半乳糖，果糖或木糖至少在一个特定位置标记为13 C，或由至少在一个特定位置由13 C标记的葡萄糖单元组成的淀粉; （b）至少在一个特定位置用13 C标记的氨基酸; （c）至少在一个特定位置用13 C标记的乳酸或柠檬酸; （d）至少在一个特定位置用13 C标记的脂肪酸; （e）至少在一个特定位置用13 C标记的甘油酯; （f）至少在一个特定位置用13 C标记的甘油; 和（g）其中位置4的二甲基氨基被标记为13 C的氨基吡啶，其中乙氧基在13位被标记为13 C的美沙西丁，其中甲氧基被标记为<13 >℃。

3. 发明公开

EP1304125A3 Diagnostic agent for liver function 有权
标题翻译：对于肝功能的诊断剂
公开(公告)号：EP1304125A3
公开(公告)日：2003-11-26
申请号：EP02029007.8
申请日：1998-10-05
申请人： Tokyo Gas Co., Ltd.
发明人： Kohno, Tadashi , Hosoi, Isaburo , Oshima, Junko , Ito, Asuka , Shibata, Kunihiko
IPC分类号： A61K51/12 , A61K51/04
CPC分类号： A61K51/1206
摘要： The present invention relates to a diagnostic agent for liver function, comprising a compound labelled with 13 C at least at one specific position selected from the group consisting of the following (a) to (c): (a) galactose, labelled with 13C at least at one specific position; (b) a fatty acid labelled with 13C at least at one specific position; (c) a glyceride labelled with 13C at least at one specific position; According to the present invention, a diagnostic agent for liver function which imposes less physical burden on a subject, can give accurate test result immediately, and can be used safely without side effects is provided. The diagnostic agent of the invention is useful for evaluating the liver function of a subject at the time when the test is carried out.

4. 发明公开

EP1304125A2 Diagnostic agent for liver function 有权
标题翻译：肝功能的诊断剂
公开(公告)号：EP1304125A2
公开(公告)日：2003-04-23
申请号：EP02029007.8
申请日：1998-10-05
申请人： Tokyo Gas Co., Ltd.
发明人： Kohno, Tadashi , Hosoi, Isaburo , Oshima, Junko , Ito, Asuka , Shibata, Kunihiko
IPC分类号： A61K51/12 , A61K51/04
CPC分类号： A61K51/1206
摘要： The present invention relates to a diagnostic agent for liver function, comprising a compound labelled with 13 C at least at one specific position selected from the group consisting of the following (a) to (f):

(a) galactose, glucose or xylose labelled with 13 C at least at one specific position or a starch composed of glucose units labelled with 13 C at least at one specific position;
(b) a polar amino acid, heterocyclic amino acid, isoleucine or valine labelled with 13 C at least at one specific position;
(c) a carboxylic acid constituting the glycolytic pathway or the citric acid cycle, labelled with 13 C at least at one specific position;
(d) a fatty acid labelled with 13 C at least at one specific position;
(e) a glyceride labelled with 13 C at least at one specific position; and
(f) glycerol labelled with 13 C at least at one specific position.
According to the present invention, a diagnostic agent for liver function which imposes less physical burden on a subject, can give accurate test result immediately, and can be used safely without side effects is provided. The diagnostic agent of the invention is useful for evaluating the liver function of a subject at the time when the test is carried out.
摘要翻译：本发明涉及用于肝功能的诊断剂，其包含至少在选自下列（a）至（f）的至少一个特定位置上用13C标记的化合物：（a）用（a）标记的半乳糖，葡萄糖或木糖 13C至少在一个特定位置处或由至少在一个特定位置处用13C标记的葡萄糖单位组成的淀粉; （b）至少在一个特定位置用13C标记的极性氨基酸，杂环氨基酸，异亮氨酸或缬氨酸; （c）至少在一个特定位置用13C标记的构成糖酵解途径或柠檬酸循环的羧酸; （d）至少在一个特定位置用13C标记的脂肪酸; （e）至少在一个特定位置用13C标记的甘油酯; 和（f）至少在一个特定位置用13C标记的甘油。根据本发明，提供一种肝脏功能诊断剂，其对受试者施加较少的身体负担，可以立即给出准确的测试结果，并且可以安全地使用而没有副作用。本发明的诊断剂可用于在进行测试时评估受试者的肝功能。

5. 发明公开

EP0966975A2 Diagnostic agents for pancreatic exocrine function 有权
标题翻译：使用13C或14C标记的氨基酸或肽作为胰腺外分泌功能的诊断剂
公开(公告)号：EP0966975A2
公开(公告)日：1999-12-29
申请号：EP99304388.4
申请日：1999-06-04
申请人： Tokyo Gas Co., Ltd.
发明人： Kohno, Tadashi , Hosoi, Isaburo , Ohshima, Junko , Shibata, Kunihiko , Ito, Asuka
IPC分类号： A61K51/08
CPC分类号： A61K51/1206 , A61K49/1815
摘要： A diagnostic agent for pancreatic exocrine function comprising an amino acid or a peptide containing at least one 13 C or 14 C atom, or a pharmaceutically acceptable salt thereof other than Bz-Tyr- 13 C-PABA is provided. A 13 C- or 14 C-labeled compound represented by the following formula (II):

X 2 -R 2 -Y 2 -Z 1 (II)

or a salt thereof,
wherein X 2 is a hydrogen atom or a protecting group,
R 2 is a peptide of 2 to 5 amino acids, an amino acid or a single bond, Y 2 is an amino acid,
Z 1 is an amino acid optionally having a protecting group, and
at least one of the amino acids in R 2 ,Y 2 and Z 1 , or at least one of the protecting groups in X 2 and Z 1 when the protecting groups contain a carbon atom, is 13 C or 14 C-labeled.
摘要翻译：对于胰腺外分泌功能，其包括氨基酸或含有至少一个<13> C或<14>的C原子，或它们的比的Bz-Tyr <13>其他药学上可接受的盐的肽的诊断剂C-PABA设置。由下式表示的<13> C-或<14> C标记的化合物（II）：X2-R2-Y2-Z1或其盐，worin X2是氢原子或保护基团，R 2是一个肽中的氨基酸或一个单键2至5个氨基酸，Y2是一种氨基酸，Z1是氨基酸任选地具有保护基团，和在R 2，Y2and Z1的氨基酸中的至少一个，或至少一个在X2和Z1中的保护基团当保护基团含有的碳原子的，为<13> C或<14> C标记。

6. 发明授权

EP1304124B1 Diagnostic agent for diabetes comprising 13C labelled compound 有权
标题翻译：包含用于糖尿病诊断剂时，13C标记组合物
公开(公告)号：EP1304124B1
公开(公告)日：2008-03-26
申请号：EP03000243.0
申请日：1998-10-19
申请人： TOKYO GAS CO., LTD.
发明人： Kohno, Tadashi , Hosoi, Isaburo , Oshima, Junko , Ito, Asuka , Shibata, Kunihiko
IPC分类号： A61K51/04 , A61P3/00
CPC分类号： A61K51/1206 , A61K49/1815

7. 发明授权

EP0989137B1 Diagnostic agents for pancreatic exocrine function 有权
标题翻译：诊断胰腺外分泌功能
公开(公告)号：EP0989137B1
公开(公告)日：2006-11-02
申请号：EP99307554.8
申请日：1999-09-24
申请人： TOKYO GAS CO., LTD.
发明人： Kohno, Tadashi , Hosoi, Isaburo , Hirayama, Junko , Shibata, Kunihiko , Ito, Asuka
IPC分类号： C08B30/00 , C08B37/16 , C08B37/00 , A61K51/00 , A61K47/26 , A61K51/12 , A61K49/00
CPC分类号： A61K51/0491 , A61K49/06 , A61K49/1815 , A61K49/189 , A61K51/06 , A61K51/1206 , A61K51/1268 , B82Y5/00 , C08B37/00

8. 发明公开

EP0989137A3 Diagnostic agents for pancreatic exocrine function 有权
标题翻译：诊断胰腺外分泌功能
公开(公告)号：EP0989137A3
公开(公告)日：2000-10-11
申请号：EP99307554.8
申请日：1999-09-24
申请人： Tokyo Gas Co., Ltd.
发明人： Kohno, Tadashi , Hosoi, Isaburo , Ohshima, Junko , Shibata, Kunihiko , Ito, Asuka
IPC分类号： C08B30/00 , C08B37/16 , C08B37/00 , A61K51/00 , A61K47/26 , A61K51/12 , A61K49/00
CPC分类号： A61K51/0491 , A61K49/06 , A61K49/1815 , A61K49/189 , A61K51/06 , A61K51/1206 , A61K51/1268 , B82Y5/00 , C08B37/00
摘要： The present invention provides a 13 C-labeled oligosaccharide or polysaccharide or a salt thereof excluding U- 13 C-maltose, 13 C-starch, 1- 13 C-maltotetraose and 1- 13 C-amylose; a derivative of the 13 C-labeled oligosaccharide or polysaccharide or salt thereof; a 13 C-labeled inclusion complex or a salt thereof, which comprises a cyclodextrin or a modified derivative thereof as a host molecule; a 13 C- or 14 C-labeled fluorescein ester compound or a salt thereof; and a diagnostic agents for pancreatic exocrine function comprising these compounds 13 C- or 14 C-labeled.

9. 发明授权

EP0966975B1 Use of 13C or 14C-labelled amino acids or peptides as dignostic agents for pancreatic exocrine function 有权
标题翻译：使用13C或14C标记的氨基酸或肽作为胰腺外分泌功能的诊断剂
公开(公告)号：EP0966975B1
公开(公告)日：2005-09-07
申请号：EP99304388.4
申请日：1999-06-04
申请人： TOKYO GAS CO., LTD.
发明人： Kohno, Tadashi , Hosoi, Isaburo , Ohshima, Junko , Shibata, Kunihiko , Ito, Asuka
IPC分类号： A61K51/08 , A61K51/12 , A61P1/00 , A61P3/00
CPC分类号： A61K51/1206 , A61K49/1815

10. 发明公开

EP0966975A3 Diagnostic agents for pancreatic exocrine function 有权
标题翻译：诊断为胰腺功能exocriene
公开(公告)号：EP0966975A3
公开(公告)日：2002-04-17
申请号：EP99304388.4
申请日：1999-06-04
申请人： Tokyo Gas Co., Ltd.
发明人： Kohno, Tadashi , Hosoi, Isaburo , Ohshima, Junko , Shibata, Kunihiko , Ito, Asuka
IPC分类号： A61K51/08 , A61K51/12
CPC分类号： A61K51/1206 , A61K49/1815
摘要： A diagnostic agent for pancreatic exocrine function comprising an amino acid or a peptide containing at least one 13 C or 14 C atom, or a pharmaceutically acceptable salt thereof other than Bz-Tyr- 13 C-PABA is provided. A 13 C- or 14 C-labeled compound represented by the following formula (II):X 2 -R 2 -Y 2 -Z 1 or a salt thereof, wherein X2 is a hydrogen atom or a protecting group, R2 is a peptide of 2 to 5 amino acids, an amino acid or a single bond, Y2 is an amino acid, Z1 is an amino acid optionally having a protecting group, and at least one of the amino acids in R 2 ,Y 2 and Z 1 , or at least one of the protecting groups in X 2 and Z 1 when the protecting groups contain a carbon atom, is 13 C or 14 C-labeled.

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