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1. 发明公开

EP4190799A1 AMINO ACID SEQUENCE DERIVED FROM SARS-COV-2 AND USE THEREOF 审中-实审
公开(公告)号：EP4190799A1
公开(公告)日：2023-06-07
申请号：EP21851571.6
申请日：2021-07-30
申请人： Toagosei Co., Ltd. , Kyoto University
发明人： YOSHIDA, Tetsuhiko , BAILEYKOBAYASHI, Nahoko , YOSHIDA, Yoshinori
IPC分类号： C07K7/08 , A61K39/215 , A61P31/14 , A61P37/04 , C07K14/165
摘要： The herein disclosed art provides amino acid sequence information that can be used to produce antibodies to protein derived from the novel coronavirus (SARS-CoV-2). Synthetic peptide having the herein disclosed amino acid sequence information is recognized as an antigen in at least one species of mammal; contains any of the following amino acid sequences: (1) MKFLVFLGIITTVAA (SEQ ID NO: 1), (2) MFVFLVLLPLVSSQC (SEQ ID NO: 2), and (3) MKIILFLALITLATC (SEQ ID NO: 3); and has a total number of amino acid residues of not more than 20.

2. 发明公开

EP4332112A1 PEPTIDE FRAGMENT AND USE THEREOF 审中-实审
公开(公告)号：EP4332112A1
公开(公告)日：2024-03-06
申请号：EP22795403.9
申请日：2022-03-25
申请人： Toagosei Co., Ltd.
发明人： BAILEYKOBAYASHI, Nahoko , YOSHIDA, Tetsuhiko
IPC分类号： C07K7/08 , C12N5/16 , C12N15/63 , C12N15/87
摘要： The present disclosure provides an artificially synthesized peptide fragment capable of efficiently introducing a target foreign substance from outside a eukaryotic cell into at least the cytoplasm of the cell. A peptide fragment disclosed herein is for introducing a target foreign substance from outside a eukaryotic cell into at least the cytoplasm of the cell, the peptide fragment being configured such that two or more of amino acid sequences VVKSLVK (SEQ ID NO: 1) are arranged in series, and another amino acid residue is not included between the amino acid sequences or a peptide linker composed of 1 to 5 amino acid residues is interposed between the amino acid sequences.

3. 发明公开

EP4124621A1 CARRIER PEPTIDE FRAGMENT FOR NUCLEOLAR LOCALIZATION AND USE THEREOF 审中-实审
公开(公告)号：EP4124621A1
公开(公告)日：2023-02-01
申请号：EP22187370.6
申请日：2022-07-28
申请人： Toagosei Co., Ltd.
发明人： BAILEYKOBAYASHI, Nahoko , YOSHIDA, Tetsuhiko
IPC分类号： C07K7/08 , C12N9/12
摘要： According to the present disclosure, a technology for efficiently introducing a desired foreign substance from the outside of eukaryotic cells into at least the cytoplasm (and the nucleolus) of the cells is provided. A method disclosed here includes (1) a step of preparing a construct for introducing a foreign substance including a carrier peptide fragment composed of any of amino acid sequences: KKRTLRKKKRKKR, KKRTLRKRRRKKR, KKRTLRKRKRKKR and KKRTLRKKRRKKR, and a foreign substance that is bound to an N-terminal side and/or C-terminal side of the carrier peptide fragment, (2) a step of supplying the construct for introducing a foreign substance to a sample containing desired eukaryotic cells, and (3) a step of incubating the sample to which the construct for introducing a foreign substance is supplied and introducing the construct into eukaryotic cells in the sample.

4. 发明公开

EP4393947A1 ANTI-PD-1 SIGNAL PEPTIDE ANTIBODY AND USE THEREOF 审中-公开
公开(公告)号：EP4393947A1
公开(公告)日：2024-07-03
申请号：EP22861170.3
申请日：2022-08-15
申请人： Toagosei Co., Ltd.
发明人： BAILEYKOBAYASHI, Nahoko , YOSHIDA, Tetsuhiko
IPC分类号： C07K16/18 , C07K14/47
CPC分类号： C07K14/47 , C07K16/18
摘要： The present disclosure provides an antibody capable of suppressing proliferation of tumor cells. The antibody disclosed herein includes signal peptide of PD-1 (Programmed cell death-1) consisting of an amino acid sequence: MQIPQAPWPVVWAVLQLGWRPGW (SEQ ID NO: 1) as an antigen.

5. 发明公开

EP3159354A1 NOVEL SYNTHETIC PEPTIDE AND USE THEREOF 有权转让
标题翻译：神经系统综合症
公开(公告)号：EP3159354A1
公开(公告)日：2017-04-26
申请号：EP15811420.7
申请日：2015-06-22
申请人： Toagosei Co., Ltd. , Keio University , National University Corporation Nagoya University
发明人： YOSHIDA, Tetsuhiko , BAILEYKOBAYASHI, Nahoko , NIWA, Mikio , KUDO, Jun , IZUMIYAMA Tomohiro , SAWADA Makoto
IPC分类号： C07K7/06 , A61K38/00 , A61P43/00 , C07K14/00 , C12N5/0735
摘要： Provided are a synthetic peptide that induces the reprogramming of a differentiated cell, a reprogramming-inducing pharmaceutical composition that contains this synthetic peptide, and a method for producing an undifferentiated cell from a differentiated cell using this synthetic peptide. The peptide provided by the present invention is a synthetic peptide having a reprogramming-inducing peptide sequence formed of the amino acid sequence given by SEQ ID NO: 1 or a modified amino acid sequence thereof. The method for producing an undifferentiated cell provided by the present invention includes inducing the reprogramming of a target cell by culturing a cell culture which contains the target cell and to which the synthetic peptide has been supplied.
摘要翻译：提供诱导分化细胞重编程的合成肽，含有该合成肽的重编程诱导药物组合物，以及使用该合成肽从分化细胞产生未分化细胞的方法。由本发明提供的肽是具有由SEQ ID NO：1所示的氨基酸序列或其修饰的氨基酸序列形成的重编程诱导肽序列的合成肽。本发明提供的未分化细胞的制造方法包括通过培养含有靶细胞的细胞培养物诱导靶细胞的重新编程，并且向其提供合成肽。

6. 发明授权

EP3088415B1 METHOD FOR INDUCING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO ENDODERMAL CELLS 有权
公开(公告)号：EP3088415B1
公开(公告)日：2019-11-06
申请号：EP14873237.3
申请日：2014-12-24
申请人： Toagosei Co., Ltd.
发明人： TANAKA, Kenichi , YOSHIDA, Tetsuhiko , BAILEYKOBAYASHI, Nahoko
IPC分类号： C07K14/47 , C12N5/0735 , C12N5/10

7. 发明授权

EP3159354B1 NOVEL SYNTHETIC PEPTIDE AND USE THEREOF 有权转让
公开(公告)号：EP3159354B1
公开(公告)日：2020-09-09
申请号：EP15811420.7
申请日：2015-06-22
申请人： Toagosei Co., Ltd. , Keio University , National University Corporation Nagoya University
发明人： YOSHIDA, Tetsuhiko , BAILEYKOBAYASHI, Nahoko , NIWA, Mikio , KUDO, Jun , IZUMIYAMA Tomohiro , SAWADA Makoto
IPC分类号： C07K7/06 , A61K38/00 , A61P43/00 , C07K14/00 , C12N5/0735

8. 发明公开

EP3604345A1 ANTITUMOR PEPTIDE HAVING PD-1 SIGNAL SEQUENCE AND UTILIZATION THEREOF 有权转让
公开(公告)号：EP3604345A1
公开(公告)日：2020-02-05
申请号：EP18776014.5
申请日：2018-03-27
申请人： Toagosei Co., Ltd. , National University Corporation Nagoya University
发明人： SAWADA, Makoto , BAILEYKOBAYASHI, Nahoko , YOSHIDA, Tetsuhiko
IPC分类号： C07K19/00 , A61K38/16 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/705
摘要： Provide is an artificially synthesized antitumor peptide that may suppress proliferation of tumor cells. The peptide provided is a synthetic peptide that contains both (1) an amino acid sequence that forms a signal peptide of a membrane protein, programmed cell death-1 (PD-1), or a modified amino acid sequence thereof in which 1, 2 or 3 amino acid residues deleted from, substituted in or added to the above amino acid sequence; and (2) an amino acid sequence that serves as a cell penetrating peptide (CPP), and wherein the synthetic peptide comprises a total of 100 or fewer amino acid residues.

9. 发明公开

EP3088415A1 METHOD FOR INDUCING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO ENDODERMAL CELLS 有权
标题翻译： VERFAHREN ZUR INDUZIERUNG DER DIFFERENZIERUNG PLURIPOTENTER STAMMZELLEN BEI ENDODERMALENEN ZELLEN
公开(公告)号：EP3088415A1
公开(公告)日：2016-11-02
申请号：EP14873237.3
申请日：2014-12-24
申请人： Toagosei Co., Ltd.
发明人： TANAKA, Kenichi , YOSHIDA, Tetsuhiko , BAILEYKOBAYASHI, Nahoko
IPC分类号： C07K14/47 , C12N5/0735 , C12N5/10
摘要： Provided are a synthetic peptide having a stem cell differentiation-inducing activity to induce differentiation of pluripotent stem cells into endodermal cells, a stem cell differentiation inducer having this peptide as an active ingredient, and a method for inducing differentiation of pluripotent stem cells using these. The synthetic peptide provided by the present invention contains a stem cell differentiation-inducing peptide sequence, and this stem cell differentiation-inducing peptide sequence is selected from an amino acid sequence constituting a signal peptide in any of amyloid precursor proteins (APP), amyloid precursor-like protein (APLP) 1 and APLP2, which are known as proteins belonging to the APP family, a partial amino acid sequence an amino acid sequence constituting this signal peptide, or a modified amino acid sequence formed by substitution, deletion and/or addition of 1, 2 or 3 amino acid residues in these amino acid sequences.
摘要翻译：提供了具有诱导多能干细胞分化为内胚层细胞的干细胞分化诱导活性的合成肽，具有该肽作为活性成分的干细胞分化诱导剂，以及使用这些肽诱导多能干细胞分化的方法。由本发明提供的合成肽含有干细胞分化诱导肽序列，该干细胞分化诱导肽序列选自淀粉样蛋白前体蛋白（APP），淀粉样蛋白前体蛋白（APLP）1和APLP2，其被称为属于APP家族的蛋白质，部分氨基酸序列构成该信号肽的氨基酸序列，或通过取代，缺失和/或添加形成的修饰的氨基酸序列在这些氨基酸序列中有1,2或3个氨基酸残基。

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